International journal of heart failure最新文献_第4页

Vitamin D Deficiency in Patients Hospitalized for Heart Failure Living in the Tropics. 热带地区心力衰竭住院病人的维生素 D 缺乏症。

International journal of heart failure Pub Date : 2023-11-14 eCollection Date: 2024-04-01 DOI: 10.36628/ijhf.2023.0025

Lucian Batista de Oliveira, Mariana Andrade de Figueiredo Martins Siqueira, Rafael Buarque de Macedo Gadêlha, Jessica Garcia, Francisco Bandeira

{"title":"Vitamin D Deficiency in Patients Hospitalized for Heart Failure Living in the Tropics.","authors":"Lucian Batista de Oliveira, Mariana Andrade de Figueiredo Martins Siqueira, Rafael Buarque de Macedo Gadêlha, Jessica Garcia, Francisco Bandeira","doi":"10.36628/ijhf.2023.0025","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0025","url":null,"abstract":"Background and objectives: Vitamin D, as a steroid hormone, has multiple effects on human body and its deficiency has been associated with an increased risk of heart failure (HF) and unfavorable outcomes. The present study investigated the prevalence of vitamin D deficiency (VDD) and its relationship with cardiometabolic parameters in patients hospitalized for HF living in the city of Recife (latitude 8° South).Methods: Analytical cross-sectional study, with men and women aged 40-64 years. The HF group was recruited during hospitalization due to decompensation. A matched control group was recruited from the general endocrine clinics. Vitamin D status was assessed by measuring serum 25-hydroxyvitamin D (25OHD), considering deficiency when 25OHD <20 ng/mL (<50 nmol/L).Results: A total of 243 patients were evaluated (HF group: 161, control group: 82). Lower serum 25OHD levels were observed in the HF group (25.2±9.4 vs. 30.0±7.7ng/mL; p<0.001), as well as a higher prevalence of VDD (27.3% vs. 9.8%; prevalence ratio, 2.80; 95% confidence interval, 1.38-5.67; p=0.002). In patients with HF, VDD was associated with diabetes mellitus (65.9% vs. 41.0%; p=0.005) and female sex (65.9% vs. 44.4%; p=0.015). In the subgroup with VDD, higher values of hemoglobin A1c (7.9% [6.0-8.9] vs. 6.2% [5.7-7.9]; p=0.006) and dyslipidemia were also observed.Conclusions: We found higher rates of VDD in patients hospitalized for HF and this was associated with deleterious laboratory metabolic parameters.","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 2","pages":"84-90"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron Deficiency in Heart Failure: A Korea-Oriented Review. 心力衰竭中的缺铁：以韩国为导向的综述。

International journal of heart failure Pub Date : 2023-10-25 eCollection Date: 2023-10-01 DOI: 10.36628/ijhf.2023.0032

Ewa A Jankowska, Piotr Ponikowski

{"title":"Iron Deficiency in Heart Failure: A Korea-Oriented Review.","authors":"Ewa A Jankowska, Piotr Ponikowski","doi":"10.36628/ijhf.2023.0032","DOIUrl":"10.36628/ijhf.2023.0032","url":null,"abstract":"Iron deficiency (ID) occurs at high frequency across the spectrum of heart failure (HF), with HF severity and race being potentially important predictors for its development. ID, irrespective of anaemia status, leads to poor outcomes in patients with HF, including exacerbated reduction in exercise capacity, poor quality of life (QoL) and increased risk of HF hospitalisation. As ID has a large public health and economic burden in Asia, and patients hospitalised with acute HF in the Asia Pacific vs. other regions commonly present with more severe clinical symptoms, there is a clear need to identify and treat ID promptly in Asian patients with HF. The biomarkers serum ferritin and transferrin saturation are used for ID diagnosis, and periodic screening is recommended in all patients with HF. The intravenous iron treatments, ferric carboxymaltose (FCM) and ferric derisomaltose, have demonstrated efficacy and tolerability in patients with acute or chronic HF and ID, with FCM shown to be cost-effective (and in some cases cost-saving). Meta-analyses support the likely benefits of intravenous FCM for improving QoL and reducing HF hospitalisation, without reducing mortality risk in patients with HF and ID. Accordingly, European Society of Cardiology guidelines recommend considering intravenous FCM for patients with symptomatic HF with left ventricular ejection fraction ≤50% who were recently hospitalised for HF and have ID. Although analyses of Asian patients with HF and ID are limited, the effects of intravenous iron would be expected to be similar to that in White populations; further clarifying studies may be of interest.","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"5 4","pages":"173-183"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Insights Into the Pathogenesis of Obesity-Related High Output Heart Failure From Gene Expression Profiling. 从基因表达谱对肥胖相关高输出量心力衰竭发病机制的新见解。

International journal of heart failure Pub Date : 2023-10-25 eCollection Date: 2023-10-01 DOI: 10.36628/ijhf.2023.0048

Huijin Lee, Hyun-Jai Cho

引用次数: 0

The Korean Society of Heart Failure: Breaking Barriers, Bridging Solutions Together! 韩国心力衰竭协会：打破障碍，共同解决问题！

International journal of heart failure Pub Date : 2023-10-18 eCollection Date: 2023-10-01 DOI: 10.36628/ijhf.2023.0045

Seok Min Kang

引用次数: 0

C-Reactive Protein Can Predict Outcomes in Patients With Takotsubo Syndrome. C 反应蛋白可预测塔克次氏综合征患者的预后。

International journal of heart failure Pub Date : 2023-10-10 eCollection Date: 2024-01-01 DOI: 10.36628/ijhf.2023.0033

Gassan Moady, BateL Yelin, Rania Sweid, Shaul Atar

{"title":"C-Reactive Protein Can Predict Outcomes in Patients With Takotsubo Syndrome.","authors":"Gassan Moady, BateL Yelin, Rania Sweid, Shaul Atar","doi":"10.36628/ijhf.2023.0033","DOIUrl":"10.36628/ijhf.2023.0033","url":null,"abstract":"Background and objectives: Takotsubo syndrome (TTS) is a form of reversible cardiomyopathy often preceded by mental or physical stressors and predominantly affects elderly women. Several cardiac and inflammatory biomarkers are involved in the pathogenesis of the disease. We aimed to investigate the correlation of C-reactive protein (CRP) level with left ventricular ejection fraction (LVEF) and clinical outcomes in patients with TTS.Methods: The study included patients with discharge-diagnosis of Takotsubo through 2017-2022 from the cardiology department. Demographic, laboratory, echocardiographic, and clinical outcomes were retrospectively obtained. We investigated the relation between CRP and LVEF, length of stay (LOS), in-hospital complications, and recurrence.Results: A total of 86 patients (93% female, mean age 68.8±12.3 years) were included in the study. The median CRP level was 17.4 (interquartile range [IQR], 6.1-40.1) mg/L, and the mean LVEF was 41.5%, (IQR, 38-50%). Complications occurred in 24 (27.9%) of the patients, and the median LOS was 3 (IQR, 3-5) days. The level of CRP was associated with lower LVEF (r=-0.39, p<0.001), longer hospital stay (r=0.25, p=0.021), and recurrence. There was no correlation between CRP and in-hospital complications. In multivariate logistic regression, poor LVEF was associated with TTS recurrence (odds ratio, 1.22; 95% confidence interval, 1.08-1.37; p=0.001). Using linear regression, only CRP was correlated with longer LOS and lower LVEF (p<0.001).Conclusions: Among patients hospitalized with TTS, CRP level was associated with poor LVEF and prolonged hospital stay but not with in-hospital complications. Poor LVEF was also associated with TTS recurrence.","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 1","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10827700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the Interplay: Exploring the Impact of Acute Heart Failure on Aspiration Pneumonia Hospitalizations. 阐明相互作用：探讨急性心力衰竭对吸入性肺炎住院的影响。

International journal of heart failure Pub Date : 2023-09-20 eCollection Date: 2023-10-01 DOI: 10.36628/ijhf.2023.0049

Min-Seok Kim

引用次数: 0

Differences in Leukocyte Transcriptomes of Morbidly Obese Patients With High Output Heart Failure: A Pilot Study. 高输出量心力衰竭病态肥胖患者白细胞转录组的差异：一项初步研究。

International journal of heart failure Pub Date : 2023-09-05 eCollection Date: 2023-10-01 DOI: 10.36628/ijhf.2023.0027

Samantha A Cintron, Janet Pierce, Mihaela E Sardiu, Diane Mahoney, Jill Peltzer, Bhanu Gupta, Qiuhua Shen

{"title":"Differences in Leukocyte Transcriptomes of Morbidly Obese Patients With High Output Heart Failure: A Pilot Study.","authors":"Samantha A Cintron, Janet Pierce, Mihaela E Sardiu, Diane Mahoney, Jill Peltzer, Bhanu Gupta, Qiuhua Shen","doi":"10.36628/ijhf.2023.0027","DOIUrl":"10.36628/ijhf.2023.0027","url":null,"abstract":"Background and objectives: Heart failure is characterized by alterations of gene expression that provide insight into the underlying pathophysiologic mechanisms. However, obesity-related high output heart failure (HOHF) is a specific phenotype of heart failure that has not been studied using gene expression. Our aim in this study was to examine the variances in leukocyte transcriptomes of morbidly obese patients with HOHF.Methods: In this cross-sectional study, we applied stranded total RNA-sequencing to six patients with morbid obesity and HOHF and 6 patients with morbid obesity and non-HOHF. Differential gene expression was calculated, and Ingenuity Pathway Analysis software was used to interpret the canonical pathways, functional changes, upstream regulators, and networks in these patients.Results: We found in patients with HOHF that there were 116 differentially expressed genes with upregulation of 114 genes and downregulation of 2 genes. The differentially expressed genes were involved with cell proliferation, mitochondrial function, erythropoiesis, erythrocyte stability, and apoptosis. The top upregulated canonical pathways associated with differentially expressed genes were autophagy, adenosine monophosphate-activated protein kinase signaling, and senescence pathways. We identified GATA binding protein 1 as an upstream regulator and nuclear factor kappa-light-chain-enhancer of activated B cells associated network.Conclusions: We are the first to report the differential gene expression in patients with obesity-related HOHF and reveal the various pathophysiologic mechanisms underlying the disease. Further research is needed to determine the role of cellular function and maintenance, inflammation, and iron homeostasis in obesity-related HOHF.","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"5 4","pages":"201-212"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Direct Oral Anticoagulants in Patients With Cardiac Amyloidosis: A Systematic Review and Meta-Analysis 心脏淀粉样变性患者直接口服抗凝剂:系统回顾和荟萃分析

International journal of heart failure Pub Date : 2023-01-01 DOI: 10.36628/ijhf.2023.0031

Spencer C. Lacy, Menhel Kinno, Cara Joyce, Mingxi D. Yu

引用次数: 0

Adverse Events in Total Artificial Heart for End-Stage Heart Failure: Insight From the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) 全人工心脏治疗终末期心力衰竭的不良事件:来自食品和药物管理局、制造商和用户设施设备体验(MAUDE)的见解

International journal of heart failure Pub Date : 2023-01-01 DOI: 10.36628/ijhf.2023.0020

Min Choon Tan, Yong Hao Yeo, Jia Wei Tham, Jian Liang Tan, Hee Kong Fong, Bryan E-Xin Tan, Kwan S Lee, Justin Z Lee

引用次数: 0

Home Bioelectrical Impedance Analysis Management System in Patients With Heart Failure: Rationale and Study Design 心力衰竭患者的家庭生物电阻抗分析管理系统:理论基础和研究设计

International journal of heart failure Pub Date : 2023-01-01 DOI: 10.36628/ijhf.2023.0018

Min Gyu Kong, Inki Moon, Hye-Sun Seo, Jon Suh, Jah Yeon Choi, Jin Oh Na, Eung Ju Kim

引用次数: 0