大海湾地区成人嗜酸性食管炎的管理、挑战和知识差距的专家意见。

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Clinical and Experimental Gastroenterology Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI:10.2147/CEG.S511469
Ahmad Jazzar, Ahmed Al-Darmaki, Evan Samuel Dellon, Mohamad Miqdady, Mohammed Attieh Alzahrani, Mohammed S Khan, Mona Al Ahmad, Osama Yousef, Sameer Al Awadhi, Wesam Al Masri, Naglaa M Kamal
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引用次数: 0

摘要

嗜酸性粒细胞性食管炎(EoE)是一种2型炎症性食管疾病,在成人中表现为吞咽困难和食物嵌塞。EoE的特点是T细胞群中辅助性T 2细胞占优势。环境因素,包括食物抗原和空气过敏原,可引发EoE。EoE对这些环境过敏原表现出免疫球蛋白E- (IgE-)和非IgE介导的过敏反应。局部抗原特异性IgE也可触发肥大细胞脱颗粒,从而加重EoE。患有特应性皮炎、哮喘、ige介导的食物过敏或变应性鼻炎的个体发生EoE的风险更高。EoE治疗的目的是达到临床改善,内镜下粘膜愈合,减少或解决组织学炎症。然而,通过常规治疗达到并维持“深度缓解”可能具有挑战性,这强调了靶向治疗的必要性。本专家意见侧重于使用新疗法改善EoE患者预后的最新全球建议。报告还重点介绍了大海湾地区管理EoE、识别挑战和解决未来教育差距的现行做法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expert Opinion on the Management, Challenges, and Knowledge Gaps Pertaining to Eosinophilic Esophagitis Among Adults in the Greater Gulf Region.

Eosinophilic esophagitis (EoE) is a type 2 inflammatory esophageal disease that presents in adults as dysphagia and food impaction. EoE is characterized by a predominance of T helper 2 cells among the T cell population. Environmental agents, including food antigens and aeroallergens, trigger EoE. EoE exhibits immunoglobulin E- (IgE-) and non-IgE-mediated allergic responses to these environmental allergens. Local antigen-specific IgE can also trigger mast cell degranulation, thereby worsening EoE. Individuals with atopic dermatitis, asthma, IgE-mediated food allergy, or allergic rhinitis are at a higher risk of developing EoE. EoE treatment aims to achieve clinical improvement, endoscopic mucosal healing, and reduction in or resolution of histological inflammation. However, attaining and maintaining "deep remission" with conventional treatments can be challenging, underscoring the need for targeted therapies. This expert opinion focuses on the latest global recommendations for using novel therapies to improve outcomes in patients with EoE. It also highlights current practices in the Greater Gulf region to manage EoE, identify challenges, and address future educational gaps.

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来源期刊
Clinical and Experimental Gastroenterology
Clinical and Experimental Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.10
自引率
0.00%
发文量
26
审稿时长
16 weeks
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