Clinical and Experimental Health Sciences最新文献

{"title":"Presumptive Molecular Interconnections Between COVID-19 And Huntington’s Disease","authors":"Duygu SARI AK, Omar Alomari, Ülkan Kılıç","doi":"10.33808/clinexphealthsci.1256952","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1256952","url":null,"abstract":"Objective: The healthcare system worldwide has faced unparalleled challenges as a result of the coronavirus disease of 2019 (COVID-19) pandemic. While respiratory tract disease is the most common symptom of COVID-19, there is increasing evidence of neurological damage caused by the virus. To guide the clinical management of the disease, it is essential to elucidate the mechanisms underlying the \u0000pathophysiology of COVID-19. Various research indicate that COVID-19 patients exhibit reduced levels of brain-derived neurotrophic factor (BDNF), which is also a hallmark of Huntington’s disease, a neurodegenerative disorder. The objective of this study is to investigate the possible links between COVID-19 and Huntington’s disease. This aim is motivated by the need to guide the clinical management of COVID-19, especially given the increasing evidence of neurological damage caused by the virus, including reduced levels of BDNF, a hallmark also observed in Huntington’s disease. \u0000Methods: The comprehensive literature review conducted for both COVID-19 and Huntington’s disease, focusing on the genes associated with both conditions. These genes were then analyzed using the STRING database to determine protein-protein interactions, aiming to elucidate the mechanisms underlying the pathophysiology of COVID-19 and its potential connections to Huntington’s disease. \u0000Results: The outcomes of the study indicate that there could be molecular-level interactions between COVID-19 and Huntington’s disease, based on the literature research and STRING database analysis. Although the primary mechanism behind these interactions is not yet fully understood, the hypothesis suggests that BDNF and its high-affinity receptor TrkB may play a crucial role. Additionally, the study highlights olfactory dysfunction as a common symptom of COVID-19, which is also linked with various neurodegenerative conditions, including Huntington’s disease. \u0000Conclusion: This work emphasizes the connection between COVID-19 and neurodegenerative diseases, particularly through the lens of olfactory dysfunction, a common symptom shared by COVID-19 and Huntington’s disease. The potential molecular interactions observed suggest that COVID-19 could exacerbate neurodegenerative processes. This underscores the critical need for further research focused on olfactory dysfunction as a key symptom, to better understand and manage the implications of COVID-19 in patients with neurodegenerative conditions.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140235654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Enzyme Inhibitory Effects of the Nanohybrid Eggplant Extract: An Unusual Pharmaceutical Form for Medicinal Plant","authors":"Ceylan Dönmez, U. Çalışkan, Nuraniye Eruygur, C. Altinkaynak, N. Özdemir","doi":"10.33808/clinexphealthsci.1074661","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1074661","url":null,"abstract":"Objective: Recently, biosynthesis/synthesis of nanoflowers has become very attractive for chemical and pharmaceutical sciences, and enhanced enzyme activities. Various plant extracts and their active compounds are effectively used as organic component for novel nanoflowers synthesis. Solanum melongena L., commonly known as eggplant in English, a vegetable and medicinal plant belongs to Solanaceae family has several advantages in materials synthesis due to cheap and obtained easily. The aim of this study is to compare the enzyme ((alpha-glucosidase (AGase), alpha-amylase (AAase), tyrosinase (Tyr), acetylcholinesterase (AChE) and butyryl cholinesterase (BChE)) inhibitory effects of the eggplant’ calyx extract and its Solanum-inorganic hybrid nanoflower (Sm-ihNFs) via in vitro experimental methods. \u0000Methods: The hybrid nanoflower was formed (NF) with organic molecules, eggplant extract (Sm), and inorganic compounds, copper to enhance the catalytic activities. The inhibition capacities of the eggplant extract, and its hybrid nanoflower were evaluated on selected enzymes (AGase, AAase, Tyr, AChE and BChE) which play significant roles physiologically by in vitro tests in this study. \u0000Results: According to inhibition percentages and IC50 values, Sm-ihNFs showed higher inhibitory activities on enzymes other than ache than the plain crude plant extract. Among all the enzymes that were studied, Sm-ihNFs demonstrated significantly higher alpha-glucosidase and alpha-amylase inhibition activities compared to acarbose. And when compared to galanthamine hydrobromide Sm-ihNFs showed higher enzyme inhibition and significant IC50 value. \u0000Conclusion: It was thought that Sm-ihNFs prepared from eggplant extract may have promising potential for antidiabetic drug formulations in the future. The hybrid nanoflowers will be promising and guide for the future work in terms of pharmaceutical and cosmeceutical industry.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Validity and Reliability of the Postpartum Symptom Inventory in Turkish Women","authors":"S. Aksoy, Nafiye Dutucu, Büşra Kaynar, Ayça Şolt Kırca","doi":"10.33808/clinexphealthsci.1281203","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1281203","url":null,"abstract":"Objective: Postpartum period is a significant period that covers approximately 6 weeks after childbirth, progresses with various symptoms, and affects the life of the woman. The study was conducted in order to test the validity and reliability of the Postpartum Symptom Inventory (PSI-20). \u0000Methods: The study was conducted on 310 participants with a descriptive, cross-sectional, and methodological design. The study data were collected through Identifying Information Form, Postpartum Symptom Inventory, and Edinburgh Postnatal Depression Scale as a parallel form. In the analysis of the data, factor analysis, Cronbach’s alpha coefficient, and item-total score correlations were used. \u0000Results: The scale consisted of 20 items under 6 subscales with a variance of 71%. The Cronbach’s alpha coefficient of the Turkish version of the scale was 0.86. According to split-half test reliability, Cronbach’s alpha coefficients of the first and second halves were found to be 0.71 and 0.73, respectively, Guttman split-half coefficient was 0.94, and the correlation coefficient between the halves was determined as 0.88. According to confirmatory factor analysis, Root Mean Square Error of Approximation Index (RMSEA) 0.072, Goodness of Fit index (GFI) value was 0.89, Comparative Fit Index (CFI) value was 0.94, Relative Fit Index (RFI) was 0.89, Incremental Fit Index (IFI) was 0.94, and Tucker-Lewis index (TLI) value was found as 0.93. \u0000Conclusion: As a result of the study, it was determined that the Turkish version of the Postpartum Symptom Inventory (PSI-20) was a valid and reliable tool in order to measure postpartum symptoms in Turkish women.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Sex Education and Counseling Based on the Ex-PLISSIT Model on Sexual Life in Primigravidas","authors":"Nermin Altunbas, Zehra Gölbaşi","doi":"10.33808/clinexphealthsci.1305002","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1305002","url":null,"abstract":"Objective: This study was conducted to determine the effect of sexual education and counseling based on the Ex-PLISSIT model on sexual function, attitudes towards sexuality during pregnancy, sexual distress, and quality of sexual life in primigravidas. \u0000Methods: This study was carried out on 62 primigravidas in a pretest posttest, a quasi-experimental control group. Primigravidas meeting the inclusion criteria were assigned to the groups by simple random sampling method. The intervention group received training and counseling sessions twice. The control group received routine care during the follow-up period. The results were compared with the evaluation forms 10 weeks after each training and counseling session. The forms were administered to the control group at the same time as the intervention group. \u0000Results: The mean scores of the intervention and control groups’ attitude towards sexuality during pregnancy in the second test (95%CI=2.33-19.01; d=0.65, p=.013) and in the posttest (95%CI=2.28-19.34; d=0.64, p=.015) were statistically significantly different. Sexual life quality scale mean scores of the intervention and control groups were statistically significant in the second test (95%CI=8.27-18.54; d=1.33, p=.000) and the posttest (95%CI=12.14-22.01; d=1.76, p=.000) level was different. In addition, the mean scores of the intervention group were higher after sexual education and counseling based on the Ex-PLISSIT model. \u0000Conclusion: In this study, sexual education and counseling based on the Ex-PLISSIT model positively affected primigravida’s attitudes towards sexuality and their quality of sexual life. Therefore, this model can be used as a cost-effective and simple counseling method to improve the sexual life.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketogenic Diet Interventions in Inborn Errors of Metabolism: A Review Article","authors":"Cansu Kök Şan, Mücahit Muslu, G. Gökçay","doi":"10.33808/clinexphealthsci.1310203","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1310203","url":null,"abstract":"Objective: The ketogenic diet, which has been used in the treatment of epilepsy since the 1920s, is a diet containing high fat, sufficient protein, and low carbohydrate. The ketogenic diet mimics the metabolic effects of fasting by shifting metabolism towards fat utilization. The ketogenic diet, which has different variants, such as the classical ketogenic diet, modified Atkins diet, and medium-chain triglyceride diet, is used in inborn errors of metabolism to target the underlying metabolic state by bypassing the damaged metabolic pathway or to treat the clinical symptoms of inborn errors of metabolism, such as epileptic seizures. In this review, we assessed the evidence for ketogenic diet interventions in the treatment of inborn errors of metabolism. \u0000Methods: The Google Scholar search engine, PubMed, Scopus, and Science Direct databases were used to find studies on the use of ketogenic diet interventions in the treatment of inborn errors of metabolism. \u0000Results: The beneficial effects of different variants of the ketogenic diet on glucose transport type 1 deficiency syndrome and pyruvate dehydrogenase complex deficiency have long been recognized. There are also favorable data on its use in myopathic glycogen storage diseases, mitochondrial diseases, and nonketotic hyperglycinemia accompanied by epilepsy. \u0000Conclusion: The evidence is mostly based on individual case reports, case series, and clinical trials with small sample sizes and is insufficient to make recommendations.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140476855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Intensive Care Experience and State Anxiety in Patients Treated in Coronary Intensive Care Units","authors":"Esra Türker, E. Yazgan","doi":"10.33808/clinexphealthsci.1254121","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1254121","url":null,"abstract":"Objective: This study aimed to determine the correlation between the intensive care experience and the state anxiety of patients hospitalized in the coronary intensive care unit. \u0000Methods: This descriptive cross-sectional study included 192 patients from the coronary intensive care unit of a university hospital. Data were collected using a Patient Information Form, the Intensive Care Experience Scale (ICE), and the Spielberger State Anxiety Inventory (STAI-I). The analysis was conducted using SPSS software version 25.0. Descriptive statistics were reported as counts, percentages, means, and standard deviations. A p-value of less than 0.05 was considered to indicate statistical significance. \u0000Results: Among the participants, 38% were aged 65 and older, 76.6% were male, 93.2% were married, 63% were admitted to the intensive care unit from the emergency room, and 88.5% had prior experience in an intensive care unit. The total and sub-dimension scores of the ICE and STAI-I were moderate. We found a weak positive correlation between the STAI-I total score and the ICE total score (r= 0.320). There was a very strong positive correlation between pessimistic experiences in the intensive care unit and the STAI-I total score (r=0.907). Additionally, there was a moderate negative correlation between satisfaction with care received in the intensive care unit and the sub-dimensions of memory of experiences (Awareness of Surroundings, Satisfaction with the Care, Recollection of Experiences) (r=0.252, r=-0.489, r=-0.496). \u0000Conclusion: The study found that pessimistic experiences in the intensive care unit can significantly impact patients' state anxiety.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Theory-Based Care on Breastfeeding Self-Efficacy, Anxiety and Breast Milk Release","authors":"Reyyan Gürel, Ayten Şentürk Erenel","doi":"10.33808/clinexphealthsci.1239306","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1239306","url":null,"abstract":"Objective: The effect of nursing care provided according to Dennis’ breastfeeding self-efficacy theory on breastfeeding self-efficacy, anxiety, and breast milk secretion was evaluated. \u0000Methods: In this quasi-experimental study, 60 mothers in the first week postpartum were examined. The mothers and their supporters in the Dennis Theory-Based Nursing Care group were trained. Before the training, mothers were given the personal information form and the breastfeeding diary form to be filled out for 15 days. The perception of breastfeeding self-efficacy of mothers was evaluated using the “Postpartum Breastfeeding Self-Efficacy Scale”. Their anxiety was determined using the “State Anxiety Scale”, and breast milk release was assessed using the “Daily Form for Baby’s Adequate Nutrition”. The parameters were measured on the first day and 15 days after the training. Routine hospital standard nursing care was provided to the mothers in the control group. \u0000Results: The number of formulas given by mothers in the Dennis Theory-Based Nursing Care group to their babies was significantly lower than the number of formulas given by the mothers in the control group (Z=–0.90, p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Spousal Support on Postpartum Depression and Quality of Life","authors":"Sümeyra Damsarsan, Besey Ören","doi":"10.33808/clinexphealthsci.1259700","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1259700","url":null,"abstract":"Objective: The study was conducted to determine the effect of spousal support on postpartum depression and quality of life. \u0000Methods: The descriptive and correlational study was conducted with 201 mothers between the 4th and 12th week postpartum in a Lokman Hekim Hospital of Ankara. The data were collected with the Personal Information Form, the Spouse Support Scale, the Edinburg Postpartum Depression Scale, and the World Health Organization Quality of Life Scale-Short Form. The data were evaluated using the SPSS 22.0 program, parametric methods, correlation and regression analyses and descriptive statistics. \u0000Results: The mean scores of the participants were 66.23±18.19 on the Spouse Support Scale, 6.14±7.90 on the Edinburg Postpartum Depression Scale and 15.09±3.72 on the World Health Organization Quality of Life Scale. The postpartum depression rate was 25.4%. There was a negative and high correlation between the Spouse Support Scale and the Edinburgh Postpartum Depression Scale (r=-.84, p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140504412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of Mental Health and Cognitive-Emotional States with Family Planning Attitudes in Young Women with Chronic Diseases","authors":"S. Çankaya, Gonca Buran, Lütfiye Güler","doi":"10.33808/clinexphealthsci.1279416","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1279416","url":null,"abstract":"Objective: The aim of this study was to determine the relationship of mental health and cognitive emotional states with family planning attitudes in young women with chronic diseases. \u0000Methods: This cross-sectional and descriptive study was conducted between 12 January 2022 and 01 April 2022. The study included a total of 410 young women with chronic diseases who were hospitalized in the internal medicine clinics of a university hospital or presented to the internal medicine clinics for examination. Data were collected using a Personal Information Form, the Mental Health Continuum–Short Form (MHC–SF), the Cognitive Emotion Regulation Questionnaire (CERQ), and the Family Planning Attitude Scale (FPAS). \u0000Results: It was found that 20.2% (n=83) of the young women with chronic diseases had scores below the FPAS (135.5±22.1) cut-off point (","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Bone Microstructure Parameters by Using Tomographic Methods and Compressive Strength Estimation","authors":"Sema Kaya, Alaettin Koç","doi":"10.33808/clinexphealthsci.1330362","DOIUrl":"https://doi.org/10.33808/clinexphealthsci.1330362","url":null,"abstract":"Objective: The aim of this study was to evaluate the microstructure of the mandible by micro computed tomography (µCT), cone beam computed tomography (CBCT) and computed tomography (CT) and to estimate the compressive strength of the bone based on the values obtained by these methods. \u0000Methods: Thirty specimens obtained from ex-vivo sheep mandible were scanned by µCT cone beam computed tomography and computed tomography. These specimens were also subjected to compression testing and compression strength values were calculated. Morphometric parameters were evaluated using ImageJ software Bland-Altman lower upper bound agreement and ICC coefficient were used to evaluate the agreement between the tomography methods used and the gold standard. Linear and multivariate stepwise regression analysis was performed to calculate the compression strength value based on the radiomorphometric parameters. Statistical significance level was accepted as .05. \u0000Results: Bone Surface/Total Volume, Bone Volume/Total Volume and Degree of Anistoropy parameters evaluated by CBCT and Fractal Dimension parameter evaluated by CT showed a statistically significant agreement with the gold standard method µCT. Bone Volume/Total Volume and Degree of Anistoropy parameters obtained with µCT (R2:0.75), Bone Volume/Total Volume, Degree of Anistoropy , Connectivity Density parameters (R2:0.62), and the Structure Model Index parameter (R2:0.13) obtained by CT can be used to predict the compression strength value. \u0000Conclusion: Bone compression strength can be estimated by CBCT and µCT methods in a desired level. Bone Volume/Total Volume and Degree of Anistoropy parameters are significant determinants of bone mechanical property in not only µCT but also CBCT method.","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140504872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}