Circulation: Heart Failure最新文献

{"title":"Letter by Shah Regarding Article, \"Reversible Cause of Heart Failure?\"","authors":"Ashish H Shah","doi":"10.1161/CIRCHEARTFAILURE.124.012724","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012724","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012724"},"PeriodicalIF":7.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Analysis of T1 Pseudonormalization in the Advanced Stage of Female Fabry Cardiomyopathy.","authors":"Hiroki Aida, Ryo Nishikawa, Toshiyuki Yano, Kei Nakata, Naoto Murakami, Atsuko Muranaka, Masato Furuhashi","doi":"10.1161/CIRCHEARTFAILURE.124.012234","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012234","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012234"},"PeriodicalIF":7.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Succinylation of SERCA2a at K352 Promotes Its Ubiquitinoylation and Degradation by Proteasomes in Sepsis-Induced Heart Dysfunction.","authors":"Ni Yang, Linus Li, Xiao-Lu Shi, Yong-Ping Liu, Ri Wen, Yu-Hang Yang, Tao Zhang, Xin-Ru Yang, Yang-Fan Xu, Chun-Feng Liu, Wanshan Ning, Tie-Ning Zhang","doi":"10.1161/CIRCHEARTFAILURE.124.012180","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012180","url":null,"abstract":"<p><strong>Background: </strong>Intracellular Ca²⁺ cycling governs effective myocardial systolic contraction and diastolic relaxation. SERCA2a (sarco/endoplasmic reticulum Ca²⁺ ATPase type 2a), which plays a crucial role in controlling intracellular Ca²⁺ signaling and myocardial cell function, is downregulated and inactivated during sepsis-induced heart dysfunction. However, the cause of this dysregulation remains unclear. In this study, we investigated the effect of lysine succinylation in lipopolysaccharide-induced septic heart dysfunction through global succinylome analysis of myocardial tissues from septic rats.</p><p><strong>Methods: </strong>We conducted a succinylome profiling and developed a protein language model-based framework to prioritize succinylation at a functionally important site, and further analysis revealed crosstalk between ubiquitination and succinylation of SERCA2a. The succinylation of SERCA2a in septic rats or lipopolysaccharide-treated cells were detected by co-immunoprecipitation. Thereafter, a desuccinylated SERCA2a^K352R was introduced and its function and stability were determined by Ca²⁺ transient and Western blot, respectively. Meanwhile, the effect on SERCA2a^K352R on heart function was assessed in vivo by echocardiography and hemodynamics.</p><p><strong>Results: </strong>We identified 10 324 succinylated lysine sites in heart tissues, including 1042 differentially succinylated lysine sites, in response to lipopolysaccharide. SERCA2a was hypersuccinylated in the myocardial tissues of septic rats and lipopolysaccharide-treated cardiomyocytes. Increased ubiquitination level, reduced protein level, and activity of SERCA2a were observed, along with increased succinylation of SERCA2a in vivo and in vitro. K352 was essential for SERCA2a succinylation, which reduced SERCA2a protein level by promoting formation of the K48 ubiquitin chain on SERCA2a and its degradation by proteasomes. Co-immunoprecipitation combined with liquid chromatography-tandem mass spectrometry identified that SIRT2 (sirtuin2), a deacylase, exhibited interaction with SERCA2a. Furthermore, SIRT2 decreased K352 succinylation of SERCA2a, suggesting that SIRT2 may function as a desuccinylase for SERCA2a.</p><p><strong>Conclusions: </strong>Succinylation of SERCA2a at K352, which was controlled by SIRT2, promotes its ubiquitinoylation and degradation by proteasomes in sepsis-induced heart dysfunction.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012180"},"PeriodicalIF":7.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Arrest, Severe Aortic Regurgitation, and Unknown Neurologic Status: A Role for Temporary Left Ventricular Assist Devices.","authors":"Anju Bhardwaj, Ismael A Salas de Armas, Jarot Guerra, Harish Devineni, Manish Patel, Sriram Nathan, Igor D Gregoric, Biswajit Kar","doi":"10.1161/CIRCHEARTFAILURE.124.011929","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011929","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011929"},"PeriodicalIF":7.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Bhimaraj et al to Letter Regarding Article, \"Pitfalls in the World of Evidence-Based Medicine: Should IABP Be en-DANGER-ed by the DanGer Shock Trial?\"","authors":"Arvind Bhimaraj, Arthur R Garan, Manreet K Kanwar","doi":"10.1161/CIRCHEARTFAILURE.124.012655","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012655","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012655"},"PeriodicalIF":7.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Dalzell and Cannon Regarding Article, \"Pitfalls in the World of Evidence-Based Medicine: Should IABP Be en-DANGER-ed by the DanGer Shock Trial?\"","authors":"Jonathan R Dalzell, Jane A Cannon","doi":"10.1161/CIRCHEARTFAILURE.124.012607","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.012607","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012607"},"PeriodicalIF":7.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Intracardiac Thrombosis Due to Long-Standing, Asymptomatic Ventricular Fibrillation Under Left Ventricular Assist Device Support.","authors":"Lara S Schlender, Marco Ochs, Reza Wakili, Robert Stöhr, Fabian Emrich, Thomas Walther, Jan Gummert, Michiel Morshuis, David M Leistner, Maria Papathanasiou","doi":"10.1161/CIRCHEARTFAILURE.124.011639","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011639","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011639"},"PeriodicalIF":7.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline-Directed Medical Therapy for Heart Failure in Transthyretin Amyloid Cardiomyopathy.","authors":"Stéphanie Kristina Schwarting, Thomas Bieber, Daniel R Davies, Fabian Aus dem Siepen, Julian Schwarting, Ulrich Grabmaier, Steffen Massberg, Mathew S Maurer, Stefan Kääb","doi":"10.1161/CIRCHEARTFAILURE.124.011796","DOIUrl":"https://doi.org/10.1161/CIRCHEARTFAILURE.124.011796","url":null,"abstract":"<p><p>Cardiac amyloidosis is an underdiagnosed cause of infiltrative cardiomyopathy, leading to heart failure across the spectrum of ejection fractions. Although there are approved disease-modulating therapies for the transthyretin subtype (transthyretin amyloid cardiomyopathy [ATTR-CM]), the role of heart failure medications remains uncertain and challenging in clinical practice. Their effects on clinical outcomes, such as mortality and hospitalization, are unknown for ATTR-CM. This review aims to explore the use of these medications in ATTR-CM, considering the disease's stage and patient-specific issues, such as fluid homeostasis, autonomic dysfunction, conduction disorders, low and fixed stroke volumes, and decreased functional capacity. As our understanding of this condition deepens, it is important to reassess the impact of contemporary heart failure medication in ATTR-CM. Finally, the relevance of guideline recommendations for heart failure drugs based on left ventricular ejection fraction should be reconsidered in the context of ATTR-CM.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011796"},"PeriodicalIF":7.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Role of Myocardial Inflammation in ATTR-CM: A Targetable Mechanism?","authors":"Aldostefano Porcari, Marianna Fontana, Mattia Riefolo","doi":"10.1161/CIRCHEARTFAILURE.124.012652","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012652","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012652"},"PeriodicalIF":7.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic Capacity of Adults With Fontan Palliation: Disease-Specific Reference Values and Relationship to Outcomes.","authors":"Alexander C Egbe, Ahmed E Ali, William R Miranda, Heidi M Connolly, Barry A Borlaug","doi":"10.1161/CIRCHEARTFAILURE.124.011981","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.011981","url":null,"abstract":"<p><strong>Background: </strong>Patients with Fontan palliation have reduced aerobic capacity because of impaired cardiac, pulmonary, and skeletal muscle function. However, the assessment of aerobic capacity in this population still relies on comparisons with people without cardiovascular disease rather than comparison with the expected aerobic capacity of other Fontan patients. The purpose of this study was to determine the expected aerobic capacity of adults with Fontan palliation.</p><p><strong>Methods: </strong>Adults with Fontan palliation who underwent a cardiopulmonary exercise test at Mayo Clinic (2003-2023) were stratified into quartiles based on the predicted peak oxygen consumption (VO₂). We assessed the correlates of predicted peak VO₂ and the relationship between predicted peak VO₂ quartiles and cardiovascular outcomes (death/transplant).</p><p><strong>Results: </strong>Of 323 patients (age, 29±9 years; 177 [55%] men), the median peak VO₂ was 19.1 (15.2-23.9) mL/kg per minute, and this corresponds to a predicted peak VO₂ of 51% (range, 19-88; interquartile range, 41-62). After multivariable adjustments, the correlates of predicted peak VO₂ were body mass index (β±SE, -2.61±0.95; 2.61% decrease in predicted peak VO₂ per 5 kg/m² increase in body mass index; <i>P</i>=0.009), systemic saturation (β±SE, 3.65±0.85; 3.65% increase in predicted peak VO₂ per 5% increase in oxygen saturation; <i>P</i><0.001), and Fontan pressure (β±SE, -1.24±0.22; 1.24% decrease in predicted peak VO₂ per 1 mm Hg increase in Fontan pressures; <i>P</i><0.001). There was a 47% increase in the risk for death/transplant from a higher predicted peak VO₂ quartile to the next lower quartile (adjusted hazard ratio, 1.47 [95% CI, 1.09-2.05]; <i>P</i>=0.01).</p><p><strong>Conclusions: </strong>The results of the current study would help calibrate the interpretation of exercise test data in adults with Fontan palliation and improve risk stratification in this population. It also underscores the need to maintain normal Fontan hemodynamics and body weight, which are important determinants of aerobic capacity.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011981"},"PeriodicalIF":7.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}