Clinical & Experimental Metastasis最新文献

{"title":"All-site radiotherapy for metastatic ewing's sarcoma: a short-term analysis of feasibility, response, and safety.","authors":"YuanYou Yang, Lu Xie, Xin Sun, Jie Xu, Gang Ren","doi":"10.1007/s10585-026-10406-0","DOIUrl":"https://doi.org/10.1007/s10585-026-10406-0","url":null,"abstract":"<p><strong>Background: </strong>Metastatic Ewing sarcoma (EWS) has a poor prognosis. While metastasis-directed therapy benefits oligometastatic disease, the role of comprehensive all-site radiotherapy in widespread disease remains underexplored. This study aimed to preliminarily assess its short-term efficacy and safety.</p><p><strong>Methods: </strong>This retrospective analysis included 21 consecutive metastatic EWS patients treated with helical tomotherapy (Aug 2024-Jun 2025). All known metastases and unresected primary tumors received radiotherapy (45-55 Gy in 20 fractions for most sites; 12-45 Gy for lung/pleural metastases). Concurrent systemic therapies included chemotherapy, tyrosine kinase inhibitors (TKIs), immune checkpoint inhibitors (ICIs), or combinations. Primary endpoints were local objective response rate (ORR, RECIST 1.1) at 2 months post-radiotherapy and acute toxicity (CTCAE 5.0). Systemic therapy subgroup analyses were exploratory.</p><p><strong>Results: </strong>Median follow-up was 6 months (range 2-11). Among 77 target lesions, ORR was 61.0% (CR 48.1%), and disease control rate (DCR) was 97.4%. Soft tissue lesions had a significantly higher CR rate than bone metastases (78.3% vs 3.2%, p < 0.001), potentially influenced by RECIST 1.1 limitations and treatment heterogeneity. Median progression-free survival (PFS) was 6.0 months (95% CI: 2.30-9.70), and median overall survival (OS) was 8.0 months (95% CI: 6.69-9.31). Combination systemic therapy was associated with improved PFS (HR 3.94, 95%CI 1.32-11.78; p = 0.014), with chemotherapy-based regimens yielding the best PFS (8.5 months). TKI-containing regimens were linked to shorter PFS (4.0 vs 8.5 months, p = 0.048) due to selection bias. Acute toxicity was manageable, with grade 3 thrombocytopenia (19.0%) and pneumonitis (4.7%) resolving with treatment.</p><p><strong>Conclusion: </strong>All-site radiotherapy achieves promising short-term local control with manageable toxicity in metastatic EWS, demonstrating feasibility and a lesion site-specific response warranting further investigation. Systemic therapy, particularly chemotherapy, correlates with improved PFS. Given high systemic progression rates, long-term outcomes may benefit from integration with more effective systemic therapies, supporting future prospective trials.</p>","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXM1 expression is induced by the brain microenvironment and supports CRC brain metastatic adaptation.","authors":"Fayhaa Khair, Inbal Greenberg, Sivan Fuchs, Guy Shapira, Asia Zubkov, Noam Shomron, Michal Raz, Ido Wolf, Tami Rubinek","doi":"10.1007/s10585-026-10397-y","DOIUrl":"https://doi.org/10.1007/s10585-026-10397-y","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redox processes in the treatment of advanced skin cancers.","authors":"Celine Gergele, Julia Berner, Sander Bekeschus","doi":"10.1007/s10585-026-10404-2","DOIUrl":"https://doi.org/10.1007/s10585-026-10404-2","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance-guided stereotactic body radiotherapy (MRIgSBRT) for nodal disease in oligometastatic setting: a single-institution study.","authors":"Giuditta Chiloiro, Giulia Panza, Angela Romano, Rosa Autorino, Ciro Mazzarella, Gabriele Turco, Marco Valerio Antonelli, Matteo Nardini, Simone Raggio, Lorenzo Placidi, Maria Antonietta Gambacorta, Luca Boldrini","doi":"10.1007/s10585-026-10407-z","DOIUrl":"https://doi.org/10.1007/s10585-026-10407-z","url":null,"abstract":"<p><p>We evaluated the feasibility and clinical outcomes of MRIgSBRT for nodal recurrence in the oligometastatic disease (OMD) setting, focusing on per-lesion outcomes and prognostic factors. We collected clinical and dosimetric data from a retrospective single-center cohort of patients treated with a 0.35 T MRIgSBRT for nodal recurrences. Endpoints included the 1-year progression-free survival (PFS), local progression-free survival (LPFS), and 3-year overall survival (OS) rate from recurrence. Per-lesion Kaplan-Meier and Cox regression assessed clinical, dosimetric, and technical predictors. 71 patients received nodal MRIgSBRT, with a total of 115 treated metastatic lesions. Local control was high: LPFS 95.5% at 12 months and 94.0% at 24/36 months. OS was favorable (100% at 12 months, 97.2% at 24 months, 95.3% at 36 months). Systemic progression drove most events: PFS 52.6% at 12 months and 24.4% at 24 months; median 12.4 months. No clinically relevant acute or late toxicity was observed. On multivariable analysis, BED₁₀ ≥ 70 Gy was independently associated with improved OS. Multiple metastases increased the risk of local failure in univariate analysis (UVA) (HR 6.30, p = 0.027). MRIgSBRT represents a safe and viable treatment option in nodal oligometastatic setting. It provides excellent and durable local control with minimal toxicity. As distant progression remains the main challenge, careful selection in low-burden disease, dose escalation to BED₁₀ ≥ 70 Gy, and thoughtful integration with systemic therapy emerge as key levers to optimize outcomes. Further prospective studies are needed to assess OMD long-term survival and quality of life and to evaluate possible further treatment optimization strategies.</p>","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nal-IRI (liposomal irinotecan) plus 5-fluorouracil and leucovorin versus 5-fluorouracil for metastatic pancreatic ductal adenocarcinoma following gemcitabine-based therapy. A systematic review and meta-analysis of randomized controlled trials.","authors":"Elsa Vitale, Alessandro Rizzo, Lorenza Maistrello, Angela Monica Sciacovelli, Raffaele De Luca, Anna Albano, Annarita Fanizzi, Raffaella Massafra, Claudio Lotesoriere, Gennaro Gadaleta-Caldarola, Salvatore Pisconti, Oronzo Brunetti","doi":"10.1007/s10585-026-10401-5","DOIUrl":"https://doi.org/10.1007/s10585-026-10401-5","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147580665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulated histopathological growth pattern of colorectal liver metastases predicts prolonged survival after repeat liver resection for recurrence.","authors":"Naoki Matsuyama, Takanori Konishi, Tsukasa Takayashiki, Shigetsugu Takano, Daisuke Suzuki, Nozomu Sakai, Isamu Hosokawa, Takashi Mishima, Hitoe Nishino, Kensuke Suzuki, Shinichiro Nakada, Masayuki Ohtsuka","doi":"10.1007/s10585-026-10403-3","DOIUrl":"https://doi.org/10.1007/s10585-026-10403-3","url":null,"abstract":"<p><p>The encapsulated histopathological growth pattern (HGP) of colorectal liver metastases (CRLMs) has been reported as a favorable prognostic factor. However, its prognostic relevance in patients undergoing treatment for recurrence after liver resection remains unclear. This study aimed to evaluate the impact of encapsulated HGP on time to surgical failure (TSF) following liver resection, and to assess whether encapsulated HGP at initial resection is associated with outcomes after repeat resection for recurrence. We retrospectively analyzed 272 patients who underwent initial liver resection for CRLMs. HGPs were classified and their associations with postoperative outcomes were examined. 61 patients were classified as having encapsulated HGP. Patients with encapsulated HGP had significantly longer TSF after liver resection than those with non-encapsulated HGP (p < 0.01). Multivariate analysis identified encapsulated HGP as an independent factor for improved TSF (Hazard ratio: 0.35, p < 0.01). Recurrence occurred less frequently in encapsulated HGP than in non-encapsulated HGP (63.9% vs 79.2%, p = 0.02). In addition, patients with encapsulated HGP had a lower incidence of multi-organ recurrence and a higher repeat resection rate for recurrence (64.1% vs 45.6%, p < 0.01). Among patients with repeat liver resection for recurrent CRLMs, post-recurrence survival was significantly longer in encapsulated HGP than in non-encapsulated HGP (p = 0.01) and encapsulated HGP at initial resection was identified as an independent factor of favorable survival after repeat liver resection (Hazard ratio: 0.09, p = 0.04). Encapsulated HGP was associated with improved TSF following liver resection for CRLMs. HGPs at initial resection may predict survival after repeat liver resection for recurrent CRLMs.</p>","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of response in lung metastases treated by sbrt from colon rectal cancer.","authors":"Donatella Caivano, D Pezzulla, P Bonome, F Palmeri, C Scaringi, M Valeriani, D Musio, V de Sanctis, M F Osti","doi":"10.1007/s10585-026-10402-4","DOIUrl":"https://doi.org/10.1007/s10585-026-10402-4","url":null,"abstract":"<p><strong>Purpose: </strong>To identify predictive factors of response in patients with lung metastases from primary colorectal cancer (CRC) treated with stereotactic body radiation therapy (SBRT). This retrospective, single-centre study included patients with histologically confirmed primary CRC, Karnofsky performance status > 60, and age > 18 years. Between 2008 and 2023, 149 lung metastases in 88 patients were treated with SBRT. Among the treated lesions, 23 were synchronous and 126 were metachronous. According to a simplified oligometastatic classification, 9 (6%) were synchronous, 57 (38%) oligorecurrent, 76 (51%) oligoprogressive, and 7 (5%) oligopersistent. Local control (LC) at 1 and 2 years was 76.8% and 64.0%, respectively. Time to polymetastatic conversion (tPMC) at 1 and 2 years was 76.0% and 73.0%. Progression-free survival (PFS) at 1 and 2 years was 76.0% and 73.0%. Overall survival (OS) at 1 and 2 years was 80.7% and 53.0%. On multivariate analysis (MVA), lesion diameter < 16 mm was the only statistically significant favorable prognostic factor for LC. No statistically significant prognostic factors were identified for tPMC or PFS on MVA. For OS, ECOG performance status 0 and female sex were the only statistically significant favorable prognostic factors on MVA. No toxicities ≥ grade 3 were reported. Outcomes and prognostic factors reported herein refer to the present single-centre cohort. In this cohort, SBRT was feasible and was associated with acceptable toxicity and encouraging local control in lung metastases from CRC. Further studies are needed to better define predictive factors and support tailored therapeutic strategies.</p>","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC01996 suppresses non-small cell lung cancer proliferation and metastasis by orchestrating the miR-12115/CNRIP1/Ras signaling axis.","authors":"Yi Zhang, Xiaojing Li, Shanshan Liu, Qian Xue, Peize Meng, Xiaolu Ge, Qingnan Zhao, Haitao Ma","doi":"10.1007/s10585-026-10399-w","DOIUrl":"10.1007/s10585-026-10399-w","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic ablative radiotherapy: an effective alternative for pancreatic metastases originating from renal cell carcinoma-experience from two European institutions.","authors":"Maria Ausilia Teriaca, Deesje Doppenberg, Tiziana Comito, Rodrigo Cartes, Lorenzo Lo Faro, Enrico Pozzo, Veronica Vernier, Ciro Franzese, Anna M E Bruynzeel, Marta Scorsetti","doi":"10.1007/s10585-026-10400-6","DOIUrl":"https://doi.org/10.1007/s10585-026-10400-6","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of tumor-derived extracellular vesicles in the establishment of the pre-metastatic niche: lessons learned from past experimentations and future directions.","authors":"Laurence Blavier, Andjela Crnjac, Yves A DeClerck","doi":"10.1007/s10585-026-10396-z","DOIUrl":"10.1007/s10585-026-10396-z","url":null,"abstract":"","PeriodicalId":10267,"journal":{"name":"Clinical & Experimental Metastasis","volume":"43 2","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12967406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147372284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}