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Turkish journal of pharmaceutical sciences最新文献

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Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of XIAP and DcR1 in Colon Carcinoma Cells Treated with 5-Fluorouracil. 染料木素通过抑制 5-氟尿嘧啶治疗的结肠癌细胞中的 XIAP 和 DcR1 增强 TRAIL 介导的细胞凋亡。
Turkish journal of pharmaceutical sciences Pub Date : 2024-03-25 DOI: 10.4274/tjps.galenos.2023.60543
Tuğbagül Çal Doğan, Sevtap Aydın Dilsiz, Hande Canpınar, Ülkü Ündeğer Bucurgat
{"title":"Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of <i>XIAP</i> and <i>DcR1</i> in Colon Carcinoma Cells Treated with 5-Fluorouracil.","authors":"Tuğbagül Çal Doğan, Sevtap Aydın Dilsiz, Hande Canpınar, Ülkü Ündeğer Bucurgat","doi":"10.4274/tjps.galenos.2023.60543","DOIUrl":"10.4274/tjps.galenos.2023.60543","url":null,"abstract":"<p><strong>Objectives: </strong>Colorectal cancer is one of the most common cancers worldwide. However, surgical intervention and chemotherapy provide only limited benefits for the recovery and survival of patients. The anticarcinogenic effect of genistein has attracted attention because epidemiological studies have shown that soybean consumption is associated with a decrease in the incidence of cancer. There are limited studies on the effects of genistein in colorectal carcinoma cells. We aimed to investigate the cytotoxic, genotoxic, and apoptotic effects of genistein in SW480 and SW620 colon adenocarcinoma cells treated with 5-fluorouracil, the basis of chemotherapy, and the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) ligand, the mediator of apoptosis, both alone and in combination.</p><p><strong>Materials and methods: </strong>Cytotoxicity and genotoxicity were determined by MTT and comet assays, respectively. The apoptotic effects were evaluated by reverse transcription-polymerase chain reaction assay, with the additional use of Annexin V FITC, mitochondrial membrane potential (MMP), caspase 3, 8, and 9 activity, and reactive oxygen species (ROS) assay kits.</p><p><strong>Results: </strong>According to our findings, genistein, 5-fluorouracil, and TRAIL had synergistic apoptotic effects because of DR5 upregulation, ROS production, and DNA damage, which were mediated by increased caspase-8, and -9 activity and decreased MMP.</p><p><strong>Conclusion: </strong>The applied combinations of these compounds may contribute to the resistance problem that may occur in treating colorectal cancer, with a decrease in <i>DcR1</i> and <i>XIAP</i> genes.</p>","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"21 1","pages":"7-24"},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation of the major compounds and determination of biological activities of the underground parts of Trachystemon orientalis 东方栟茶地下部分主要化合物的分离及其生物活性的测定
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-28 DOI: 10.4274/tjps.galenos.2024.60980
Ayşe Nur Koz, Tuğba Subaş, M. Badem, Ş. Kanbolat, U. Özgen, S. Şener, Adem Demir, İhsan Çalış
{"title":"Isolation of the major compounds and determination of biological activities of the underground parts of Trachystemon orientalis","authors":"Ayşe Nur Koz, Tuğba Subaş, M. Badem, Ş. Kanbolat, U. Özgen, S. Şener, Adem Demir, İhsan Çalış","doi":"10.4274/tjps.galenos.2024.60980","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.60980","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"17 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Rosmarinic Acid and Epigallocatechin Gallate Against Doxorubicin-İnduced Cytotoxicity and Genotoxicity on CHO-K1 Cells 迷迭香酸和表没食子儿茶素没食子酸酯对多柔比星诱导的 CHO-K1 细胞细胞毒性和遗传毒性的保护作用
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-20 DOI: 10.4274/tjps.galenos.2024.80552
S. Helvacıoğlu, M. Hamitoğlu, E. Yıldırım, Şenay VURAL KORKUT, A. Yaba, Ahmet Aydin
{"title":"Protective Effect of Rosmarinic Acid and Epigallocatechin Gallate Against Doxorubicin-İnduced Cytotoxicity and Genotoxicity on CHO-K1 Cells","authors":"S. Helvacıoğlu, M. Hamitoğlu, E. Yıldırım, Şenay VURAL KORKUT, A. Yaba, Ahmet Aydin","doi":"10.4274/tjps.galenos.2024.80552","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.80552","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"79 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140447854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thirdhand Smoke Exacerbated H2O2-Driven Airway Responses in A549 Cells 三手烟加剧了 A549 细胞中 H2O2 驱动的气道反应
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.36153
Rengin Reis, Kübra Kolci̇, Yağmur Özhan, G. Coşkun, Hande Sipahi
{"title":"Thirdhand Smoke Exacerbated H2O2-Driven Airway Responses in A549 Cells","authors":"Rengin Reis, Kübra Kolci̇, Yağmur Özhan, G. Coşkun, Hande Sipahi","doi":"10.4274/tjps.galenos.2024.36153","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.36153","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"85 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Simulated Gastrointestinal Fluid: Viscosity, Surface Tension and Ph on Dissolution and Rheology Assessment of Viscosity on Two Commercial Products of Candesartan Cilexetil 模拟胃肠液的影响：粘度、表面张力和 Ph 值对坎地沙坦西来替酯两种商用产品溶解和流变性的影响
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.35737
Samah Ata, Rana Sejare, Ola Tarawneh, Rania Hamed, Mohammad Al-sabi, Samar Bishtawi, H. Mahfouz, Sameer Alkouz
{"title":"The Impact of Simulated Gastrointestinal Fluid: Viscosity, Surface Tension and Ph on Dissolution and Rheology Assessment of Viscosity on Two Commercial Products of Candesartan Cilexetil","authors":"Samah Ata, Rana Sejare, Ola Tarawneh, Rania Hamed, Mohammad Al-sabi, Samar Bishtawi, H. Mahfouz, Sameer Alkouz","doi":"10.4274/tjps.galenos.2024.35737","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.35737","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"151 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Combined Treatment of Levofloxacin and Metformin on the Diabetes Related Behavioral and Biochemical Alterations 左氧氟沙星和二甲双胍联合治疗对糖尿病相关行为和生化改变的影响
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.26786
Poonam Singh, Vaibhav Walia, P. Verma
{"title":"Effect of Combined Treatment of Levofloxacin and Metformin on the Diabetes Related Behavioral and Biochemical Alterations","authors":"Poonam Singh, Vaibhav Walia, P. Verma","doi":"10.4274/tjps.galenos.2024.26786","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.26786","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"26 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-(1H-pyrazole-1-yl/1H-1,2,4-triazole-1-yl)-N-propananilide derivatives: Design, Synthesis and Neuroprotectivity Potential Against 6-OHDA Induced Neurotoxicity Model 3-(1H-吡唑-1-基/1H-1,2,4-三唑-1-基)-N-丙酰苯胺衍生物：针对 6-OHDA 诱导的神经毒性模型的设计、合成和神经保护潜力
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.72365
Ayşe Hande Tarıkoğulları Doğan, Merve Saylam, Sinem Yılmaz, Sulunay Parlar, Petek Ballar, Vildan Alptuzun
{"title":"3-(1H-pyrazole-1-yl/1H-1,2,4-triazole-1-yl)-N-propananilide derivatives: Design, Synthesis and Neuroprotectivity Potential Against 6-OHDA Induced Neurotoxicity Model","authors":"Ayşe Hande Tarıkoğulları Doğan, Merve Saylam, Sinem Yılmaz, Sulunay Parlar, Petek Ballar, Vildan Alptuzun","doi":"10.4274/tjps.galenos.2024.72365","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.72365","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"72 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139781500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-(1H-pyrazole-1-yl/1H-1,2,4-triazole-1-yl)-N-propananilide derivatives: Design, Synthesis and Neuroprotectivity Potential Against 6-OHDA Induced Neurotoxicity Model 3-(1H-吡唑-1-基/1H-1,2,4-三唑-1-基)-N-丙酰苯胺衍生物：针对 6-OHDA 诱导的神经毒性模型的设计、合成和神经保护潜力
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.72365
Ayşe Hande Tarıkoğulları Doğan, Merve Saylam, Sinem Yılmaz, Sulunay Parlar, Petek Ballar, Vildan Alptuzun
{"title":"3-(1H-pyrazole-1-yl/1H-1,2,4-triazole-1-yl)-N-propananilide derivatives: Design, Synthesis and Neuroprotectivity Potential Against 6-OHDA Induced Neurotoxicity Model","authors":"Ayşe Hande Tarıkoğulları Doğan, Merve Saylam, Sinem Yılmaz, Sulunay Parlar, Petek Ballar, Vildan Alptuzun","doi":"10.4274/tjps.galenos.2024.72365","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.72365","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"547 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139841164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Combined Treatment of Levofloxacin and Metformin on the Diabetes Related Behavioral and Biochemical Alterations 左氧氟沙星和二甲双胍联合治疗对糖尿病相关行为和生化改变的影响
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.26786
Poonam Singh, Vaibhav Walia, P. Verma
{"title":"Effect of Combined Treatment of Levofloxacin and Metformin on the Diabetes Related Behavioral and Biochemical Alterations","authors":"Poonam Singh, Vaibhav Walia, P. Verma","doi":"10.4274/tjps.galenos.2024.26786","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.26786","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"57 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139841779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thirdhand Smoke Exacerbated H2O2-Driven Airway Responses in A549 Cells 三手烟加剧了 A549 细胞中 H2O2 驱动的气道反应
Turkish journal of pharmaceutical sciences Pub Date : 2024-02-13 DOI: 10.4274/tjps.galenos.2024.36153
Rengin Reis, Kübra Kolci̇, Yağmur Özhan, G. Coşkun, Hande Sipahi
{"title":"Thirdhand Smoke Exacerbated H2O2-Driven Airway Responses in A549 Cells","authors":"Rengin Reis, Kübra Kolci̇, Yağmur Özhan, G. Coşkun, Hande Sipahi","doi":"10.4274/tjps.galenos.2024.36153","DOIUrl":"https://doi.org/10.4274/tjps.galenos.2024.36153","url":null,"abstract":"","PeriodicalId":101423,"journal":{"name":"Turkish journal of pharmaceutical sciences","volume":"133 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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