透明质酸漱口水对糖尿病大鼠腭继发性创面愈合的临床疗效评价

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Clinical and Experimental Health Sciences Pub Date : 2023-09-12 DOI:10.33808/clinexphealthsci.1258371

Ezgi AKÇE, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hatice Selin YILDIRIM

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摘要

目的:观察透明质酸(HA)漱口水对糖尿病(D)大鼠继发性腭面创面愈合的影响。& # x0D;方法:将60只雄性Wistar白化大鼠分为糖尿病组和非糖尿病组。随机选取30只大鼠，先腹腔注射烟酰胺110 mg/kg，然后腹腔注射链脲佐菌素65 mg/kg溶液15 min，诱导糖尿病。在上颚中央行5毫米切口切除。之后，每组处死6只动物。然后，两组再细分为两组:0.12% HA漱口水和生理盐水(S) (n=12每组)，取决于给药剂的创面(WA)。在第7天和第14天，每组各取6只大鼠，利用Image J软件进行摄影测量。结果:各组心肌WA均随时间延长而降低(p

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Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid (HA) mouthwash on healing of secondary palatal wound in diabetic (D) rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic (ND) groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mg/kg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mg/kg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12% HA mouthwash and saline (S) (n=12 per group), depending on the agent to be administered to the wound area (WA). On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group (p

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Clinical and Experimental Health Sciences MEDICINE, RESEARCH & EXPERIMENTAL-

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