Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)最新文献

{"title":"[In vitro profile for allergens and their association with pollen distribution volumes in Mexico City].","authors":"Gandhi Fernando Pavón-Romero, Jessica Cruz-Pérez, Ximena Cabrera-González, Esteban Payan-Espíndola, Fernando Ramírez-Jiménez, Daniela Galindo Castañeda, Luis M Terán","doi":"10.29262/ram.v72i3.1532","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1532","url":null,"abstract":"<p><strong>Introdution: </strong>Allergic sensitization (AS) assessed through in vitro methods (iv-M) has shown adequate sensitivity and diagnostic correlation. Recently, AS profiles have been compared with pollen distribution, which strengthens the clinical relevance of their results in the population where they are applied.</p><p><strong>Objetive: </strong>Describe the pattern of AS using iv-M, as well as the dispersion volume of the main pollens in Mexico City (CDMX) identified through iv-M.</p><p><strong>Methods: </strong>Aeroallergen profiles (iv-M-EUROIMMUN/Lübeck) from 197 patients with allergic rhinitis recruited in 2022 were analyzed. Results were grouped by family and species. Similarly, the distribution of the most relevant pollens was studied retrospectively using iv-M data from 2017 to 2022 (www.rema.atmosfera.unam.mx). Frequency/SA (χ²) and median/pollen volume (Wilcoxon) analyses were performed using SPSS v.21, considering a p-value< 0.05 as statistically significant. Results: Weeds and trees were the predominant groups (~65% vs. grasses at 42.5%, p<0.01). Specifically, the Chenopodiaceae-Amaranthaceae (Ch-A) family (57.8% vs. Asteraceae at 20.8%, p<0.001) and the Oleaceae family (44.6% vs. Fabaceae/Fagaceae at ~31.9%, p<0.001) shaped the results. Among the main pollens, Salsola kali (50.7%), Atriplex hortensis (41.6%), and Fraxinus sp. (38%) stood out. This profile was not influenced by age or sex. Regarding pollen distribution, the Ch-A family showed high levels until 2021, when they began to decline (p<0.001). In contrast, Fraxinus sp. pollen showed high volumes only during specific months (p<0.001).</p><p><strong>Conclusion: </strong>The identification of Ch-A is likely related to the presence of Ole-like-1 in Fraxinus, the species with the highest distribution volume. iv-M found that there was more SA in the Ch-A family and Fraxinus sp., both of which had more pollen spread in the years before the diagnostic evaluation.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"97"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Pantry mites as an environmental risk factor triggering allergies in Panama].","authors":"Ingrid Lorena Murgas-Centeno, Juan José Lezcano, Lyska Y Castillo E, Leandra Abarca-Gómez, Lisbeth Hurtado, Roberto Julio Miranda","doi":"10.29262/ram.v72i3.1481","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1481","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of house mites in food pantries and assess it as a possible environmental risk factor triggering allergic diseases in the provinces of Panama and Panama Oeste.</p><p><strong>Methods: </strong>This was a descriptive, cross-sectional exploratory study with a quantitative approach to the composition of house mites present in home pantries over a 12-month period. Data were processed using Minitab^® 17, Epi Info^® 7.2.5.0, and Microsoft Excel^®. Odds ratios (ORp) were calculated between food and dust contaminated with mites among allergic participants.</p><p><strong>Results: </strong>A total of 326 dust samples and 330 food samples were obtained, with 100% participation (n = 330) for the surveys. The non-economically active population was the occupational group with the highest participation rate, at 64.2%. The OR for dust was CI95%: 1.11 (0.4972.501), p (0.7912), and for powdered foods, CI95%: 1.15 (0.704-1.8920), p (0.5676).</p><p><strong>Conclusions: </strong>As with bedrooms, pantries provide the right environmental conditions for the development and proliferation of house dust mites, constituting a significant source of allergens within homes.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"27-36"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Autoimmunity in Patients with CTLA-4 Haploinsufficiency].","authors":"María Isabel Saad Manzanera, Iris Guendaranashii García Acevedo, Mariana Guadalupe Jiménez Fonseca, Salmahk Karen Aviles Tenorio, Paula Isabel Ramirez Molina, Jacqueline Edith Mut Quej, Patricia María O Farrill Romanillos, Diana Andrea Herrera Sánchez, Gabriela López Herrera","doi":"10.29262/ram.v72i3.1527","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1527","url":null,"abstract":"<p><strong>Background: </strong>CTLA4 deficiency is a disorder caused by mutations in the CTLA4 gene. T (TL) and B (BL) lymphocyte activity is affected, generating complex autoimmune dysregulation and immunodeficiency syndromes with variable clinical spectrum and diagnostic difficulty.</p><p><strong>Case report: </strong><i>Clinical Presentation</i>: A 16-year-old male with no significant family history presented with autoimmune hemolytic anemia, thrombocytopenia, episodes of diarrhea, atopic dermatitis, respiratory tract infections, rhinosinusitis, and recurrent otitis media, with multiple antibiotic therapies. Laboratory tests indicated immunoglobulin replacement and prophylactic antibiotic therapy with improvement. He continued to experience intermittent diarrhea and skin lesions. Biopsies ruled out infectious etiologies, and the patient was diagnosed with lichen planus, nummular eczema, and enteropathy associated with immunodeficiency. Treatment with immunosuppressants was initiated. Genetic testing diagnosed heterozygous CTLA4 deficiency. <i>Laboratory results</i>: IgA 1 mg, IgG 356 mg, IgM 2 mg, Leukocytes 9700/mm3, Neutrophils 8179/mm3, Monocytes 442/mm3, Lymphocytes 1055/mm3, LT 86.12% 909/mm3, LB 0.85% 9/mm3, NK cells 14.75% 156/mm3, LTCD4+ 60.82% 553/mm3, LTCD8+ 35.44% 322/mm3, isotype-switched memory LB 0%, non-isotype-switched memory LB 1.83%, CD21low LB 30.94%, LTnaive 8.84%, LTLmemory 82.66%.</p><p><strong>Conclusion: </strong>The diagnosis of this pathology is difficult due to its wide clinical presentation. Impaired LT and LB function leads to severe autoimmune processes and progressive hypogammaglobulinemia, recurrent infections, and malignancies. Immunoglobulin, prophylactic antibiotics, immunosuppressants, and bone marrow transplantation are the mainstays of treatment. Recognizing this genetic defect allows for targeted treatment (abatacept) that will improve the quality of life and prognosis of patients.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the accelerated stability of an allergen extract in combination with an inactivated bacterial suspension using the Advanced Kinetic Model (AKM)].","authors":"Jenaro Hernandez, Guillermo Guidos, Cesar Reyes-López","doi":"10.29262/ram.v72i3.1543","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1543","url":null,"abstract":"<p><strong>Introduction: </strong>The coadministration of allergen extracts with bacterial preparations has gained clinical relevance in subcutaneous immunotherapy for respiratory allergic diseases. However, there are no systematic studies evaluating the physicochemical stability or preservation of immunological activity of these mixtures. This study aimed to characterize the stability of a combined formulation using the Advanced Kinetic Model (AKM), a mathematical approach to shelf-life prediction based on nonlinear kinetics.</p><p><strong>Methods: </strong>A lyophilized mite extract (D. pteronyssinus/D. farinae) and an inactivated bacterial suspension (IPI-Asac) were used. Incubations were performed at 4, 15, 30, 37, and 45°C for up to 90 days, with chromatographic (SEC-HPLC), electrophoretic (SDS-densitometric PAGE), and functional (ELISA-IgE) analyses. The samples were studied separately and in a 4:1 ratio (extract:bacteria). The AKM model was applied to the IgE-binding loss data to extrapolate long-term stability.</p><p><strong>Results: </strong>No significant differences were observed between the extract alone and the mixture in terms of aggregation, protein degradation, or loss of IgE-binding capacity. At 15°C, >90% activity was retained for up to 90 days. Conclusion: The AKM model predicted a retention of 75% functional activity at 4°C for up to 1.5 years. The bacterial suspension did not alter the degradation kinetics or biophysical profiles.</p><p><strong>Conclusions: </strong>The data obtained suggest that the inclusion of an inactivated bacterial suspension does not compromise the conformational or functional stability of the allergens. The maintenance of IgE-specific activity under simulated storage conditions supports the technical feasibility of a coformulation. The application of the AKM model provided robust predictions of biological longevity without requiring prolonged stability studies under real-world conditions. The blending of allergenic extracts with inactivated bacterial suspensions preserves their immunological and biophysical properties under accelerated thermal conditions. These findings support the possibility of formulating combination products without negatively impacting immunotherapeutic efficacy, justifying additional clinical studies and multi-batch validation.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"102"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Erythema nodosum: a case report].","authors":"Maura Patricia López-Reynoso, Luis Tonatiuh Fernández-Mendoza, Amairani de Jesús Bernal-Ocampo","doi":"10.29262/ram.v72i3.1506","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1506","url":null,"abstract":"<p><strong>Background: </strong>Erythema nodosum is the most common clinical-pathological variant of panniculitis, presenting with erythematous nodular lesions. Infections are the most common cause. However, other causes cannot be ruled out: immunological, inflammatory, or metabolic. Therefore, the diagnosis must be multidisciplinary and direct treatment toward the underlying cause, as in most cases, it is usually the tip of the iceberg of a significant pathological process.</p><p><strong>Case report: </strong>An 18-year-old female patient with a history of hepatoblastoma, nephrocalcinosis, and recurrent infections presented one month later with characteristic erythematous lesions on the left tibia, with subsequent edema and limited movement. Paraclinical studies were performed, and the diagnosis of septal panniculitis without vasculitis and perivascular inflammatory infiltrate was confirmed by biopsy.</p><p><strong>Conclusion: </strong>Although erythema nodosum usually heals spontaneously, it can be the initial expression of infectious, immunological, or genetic diseases, so an early and multidisciplinary diagnostic approach is important to guide treatment and improve prognosis.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"64-67"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Anaphylaxis to ceftriaxone in pediatric patients: Challenges and management].","authors":"María Rosina López-Forte, Pablo Perea-Valle","doi":"10.29262/ram.v72i3.1492","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1492","url":null,"abstract":"<p><strong>Background: </strong>Cephalosporin-induced anaphylaxis is uncommon (6.1/10,000 exposures), and the diagnosis in pediatrics entails challenges due to nonspecific clinical histories and lack of standardized diagnostic tests. G-Penicillin has demonstrated diagnostic utility in the absence of penicilloilpolylisin, with a negative predictive value up to 95.2% when combined with controlled oral challenge. The basophil activation test (BAT) has a variable sensitivity (3875%), depending on the assessed biomarker.</p><p><strong>Case report: </strong>A 13-year-old male presented anaphylaxis two minutes after receiving intramuscular ceftriaxone. He presented with pharyngeal pruritus, facial angioedema, dyspnea, vomiting, and altered alertness. The condition resolved with intramuscular adrenaline and intravenous crystalloid administration. <i>Test results</i>: BAT for ceftriaxone and cefuroxime were negative. Skin tests were negative for penicillin and cefuroxime and positive for ceftriaxone. <i>Outcome</i>: Oral challenge with amoxicillin was tolerated. The use of ceftriaxone and cephalosporins with an identical R1 side chain were contraindicated.</p><p><strong>Conclusions: </strong>When dealing with a patient with drug allergy, clinicians should implement diagnostic tools that include skin testing with specific antibiotics and oral challenge. It is important to reconsider unconfirmed allergy labels, as it is estimated that between 58% and 75% of pediatric patients diagnosed with cephalosporin allergy present low-risk symptoms and could be delabeled with appropriate protocols. Cephalosporin anaphylaxis requires a combined evaluation. Penicillin G skin testing and oral challenge are key tools to guide safe antibiotic treatment.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"69"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[DRESS syndrome associated with levetiracetam use in a pediatric patient. A case report].","authors":"Tania Guadalupe Gómez-Moreno, José de Jesús Antonio Ramírez-Hernández, Osvaldo Rafael Ramírez-Ibarra","doi":"10.29262/ram.v72i3.1549","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1549","url":null,"abstract":"<p><strong>Background: </strong>DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a drug-related hypersensitivity reaction that manifests with eosinophilia, systemic symptoms, and is sometimes life-threatening. It is clinically characterized by a generalized rash, fever, facial edema, and multiorgan failure. It may be accompanied by paraclinical findings such as leukocytosis, eosinophilia, and abnormalities in renal and liver function tests.</p><p><strong>Case report: </strong>We present the case of a 10-year-old female patient hospitalized with a diagnosis of pansinusitis complicated by epidural empyema requiring surgical drainage. Prior to this, she was treated with levetiracetam. After surgery, she was maintained on a triple regimen of vancomycin, ceftriaxone, and metronidazole. Upon completion of this treatment, she developed a generalized dermatosis that did not respond to second-generation antihistamines or corticosteroids. After this, the patient presented with fever, facial edema, and a seizure. Laboratory studies were ordered, revealing leukocytosis and eosinophilia. DRESS syndrome was suspected, with a RegiSCAR score of 5, corresponding to a probable case. Treatment with immunoglobulin was initiated, with clinical improvement and resolution of the condition observed.</p><p><strong>Conclusions: </strong>DRESS syndrome is a severe drug-induced reaction, with an estimated mortality rate of 10%. Early recognition and timely initiation of treatment are essential for prognosis and prevention of potential complications.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"103"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Late diagnosis of allergic pulmonary aspergillosis in a patient with post-tuberculosis pulmonary sequelae: a fatal case].","authors":"Brenda Guendulain-Velázquez","doi":"10.29262/ram.v72i3.1504","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1504","url":null,"abstract":"<p><strong>Introduction: </strong>Allergic pulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus fumigatus antigens. Its diagnosis can be delayed when it overlaps with other pulmonary conditions. We present the case of a patient with a history of childhood asthma and post-tuberculosis pulmonary sequelae, treated for years as severe asthma without improvement. ABPA was confirmed, but the late diagnosis limited therapeutic options, resulting in a fatal outcome.</p><p><strong>Case report: </strong>A 61-year-old woman with a history of childhood asthma, hypertension, sleep apnea, and chronic cor pulmonale presented with pulmonary tuberculosis in 2000, which resolved after treatment, leaving sequelae such as bronchiectasis and oxygen dependence. She presented with persistent dyspnea and frequent exacerbations, with no improvement with treatment for severe asthma. Paraclinical tests: total IgE 2321 IU/mL, eosinophilia 908.4. Skin tests and specific IgG/IgE for Aspergillus fumigatus were positive. ABPA was diagnosed according to the International Society of Human and Animal Mycology (ISHAM) criteria. The patient was started on itraconazole and steroids. However, he developed massive hemoptysis, septic shock, and died in March 2025.</p><p><strong>Conclusion: </strong>Allergic bronchopulmonary aspergillosis is an immunologically mediated disease. It occurs in patients with a history of asthma or cystic fibrosis. In susceptible individuals, Aspergillus produces an exaggerated immune response. In this case, the history of tuberculosis and bronchiectasis delayed diagnosis, resulting in delayed management and fatal complications. This scenario underscores the need for a high index of suspicion for ABPA in patients with bronchiectasis, asthma, and cystic fibrosis with refractory respiratory symptoms. Early diagnosis and timely treatment can improve the prognosis and reduce potentially fatal complications.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"72"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ormond syndrome: a rare diagnosis in a patient with hypogammaglobulinemia secondary to rituximab].","authors":"Jaime Armando Soto-Domínguez, Vanessa Daniela Castillo-Leon, Alejandra Rodríguez-Carbajal, Marya Lizzeth Solís-Rosaldo, Gómez Hernandez-Noemí","doi":"10.29262/ram.v72i3.1515","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1515","url":null,"abstract":"<p><strong>Introduction: </strong>Ormond syndrome, or idiopathic retroperitoneal fibrosis, is a rare disease with an annual incidence of 0.1 to 0.4 cases per 100,000 inhabitants and a prevalence of 1.4 per 100,000 inhabitants. It primarily affects men (2-3:1), with diagnosis between 40 and 60 years of age. It is characterized by the growth of fibroinflammatory tissue in the retroperitoneum, with possible compression of vascular and urinary structures. Its diagnosis is complex and requires ruling out malignancy or other secondary causes. We present a case with a late diagnosis and referral to immunology due to hypogammaglobulinemia secondary to rituximab.</p><p><strong>Case report: </strong>A 54-year-old male patient with chronic kidney disease on hemodialysis was diagnosed in 2006 with retroperitoneal fibrosis after findings of ureteral stenosis and periaortic masses. Biopsies were performed, ruling out malignancy and IgG4-RD. In 2023, the patient received rituximab for inflammatory reactivation, with clinical improvement, but developed severe hypogammaglobulinemia (IgG <500 mg/dL), prompting referral to the immunology department. Subcutaneous immunoglobulin was started, with clinical stabilization. A relevant prior finding was low IgG3 levels before rituximab, with no clear relationship to Ormond syndrome.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering Ormond syndrome in unexplained retroperitoneal fibrosis and the need for a multidisciplinary approach. It also underscores the importance of early diagnosis and close follow-up in patients with chronic fibroinflammatory disease, as well as immunological monitoring in those receiving immunosuppression, to prevent and treat associated complications. Given its rarity, it is essential to document more cases to improve understanding and management of this condition.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the allergenic capacity of three pollen grains in a tropical region (Medellín, Colombia).","authors":"Ruth Ramírez, Fernando Alzate-Guarín, Álex Espinosa-Correa, Idoia Postigo-Resa, Jorge Sánchez","doi":"10.29262/ram.v72i3.1482","DOIUrl":"https://doi.org/10.29262/ram.v72i3.1482","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the frequency of IgE sensitization and allergenic capacity of pollen grains of <i>Artocarpus communis, Cecropia peltata</i> and <i>Fraxinus uhdei</i> in allergic rhinitis patients.</p><p><strong>Methods: </strong>A cross-sectional study with comparative groups: a rhinitis group and a control group. The three pollen extracts were prepared, and IgE sensitization was assessed using the skin prick test and serum-specific IgE. Allergenicity and clinical relevance were subsequently evaluated using the basophil activation test (BAT) and the nasal challenge test (NCT).</p><p><strong>Results: </strong>A total of 60 people were included in the control group and 60 in the case group. None in the control group and a total of 8 (13.3%) from the rhinitis group were sensitized to one of the 3 pollen extracts: two (3.3%) to <i>A. communis</i>, two (3.3%) to <i>C. peltata</i> and four (6.6%) to <i>F. uhdei</i>. All three extracts were able to induce basophil activation in patients with IgE sensitization, but not in those without sensitization. NCT was performed in the eight patients with IgE sensitization, resulting positive for 1/2 patients with Artocarpus, 1/2 with <i>Cecropia</i> y 2/4 with <i>Fraxinus</i>.</p><p><strong>Conclusions: </strong>All three pollen sources tested induce IgE sensitization and clinical symptoms, highlighting the importance of evaluating the allergenicity of native plant sources for each region.</p>","PeriodicalId":101421,"journal":{"name":"Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)","volume":"72 3","pages":"37-44"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}