Clinical and Experimental Gastroenterology最新文献

Tumor-Stroma Ratio is a Critical Indicator of Peritoneal Metastasis in Gastric Cancer. 肿瘤间质比是胃癌腹膜转移的重要指标。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.2147/CEG.S482377

Lin Zhong, Hongyun Huang, Dong Hou, Shihai Zhou, Yu Lin, Yue Yu, Jinhao Yu, Fanghai Han, Lang Xie

{"title":"Tumor-Stroma Ratio is a Critical Indicator of Peritoneal Metastasis in Gastric Cancer.","authors":"Lin Zhong, Hongyun Huang, Dong Hou, Shihai Zhou, Yu Lin, Yue Yu, Jinhao Yu, Fanghai Han, Lang Xie","doi":"10.2147/CEG.S482377","DOIUrl":"10.2147/CEG.S482377","url":null,"abstract":"Objective: This study aims to investigate the correlation between the tumor-stroma ratio (TSR) and peritoneal metastasis (PM) in gastric cancer (GC) and constructs a diagnostic model based on preoperative examination data.Methods: To determine the feasibility of obtaining TSR in GC patients through preoperative examinations, the consistency of TSR between endoscopic biopsy tissues and postoperative histopathological tissues was evaluated. Additionally, the correlation between TSR and PM in GC was analyzed using Gene Expression Omnibus (GEO) datasets. To validate TSR's clinical potential in diagnosing PM, 640 GC patients from two medical centers were enrolled. A training cohort of 330 patients evaluated TSR and synchronous PM correlation, and a validation cohort of 310 patients was used. An additional cohort of 510 patients was established to investigate TSR and metachronous PM. A diagnostic model based on preoperative data was developed and a nomogram constructed.Results: The TSR shows good consistency between endoscopic biopsy tissues and postoperative histopathological tissues. A significant correlation between TSR and PM was observed. The TSR-based model, combined with CA125, CA724 and Borrmann type, exhibited strong diagnostic effectiveness and considerable predictive efficacy, with an Area Under the Curve (AUC) of 0.85 in the training cohort, 0.73 in the external validation cohort, and 0.72 in the metachronous PM cohort.Conclusion: The TSR emerges as a crucial marker for PM in GC, with the developed model, based on TSR and preoperative examination data, demonstrating substantial diagnostic and predictive capabilities.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"18 ","pages":"11-24"},"PeriodicalIF":2.5,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Leaks and Fistulas After Laparoscopic Sleeve Gastrectomy: Challenges and Solutions. 腹腔镜袖式胃切除术后渗漏和瘘管的处理：挑战和解决方案。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI: 10.2147/CEG.S461534

Jordan Gipe, Alexandra Z Agathis, S Q Nguyen

{"title":"Managing Leaks and Fistulas After Laparoscopic Sleeve Gastrectomy: Challenges and Solutions.","authors":"Jordan Gipe, Alexandra Z Agathis, S Q Nguyen","doi":"10.2147/CEG.S461534","DOIUrl":"10.2147/CEG.S461534","url":null,"abstract":"Postoperative leaks after sleeve gastrectomy are a troublesome complication that occur in 0.7-5.3% of cases depending on the referenced source. These complications cause significant morbidity for patients requiring prolonged hospitalizations, nutritional support, intravenous antibiotics, and at times additional operations and procedures that risk further downstream complications. The patient presentation varies from relatively benign with minimal or no symptomatology, to the acutely ill with life-threatening sepsis. The management of gastric leak is dependent on a multitude of factors, including the initial presentation as well the surgeon's experience and preference. Here, we will summarize the current literature and discuss the different options that exist for the management of gastric leaks after sleeve gastrectomy including laparoscopic lavage, endoscopic stenting, endoscopic pigtail catheters, endoscopic vacuum therapy, and salvage surgical operations such as fistula jejunostomy and total gastrectomy. The aim is to provide a source for surgeons to reference when they encounter this disease pathology and to shed light on a daunting challenge for the modern bariatric surgeon.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"18 ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study. 精神分裂症和重度抑郁症与便秘的关联：一项孟德尔随机研究。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S485504

Jiali Liu, Yebao Huang, Xiaoshuo Fu, Jiali Wei, Ping Wei

{"title":"Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study.","authors":"Jiali Liu, Yebao Huang, Xiaoshuo Fu, Jiali Wei, Ping Wei","doi":"10.2147/CEG.S485504","DOIUrl":"https://doi.org/10.2147/CEG.S485504","url":null,"abstract":"Objective: Psychiatric disorders have been associated with Constipation in observational studies, although their causal relationships remain uncertain. We used Mendelian randomization analysis to infer causality between Schizophrenia and Major Depressive Disorder with Constipation.Methods: The exposure of interest was Psychiatric disorders, including Schizophrenia (SCZ) and Major Depressive Disorder (MDD). Summary statistics for psychiatric disorders were recruited from the PGC, SCZ (30,490 cases and 312,009 controls), MDD (170,756 cases and 329,443 controls), whereas Constipation summary genetic data were obtained from a FinnGen involving 17,246 cases and 201,546 controls. The inverse variance weighted (IVW) method was used as the primary analysis to assess the causal relationship between SCZ and MDD with Constipation.Results: LDSC indicated that Constipation was genetically correlated with Psychiatric disorders (r g range: |0.04-0.05). The Mendelian randomization analysis indicated that there was significant evidence that genetically determined SCZ (OR = 1.05, 95% CI = 1.02-1.07, P<0.01) and MDD (OR = 1.21, 95% CI = 1.10-1.33, P<0.01) were statistically significantly causally associated with the risk of Constipation. SCZ effects remained within the range of practical equivalence (ROPE).Conclusion: The Mendelian randomization analysis suggested that SCZ and MDD increase the risk of Constipation. However, the association between SCZ and constipation, predominantly within the ROPE range, suggested only limited clinical implications.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"349-357"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States [Corrigendum]. 勘误：美国肠易激综合征伴便秘患者负担和治疗情况回顾[更正]。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S506887

引用次数: 0

Therapeutic Potential of Etrasimod in the Management of Moderately-to-Severely Active Ulcerative Colitis: Evidence to Date. 依曲莫德在治疗中度至重度活动性溃疡性结肠炎中的治疗潜力：迄今为止的证据。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S391706

Kerri Glassner, Christopher Fan, Malcolm Irani, Bincy P Abraham

{"title":"Therapeutic Potential of Etrasimod in the Management of Moderately-to-Severely Active Ulcerative Colitis: Evidence to Date.","authors":"Kerri Glassner, Christopher Fan, Malcolm Irani, Bincy P Abraham","doi":"10.2147/CEG.S391706","DOIUrl":"https://doi.org/10.2147/CEG.S391706","url":null,"abstract":"Etrasimod is a sphingosine 1 phosphate (S1P) receptor modulator approved for the treatment of moderate to severely active ulcerative colitis (UC). Etrasimod selectively activates S1P1,4,5 receptors with no detectable activity on S1P2,3. The ELEVATE clinical trials evaluated the efficacy and safety of etrasimod for UC. Etrasimod showed clinically significant improvement in clinical remission at weeks 12 and 52 compared to placebo. Etrasimod showed greater efficacy in patients who were biologic naive. Etrasimod was also effective in a subgroup of patients with isolated proctitis. The medication should be avoided in pregnancy and lactation, certain cardiac conditions including brady-arrythmias, and those with a history of skin cancer. Etrasimod has a shorter half-life and fewer drug-drug and food interactions as compared to the S1P receptor modulator ozanimod. In addition, no dosing titration is required. Etrasimod is a promising treatment option for UC patients with moderate to severe inflammation, particularly those who have no prior biologic exposure, are not considering pregnancy, and prefer oral therapy.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"337-345"},"PeriodicalIF":2.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Tumor Budding and Survivin Expression in Colorectal Cancer. 结直肠癌中肿瘤萌发与 Survivin 表达之间的相关性

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S477718

Guangping Zhang, Qingzhong Min

{"title":"Correlation Between Tumor Budding and Survivin Expression in Colorectal Cancer.","authors":"Guangping Zhang, Qingzhong Min","doi":"10.2147/CEG.S477718","DOIUrl":"10.2147/CEG.S477718","url":null,"abstract":"Aim: Correlation of Survivin expression levels in tumor tissues and degree of tumor outgrowth with colorectal cancer characteristics.Methods: The pathological tissues of 90 cases of colorectal cancer were observed by HE staining, and the tumor budding was judged by Ueno standard, and the expression of Survivin was detected by immunohistochemistry (IHC) technique (EnVision method), so as to analyze the correlation between tumor budding, the expression level of Survivin and the degree of tumor budding, and the correlation between the tumor budding and the patients' clinical characteristics.Results: The expression level of Survivin was significantly correlated with TNM stage, lymph node metastasis and distant metastasis in patients with colorectal cancer; tumor outgrowth was significantly correlated with TNM stage, lymph node metastasis and distant metastasis in patients with colorectal cancer (P < 0.05); the expression level of Survivin was significantly correlated with the degree of tumor budding in patients with colorectal cancer (P < 0.05).Conclusion: In this paper, we tested the relationship between Survivin and tumor budding in colon cancer, and analyzed its relationship with clinicopathological features, with a view to providing a reference for the mechanism related to colorectal cancer.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"331-336"},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting Survival Among Colorectal Cancer Patients: Development and Validation of Polygenic Survival Score. 预测结直肠癌患者的生存期：多基因生存评分的开发与验证

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-10-14 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S464324

Rawan M Maawadh, Chao Xu, Rizwan Ahmed, Nasir Mushtaq

{"title":"Predicting Survival Among Colorectal Cancer Patients: Development and Validation of Polygenic Survival Score.","authors":"Rawan M Maawadh, Chao Xu, Rizwan Ahmed, Nasir Mushtaq","doi":"10.2147/CEG.S464324","DOIUrl":"10.2147/CEG.S464324","url":null,"abstract":"Purpose: Colorectal cancer is the second leading cause of cancer-related death in the United States. A multi-omics approach has contributed in identifying various cancer-specific mutations, epigenetic alterations, and cells response to chemotherapy. This study aimed to determine the factors associated with colorectal cancer survival and develop and validate a polygenic survival scoring system (PSS) using a multi-omics approach.Patients and methods: Data were obtained from the Cancer Genome Atlas (TCGA). Colon Adenocarcinoma (TCGA-COAD) data were used to develop a survival prediction model and PSS, whereas rectal adenocarcinoma (TCGA-READ) data were used to validate the PSS. Cox proportional hazards regression analysis was conducted to examine the association between the demographic characteristics, clinical variables, and mRNA gene expression.Results: Overall accuracy of PSS was also evaluated. The median overall survival for TCGA-COAD patients was 7 years and for TCGA-READ patients was 5 years. The multivariate Cox proportional hazards model identified age, cancer stage, and expression of nine genes as predictors of colon cancer survival. Based on the median PSS of 0.38, 48% of TCGA-COAD patients had high mortality risk. Patients in the low risk group had significantly higher 5-year survival rates than those in the high group (p <0.0001). The PSS demonstrated a high overall accuracy in predicting colorectal cancer survival.Conclusion: This study integrated clinical and transcriptome data to identify survival predictors in patients with colorectal cancer. PSS is an accurate and valid measure for estimating colorectal cancer survival. Thus, it can serve as an important tool for future colorectal cancer research.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"317-329"},"PeriodicalIF":2.5,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractory Crohn's Disease: Perspectives, Unmet Needs and Innovations. 难治性克罗恩病：观点、未满足的需求和创新。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-10-10 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S434014

Luisa Bertin, Martina Crepaldi, Miriana Zanconato, Greta Lorenzon, Daria Maniero, Caterina De Barba, Erica Bonazzi, Sonia Facchin, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Andrea Buda, Fabiana Zingone, Edoardo Vincenzo Savarino, Brigida Barberio

{"title":"Refractory Crohn's Disease: Perspectives, Unmet Needs and Innovations.","authors":"Luisa Bertin, Martina Crepaldi, Miriana Zanconato, Greta Lorenzon, Daria Maniero, Caterina De Barba, Erica Bonazzi, Sonia Facchin, Marco Scarpa, Cesare Ruffolo, Imerio Angriman, Andrea Buda, Fabiana Zingone, Edoardo Vincenzo Savarino, Brigida Barberio","doi":"10.2147/CEG.S434014","DOIUrl":"https://doi.org/10.2147/CEG.S434014","url":null,"abstract":"Crohn's disease (CD) is a complex, chronic inflammatory bowel disease characterized by unpredictable flare-ups and periods of remission. Despite advances in treatment, CD remains a significant health burden, leading to substantial direct healthcare costs and out-of-pocket expenses for patients, especially in the first-year post-diagnosis. The impact of CD on patients' quality of life is profound, with significant reductions in physical, emotional, and social well-being. Despite advancements in therapeutic options, including biologics, immunomodulators, and small molecules, many patients struggle to achieve or maintain remission, leading to a considerable therapeutic ceiling. This has led to an increased focus on novel and emerging treatments. This context underscores the importance of exploring advanced and innovative treatment options for managing refractory CD. By examining the latest approaches, including immunomodulators, combination therapies, stem cell therapies, and emerging treatments like fecal microbiota transplantation and dietary interventions, there is an opportunity to gain a comprehensive understanding of how best to address and manage refractory cases of CD.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"261-315"},"PeriodicalIF":2.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-Generated Images in Perianal Disease: An Evolving Tool in Proctology. 肛周疾病中患者生成的图像：肛肠科不断发展的工具。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-08-08 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S466984

Vipul D Yagnik, Kaushik Bhattacharya, Pankaj Garg, Prema Ram Choudhary, Mrunal Sadhu, Sushil Dawka

{"title":"Patient-Generated Images in Perianal Disease: An Evolving Tool in Proctology.","authors":"Vipul D Yagnik, Kaushik Bhattacharya, Pankaj Garg, Prema Ram Choudhary, Mrunal Sadhu, Sushil Dawka","doi":"10.2147/CEG.S466984","DOIUrl":"10.2147/CEG.S466984","url":null,"abstract":"This article explores the potential benefits and challenges of incorporating Patient-Generated Images (PGIs) into the clinical practice for perianal conditions. PGIs refer to photographs (and video) captured by patients themselves of affected areas of their own bodies to illustrate potential pathologies. It facilitates remote patient assessments and swift evaluation for coloproctologist. They potentially reduce the need for in person follow-up particularly after operation if the patient is asymptomatic. However, concerns with PGI include quality of images, risk of misinterpretation, ethical, legal, and practical problems, especially when imaging private or sensitive body regions. Any platform transmitting and storing PGIs should prioritize data protection with advanced encryption. Comprehensive guidelines should be developed by collaboration between healthcare administrators, regulators, and professionals, and a thorough framework formulated to ensure that quality care is delivered always while respecting patient privacy and dignity. It should be considered as complementary to, rather than a replacement for, traditional clinical consultations. However, patient awareness and education regarding the limitations are key to ensuring that this modality is not misinterpreted or misused.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"255-259"},"PeriodicalIF":2.5,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11319093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States. 美国肠易激综合征伴便秘患者负担和治疗情况回顾。

IF 2.5

Clinical and Experimental Gastroenterology Pub Date : 2024-08-02 eCollection Date: 2024-01-01 DOI: 10.2147/CEG.S464375

Morgan Allyn Sendzischew Shane, Johannah Ruddy, Michael Cline, David P Rosenbaum, Susan Edelstein, Baharak Moshiree

{"title":"Review of the Patient Burden and Therapeutic Landscape of Irritable Bowel Syndrome with Constipation in the United States.","authors":"Morgan Allyn Sendzischew Shane, Johannah Ruddy, Michael Cline, David P Rosenbaum, Susan Edelstein, Baharak Moshiree","doi":"10.2147/CEG.S464375","DOIUrl":"10.2147/CEG.S464375","url":null,"abstract":"Irritable bowel syndrome (IBS) is a common disorder of the gut-brain axis. IBS with constipation (IBS-C) accounts for approximately one-third of IBS cases and is associated with substantial burden of illness and decreased quality of life. This narrative review provides an overview of the current and upcoming treatment options and disease management for IBS-C from a US perspective and discusses the importance of the relationship between patient and health care provider in diagnosis and treatment. A positive diagnostic strategy for IBS-C is recommended, based on clinical history, physical examination, and minimal laboratory tests. An effective communication strategy between patients and health care professionals is essential to ensure early diagnosis and reduce both health care costs and overall disease burden. Treatment typically begins with lifestyle interventions and nonpharmacologic options, such as dietary interventions, fiber supplements, and osmotic laxatives. In patients with inadequate response to these therapies, 4 currently available therapies (lubiprostone, linaclotide, plecanatide, and tenapanor) approved by the US Food and Drug Administration may relieve IBS-C symptoms. These agents are generally well tolerated and efficacious in improving IBS-C symptoms, including constipation and abdominal pain. In patients with persistent abdominal pain and/or psychological symptoms, brain-gut behavioral therapy or neuromodulator therapy may be beneficial.","PeriodicalId":10208,"journal":{"name":"Clinical and Experimental Gastroenterology","volume":"17 ","pages":"227-253"},"PeriodicalIF":2.5,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0