Circulation: Heart Failure最新文献

{"title":"Insight Into the Formation of Apical Aneurysm in Hypertrophic Cardiomyopathy by Comprehensive Coronary Physiological Assessment.","authors":"Takashi Hiruma, Hiroyuki Kiriyama, Shun Kitamura, Shun Minatsuki, Norihiko Takeda","doi":"10.1161/CIRCHEARTFAILURE.125.013043","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013043","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013043"},"PeriodicalIF":8.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Multiomics for Prognostic Assessment in Pulmonary Arterial Hypertension.","authors":"Hongyang Pi, Samuel G Rayner, Ali Shojaie, Sina A Gharib, Peter J Leary, Lu Xia","doi":"10.1161/CIRCHEARTFAILURE.125.013084","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013084","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013084"},"PeriodicalIF":8.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Mechanics in Heart Failure With Preserved Ejection Fraction: Effect of a No-Implant Interatrial Shunt.","authors":"Michal Laufer-Perl, Nir Flint, Yaron Arbel, Fawaz Alenezi, Veraprapas Kittipibul, Dmitry Yaranov, Tamaz Shaburishvili, Rohit Amin, Marat Fudim","doi":"10.1161/CIRCHEARTFAILURE.124.012573","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012573","url":null,"abstract":"<p><strong>Background: </strong>The atria play an important role in the pathophysiology of heart failure with preserved ejection fraction. Decreased left atrial strain is associated with worse clinical outcomes. The impact of no-implant interatrial shunting on atrial structure and function has not been described.</p><p><strong>Methods: </strong>We characterized the left atrial (LA) and right atrial strain-pressure relationship at rest and during exercise, before and after creation of a no-implant interatrial shunt. We included patients with New York Heart Association class II, III, or ambulatory IV heart failure with a left ventricular ejection fraction ≥40% and elevated LA wedge pressure during supine ergometry (≥25 mm Hg). Exercise hemodynamics and echocardiographic measurements were analyzed at baseline, 1 month and 6 months (echo only) following transcatheter, transeptal creation of a 7 mm no-implant interatrial shunt.</p><p><strong>Results: </strong>A total of 33 patients were enrolled/included in the study. At 1 month, LA pressure at rest was significantly reduced from 19.7±7.0 to 17.2±5.0 mm Hg (<i>P</i>=0.044), and from 39.7±10.5 to 33.6±11.1 mm Hg (<i>P</i>=0.002) during exercise. Reductions in LA pressure were associated with a mean decrease of 55.4 mm Hg/W·kg in LA work (<i>P</i><0.001). Echo measurements demonstrated significant improvements in LA reservoir strain of +4.0% (<i>P</i>=0.015) and +4.1% (<i>P</i>=0.046) at 1 and 6 months, respectively. Modest improvements were observed in LA conduit and contractile strain, with a similar overall trend in right atrial strain measurements. These findings were associated with a significant reduction in LA volumes and an increase in right atrial volume. There was no change in right atrial pressure or measures of right ventricular function.</p><p><strong>Conclusions: </strong>Hemodynamic and strain assessment in patients with heart failure with preserved ejection fraction suggests that a no-implant interatrial shunt can significantly improve the pressure-function relationship of the LA.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04583527; URL: https://www.clinicaltrials.gov; Unique identifier: NCT04838353; URL: https://www.clinicaltrials.gov; Unique identifier: NCT05501652.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012573"},"PeriodicalIF":8.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Müller Regarding Article, \"Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis\".","authors":"Paulo de Tarso Müller","doi":"10.1161/CIRCHEARTFAILURE.125.012997","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.012997","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012997"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Heart Transplant Listings by Insurance and Race During the COVID Public Health Emergency.","authors":"Daniel K Fox, R J Waken, Fengxian Wang, Khavya Avula, David S Raymer, Justin M Vader, Joel D Schilling, Karen E Joynt Maddox","doi":"10.1161/CIRCHEARTFAILURE.124.012306","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012306","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic inequities in access to heart transplantation, including those based on insurance coverage and race or ethnicity, are well documented. During the COVID pandemic, the federal government declared a Public Health Emergency (PHE), which prevented states from disenrolling people from Medicaid. We sought to determine whether this policy was associated with changes in the insurance or racial composition of the heart transplant waiting list.</p><p><strong>Methods: </strong>Using the United Network for Organ Sharing thoracic data set, we conducted an observational cohort study that analyzed weekly counts of adults (aged >17 years) added to the heart transplant waitlist between January 1, 2018 and December 31, 2022. We obtained ratios of pre-PHE to PHE waitlisting rates by payer and race while accounting for demographics, trends over time, and overdispersion using latent lognormal Poisson dynamic generalized linear models.</p><p><strong>Results: </strong>There were 8224 heart transplant listings before the PHE and 12 261 during. We found no change in listing among privately insured (rate ratio [RR], 1.06 [95% CI, 0.91-1.24]), Medicare (RR, 1.11 [95% CI, 0.94-1.30]), or other government coverage listings (RR, 1.13 [95% CI, 0.91-1.39]), but did find an increase in Medicaid-covered listings (RR, 1.19 [95% CI, 1.01-1.42]). We found no increase in transplant listings during the PHE for patients who were White (RR, 1.03 [95% CI, 0.90-1.21]), but did find increases among patients who were Black (rate ratio, 1.20 [95% CI, 1.04-1.43]), Hispanic (RR, 1.24 [95% CI, 1.06-1.49]), and Asian/American Indian or Alaska Native/Hawaiian or Pacific Islander/multiracial (RR, 1.36 [95% CI, 1.14-1.66]).</p><p><strong>Conclusions: </strong>The COVID-related PHE was associated with changes in the insurance and racial composition of the heart transplantation waitlist that, if maintained, could reduce socioeconomic inequities in access to heart transplantation.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012306"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy.","authors":"Julien Ochala, Miao Feng, Qian Wang, Chahida Chaami, Edgar E Nollet, Christopher T A Lewis, Anthony L Hessel, Michelle Michels, Kenneth C Bedi, Kenneth B Margulies, Jose R Pinto, Kenneth S Campbell, Diederik W D Kuster, Jolanda van der Velden","doi":"10.1161/CIRCHEARTFAILURE.124.012614","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.012614","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic cardiomyopathy is often linked to likely pathogenic and pathogenic variants in genes encoding myofilament proteins. The exact molecular mechanisms by which these lead to cardiac dysfunction and metabolic remodeling remain incompletely understood. Hence, here, we sought to determine whether likely pathogenic and pathogenic variants in thick (<i>MYL2</i>) and thin (<i>TNNI3</i> or <i>TNNT2</i>) filament genes modulate the myosin super-relaxed state, a critical molecular regulator of heart energetics.</p><p><strong>Methods: </strong>We isolated cardiac strips from the septum of 13 patients with hypertrophic cardiomyopathy with <i>MYL2</i>, <i>TNNI3</i>, or <i>TNNT2</i> gene variants and 10 nonfailing donors. We performed 2'-(or-3')-<i>O</i>-(<i>N</i>-methylanthraniloyl) ATP chase experiments and x-ray diffraction as well as all-atomistic molecular dynamics simulations.</p><p><strong>Results: </strong>We observed that, despite preserved myofilament lattice, likely pathogenic and pathogenic variants in thick and thin filament proteins have opposite effects on cardiac myosin autoinhibition and the subsequent proportion of myosin molecules in the ATP-preserving super-relaxed state. As expected, <i>MYL2</i>-associated thick filament variants depressed myosin super-relaxation. However, with <i>TNNI3</i>- or <i>TNNT2</i>-related thin filament variants, myosin heads adopt an energy-saving biochemical hibernating state. Ultimately, these thin filament defects blunted the in vitro response to the hypertrophic cardiomyopathy-targeted inhibitor, mavacamten.</p><p><strong>Conclusions: </strong>Our findings indicate that, in hypertrophic cardiomyopathy, cardiac myosin super-relaxed state, associated ATP consumption, and in vitro mavacamten responsiveness depend on the type of myofilament variants. Our data warrant careful analyses of variant-specific responses to myosin inhibitors in the clinic.</p>","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e012614"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic Myocarditis in Children From Toxocara Canis: A Case and Review of the Literature.","authors":"Joe Stephenson, Mario O'Connor, Maria Hoyos, Anthony Merlocco, Jason Johnson, Hugo Martinez","doi":"10.1161/CIRCHEARTFAILURE.124.011531","DOIUrl":"10.1161/CIRCHEARTFAILURE.124.011531","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e011531"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Tang et al to Letter Regarding Article, \"Impaired Exercise Capacity in High-Risk Diabetic Cardiomyopathy: The ARISE-HF Cardiopulmonary Exercise Testing Subanalysis\".","authors":"W H Wilson Tang, Yuxi Liu, James L Januzzi, Gregory D Lewis","doi":"10.1161/CIRCHEARTFAILURE.125.013099","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013099","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013099"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There's No Place Like Home: Using Ambulatory Invasive Hemodynamic Monitoring to Facilitate Early Discharge From Heart Failure Hospitalization.","authors":"Matthew R Carey, Michael M Givertz","doi":"10.1161/CIRCHEARTFAILURE.125.013274","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013274","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013274"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Status in Large Heart Failure Trials: A Call to Action.","authors":"Nina Manian, Michelle Doering, Karen E Joynt Maddox, Nancy K Sweitzer, Mustafa Husaini","doi":"10.1161/CIRCHEARTFAILURE.125.013031","DOIUrl":"10.1161/CIRCHEARTFAILURE.125.013031","url":null,"abstract":"","PeriodicalId":10196,"journal":{"name":"Circulation: Heart Failure","volume":" ","pages":"e013031"},"PeriodicalIF":8.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}