{"title":"补充维生素D3对大鼠颅骨骨缺损再生影响的影像学评价","authors":"Gülce Nil VARLIHAN, Ömer Birkan AĞRALI, Hatice Selin YILDIRIM, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hafize ÖZTÜRK ÖZENER","doi":"10.33808/clinexphealthsci.1262852","DOIUrl":null,"url":null,"abstract":"Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
 Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software. 
 Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p","PeriodicalId":10192,"journal":{"name":"Clinical and Experimental Health Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.3000,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats\",\"authors\":\"Gülce Nil VARLIHAN, Ömer Birkan AĞRALI, Hatice Selin YILDIRIM, Sibel DEMİRCİ DELİPINAR, Leyla KURU, Hafize ÖZTÜRK ÖZENER\",\"doi\":\"10.33808/clinexphealthsci.1262852\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
 Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software. 
 Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p\",\"PeriodicalId\":10192,\"journal\":{\"name\":\"Clinical and Experimental Health Sciences\",\"volume\":\"45 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2023-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Health Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33808/clinexphealthsci.1262852\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Health Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33808/clinexphealthsci.1262852","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Radiographic Evaluation of the Effect of Vitamin D3 Supplementation on Regeneration of Calvarial Bone Defects in Rats
Aim: The present study was aimed to evaluate radiographically the effect of orally administered vitamin D3 on guided bone regeneration in calvarial critical size defects (CSD) in rats.
Methods: Two calvarial CSD were created in 12 male Sprague-Dawley rats. One of the defects was left empty (E defect), while the other one was treated with deproteinized bovine bone graft and collagen-based resorbable membrane (GM-filled defect). Following surgical intervention, rats were randomly assigned into two groups; the control group was administered distilled water, and the test group was treated with 2 µg /kg vitamin D3 by gavage once a day for 8 weeks. Radiological images were obtained from rats on 4th and 8th weeks. The area fraction of newly formed osteoid was determined using Image Fiji Analysis Software.
Results: The percentages of area fraction in the GM-filled defects were statistically higher than the E defects in both study groups at 4th and 8th weeks (p
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