Reaction Chemistry & Engineering最新文献

{"title":"Alkaline silver nitrate exhibits versatility in the instant oxidation of furans to bioplastic precursors and its mechanistic insights","authors":"Ravi Kumar Kunchala, Meera Cheviri, Paramdeep Kaur, Bhawana Devi, Lakshmanan Potturaja, Vishnu Bakthavachalam, Senthil Murugan Arumugam, Alisha Alisha, Jyoti Baghel and Sasikumar Elumalai","doi":"10.1039/D5RE00509D","DOIUrl":"https://doi.org/10.1039/D5RE00509D","url":null,"abstract":"<p >2-Furoic acid (FA) and 2,5-furandicarboxylic acid (FDCA) are important precursor molecules to produce bio-based polymeric materials (including polyethylene furanoate, PEF). Here, we report high FA and FDCA yields of &gt;90% within 1 min using furfural and 2,5-diformylfuran (DFF), respectively, in an AgNO<small>₃</small>–KOH system under room temperature conditions. Mechanistic investigations show that Ag<small>⁺</small> and <em>in situ</em> generated Ag<small>₂</small>O act as redox mediators and are ultimately converted into metallic silver nanoparticles (Ag NPs), as confirmed by XRD, EDX, HRTEM, and XPS characterization. Density functional theory (DFT) calculations reveal energetically favourable Ag<small>⁺</small>- and Ag<small>₂</small>O-mediated oxidation pathways, consistent with the experimental observations. <small>¹</small>H NMR, ESI-MS, and UV-vis spectrophotometric methods further support the proposed mechanism. The recovered Ag NPs were subsequently recycled after regeneration and integrated with TiO<small>₂</small> to form Ag/TiO<small>₂</small> nanocomposites, which exhibit efficient photocatalytic degradation of methyl orange dye. Overall, this work establishes a silver-mediated redox platform that combines biomass upgrading with environmental remediation in a closed loop.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1157-1174"},"PeriodicalIF":3.1,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zeolite-catalyzed solvent-free transoximation of carbonyl compounds and cyclohexanone oxime","authors":"Mengting Li, Yongrui Wang, Yibin Luo and Xingtian Shu","doi":"10.1039/D5RE00514K","DOIUrl":"https://doi.org/10.1039/D5RE00514K","url":null,"abstract":"<p >Carbonyl compounds were transformed to oximes by the transoximation reaction with HY zeolite under solvent-free conditions through the reaction–distillation coupling process. First, single-factor experiments were conducted to investigate the effects of temperature, feed molar ratio, catalyst loading, and vacuum degree on the yield of cyclododecanone oxime (CDOX). Secondly, the Plackett–Burman screening and Box–Behnken response surface methodology were further utilized to optimize the process parameters, and the optimal conditions were obtained: a temperature of 90 °C, a cyclododecanone (CDON)/cyclohexanone oxime (CHO) molar ratio of 1.4 : 1, a catalyst loading of 1.6 g, and a vacuum degree of 240 mbar. Under these conditions, the yield of CDOX can reach 99.45%, which is similar to the predicted value of 99.76% by response surface methodology. Furthermore, a large pore size and Brønsted acidity of the zeolite are essential for good catalytic performance, and HY-5 shows the highest yield of CDOX under the reaction–distillation process. The catalyst can be recovered and reused several times, and the mechanism was proposed.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1138-1147"},"PeriodicalIF":3.1,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal single-atom modified TiO2 or g-C3N4: reaction mechanism and research progress as semiconductor photocatalysts","authors":"Ling He, Jiajun Yang, Shuang Zhang, Wenlu Li, Ying Shi and Siqin Zhao","doi":"10.1039/D5RE00549C","DOIUrl":"https://doi.org/10.1039/D5RE00549C","url":null,"abstract":"<p >As photocatalytic materials, TiO<small>₂</small> and g-C<small>₃</small>N<small>₄</small> are widely used in the degradation of organic pollutants, removal of volatile organic compounds or nitrogen oxides, and photocatalytic reduction of CO<small>₂</small>, among other applications, and have excellent prospects for use. However, due to the large band gap of TiO<small>₂</small>, its absorption of visible light is limited, and the electron–hole pair is easy to recombine, resulting in poor photocatalytic performance. Although g-C<small>₃</small>N<small>₄</small> can absorb visible light, its limited absorption range and insufficient utilization of long-wavelength light also restrict its photocatalytic performance. Single-atom modified TiO<small>₂</small> or g-C<small>₃</small>N<small>₄</small> has become a new strategy to overcome these challenges. TiO<small>₂</small> and g-C<small>₃</small>N<small>₄</small> are widely used as ideal carriers for single-atom photocatalysts, benefiting from their strong metal–support interactions (SMSIs), high coordination flexibility, excellent chemical stability, defect tolerance, and scalability. Single-atom modified TiO<small>₂</small> or g-C<small>₃</small>N<small>₄</small> can precisely tailor the electronic structure, introduce crystalline defects, and optimize light absorption characteristics. They effectively address key limitations in photocatalysis, including rapid charge recombination, a narrow visible light response range, and low atomic utilization efficiency, thereby enhancing overall performance. In this paper, we summarize the research progress on single-atom modified TiO<small>₂</small> or g-C<small>₃</small>N<small>₄</small> photocatalysts, including those modified with Cu, Fe, Pt, Ag, and Au, and analyze their excellent photocatalytic performance and possible reaction mechanisms in detail. Finally, a brief perspective has been proposed to improve the photocatalytic activity by single-atom modified TiO<small>₂</small> or g-C<small>₃</small>N<small>₄</small> in solving energy and environmental problems.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 4","pages":" 791-815"},"PeriodicalIF":3.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scalable optofluidic microreactor with immobilized Pt–CdS catalysts for visible light-driven photocatalytic hydrogen evolution from water","authors":"Ameer Suhail, D. Pamu and Nageswara Rao Peela","doi":"10.1039/D5RE00413F","DOIUrl":"https://doi.org/10.1039/D5RE00413F","url":null,"abstract":"<p >Addressing climate change, environmental pollution, and escalating energy demand requires a global shift toward renewable energy alternatives. Green hydrogen, produced through photocatalytic water splitting, offers a promising alternative; however, the efficiency and scalability of existing systems remain limited. This study introduces a scalable, efficient, and cost-effective optofluidic microreactor system for visible-light-driven photocatalytic hydrogen evolution from water, fabricated using a cheap laser-lithography-assisted wet chemical etching process. The CdS nanowire photocatalysts, synthesized <em>via</em> a solvothermal method and modified with a Pt cocatalyst, were immobilized on the microreactor walls by a spray coating method using colloidal silica as a binder. A parametric study is conducted to optimize the reactor plate fabrication and catalyst coating, resulting in an optimized system. The optofluidic device with optimum design produced hydrogen gas bubbles at a maximum rate of 60.7 μmol h<small>⁻¹</small> (1.21 mmol g<small>⁻¹</small> h<small>⁻¹</small> mass-normalized, 12.48 mmol m<small>⁻²</small> h<small>⁻¹</small> area-normalized) under 250 W LED lamp illumination. The apparent quantum yield (AQY) of the optimized system for hydrogen evolution was calculated to be 0.11% in the wavelength range of 400 to 700 nm. The potential scalability of the optofluidic microreactor system was discussed in the context of large-area reactor fabrication, highlighting its prospective application in practical solar hydrogen production.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 4","pages":" 853-873"},"PeriodicalIF":3.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of metal-based ionic liquid catalysts and their application to degrade waste polyester fiber","authors":"Ruitong Ma, Bing Liu, Ruibo Wang, Zhijiong Wu and Liying Guo","doi":"10.1039/D5RE00388A","DOIUrl":"https://doi.org/10.1039/D5RE00388A","url":null,"abstract":"<p >Four types of metal-based ionic liquid catalysts [DA-2PS][FeCl<small>₄</small>]<small>₂</small>, [DA-2PS][MnCl<small>₃</small>]<small>₂</small>, [DA-2PS][AlCl<small>₄</small>]<small>₂</small>, and [DA-2PS][SnCl<small>₅</small>]<small>₂</small> were prepared. Their structure and thermal properties were characterized and analyzed by FTIR, <small>¹</small>H NMR, and TGA. The type of acid was analyzed using pyridine infrared spectroscopy. Waste polyester fiber (PET) was used as the sample for glycolysis, and the performance of the four metal-based ionic liquid catalysts in degrading PET was investigated. By optimizing the process parameters, the best reaction conditions were obtained, and the chemical structure and purity of the degradation product bis(hydroxyethyl) terephthalate (BHET) were analyzed. The results showed that the four metal-based ionic liquid catalysts were successfully synthesized and exhibited good thermal stability, among which [DA-2PS][FeCl<small>₄</small>]<small>₂</small> demonstrated the best catalytic performance. Under the conditions of a temperature of 190 °C, a mass ratio of ethylene glycol to PET of 9 : 1, a reaction time of 7 h, and a catalyst amount of 2.5% of the total mass of the reactants, the PET conversion reached 96.5%, and the BHET yield was 89.1%. Furthermore, the catalyst maintained high catalytic activity even after six cycles of use, indicating that the synthesized metal-based ionic liquid catalysts exhibit excellent catalytic degradation performance for PET, providing a theoretical basis for the chemical recycling of waste polyester fiber.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1094-1107"},"PeriodicalIF":3.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into the thermal pyrolysis of high-density polyethylene and polypropylene: towards sustainable hydrogen production and carbon valorization","authors":"Vanessa Maria Pohl, Cedric Karel Fonzeu Monguen, Dominik Julian Heitlinger, Patrick Lott and Olaf Deutschmann","doi":"10.1039/D5RE00442J","DOIUrl":"https://doi.org/10.1039/D5RE00442J","url":null,"abstract":"<p >High-temperature pyrolysis of plastic waste presents a viable approach for concurrent hydrogen production and carbon material synthesis, contributing to energy recovery and environmental remediation. This study investigates the pyrolysis behavior of high-density polyethylene (HDPE), polypropylene (PP), and their mixtures in a high-temperature laboratory-scale reactor across a temperature range of 700 °C to 1600 °C. The objective was to assess how polymer composition and temperature influence the distribution of gaseous, liquid, and solid products. Gas phase analysis revealed a strong temperature dependence in hydrogen and hydrocarbon yields, with distinct variations between individual polymers and their mixtures. This underscores the relevance of investigating the pyrolysis of mixtures, as plastic wastes typically contain multiple polymer materials. Liquid products, primarily hydrocarbons, exhibited increased aromaticity and decreased yields at higher temperatures, indicating enhanced secondary cracking. Solid carbonaceous residues were characterized using Raman spectroscopy and X-ray diffraction (XRD). Raman spectroscopy revealed a decline in graphitization degree with increasing temperature, suggesting higher defect density and reduced structural (graphitic) ordering. Conversely, XRD data demonstrated increased crystallite sizes and decreased interlayer spacing with temperature, implying the formation of more ordered crystalline domains. PP pyrolysis resulted in carbon with the highest graphitization degree and crystallinity at moderate temperatures. The HDPE/PP mixture exhibited a synergistic effect that improves graphitic ordering and crystallite growth, surpassing the simple average of the pure components, particularly between 1200 °C and 1400 °C. At 1600 °C, thermal effects dominate, minimizing the influence of specific polymers and leading to converge all samples toward similar carbon structural characteristics. These findings underscore the critical role of polymer composition and temperature in optimizing pyrolysis processes for thermochemical hydrogen generation and carbon capture from mixed plastic waste.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1026-1039"},"PeriodicalIF":3.1,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2026/re/d5re00442j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of operational parameter driven mechanistic and empirical kinetic models for photocatalytic degradation of emerging contaminants","authors":"Pubali Mandal, Abhradeep Majumder, Lavanya Bonthu, Alagu Lavanya Thangaperumal, Manoj Kumar Yadav, Ahalya S and Nadeem A. Khan","doi":"10.1039/D5RE00491H","DOIUrl":"https://doi.org/10.1039/D5RE00491H","url":null,"abstract":"<p >Emerging contaminants (ECs) are ubiquitous in various aquatic systems due to their unique physicochemical properties and low environmental concentrations. Over the years, photocatalysis has shown significant promise in irradicating ECs; however, it is characterized by high operational costs, and its efficacy reduces when applied to real-time samples. This is typically attributed to inconsistent contaminant concentrations, overuse or underuse of photocatalyst dose, irradiation time, and light intensity. Hence, optimization of the photocatalytic systems is the need of the hour. In this context, 6 different mechanistic and empirical models have been used to model 7 datasets in this study. Intrinsic kinetic models demonstrated significantly better performance across all datasets compared to Langmuir–Hinshelwood and pseudo-first-order kinetic models, with <em>R</em><small>²</small> values ranging from 0.87 to 0.98. Model 1, which considered the roles of both hydroxyl and superoxide radicals in photocatalytic degradation, outperformed the other models for most datasets (average <em>R</em><small>²</small> = 0.937, RMSE = 8.057). Models 2, 3, and 5, which were developed based on system behavior, driving radicals being hydroxyl radicals, and the power law, respectively, also exhibited good fitting (average <em>R</em><small>²</small> = 0.918, RMSE = 8.976). The results suggested that these models can be effectively used for system optimization, minimizing resource inputs, and maximizing contaminant removal, thereby bridging the gaps between laboratory and pilot-scale studies.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1074-1093"},"PeriodicalIF":3.1,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upgrading sugarcane straw into biopigments via enzymatic hydrolysis and fermentation by Monascus ruber: integrating statistical analysis and kinetic modeling","authors":"Lucas Ramos, Maria Luiza Gamboa, Gabriel Leda Arruda, Júlio C. Santos, Félix Monteiro Pereira and Anuj Kumar Chandel","doi":"10.1039/D5RE00500K","DOIUrl":"https://doi.org/10.1039/D5RE00500K","url":null,"abstract":"<p >In this work, the Kraft process was employed for lignin extraction from sugarcane straw, and the resulting cellulosic pulp was fractionated, chemically characterized, and subsequently subjected to enzymatic hydrolysis. Delignification was based on a modified Kraft process using an AU/E-20 Regmed rotary reactor, which allowed four simultaneous reactions with a useful volume of 1 L each. A solid loading of 10% (60 g biomass to 0.6 L alkaline solution containing 3.5 M NaOH and 0.61 M Na<small>₂</small>S) was applied under all tested conditions. The adopted sulfidity was 25%, and the active alkali charge relative to biomass was 9% (w/w), ensuring effective lignin solubilization while preserving the structural carbohydrates. Through mathematical modeling, the kinetic profile of enzymatic hydrolysis was monitored over time. A 2<small>²</small> factorial experimental design was applied to evaluate the effects of solid content (%, w/v) and enzyme loading (FPU g<small>⁻¹</small>) on sugarcane straw hydrolysis. Delignification resulted in approximately 60% lignin removal. The delignified pulp exhibited high enzymatic accessibility, with digestibility values exceeding 80% for both glucan and xylan, indicating a substantial improvement in biomass susceptibility to enzymatic attack and conversion efficiency. These results confirm the effectiveness of the modified Kraft process as a pretreatment strategy. The hydrolysate was subsequently used for biopigment production by the fungus <em>Monascus ruber</em> in submerged cultivation, evaluating the influence of hydrolysate concentration and cultivation temperature. Maximum pigment production reached 9.54 AU, 10 AU, and 14.65 AU for yellow, orange, and red pigments, respectively. Lower cultivation temperatures and reduced hydrolysate concentrations favored overall pigment production.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 6","pages":" 1262-1273"},"PeriodicalIF":3.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured CeO2 with different morphologies for methoxycarbonylation of 2,4-toluene diamine with dimethyl carbonate","authors":"Mengli Dong, Han Yu, Xinqiang Zhao, Yao Lu, Hualiang An and Yanji Wang","doi":"10.1039/D5RE00469A","DOIUrl":"https://doi.org/10.1039/D5RE00469A","url":null,"abstract":"<p >The methoxycarbonylation of 2,4-toluene diamine (TDA) to dimethyl toluene-2,4-dicarbamate (TDC) is an important reaction step in the phosgene-free synthesis of toluene diisocyanate (TDI). To further clarify the catalytic mechanism and enhance the catalytic performance of CeO<small>₂</small>, a series of CeO<small>₂</small> catalysts with different morphologies were prepared and their catalytic performance in TDA methoxycarbonylation was evaluated. The results show that spherical cerium dioxide (CeO<small>₂</small>-S) has better catalytic performance. Combining characterization methods such as TEM, XRD, BET, TPD, XPS, Raman spectroscopy and H<small>₂</small>-TPR, the reasons for the differences in the catalytic performance of the different CeO<small>₂</small> catalysts were analyzed, and it is found that the total acid amount, medium-strong acid sites, lattice oxygen content and specific surface area of CeO<small>₂</small> are positively correlated with their catalytic performance. Under optimized conditions, TDA was completely converted, the yield of TDC reached 86.8%, and the total yield of methyl carbamates (including monomethyl carbamate and TDC) reached as high as 96.5%. CeO<small>₂</small>-S could be reused four times without significant change in activity. Through designed experiments, it is determined that both pathways with methyl 3-amino-4-methyl-<em>N</em>-phenyl carbamate (4-TMC) and methyl 2-methyl-5-amino-<em>N</em>-phenyl-carbamate (2-TMC) as intermediates could eventually generate TDC. Finally, a synergistic catalytic mechanism of acid sites and lattice oxygen in CeO<small>₂</small> for the methoxycarbonylation of TDA was established.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 1040-1052"},"PeriodicalIF":3.1,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlling explosive and highly energetic reactions: scaling up the liquid-phase aerobic oxidation of alcohols and aldehydes in flow","authors":"Boris Guicheret, Marco Antonio Dos-Santos, Claude de Bellefon, Laurent Vanoye, Régis Philippe and Alain Favre-Réguillon","doi":"10.1039/D5RE00444F","DOIUrl":"https://doi.org/10.1039/D5RE00444F","url":null,"abstract":"<p >Multiphasic continuous-flow reactors can improve the sustainability of the synthesis of active pharmaceutical ingredients (APIs). Although this technology has been proven at the laboratory scale, its implementation at the pilot scale remains limited, especially for oxidation reactions using oxygen, a cost-effective and readily available green oxidizing agent. This limitation largely stems from the hazardous nature of these reactions and the challenges related to scaling up the gas–liquid process. Here, we present two examples of the successful, seamless scale-up of the aerobic oxidation of primary alcohols and aliphatic aldehydes in a compact heat exchanger reactor, while preserving the segmented flow characteristics and intensified conditions observed at the laboratory scale. Using a Kobelco SMCR® with a total reactive volume of 43 mL, a productivity of 20 g h<small>⁻¹</small> and 692 g h<small>⁻¹</small> could be achieved for the aerobic oxidation of benzyl alcohol into benzaldehyde and 2-ethylhexanal into 2-ethylhexanoic acid, respectively. The results crucially demonstrate the potential for implementing milli-structured reactors in pharmaceutical process chemistry.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 6","pages":" 1295-1306"},"PeriodicalIF":3.1,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148202873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}