Chirality最新文献_第3页

Observation of the Liquid–Liquid Phase Separation of FUS-LC Using Vacuum-Ultraviolet Circular Dichroism Spectroscopy 利用真空-紫外光圆二色光谱观测 FUS-LC 的液-液相分离。

IF 2.8 4区化学

Chirality Pub Date : 2024-08-11 DOI: 10.1002/chir.23707

Kentaro Fujii, Yudai Izumi, Nobuo Maita, Koichi Matsuo, Masato Kato

引用次数: 0

Inherently Chiral Oligomers Based on Indole–Benzothiophene Core 基于吲哚-苯并噻吩核心的固有手性低聚物。

IF 2.8 4区化学

Chirality Pub Date : 2024-08-07 DOI: 10.1002/chir.23710

Bartlomiej Bonczak, Sara Grecchi, Malinee Niamlaem, Gerardo Salinas, Roberto Cirilli, Serena Arnaboldi

{"title":"Inherently Chiral Oligomers Based on Indole–Benzothiophene Core","authors":"Bartlomiej Bonczak, Sara Grecchi, Malinee Niamlaem, Gerardo Salinas, Roberto Cirilli, Serena Arnaboldi","doi":"10.1002/chir.23710","DOIUrl":"10.1002/chir.23710","url":null,"abstract":"<p>In recent years, transductors of chiral information based on conducting polymers have gained considerable attention. In particular, inherently chiral materials, which allow differentiation between the antipodes of a chiral analyte in terms of energetic variations, are highly desired. In this work, we successfully synthesized a novel inherently chiral oligomer based on an indole–benzothiophene core, namely, 2-([2,2′-bithiophen]-5-yl)-3-(2-([2,2′-bithiophen]-5-yl)benzo[<i>b</i>]thiophen-3-yl)-<i>N</i>-methylindole (BTIndT<sub>4</sub>). The electrochemical characterization evidences a stabilization of electrogenerated radical cations due to the presence of the indole group, which guides the oligomerization, producing well-ordered polymeric matrices. Furthermore, the in situ electrochemical conductance analysis demonstrates a simultaneous intrachain and interchain transfer of charge carriers. Finally, the highly efficient enantiorecognition capabilities of the antipodes of the oligo-BTIndT<sub>4</sub> films toward the enantiomers of tryptophan and 3,4-dihydroxyphenylalanine (DOPA), as model chiral analytes, were demonstrated.</p>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chir.23710","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review 使用质谱方法分析手性药物的对映体：全面综述。

IF 2.8 4区化学

Chirality Pub Date : 2024-08-06 DOI: 10.1002/chir.23705

Bhaskar Vallamkonda, Sonika Sethi, PhanikumarReddy Satti, Dipak Kumar Das, Suman Yadav, Vinod Kumar Vashistha

{"title":"Enantiomeric Analysis of Chiral Drugs Using Mass Spectrometric Methods: A Comprehensive Review","authors":"Bhaskar Vallamkonda, Sonika Sethi, PhanikumarReddy Satti, Dipak Kumar Das, Suman Yadav, Vinod Kumar Vashistha","doi":"10.1002/chir.23705","DOIUrl":"10.1002/chir.23705","url":null,"abstract":"<div>\u0000 \u0000 <p>Chirality plays a crucial role in the drug development process, influencing fundamental chemical and biochemical processes and significantly affecting our daily lives. This review provides a comprehensive examination of mass spectrometric (MS) methods for the enantiomeric analysis of chiral drugs. It thoroughly investigates MS-hyphenated techniques, emphasizing their critical role in achieving enantioselective analysis. Furthermore, it delves into the intricate chiral recognition mechanisms inherent in MS, elucidating the fundamental principles that govern successful chiral separations. By critically assessing the obstacles and potential benefits associated with each MS-based method, this review offers valuable insights for researchers navigating the complexities of chiral analysis. Both qualitative and quantitative approaches are explored, presenting a comparative analysis of their strengths and limitations. This review is aimed at significantly enhancing the understanding of chiral MS methods, serving as a crucial resource for researchers and practitioners engaged in enantioselective studies.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141892995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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First Principles Simulations of Optical Rotation of Chiral Molecular Crystals 手性分子晶体光学旋转的第一原理模拟。

IF 2.8 4区化学

Chirality Pub Date : 2024-08-05 DOI: 10.1002/chir.23709

Emmanuel Forson, Taylor Parsons, Marco Caricato

{"title":"First Principles Simulations of Optical Rotation of Chiral Molecular Crystals","authors":"Emmanuel Forson, Taylor Parsons, Marco Caricato","doi":"10.1002/chir.23709","DOIUrl":"10.1002/chir.23709","url":null,"abstract":"<div>\u0000 \u0000 <p>In this work, we present simulations of the optical rotation (OR) for five molecular crystals at density functional theory level with periodic boundary conditions (DFT-PBC). Calculations are compared with experimental measurements and show semi-quantitative agreement with experimental data for three of the crystals: tartatic acid, benzil, and pentaerythritol. For the other two crystals, aspartic acid and glutamic acid, the calculated data are in qualitative agreement with, but two orders of magnitude smaller than, the experimental data. We provide some arguments that support the theoretical predictions and suggest that the experiments should be revisited. We also find that the position of H centers provided in experimental X-ray data is not sufficiently reliable for simulating OR, and better results are obtained when H atoms are allowed to relax while keeping heavier elements fixed at the experimental positions. Comparison with molecular cluster calculations with a better functional and a larger basis set indicate that the role of intermolecular interactions (reproduced with the PBC technique) is as or more important than the choice of model chemistry. Despite the current limitations in the level of theory that can be employed, these simulations provide a promising avenue to investigate the effect of intermolecular interactions on this sensitive electronic property of molecules and materials.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Image, Volume 36, Issue 6 封面图片，第 36 卷第 6 期

IF 2.8 4区化学

Chirality Pub Date : 2024-07-30 DOI: 10.1002/chir.23666

Massimiliano Gaeta, Gabriele Travagliante, Matteo Barcellona, Maria Elena Fragalà, Roberto Purrello, Alessandro D'Urso

引用次数: 0

Helicenes on Surfaces: Stereospecific On-Surface Chemistry, Single Enantiomorphism, and Electron Spin Selectivity 表面上的烯烃：立体特异性表面化学、单一对映体和电子自旋选择性。

IF 2.8 4区化学

Chirality Pub Date : 2024-07-30 DOI: 10.1002/chir.23706

Karl-Heinz Ernst

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Structural Investigations of Cargo Molecules Inside Icosahedrally Symmetric Encapsulin by VUVCD Spectroscopic Measurements 通过紫外可见分光光度法测量二十面体对称包囊蛋白内货物分子的结构。

IF 2.8 4区化学

Chirality Pub Date : 2024-07-30 DOI: 10.1002/chir.23700

Shiori Kumamoto, Akima Yamamoto, Yu Shiratsuchi, Koichi Matsuo, Akifumi Higashiura, Daisuke Hira

{"title":"Structural Investigations of Cargo Molecules Inside Icosahedrally Symmetric Encapsulin by VUVCD Spectroscopic Measurements","authors":"Shiori Kumamoto, Akima Yamamoto, Yu Shiratsuchi, Koichi Matsuo, Akifumi Higashiura, Daisuke Hira","doi":"10.1002/chir.23700","DOIUrl":"10.1002/chir.23700","url":null,"abstract":"<p>Prokaryotes organize intracellular compartments with protein-based organelles called encapsulins. Encapsulins with icosahedral symmetry can encapsulate specific cargo proteins mediated by targeting peptides or encapsulation-mediating domains. Encapsulins have been used in eukaryotic cells for bioengineering, vaccine development, and nanoparticle alignment. Their versatility makes them attractive for research; however, detailed structural information on encapsulins is crucial for further applied research. However, cargo proteins are randomly oriented inside the icosahedral encapsulins. The random orientation of cargo proteins presents a challenge for structural analysis that relies on averaging processes such as x-ray crystallography and cryo-electron microscopy (cryo-EM) single-particle imaging. Therefore, we aimed to accurately estimate the secondary structure content and elucidate the structure of cargo proteins inside the particle by measuring the circular dichroism (CD) spectra using vacuum ultraviolet circular dichroism (VUVCD) spectroscopy. Thus, the structure of the cargo protein inside encapsulin was evaluated. This approach could potentially set a standard for evaluating cargo proteins inside particles in future applied research on encapsulins.</p>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chir.23700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Chirality Answer Whether We Are Alone? 手性能回答我们是否孤独吗？

IF 2.8 4区化学

Chirality Pub Date : 2024-07-25 DOI: 10.1002/chir.23708

Gintautas Bagdžiūnas

{"title":"Can Chirality Answer Whether We Are Alone?","authors":"Gintautas Bagdžiūnas","doi":"10.1002/chir.23708","DOIUrl":"10.1002/chir.23708","url":null,"abstract":"<div>\u0000 \u0000 <p>Detecting biosignatures of life in extraterrestrial environments remains one of the primary objectives of scientific inquiry. Currently, both remote and direct detection methods are primarily aimed at identifying key molecular classes fundamental to terrestrial biology. However, a more universally applicable spectroscopic approach could involve searching for homochiral molecules. Thus, this perspective delves into the significance of homochirality as a critical factor in the origin of life. Without homochirality, the formation of self-recognizing and self-replicating complex molecules would be hindered. The various hypotheses concerning the origin of homochiral molecules have been explored and analyzed within this context. This perspective emphasizes the potential for discovering extraterrestrial microscopic life through the detection of homochiral molecules using chirodetecting methods such as chromatography and chiroptical spectroscopy or circular polarimetry as a promising remote technique. This discussion highlights the importance of homochirality in the broader search for life beyond Earth and underscores the need for innovative methodologies and instrumentation in astrobiological research. These techniques can be an effective method for detecting homochirality on future planetary missions.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Regulation of Supramolecular Chirality in Achiral Side-Chain Azobenzene Liquid-Crystalline Polymers 手性侧链偶氮苯液晶聚合物中超分子手性的双重调控。

IF 2.8 4区化学

Chirality Pub Date : 2024-07-21 DOI: 10.1002/chir.23701

Chenrong Yuan, Ge Shi, Junle Zhang, Zhenqian Zhang, Yanjie He, Wenjie Zhang, Xiaoguang Qiao, Minying Liu, Xinchang Pang

{"title":"Dual-Regulation of Supramolecular Chirality in Achiral Side-Chain Azobenzene Liquid-Crystalline Polymers","authors":"Chenrong Yuan, Ge Shi, Junle Zhang, Zhenqian Zhang, Yanjie He, Wenjie Zhang, Xiaoguang Qiao, Minying Liu, Xinchang Pang","doi":"10.1002/chir.23701","DOIUrl":"10.1002/chir.23701","url":null,"abstract":"<div>\u0000 \u0000 <p>Azobenzene (Azo) liquid-crystalline polymers are intriguing due to their unique photo-induced isomerization and supramolecular chirality. However, clarification on multicomponent chiral induction towards Azo polymers remains ambiguous and challenging. Herein, chiral solvents and amines were employed to control the chiroptical activity of achiral Azo polymers. Methyl <i>L</i>-/<i>D</i>-lactate was added as the poor solvent and chiral inducer to achieve the first chiral induction in Azo aggregates. Chiral amines were utilized for the second chiral induction based on the acid–base interactions between the carboxyl groups of polymers and amines. The chiral enhancement and inversion of Azo units could be observed through the synergistic or antagonistic effect between solvents and amines. The impacts of solvent, chemical structures, feed ratio, enantiomeric excess, and temperature on supramolecular chirality were systematically studied. Furthermore, this system displayed the chiroptical switching property and chiral recovery under reversible irradiation.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical Activity of Nonactin and Its Cation Complexes Nonactin 及其阳离子复合物的光学活性

IF 2.8 4区化学

Chirality Pub Date : 2024-07-21 DOI: 10.1002/chir.23703

Afton Gustafson, Bart Kahr

引用次数: 0