Chirality最新文献_第2页

Structure Assessment and Impacts of Lipids' Chemistry on the Structuration of Polyhydroxyalkanoate Biosynthesized by Bacillus licheniformis AZU-A5 地衣芽孢杆菌 AZU-A5 生物合成的聚羟基烷酸酯的结构评估及脂类化学成分对其结构的影响

IF 2.8 4区化学

Chirality Pub Date : 2024-10-15 DOI: 10.1002/chir.23722

Mohamed I. A. Ibrahim, Mahmoud E. Esmael, Tamer R. Elmashi, Tatsuki Haga, Reda A. Bayoumi, Mohamed M. Eldanasoury, Mahmoud R. Sofy, Koichi Matsuo, Abdelrahman M. Khattab

{"title":"Structure Assessment and Impacts of Lipids' Chemistry on the Structuration of Polyhydroxyalkanoate Biosynthesized by Bacillus licheniformis AZU-A5","authors":"Mohamed I. A. Ibrahim, Mahmoud E. Esmael, Tamer R. Elmashi, Tatsuki Haga, Reda A. Bayoumi, Mohamed M. Eldanasoury, Mahmoud R. Sofy, Koichi Matsuo, Abdelrahman M. Khattab","doi":"10.1002/chir.23722","DOIUrl":"https://doi.org/10.1002/chir.23722","url":null,"abstract":"<p>The current study exploited cheese whey supernatant (CWS) as a renewable resource for polyhydroxyalkanoates (PHAs) formation. Structure identification and investigating the influence of lipid membranes' chemistry on PHA structuration were detailed. Approximately 66 bacterial isolates from dairy products companies in Egypt were screened for PHA production, and the bacterial isolate AZU-A5, identified as <i>Bacillus licheniformis</i> strain AZU-A5, showed the highest production PHA 0.93 g L<sup>−1</sup>) using whey lactose. The highest PHA rate in the individual design was 1.59 g L<sup>−1</sup> with a recovery yield of 33.08% (w w<sup>−1</sup>), while the production rate in the statistical design reached 1.75 g L<sup>−1</sup> PHA and 51.60% PHA content. Structurally, the PHA was identified as polyhydroxy-3R-butyrate (R-PH3B). The fibrous texture by SEM highlighted the self-assembly of PHB. The CD analysis of the PHA films suggested favorable hydrophobic interactions between lipids and PHB. Higher lipid contents not only caused a decrement in the CD signal of PHB but also bathochromic effects occurred. The chain length of lipids exerted high impacts on interactions (CD) and structuration of PHB (Δλ). The unsaturation showed little influence on CD and negligible effect on Δλ, while the head group exerted no effect on CD with a considerable impact on Δλ.</p>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chir.23722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Optical Activities of Organic Crystals: Crystal Orbital Formulation of Anisotropic Gyration 有机晶体的光学活性：各向异性回旋的晶体轨道模型

IF 2.8 4区化学

Chirality Pub Date : 2024-10-15 DOI: 10.1002/chir.23719

Masashi Hatanaka

引用次数: 0

Enantioselective Separation and Pharmacokinetics of a Chiral 1,4-Dihydropyrimidine Derivative in Rats: A Combined Chromatography and Docking Approach 手性 1,4-二氢嘧啶衍生物在大鼠体内的对映选择性分离和药代动力学：色谱与对接相结合的方法

IF 2.8 4区化学

Chirality Pub Date : 2024-10-13 DOI: 10.1002/chir.23723

Chiriki Devi Sri, Syed Faizan, Muttavarapu Rohit Chandra, B. R. Prashantha Kumar, B. M. Gurupadayya

{"title":"Enantioselective Separation and Pharmacokinetics of a Chiral 1,4-Dihydropyrimidine Derivative in Rats: A Combined Chromatography and Docking Approach","authors":"Chiriki Devi Sri, Syed Faizan, Muttavarapu Rohit Chandra, B. R. Prashantha Kumar, B. M. Gurupadayya","doi":"10.1002/chir.23723","DOIUrl":"https://doi.org/10.1002/chir.23723","url":null,"abstract":"<div>\u0000 \u0000 <p>Chirality in 1,4-Dihydropyrimidines influences their pharmacological properties and synthetic strategies. Enantiomers of chiral drugs often exhibit different pharmacokinetic profiles. Therefore, separating and studying individual enantiomers is crucial to optimize drug efficacy and safety. Enantiomeric separation of ±4-(4-chlorophenyl)-6-methyl-2-oxo-N-(O-toyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (DP-1), which is a 1,4-Dihydropyrimidine derivative is achieved on CHIRALCEL® OD-H column (particle size: 5 μm, inner diameter: 4.6 mm, length:150 mm), following by investigating the kinetic properties of (R) and (S) enantiomers. The separation was achieved with a mobile phase composed of 70% (v/v) isopropyl alcohol and 30% (v/v) n-hexane. For the bioanalytical study, acetonitrile was used to precipitate the rat plasma samples and validated the method according to USFDA guidelines. The validated bioanalytical method was then successfully applied to determine the pharmacokinetic parameters of the drug in biological samples. Molecular modeling techniques, specifically docking simulations, were employed to predict the elution order of DP-1 enantiomers. The docking results revealed moderate binding interactions between the enantiomers and the chiral stationary phase (CSP), which aligns with the theoretical expectation that stronger interactions lead to longer retention times on the column.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chiral Self-Sorting Process With C2 Symmetric Bisimidazoline Ligands 使用 C2 对称双咪唑啉配体的手性自分选过程

IF 2.8 4区化学

Chirality Pub Date : 2024-10-10 DOI: 10.1002/chir.23720

Caitlyn Dussart, Aline Maisse-François, Stéphane Bellemin-Laponnaz

引用次数: 0

Determination of Ibuprofen Enantiomers in Mouse Blood Using Liquid Chromatography–Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study 利用液相色谱-串联质谱法测定小鼠血液中的布洛芬对映体及其在药代动力学研究中的应用

IF 2.8 4区化学

Chirality Pub Date : 2024-10-08 DOI: 10.1002/chir.23721

Yuexin Li, Jinglai Li, Huanhuan Yang, Huan Luo, Shiqi Liu, Furong Han, Zhipeng Ruan, Zhili Xiong

{"title":"Determination of Ibuprofen Enantiomers in Mouse Blood Using Liquid Chromatography–Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study","authors":"Yuexin Li, Jinglai Li, Huanhuan Yang, Huan Luo, Shiqi Liu, Furong Han, Zhipeng Ruan, Zhili Xiong","doi":"10.1002/chir.23721","DOIUrl":"10.1002/chir.23721","url":null,"abstract":"<div>\u0000 \u0000 <p>The aim of this study was to establish a simple, fast, and sensitive method with liquid chromatography–tandem mass spectrometry (LC–MS/MS) for simultaneously determining ibuprofen enantiomers using mouse blood in very small volumes. LC–MS/MS equipped with an electrospray ionization (ESI) source was used in negative ion mode and multiple-reaction monitoring mode. Enantiomer chromatographic separation was carried out on a Lux® 5 μm Cellulose-3 (250 × 4.6 mm, 5 μm) column at a flow rate of 0.6 mL/min. Samples were pretreated by extracting only 5 μL of blood with 40 μL of acetonitrile (containing 1.3% formic acid) so that a concentration-time profile could be completed using a single mouse. 2-(4-Propylphenyl) propanoic acid was used as an internal standard. Standard curves for each enantiomer were linear from 0.04 to 80.00 μg/mL, demonstrating a lower limit of quantitation (LLOQ) than all previously reported methods. This method was completely validated and successfully executed to investigate the pharmacokinetics of ibuprofen enantiomers after intravenous administration of racemic ibuprofen, (S)-(+)-ibuprofen, and (R)-(−)-ibuprofen in Kunming mice, respectively. The results showed that the pharmacokinetic profiles of the (R)-(−)-ibuprofen and (S)-(+)-ibuprofen were significantly different, indicating the unidirectional inversion of R-(−)-ibuprofen to (S)-(+)-ibuprofen.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Experimental Determination of the Chiral and Achiral Shape Diagrams of Tellurium Nanocrystals 碲纳米晶体手性和非手性形状图的实验测定。

IF 2.8 4区化学

Chirality Pub Date : 2024-10-01 DOI: 10.1002/chir.23716

Daniel Vasiliev, Shay Tirosh, Assaf Ben-Moshe

{"title":"Experimental Determination of the Chiral and Achiral Shape Diagrams of Tellurium Nanocrystals","authors":"Daniel Vasiliev, Shay Tirosh, Assaf Ben-Moshe","doi":"10.1002/chir.23716","DOIUrl":"10.1002/chir.23716","url":null,"abstract":"<p>The interface between chirality and crystallization and mechanisms by which chirality propagates from crystal structure to overall shapes of crystals are a key topic in crystallography and stereochemistry. Recently, nanocrystals attracted attention as useful model systems for this kind of studies. Specifically, tellurium nanocrystals have been used to address questions on relations between chirality of the crystal structure and that of the overall shape. Previous studies of this system did not offer a comprehensive shape diagram and did not survey all the factors that determine whether shapes that form are chiral or not. In the current report, the distribution of chiral and achiral shapes in this system as a function of different physical and chemical parameters is determined experimentally. It is shown that there is a common logic for formation of chiral shapes, that is, growth at conditions that favor the growth of more reactive nuclei. The experiments also reveal more morphologies than previously encountered, suggesting that a systematic change of conditions in nanocrystal growth is key for identifying morphologies that exist only in a narrow range of conditions.</p>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 10","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/chir.23716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

6-Methoxy-2-Naphthoate as a Standard Chromophore for Chiroptical Studies by Fluorescence-Detected Exciton-Coupled Circular Dichroism 将 6-甲氧基-2-萘甲酸酯作为标准色团，通过荧光检测的激子耦合环二色性进行智光学研究

IF 2.8 4区化学

Chirality Pub Date : 2024-09-24 DOI: 10.1002/chir.23718

Yui Nagase, Yoshiki Naka, Tatsuo Nehira

引用次数: 0

Design, Synthesis, and Applications of Bis-Amido HPLC Pirkle-Type Chiral Stationary Phases 双酰亚胺 HPLC Pirkle 型手性固定相的设计、合成与应用

IF 2.8 4区化学

Chirality Pub Date : 2024-09-15 DOI: 10.1002/chir.23715

Maria Aurora Guarducci, Simone Manetto, Marco Pierini, Giulia Mazzoccanti, Claudio Villani

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Catalytic Performance of Chiral Tetraaza-Bridged Calix[4]arene[2]triazine Derivatives for Enantioselective Michael Reactions 手性四氮杂菖蒲[4]炔[2]三嗪衍生物在手性迈克尔反应中的催化性能

IF 2.8 4区化学

Chirality Pub Date : 2024-09-12 DOI: 10.1002/chir.23711

Ummu Ozgun, Hayriye Nevin Genc

引用次数: 0

Enantiomer Recognition by the Difference in Adsorption Rates on the Surfaces of Chiral Crystals 通过手性晶体表面吸附速率的差异识别对映体

IF 2.8 4区化学

Chirality Pub Date : 2024-09-12 DOI: 10.1002/chir.23717

Eduard Belonogov, Ekaterina Ermolaeva, Ilya Zinoviev, Zhi-hui Zhang, Vladimir Guskov

{"title":"Enantiomer Recognition by the Difference in Adsorption Rates on the Surfaces of Chiral Crystals","authors":"Eduard Belonogov, Ekaterina Ermolaeva, Ilya Zinoviev, Zhi-hui Zhang, Vladimir Guskov","doi":"10.1002/chir.23717","DOIUrl":"https://doi.org/10.1002/chir.23717","url":null,"abstract":"<div>\u0000 \u0000 <p>The chirality of biopolymers remains one of the mysteries of Life. For such objects, the phenomenon of supramolecular chirality (SMC) is vital. Enantiomers can be recognized by the adsorption on surfaces with SMC. However, the mechanisms of such chiral recognition are still unknown. In this work, the adsorption kinetics of menthol test enantiomers on the surfaces of γ-glycine and NiSO<sub>4</sub>•6H<sub>2</sub>O chiral crystals was studied. It was found that the difference in adsorption was observed in nonequilibrium state more often than in equilibrium. If the enantioselectivity in equilibrium state was observed, the enantioselectivity coefficient α at nonequilibrium conditions was higher. The maximum α in nonequilibrium state was 2.44 for γ-glycine crystals and 2.12 for NiSO<sub>4</sub>•6H<sub>2</sub>O crystals. Even if no differences in adsorption were observed under adsorption–desorption equilibrium conditions, a significant enantioselectivity at nonequilibrium conditions was found. This has proved the possibility of chiral recognition on surfaces with SMC by the differences in adsorption rates. Such novel chiral recognition mechanism can provide enhanced enantioselectivity in adsorption, catalysis, chromatographic separation, and chemical sensing.</p>\u0000 </div>","PeriodicalId":10170,"journal":{"name":"Chirality","volume":"36 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0