Chronic Respiratory Disease最新文献

{"title":"Comparison of peak expiratory Flow(PEF) and COPD assessment test (CAT) to assess COPD exacerbation requiring hospitalization: A prospective observational study.","authors":"Jie Cen,&nbsp;Lei Weng","doi":"10.1177/14799731221081859","DOIUrl":"https://doi.org/10.1177/14799731221081859","url":null,"abstract":"<p><strong>Background: </strong>Acute exacerbation of chronic obstructive pulmonary disease (COPD) resulting in hospitalization is significantly associated with the increased morbidity and mortality, but there is a lack of an effective method to assess it. This study aimed to compare the ability of peak expiratory flow (PEF) and COPD assessment test (CAT) to assess COPD exacerbations requiring hospitalization.</p><p><strong>Methods: </strong>A cohort of 110 patients with moderate to severe COPD was studied over a period of 12 months, and their daily morning PEFs and CAT scores were recorded throughout the study.</p><p><strong>Results: </strong>After 12 months of follow-up, 72 patients experienced 156 COPD exacerbations, 74 (47%) that resulted in hospitalization and 82 (53%) that did not result in hospitalization. Change in CAT score from baseline to exacerbation was significantly related to change in PEF and Spearman's rho =0.375 (95% CI, 0.227 to 0.506; p < .001). Change in PEF and CAT score from baseline to hospitalized exacerbation was significantly larger than that from baseline to non-hospitalized exacerbation (p < .05). Multivariable analysis indicated that ΔPEF (OR 1.11, 95% CI 1.06-1.16, p < .001) and ΔCAT (OR 1.64 95% CI 1.18-2.27, p = .003) were independently associated with risk of hospitalized exacerbation. ROC analysis indicated that the optimal cutoff value of ΔPEF for identifying hospitalized exacerbation was 49 L/min (27% from baseline), with a sensitivity and specificity of 82.7% and 76.7% (area under the curve [AUC] = 0.872 (95% CI 0.80-0.944, p < .05). The optimal cutoff value of ΔCAT score for identifying hospitalized exacerbation was 10.5 (63% from baseline), with a sensitivity and specificity of 67.3% and 77.4% [AUC]=0.763 (95% CI 0.67-0.857, p < .05). The AUC of ΔPEF and ΔCAT combined for the identification of hospitalized exacerbation was 0.900 (95% CI 0.841-0.959, p < .05), which was larger than that of ΔCAT or ΔPEF.</p><p><strong>Conclusions: </strong>ΔPEF and ΔCAT were independently associated with risk of hospitalized exacerbation. Compared with CAT, PEF was superior to identify hospitalized exacerbation. Identification via PEF and CAT combined is more effective than using PEF or CAT alone. These results help to assess the severity of COPD exacerbation and provide valuable information for clinical decision-making.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221081859"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/89/10.1177_14799731221081859.PMC8883293.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39669791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tidal volume expandability affected by flow, dynamic hyperinflation, and quasi-fixed inspiratory time in patients with COPD and healthy individuals.","authors":"Ming-Lung Chuang","doi":"10.1177/14799731221133390","DOIUrl":"https://doi.org/10.1177/14799731221133390","url":null,"abstract":"<p><p>Exertional dyspnea (ED) and impaired exercise performance (EP) are mainly caused by dynamic hyperinflation (DH) in chronic obstructive pulmonary disease (COPD) patients by constraining tidal volume expansion at peak exercise (V_Tpeak). As V_Tpeak is the product of inspiratory time (T_Ipeak) and flow (V_T/T_Ipeak), it was hypothesized that V_Tpeak and V_Tpeak/total lung capacity (V_Tpeak/TLC) may be affected by T_Ipeak and V_T/T_Ipeak. Hence, the study investigated the (1) effect of T_Ipeak and V_T/T_Ipeak on V_Tpeak expansion, (2) factors associated with T_Ipeak, expiratory time (T_Epeak), V_T/T_Ipeak, and V_Tpeak/TLC, and (3) relationships between V_T/T_Ipeak and V_Tpeak/TLC with ED and EP in COPD patients and controls. The study enrolled 126 male stable COPD patients and 33 sex-matched controls. At peak exercise, T_Ipeak was similar in all subjects (COPD versus controls, mean ± SD: 0.78 ± 0.17 s versus 0.81 ± 0.20 s, <i>p</i> = NS), whereas the COPD group had lower V_T/T_Ipeak (1.71 ± 0.49 L/s versus 2.58 ± 0.69 L/s, <i>p</i> < .0001) and thus the COPD group had smaller V_Tpeak (1.31 ± 0.34 L versus 2.01 ± 0.45 L,<i>p</i> < .0001) and V_Tpeak/TLC (0.22 ± 0.06 vs 0.33 ± 0.05, <i>p</i> < .0001). T_Ipeak, T_Epeak, and V_T/T_Ipeak were mainly affected by exercise effort, whereas V_Tpeak/TLC was not. T_Epeak, V_T/T_Ipeak, and V_Tpeak/TLC were inversely changed by impaired lung function. T_Ipeak was not affected by lung function. Dynamic hyperinflation did not occur in the controls, however, V_Tpeak/TLC was strongly inversely related to DH (r = -0.79) and moderately to strongly related to lung function, ED, and EP in the COPD group. There was a slightly stronger correlation between V_Tpeak/TLC with ED and EP than V_T/T_Ipeak in the COPD group (|r| = 0.55-0.56 vs 0.38-0.43). In summary, T_Ipeak was similar in both groups and the key to understanding how flow affects lung expansion. However, the DH volume effect was more important than the flow effect on ED and EP in the COPD group.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221133390"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/a1/10.1177_14799731221133390.PMC9549191.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33494153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and validating a chronic obstructive pulmonary disease quick screening questionnaire using statistical learning models.","authors":"Xiaoyue Wang,&nbsp;Hong He,&nbsp;Liang Xu,&nbsp;Cuicui Chen,&nbsp;Jieqing Zhang,&nbsp;Na Li,&nbsp;Xianxian Chen,&nbsp;Weipeng Jiang,&nbsp;Li Li,&nbsp;Linlin Wang,&nbsp;Yuanlin Song,&nbsp;Jing Xiao,&nbsp;Jun Zhang,&nbsp;Dongni Hou","doi":"10.1177/14799731221116585","DOIUrl":"https://doi.org/10.1177/14799731221116585","url":null,"abstract":"<p><strong>Background: </strong>Active targeted case-finding is a cost-effective way to identify individuals with high-risk for early diagnosis and interventions of chronic obstructive pulmonary disease (COPD). A precise and practical COPD screening instrument is needed in health care settings.</p><p><strong>Methods: </strong>We created four statistical learning models to predict the risk of COPD using a multi-center randomized cross-sectional survey database (<i>n</i> = 5281). The minimal set of predictors and the best statistical learning model in identifying individuals with airway obstruction were selected to construct a new case-finding questionnaire. We validated its performance in a prospective cohort (<i>n</i> = 958) and compared it with three previously reported case-finding instruments.</p><p><strong>Results: </strong>A set of seven predictors was selected from 643 variables, including age, morning productive cough, wheeze, years of smoking cessation, gender, job, and pack-year of smoking. In four statistical learning models, generalized additive model model had the highest area under curve (AUC) value both on the developing cross-sectional data set (AUC = 0.813) and the prospective validation data set (AUC = 0.880). Our questionnaire outperforms the other three tools on the cross-sectional validation data set.</p><p><strong>Conclusions: </strong>We developed a COPD case-finding questionnaire, which is an efficient and cost-effective tool for identifying high-risk population of COPD.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221116585"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/09/10.1177_14799731221116585.PMC9373185.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40594770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>The Recovery Journey</i> and <i>the Rehabilitation Boat</i> - A qualitative study to explore experiences of COVID-19 rehabilitation.","authors":"Charlotte Gerlis,&nbsp;Amy Barradell,&nbsp;Nikki Y Gardiner,&nbsp;Emma Chaplin,&nbsp;Amye Goddard,&nbsp;Sally J Singh,&nbsp;Enya Daynes","doi":"10.1177/14799731221114266","DOIUrl":"https://doi.org/10.1177/14799731221114266","url":null,"abstract":"<p><strong>Introduction: </strong>There are early data to suggest that a rehabilitation programme can help with on-going symptoms of COVID-19, including breathlessness, exercise limitation and fatigue. As yet, there are no published data to understand patients' perceived acceptability of a rehabilitation programme for COVID-19.</p><p><strong>Methods: </strong>2 focus groups (<i>n</i> = 9) and 4 one to one interviews were conducted with participants who attended a rehabilitation program following COVID-19. Interviews were analysed using reflexive thematic analysis with an inductive approach.</p><p><strong>Results: </strong>Two overarching themes were generated from the data. The first, The Recovery Journey is sub-divided into five sub-themes of Expectations, Individual and Varied Journeys, Mental and Physical Improvements, Self-values and The Journey Continues. The second overarching theme, The Rehabilitation boat contains five subthemes: Programme Delivery, Safe and Supportive, Validation and Assurance, Shared Reflections and Education.</p><p><strong>Conclusion: </strong>A rehabilitation programme for post COVID-19 symptoms was considered to be acceptable and viewed positively in terms of improving physical and mental symptoms. The opportunity to share the experience with others in the same boat was highly valued in the context of an unexpected and potentially lonely COVID-19 recovery.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221114266"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/39/73/10.1177_14799731221114266.PMC9297070.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40627256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of suspected poor bone health in people with chronic obstructive pulmonary disease - a cross-sectional exploratory study.","authors":"Erin Cecins,&nbsp;Vinicius Cavalheri,&nbsp;Dennis R Taaffe,&nbsp;Anne-Marie Hill,&nbsp;Sarah Hug,&nbsp;Kylie Hill","doi":"10.1177/14799731221120429","DOIUrl":"https://doi.org/10.1177/14799731221120429","url":null,"abstract":"<p><strong>Background: </strong>Compared to the general population, adults with chronic obstructive pulmonary disease (COPD) have an increased prevalence of osteoporosis. Despite the known risk factors and potential complications of compromised bone health in COPD, little is known about whether poor bone health is routinely suspected. We measured, in people with COPD, the prevalence of those who had one or more indicators suggestive of suspected poor bone health, and compared the characteristics of those with versus without these indicators.</p><p><strong>Methods: </strong>Data were collected from adults with COPD presenting to three tertiary hospitals. Indicators of suspected poor bone health were defined as any of the following criteria: (i) self-reported problems with bone health, (ii) previous imaging for bone health, (iii) history of fragility fracture or, (iv) advised to use medication/supplements to optimise bone health. Characteristics compared between those with versus without indicators of suspected poor bone health comprised age, sex, body mass index (BMI), FEV₁% predicted and recruitment setting.</p><p><strong>Results: </strong>361 participants were included (age 70 ± 10, BMI 27.9 ± 7.8 kg/m², FEV₁% predicted 49 ± 20; 161 [45%] female). Indicators suggestive of suspected poor bone health were present in 53% (95% confidence interval [CI] 47-58) of the participants. The odds of this outcome increased with advancing age (odds ratio; OR [95% CI] 1.05 [1.03 to 1.08]) and being female (OR [95% CI] 3.4 [2.2 to 5.7]) .</p><p><strong>Conclusion: </strong>In people with COPD, the odds of having indicators suggestive of suspected poor bone health increase with advancing age and in females. Further work is required to promote the importance of bone health in this population.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221120429"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/d7/10.1177_14799731221120429.PMC9459490.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40353959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD.","authors":"Zewari S,&nbsp;van den Borst B,&nbsp;van den Elshout Fj,&nbsp;Vercoulen Jh,&nbsp;Dekhuijzen Pn,&nbsp;Heijdra Yf,&nbsp;Vos Pj","doi":"10.1177/14799731211052305","DOIUrl":"https://doi.org/10.1177/14799731211052305","url":null,"abstract":"<p><strong>Objectives: </strong>Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients.</p><p><strong>Methods: </strong>We performed a comparison between 80 obese COPD patients (COPD_OB) with 80 age- and FEV₁ matched normal-weight COPD patients (COPD_NW). Dyspnea was assessed by the mMRC scale and the Borg dyspnea score before and after a 6 min walk test. Further characterization included spirometry, body plethysmography and metronome paced tachypnea (MPT) to estimate dynamic hyperinflation. Body composition was assessed with bioelectrical impedance analysis. Associations between dyspnea scores and BMI and body composition groups were studied using logistic regression models.</p><p><strong>Results: </strong>COPD_OB patients had attenuated increases in TLC, FRC and RV compared to COPD_NW patients (<i>p</i> < 0.01). The groups had comparable 6 min walking distance and ΔFRC upon MPT (<i>p</i> > 0.05). Compared to COPD_NW, COPD_OB patients reported more often a mMRC ≥ 2 (65 vs 46%; <i>p</i> = 0.02; OR 3.0, 95% CI 1.4-6.2, <i>p</i> < 0.01) and had higher ΔBorg upon 6MWT: 2.0 (SEM 0.20) vs. 1.4 (SEM 0.16), <i>p</i> = 0.01; OR for ΔBorg ≥ 2: 2.4, 95% CI 1.1-5.2, <i>p</i> = 0.03. Additional logistic regression analyses on the associations between body composition and dyspnea indicated that increased body fat percentage, fat mass index and waist-to-hip ratio were associated with higher ORs for mMRC ≥ 2 and ΔBorg upon 6MWT ≥ 2.</p><p><strong>Conclusion: </strong>Despite its beneficial effect on resting lung hyperinflation, adiposity is associated with increased weight-bearing exercise-induced dyspnea in COPD.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731211052305"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39596087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30 s sit-to-stand power is positively associated with chest muscle thickness in COVID-19 survivors.","authors":"Rodrigo Núñez-Cortés,&nbsp;Carlos Cruz-Montecinos,&nbsp;Francisco Martinez-Arnau,&nbsp;Rodrigo Torres-Castro,&nbsp;Esteban Zamora-Risco,&nbsp;Sofía Pérez-Alenda,&nbsp;Lars L Andersen,&nbsp;Joaquín Calatayud,&nbsp;Estanislao Arana","doi":"10.1177/14799731221114263","DOIUrl":"https://doi.org/10.1177/14799731221114263","url":null,"abstract":"<p><strong>Introduction: </strong>After hospitalization, early detection of musculoskeletal sequelae might help healthcare professionals to improve and individualize treatment, accelerating recovery after COVID-19. The objective was to determine the association between the 30s sit-to-stand muscle power (30s-STS) and cross-sectional area of the chest muscles (pectoralis) in COVID-19 survivors.</p><p><strong>Method: </strong>This cross-sectional study collected routine data from COVID-19 survivors one month after hospitalization: 1) a chest computed tomography (CT) scan and 2) a functional capacity test (30s-STS). The pectoralis muscle area (PMA) was measured from axial CT images. For each gender, patients were categorized into tertiles based on PMA. The 30s-STS was performed to determine the leg extension power. The allometric and relative STS power were calculated as absolute 30s-STS power normalized to height squared and body mass. The two-way ANOVA was used to compare the gender-stratified tertiles of 30s-STS power variants.</p><p><strong>Results: </strong>Fifty-eight COVID-19 survivors were included (mean age 61.2 ± 12.9 years, 30/28 (51.7%/48.3%) men/women). The two-way ANOVA showed significant differences between the PMA tertiles in absolute STS power (<i>p</i> = .002) and allometric STS power (<i>p</i> = .001). There were no significant gender x PMA tertile interactions (all variables <i>p</i> > .05). The high tertile of PMA showed a higher allometric STS power compared to the low and middle tertile, <i>p</i> = .002 and <i>p</i> = .004, respectively. Absolute STS power and allometric STS power had a moderate correlation with the PMA, r = 0.519 (<i>p</i> < .001) and r = 0.458 (<i>p</i> < .001) respectively.</p><p><strong>Conclusion: </strong>The 30s-STS power is associated with pectoralis muscle thickness in both male and female COVID-19 survivors. Thus, this test may indicate global muscle-wasting and may be used as a screening tool for lower extremity functional capacity in the early stages of rehabilitation planning in COVID-19 survivors.</p>","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":"14799731221114263"},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/19/10.1177_14799731221114263.PMC9379968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40715310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The untapped potential of physical activity monitoring for quality assurance of field-based walking tests in clinical respiratory trials","authors":"M. Orme, Ilaria Pina, Sally J. Singh","doi":"10.1177/14799731221089318","DOIUrl":"https://doi.org/10.1177/14799731221089318","url":null,"abstract":"Field-based walking tests are well-established outcome measures in clinical research trials and in the evaluation of routine clinical services, including pulmonary rehabilitation. Despite widespread use, there has been little attention to, or reporting of, the quality assurance of these tests. Physical activity monitoring has become increasingly popular and data from activity monitors could be used for quality assurance of field-based walking tests. We provide examples in this article of data-driven insights possible with this approach, using data from waist-worn accelerometry, for the incremental shuttle walking test (ISWT), endurance shuttle walk test (ESWT) and six-minute walk test (6MWT). Given the multitude of devices to measure physical activity and the range metrics to describe physical activity, we also comment on some of the technical considerations to using activity monitors for walking test quality assurance. Data-driven approaches to quality assurance are already commonplace for other outcome measures in clinical respiratory trials, but little is known about this approach for field-based walking tests. The application of physical activity monitoring may be extended to other field-based exercise tests and additional rehabilitation services. This may be more challenging for self-paced walking tests such as the 6MWT. Future work should apply this approach to research trials and service evaluations to explore the impact of field-based walking test quality on performance (e.g. distance on the ISWT or time achieved for the ESWT), responsiveness to interventions (e.g. pulmonary rehabilitation) and effectiveness of training procedures (e.g. remote training for multi-site trials).","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45340584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pulmonary hypertension on exercise capacity and gas exchange in patients with chronic obstructive pulmonary disease living at high altitude","authors":"M. González-García, C. Aguirre-Franco, Leslie Vargas-Ramirez, M. Barrero, C. Torres-Duque","doi":"10.1177/14799731221104095","DOIUrl":"https://doi.org/10.1177/14799731221104095","url":null,"abstract":"Background: Pulmonary hypertension (PH) is associated with decreased exercise tolerance in chronic obstructive pulmonary disease (COPD) patients, but in the altitude the response to exercise in those patients is unknown. Our objective was to compare exercise capacity, gas exchange and ventilatory alterations between COPD patients with PH (COPD-PH) and without PH (COPD-nonPH) residents at high altitude (2640 m). Methods: One hundred thirty-two COPD-nonPH, 82 COPD-PH, and 47 controls were included. Dyspnea by Borg scale, oxygen consumption (VO2), work rate (WR), ventilatory equivalents (VE/VCO2), dead space to tidal volume ratio (VD/VT), alveolar-arterial oxygen tension gradient (AaPO2), and arterial-end-tidal carbon dioxide pressure gradient (Pa-ETCO2) were measurement during a cardiopulmonary exercise test. For comparison of variables between groups, Kruskal-Wallis or one-way ANOVA tests were used, and stepwise regression analysis to test the association between PH and exercise capacity. Results: All COPD patients had a lower exercise capacity and higher PaCO2, A-aPO2 and VD/VT than controls. The VO2 % predicted (61.3 ± 20.6 vs 75.3 ± 17.9; p < 0.001) and WR % predicted (65.3 ± 17.9 vs 75.3 ± 17.9; p < 0.001) were lower in COPD-PH than in COPD-nonPH. At peak exercise, dyspnea was higher in COPD-PH (p = 0.011). During exercise, in COPD-PH, the PaO2 was lower (p < 0.001), and AaPO2 (p < 0.001), Pa-ETCO2 (p = 0.033), VE/VCO2 (p = 0.019), and VD/VT (p = 0.007) were higher than in COPD-nonPH. In the multivariate analysis, PH was significantly associated with lower peak VO2 and WR (p < 0.001). Conclusion: In COPD patients residing at high altitude, the presence of PH was an independent factor related to the exercise capacity. Also, in COPD-PH patients there were more dyspnea and alterations in gas exchange during the exercise than in those without PH.","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42004281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “A review of respiratory manifestations and their management in Ehlers-Danlos syndromes and hypermobility spectrum disorders”","authors":"","doi":"10.1177/14799731211049699","DOIUrl":"https://doi.org/10.1177/14799731211049699","url":null,"abstract":"Chohan K, Mittal N, McGillis L et al. A review of respiratory manifestations and their management in EhlersDanlos syndromes and hypermobility spectrum disorders. Chronic Respiratory Disease. 2021; 18: 1-14. doi: 10.1177/ 14799731211025313 The correct list of references for this article can be found below: 1. Malfait F, Francomano C, Byers P, et al. The 2017 international classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet 2017; 175:8-26 2. Callewaert B, Malfait F, Loeys B, et al. Ehlers-Danlos syndromes and Marfan syndrome. Best Pract Res Clin Rheumatol 2008; 22:165-189 3. Demmler JC, AtkinsonMD,Reinhold EJ, et al. Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case-control comparison. BMJOpen 2019; 9:e031365 4. Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 2000; 27:1777-1779 5. Castori M, Tinkle B, Levy H, et al. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet 2017; 175: 148-157 6. Cederlof M, Larsson H, Lichtenstein P, et al. Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings. BMCPsychiatry 2016; 16: 207 7. Ayres JG, Pope FM, Reidy JF, et al. Abnormalities of the lungs and thoracic cage in the Ehlers-Danlos syndrome. Thorax 1985; 40:300-305 8. Shields LB, Rolf CM, Davis GJ, et al. Sudden and unexpected death in three cases of Ehlers-Danlos syndrome type IV. J Forensic Sci 2010; 55:1641-1645 9. Morgan AW, Pearson SB, Davies S, et al. Asthma and airways collapse in two heritable disorders of connective tissue. Ann Rheum Dis 2007; 66:1369-1373 10. Castori M, Hakim A. Contemporary approach to joint hypermobility and related disorders. Curr Opin Pediatr 2017; 29:640-649 11. Yost BA, Vogelsang JP, Lie JT. Fatal hemoptysis in Ehlers-Danlos syndrome. Old malady with a new curse. Chest 1995; 107:1465-1467 12. Herman TE, McAlister WH. Cavitary pulmonary lesions in type IV Ehlers-Danlos syndrome. Pediatr Radiol 1994; 24:263-265 13. Park MA, Shin SY, Kim YJ, et al. Vascular EhlersDanlos syndrome with cryptorchidism, recurrent pneumothorax, and pulmonary capillary hemangiomatosis-like foci: A case report. Medicine (Baltimore) 2017; 96:e8853 14. Reychler G, Liistro G, Pierard GE, et al. Inspiratory muscle strength training improves lung function in patients with the hypermobile Ehlers-Danlos syndrome: A randomized controlled trial. Am J Med Genet A 2019; 179: 356-364 15. Castori M, Camerota F, Celletti C, et al. Natural history and manifestations of the hypermobility type EhlersDanlos syndrome: a pilot study on 21 patients. Am J Med Genet A 2010; 152A:556-564 16. Gazit Y, Nahir AM, Grahame R, et al. Dysautonomia in the joint hypermobility syndrome. Am J Med 2003; 115: 33-40 17. Sim","PeriodicalId":10217,"journal":{"name":"Chronic Respiratory Disease","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41861834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}