Clinical and experimental rheumatology最新文献_第5页

Novel use of abrocitinib in refractory ulcerative panniculitis with vasculitis: a case report. 阿布替尼在难治性溃疡性全身炎合并血管炎中的新应用：1例报告。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/13rf0m

Sheng Qiu, Zhenhua Ying

引用次数: 0

The performance of histological criteria for IgG4-related disease in clinical practice. 临床实践中igg4相关疾病组织学标准的表现

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/peqyb4

Alojzija Hočevar, Aleš Grošelj, Gregor Hawlina, Matic Koželj, Andrej Škoberne, Jože Pižem, Vesna Jurčić

引用次数: 0

From pain catastrophising to multidimensional psychological distress: unravelling the complexity of difficult-to-treat psoriatic arthritis. 从疼痛灾难到多维心理困扰：揭开难治性银屑病关节炎的复杂性。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/2pmt67

Damiano Currado, Francesca Saracino, Francesco De Vincenzo, Francesca Trunfio, Annalisa Marino, Lyubomyra Kun, Erika Corberi, Ludovica Lamberti, Leonardo Frascà, Onorina Berardicurti, Marta Gatti, Marta Vomero, Roberto Giacomelli, Luca Navarini

{"title":"From pain catastrophising to multidimensional psychological distress: unravelling the complexity of difficult-to-treat psoriatic arthritis.","authors":"Damiano Currado, Francesca Saracino, Francesco De Vincenzo, Francesca Trunfio, Annalisa Marino, Lyubomyra Kun, Erika Corberi, Ludovica Lamberti, Leonardo Frascà, Onorina Berardicurti, Marta Gatti, Marta Vomero, Roberto Giacomelli, Luca Navarini","doi":"10.55563/clinexprheumatol/2pmt67","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/2pmt67","url":null,"abstract":"Objectives: Pain catastrophising (PC), a maladaptive cognitive response to pain, has been implicated in poor outcomes in inflammatory arthritis, but its relationship with psoriatic arthritis difficult-to-treat (D2T) remains underexplored. This study aimed to investigate how the D2T phenotype impacts pain catastrophising (PC) and its domains (helplessness, rumination, magnification), along with other psychosocial and functional dimensions in PsA patients.Methods: A cross-sectional study was conducted in a cohort of 182 PsA patients. Clinical and psychosocial data were collected, including Disease Activity for Psoriatic Arthritis (DAPSA), Minimal Disease Activity (MDA), Pain Catastrophising Scale (PCS), HADS anxiety and HADS depression. Univariable and multivariable regressions were used to evaluate psychometric variables associated with D2T.Results: Univariable analysis showed a significant association between high PCS scores and D2T status. Multivariable models, adjusted for age, sex, disease duration, BMI, fibromyalgia, and disease activity, confirmed this relationship (b=7.637, 95% CI 3.261-12.014, p=0.001), specifically with PCS' dimensions helplessness and rumination, but not magnification. Additionally, D2T predicted higher HADS anxiety scores, while its association with HADS depression was not statistically significant.Conclusions: Our results indicate that D2T status remains a significant predictor of PC, even when controlling for relevant clinical characteristics, including fibromyalgia and disease activity, highlighting the intricate relationship between D2T PsA and psychological dimensions, which may exacerbate disease burden and hinder treatment targets.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritenon extensor tendon inflammation at metacarpophalangeal joints level: a valuable ultrasound finding in the differential diagnosis between psoriatic arthritis and rheumatoid arthritis? 掌指关节水平的腹膜伸肌腱炎症：银屑病关节炎和类风湿关节炎鉴别诊断中的一个有价值的超声发现？

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/b90gug

Tadashi Okano, Marco Di Carlo, Fausto Salaffi, Emilio Filippucci

{"title":"Peritenon extensor tendon inflammation at metacarpophalangeal joints level: a valuable ultrasound finding in the differential diagnosis between psoriatic arthritis and rheumatoid arthritis?","authors":"Tadashi Okano, Marco Di Carlo, Fausto Salaffi, Emilio Filippucci","doi":"10.55563/clinexprheumatol/b90gug","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/b90gug","url":null,"abstract":"Objectives: Ultrasound (US) detection of peritenon extensor tendon inflammation (PTI) was found highly specific for spondyloarthropathies (SpA), including psoriatic arthritis (PsA). However, this finding has not been extensively investigated. This study aimed to investigate the value of PTI at metacarpophalangeal (MCP) joint level in the differential diagnosis between rheumatoid arthritis (RA) and PsA, and analyse the differences between early (less than 1 year of disease duration) and established (more than 1 year of disease duration) disease groups.Methods: Consecutive RA and PsA patients with clinical involvement of at least one MCP joint were enrolled. The 2nd to the 5th MCP joints of both hands were scanned on the dorsal aspect to detect intra-articular and peri-tendinous inflammatory findings using both B-mode and power Doppler (PD) mode.Results: The study included a total of 69 patients, 37 patients with RA and 32 patients with PsA. PTI was found in a significantly higher number of patients with PsA rather than in RA patients. Conversely, there was no statistical difference in terms of PTI prevalence between RA and PsA patients in the early disease groups. On the other hand, no statistically significant difference was found in terms of synovitis prevalence between RA and PsA patients.Conclusions: PTI was found more frequently in PsA rather than in RA patients. Nevertheless, since no statistically significant difference was found between RA and PsA patients with less than 1 year of disease duration, PTI may represent an inflammatory feature of the early phases of both the diseases.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-CD19 chimeric antigen receptor T cell therapy achieved rapid and sustained remission in a patient with systemic lupus erythematosus-associated refractory immune thrombocytopenia. 抗cd19嵌合抗原受体T细胞治疗在系统性红斑狼疮相关难治性免疫性血小板减少症患者中实现了快速和持续的缓解。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/pn0yyk

Xuan Zhao, Lei Zhang, Xiaoyu Zhang, Xiaojun Liu, Yinli Zhang, Yanfen Liu, Ximei Tian, Xueyan Men, Lulu Lv, Yi Feng, Junhong Song, Tan Xie, Shengyun Liu, Yi Zhang

引用次数: 0

Efficacy and glucocorticoid sparing of dupilumab in IgG4-related disease: a case series and literature review. dupilumab在igg4相关疾病中的疗效和糖皮质激素节约：病例系列和文献综述

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-31 DOI: 10.55563/clinexprheumatol/nui493

Flora Finet, Lucile Sesé, Sébastien Abad, Ondine Walter, Chantal Raherison-Semjen, Achille Aouba, Marine Trenec, Alban Deroux, Nicolas Schleinitz, Benjamin Terrier, Robin Dhôte

{"title":"Efficacy and glucocorticoid sparing of dupilumab in IgG4-related disease: a case series and literature review.","authors":"Flora Finet, Lucile Sesé, Sébastien Abad, Ondine Walter, Chantal Raherison-Semjen, Achille Aouba, Marine Trenec, Alban Deroux, Nicolas Schleinitz, Benjamin Terrier, Robin Dhôte","doi":"10.55563/clinexprheumatol/nui493","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/nui493","url":null,"abstract":"Objectives: IgG4-related disease (IgG4-RD) is a multisystem fibro-inflammatory disorder for which glucocorticoids (GC) represent the initial therapeutic intervention. Second-line treatments are not currently codified. The use of dupilumab, an inhibitor of interleukin (IL)-4 and IL-13 signalling, has recently been described as a potential alternative treatment. The aim of this study was to describe the characteristics of patients IgG4-RD treated with dupilumab and to evaluate its impact on disease control.Methods: We conducted a French multicentre retrospective study based on standardised questionnaires distributed to physicians via professional networks. The patients included had to meet 2019 ACR/EULAR criteria or the comprehensive diagnostic criteria for IgG4-RD, and to have been treated with dupilumab. Efficacy was assessed using the IgG4-Related Disease Responder Index.Results: A total of seven patients were included in the study. The rationale for initiating dupilumab was based on the presence of severe asthma, nasosinusal polyps and/or atopic dermatitis. A complete response was observed in three patients, while four patients displayed a partial response. In all cases, GC sparing was achieved. A review of the literature revealed nine out of the ten cases reported where a partial or complete reduction of the disorder was documented, along with GC sparing.Conclusions: These preliminary findings need to be confirmed, but may offer arguments in favour of a possible efficacy of dupilumab in the treatment of IgG4-RD.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung involvement in psoriatic arthritis patients: cross-sectional study on prevalence, clinical characteristics, and risk factors of a neglected comorbidity. 银屑病关节炎患者肺部受累：一种被忽视的合并症的患病率、临床特征和危险因素的横断面研究

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-30 DOI: 10.55563/clinexprheumatol/iqfq8c

Benedetta Monosi, Ilaria Cristiano, Eugenio Capparelli, Andrea Cito, Paola Conigliaro, Gemma Lepri, Serena Guiducci, Ermanno Puxeddu, Paola Rogliani, Florenzo Iannone, Giuseppe Lopalco, Maria Sole Chimenti

{"title":"Lung involvement in psoriatic arthritis patients: cross-sectional study on prevalence, clinical characteristics, and risk factors of a neglected comorbidity.","authors":"Benedetta Monosi, Ilaria Cristiano, Eugenio Capparelli, Andrea Cito, Paola Conigliaro, Gemma Lepri, Serena Guiducci, Ermanno Puxeddu, Paola Rogliani, Florenzo Iannone, Giuseppe Lopalco, Maria Sole Chimenti","doi":"10.55563/clinexprheumatol/iqfq8c","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/iqfq8c","url":null,"abstract":"Objectives: We aimed to assess lung involvement in patients with psoriatic arthritis (PsA), hypothesising that lung diseases (LDs) represent a distinct comorbidity of PsA and that the association between these two conditions is not merely coincidental.Methods: Cross-sectional study of 322 patients with a diagnosis of PsA from three Italian centres. Each patient underwent a chest high-resolution CT prior to the start of a biological DMARDs. After pneumologists' evaluation, patients were divided into three groups [chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), and non-LD]. Univariate and multivariate statistical analysis were performed to analyse demographic and clinical characteristics of the total cohort and to compare disease characteristics between PsA patients with and without lung involvement.Results: COPD was diagnosed in 39 patients (12.1%) and ILD in 27 patients (8.4%). The inflammatory burden [DAPSA>14 (OR 4.3, p.adj=0.03), swollen joint count (SJC)>3 (OR 3.2, p.adj=0.02), PASI>10 (OR 3.6, p.adj=0.008), BMI ≥30 (OR 3, p.adj=0.04)] emerged as the most important risk factor for COPD development in PsA patients. This association was weaker in patients with ILD and PsA, since just SJC emerged as a risk factor for ILD development [SJC>3 (OR 3, p.adj=0.04)]. Old age (≥65 years) increased the risk of COPD by up to 9.6 times (p.adj=0.004) and ILD by up to 7.6 times (p.adj=0.04).Conclusions: Our data support the hypothesis of a correlation between PsA and LDs highlighting that non-traditional risk factors may contribute to the development of LDs in PsA patients, especially in cases of uncontrolled, active articular disease.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polypharmacy and comorbidities are not higher at diagnosis in patients with polymyalgia rheumatica compared to osteoarthritis. 与骨关节炎相比，风湿性多肌痛患者的多药性和合并症在诊断时并不高。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-30 DOI: 10.55563/clinexprheumatol/z9264f

Marco Amedeo Cimmino, Dario Camellino, Paolo Vittorio Clini, Maurizio Cutolo, Elvis Hysa

{"title":"Polypharmacy and comorbidities are not higher at diagnosis in patients with polymyalgia rheumatica compared to osteoarthritis.","authors":"Marco Amedeo Cimmino, Dario Camellino, Paolo Vittorio Clini, Maurizio Cutolo, Elvis Hysa","doi":"10.55563/clinexprheumatol/z9264f","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/z9264f","url":null,"abstract":"Objectives: Polypharmacy, the prescription of multiple drugs for an individual patient, is increasing in ageing individuals with comorbidities. In polymyalgia rheumatica (PMR), an inflammatory disease of the elderly causing pain and stiffness in the girdles, cardiovascular disease and lymphoproliferative disorders could be increased. Our study evaluated polypharmacy and comorbidities in PMR patients at diagnosis.Methods: Patients fulfilling the 2012 EULAR/ACR criteria for PMR and sex and age-matched controls with hand osteoarthritis (OA) were evaluated. The Rheumatic Diseases Comorbidity Index (RDCI) was used.Results: 84 PMR patients (mean age 73.4±9 years, 65.1% women) and 84 controls (mean age 72.4±8.2, 65.1% women) were studied. The mean number of drugs assumed by PMR patients was 2.7±2.3 versus 3.1±2.5 of controls (p=0.168). Sixteen PMR patients versus 5 controls had no treatment, 56 vs. 67 took 1-5 drugs, and 12 versus 12 >5 drugs (p=0.03). PMR patients with hip pain assumed less drugs (p=0.008) and those with morning stiffness (MS) >45 minutes assumed more drugs (p=0.001). The mean RDCI was 1.56±1.29 in PMR patients and 1.51±1.38 in controls (p=0.62). The number of drugs assumed and RDCI significantly correlated (p<0.001), and both were directly associated with age (p<0.001). At multiple logistic regression, age (p=0.004) and MS (p=0.025) directly, whereas hip pain (p=0.008) and fever (p=0.015) indirectly predicted number of drugs assumed. Age (p<0.001) and white blood cells (p=0.011) directly, whereas fever (p=0.024) indirectly predicted RDCI.Conclusions: At the time of diagnosis, PMR patients do not show an increased comorbidity index nor number of drugs assumed compared to OA controls.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the 'risk': Comments on the FAERS data regarding the safety of JAK inhibitors by Mikaeili et al. 探索“风险”：对Mikaeili等人关于JAK抑制剂安全性的FAERS数据的评论。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-15 DOI: 10.55563/clinexprheumatol/9m9nbq

Emre Bilgin

引用次数: 0

Comment on: Beyond diagnosis: exploring the significance of IgG4+ plasma cell count through immunostaining in IgG4-related disease. 点评：超越诊断：通过免疫染色探讨IgG4+浆细胞计数在IgG4相关疾病中的意义。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-14 DOI: 10.55563/clinexprheumatol/fr0v5l

Ming-Wei Chiang, Po-Chang Wu

引用次数: 0