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FINEARTS-HF: Improving outcomes in heart failure with preserved or mildly reduced ejection fraction. finhearts - hf：改善心力衰竭患者射血分数保留或轻度降低的结局。
IF 5.2 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-05-01 DOI: 10.3949/ccjm.93a.25081
Salman Salahuddin
{"title":"FINEARTS-HF: Improving outcomes in heart failure with preserved or mildly reduced ejection fraction.","authors":"Salman Salahuddin","doi":"10.3949/ccjm.93a.25081","DOIUrl":"10.3949/ccjm.93a.25081","url":null,"abstract":"<p><p>The FINEARTS-HF (Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure, N Engl J Med 2024; 391(16):1475-1485) trial evaluated finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in patients with left ventricular ejection fraction 40% or greater. Finerenone reduced the composite risk of hospitalization for heart failure or cardiovascular death by 16% relative to placebo (rate ratio 0.84, <i>P</i> = .007), primarily by lowering admissions for heart failure. Finerenone is the first mineralocorticoid receptor antagonist to improve outcomes in this patient population.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 5","pages":"273-277"},"PeriodicalIF":5.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'All that wheezes is not asthma'-a reminder that the physical examination. “所有的呼哧呼哧声都不是哮喘”——这提醒我们，身体检查。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93b.04026
Brian F Mandell
{"title":"'All that wheezes is not asthma'-a reminder that the physical examination.","authors":"Brian F Mandell","doi":"10.3949/ccjm.93b.04026","DOIUrl":"https://doi.org/10.3949/ccjm.93b.04026","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"193-195"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply: Finding the cause of severe hypokalemia. 回复：寻找严重低钾血症的原因。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93c.04002
Enmanuel A Leiva-Murillo, Erwin Bechtold-Javier, Pol Candela-Parrilla, Ana Matas-García
{"title":"In Reply: Finding the cause of severe hypokalemia.","authors":"Enmanuel A Leiva-Murillo, Erwin Bechtold-Javier, Pol Candela-Parrilla, Ana Matas-García","doi":"10.3949/ccjm.93c.04002","DOIUrl":"https://doi.org/10.3949/ccjm.93c.04002","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"198"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Palatal mass with an overlying white lesion. 腭部肿块，上覆白色病变。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.25050
Takuma Watanabe
{"title":"Palatal mass with an overlying white lesion.","authors":"Takuma Watanabe","doi":"10.3949/ccjm.93a.25050","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25050","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"199-200"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treating perinatal mood and anxiety disorders: A call to action. 治疗围产期情绪和焦虑障碍：行动呼吁。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.26002
Lulu Zhao
{"title":"Treating perinatal mood and anxiety disorders: A call to action.","authors":"Lulu Zhao","doi":"10.3949/ccjm.93a.26002","DOIUrl":"https://doi.org/10.3949/ccjm.93a.26002","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"207-209"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical application of the complement system: A historical perspective. 补体系统的临床应用：一个历史的视角。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.26014
Adam J Brown
{"title":"Clinical application of the complement system: A historical perspective.","authors":"Adam J Brown","doi":"10.3949/ccjm.93a.26014","DOIUrl":"https://doi.org/10.3949/ccjm.93a.26014","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"237-239"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpreting the DIGIT-HF trial: Time for a new look at digitalis? 解读DIGIT-HF试验：是时候重新审视洋地黄了？
IF 5.2 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.25098
Enmanuel A Leiva-Murillo, Oriol Ventosa-Blázquez, Eduard Solé-González
{"title":"Interpreting the DIGIT-HF trial: Time for a new look at digitalis?","authors":"Enmanuel A Leiva-Murillo, Oriol Ventosa-Blázquez, Eduard Solé-González","doi":"10.3949/ccjm.93a.25098","DOIUrl":"10.3949/ccjm.93a.25098","url":null,"abstract":"<p><p>The DIGIT-HF (Digitoxin to Improve Outcomes in Patients With Advanced Chronic Heart Failure; N Engl J Med 2025; 393(12):1155-1165) trial compared digitoxin with placebo, added to guideline-directed medical therapy in patients with heart failure with reduced ejection fraction (HFrEF). Compared with placebo, digitoxin reduced the incidence of the composite endpoint of death from any cause or first hospitalization for worsening heart failure by 18% over a median follow-up of 36 months (hazard ratio 0.82, 95% confidence interval 0.69-0.98). There were no statistically significant differences in the rates of all-cause mortality, first hospitalization, or serious adverse events.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"218-226"},"PeriodicalIF":5.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement inhibition: A whole new world. 补体抑制：一个全新的世界。
IF 5.2 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.25076
Nicholas Salupo, Korey Bartolomeo, Elias Bassil, Corey Cavanaugh, Georges Nakhoul, Jonathan Taliercio, Ali Mehdi
{"title":"Complement inhibition: A whole new world.","authors":"Nicholas Salupo, Korey Bartolomeo, Elias Bassil, Corey Cavanaugh, Georges Nakhoul, Jonathan Taliercio, Ali Mehdi","doi":"10.3949/ccjm.93a.25076","DOIUrl":"10.3949/ccjm.93a.25076","url":null,"abstract":"<p><p>The complement system is a central component of the innate immune system, and it is a bridge to the adaptive immune system. With this broad functional reach, dysregulation of this system contributes to a wide range of inflammatory and autoimmune conditions. Drugs that inhibit the complement system have dramatically improved outcomes in many previously untreatable diseases, and the number of approved indications is growing rapidly, requiring specialists and generalists alike to be familiar with these drugs.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"227-236"},"PeriodicalIF":5.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options. 围产期抑郁症药物治疗的最新指南：了解药物选择。
IF 5.2 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93a.25052
Rebeca Ortiz Worthington, Zehra Aftab, Nicole Leong, Jason Alexander
{"title":"Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options.","authors":"Rebeca Ortiz Worthington, Zehra Aftab, Nicole Leong, Jason Alexander","doi":"10.3949/ccjm.93a.25052","DOIUrl":"10.3949/ccjm.93a.25052","url":null,"abstract":"<p><p>The 2023 American College of Obstetricians and Gynecologists (ACOG) guideline on perinatal mental health conditions recommends prescribing and titrating pharmacotherapy for perinatal depression, with the selective serotonin reuptake inhibitors sertraline and escitalopram as first-line medications for patients who have not previously taken any medications for mood disorders. A subsequent ACOG Clinical Practice Update addresses zuranolone for postpartum depression. The authors present an overview of the guideline's recommendations on pharmacotherapy for treating perinatal depression and summarize actionable recommendations for nonpsychiatric clinicians.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"201-205"},"PeriodicalIF":5.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding the cause of severe hypokalemia. 找到严重低钾血症的原因。
IF 4.1 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2026-04-01 DOI: 10.3949/ccjm.93c.04001
Philip S Mehler, Dennis Gibson
{"title":"Finding the cause of severe hypokalemia.","authors":"Philip S Mehler, Dennis Gibson","doi":"10.3949/ccjm.93c.04001","DOIUrl":"https://doi.org/10.3949/ccjm.93c.04001","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"198"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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