一种预测食管癌免疫细胞浸润和预后的cdkn2b相关免疫预后模型

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Clinical and Experimental Gastroenterology Pub Date : 2025-04-18 eCollection Date: 2025-01-01 DOI:10.2147/CEG.S510078
Xiulan Peng, Juping Han, Juan Huang, Longshu Zhou, Xianzhe Chen, Wen Zhou
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引用次数: 0

摘要

目的:研究表明,细胞周期蛋白依赖性蛋白激酶抑制剂2B (CDKN2B)缺失是食管癌(EC)最常见的变化之一,影响其进展和预后。本研究探讨CDKN2B缺失、免疫表型和EC预后之间的关系。方法:研究肿瘤基因组图谱(TCGA) EC样本中CDKN2B的状态和RNA表达,鉴定野生型CDKN2B (CDKN2BWT)和缺失型CDKN2B (CDKN2Bdeletion)免疫相关基因的差异表达。我们还基于这些基因构建了免疫预后模型(IPM)。随后,分析了IPM对EC免疫微环境的影响。最后,我们将IPM与其他临床因素结合,建立nomogram。结果:CDKN2B缺失导致EC免疫应答下调。基于CDKN2B缺失状态共鉴定了136个免疫相关基因,并选择了3个具有显著个体靶点潜力的基因进行模型构建。IPM在鉴别预后不良的低风险和高风险患者方面表现良好,其预测能力独立于传统临床特征。高危EC患者T滤泡辅助细胞(Tfh)和巨噬细胞M0升高,静息CD4记忆性T细胞、静息期B细胞浸润水平降低。为临床应用而开发的nomogram显示出良好的预测效果。结论:我们的研究结果表明CDKN2B缺失与EC的生存和免疫微环境有关。IPM不仅是免疫应答和预后的有效指标,也提示了EC患者免疫治疗的潜在靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A CDKN2B-Associated Immune Prognostic Model for Predicting Immune Cell Infiltration and Prognosis in Esophageal Carcinoma.

Objective: Studies have indicated that cyclin dependent protein kinase inhibitor 2B (CDKN2B) deletion is one of the most common changes in esophageal cancer (EC) which affects its progression and prognosis. This study explored the association between CDKN2B deletion, immunophenotype, and the prognosis of EC.

Methods: We investigated CDKN2B status and RNA expression, identified differentially expressed immune-associated genes between wild-type CDKN2B (CDKN2BWT) and deleted CDKN2B (CDKN2Bdeletion) in Cancer Genome Atlas (TCGA) EC samples. We also a constructed an immune prognostic model (IPM) based on these genes. Thereafter, the effects of IPM on the immune microenvironment of EC were analyzed. Finally, we established a nomogram by integrating the IPM and other clinical factors.

Results: CDKN2B deletion leads to downregulation of the immune response in EC. A total of 136 immune-associated genes were identified based on the CDKN2B deletion status, and three genes with remarkable potential as individual targets were selected for model construction. An IPM was developed and validated, it showed good performance in differentiating patients with a low or high risk of poor prognosis, and its predictive ability was independent of traditional clinical features. High-risk patients with EC had increased T follicular helper cells (Tfh) and M0 macrophages, and lower infiltration levels of resting CD4 memory T cells resting, and naive B cells. The nomogram developed for clinical application showed good predictive performance.

Conclusions: Our results suggested that CDKN2B deletion was associated with the survival and immune microenvironment in EC. IPM is not only an effective indicator of the immune response and prognosis, but also suggest potential targets for immunotherapy in patients with EC.

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来源期刊
Clinical and Experimental Gastroenterology
Clinical and Experimental Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.10
自引率
0.00%
发文量
26
审稿时长
16 weeks
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