Samantha A Cintron, Janet Pierce, Mihaela E Sardiu, Diane Mahoney, Jill Peltzer, Bhanu Gupta, Qiuhua Shen
{"title":"Differences in Leukocyte Transcriptomes of Morbidly Obese Patients With High Output Heart Failure: A Pilot Study.","authors":"Samantha A Cintron, Janet Pierce, Mihaela E Sardiu, Diane Mahoney, Jill Peltzer, Bhanu Gupta, Qiuhua Shen","doi":"10.36628/ijhf.2023.0027","DOIUrl":"10.36628/ijhf.2023.0027","url":null,"abstract":"<p><strong>Background and objectives: </strong>Heart failure is characterized by alterations of gene expression that provide insight into the underlying pathophysiologic mechanisms. However, obesity-related high output heart failure (HOHF) is a specific phenotype of heart failure that has not been studied using gene expression. Our aim in this study was to examine the variances in leukocyte transcriptomes of morbidly obese patients with HOHF.</p><p><strong>Methods: </strong>In this cross-sectional study, we applied stranded total RNA-sequencing to six patients with morbid obesity and HOHF and 6 patients with morbid obesity and non-HOHF. Differential gene expression was calculated, and Ingenuity Pathway Analysis software was used to interpret the canonical pathways, functional changes, upstream regulators, and networks in these patients.</p><p><strong>Results: </strong>We found in patients with HOHF that there were 116 differentially expressed genes with upregulation of 114 genes and downregulation of 2 genes. The differentially expressed genes were involved with cell proliferation, mitochondrial function, erythropoiesis, erythrocyte stability, and apoptosis. The top upregulated canonical pathways associated with differentially expressed genes were autophagy, adenosine monophosphate-activated protein kinase signaling, and senescence pathways. We identified GATA binding protein 1 as an upstream regulator and nuclear factor kappa-light-chain-enhancer of activated B cells associated network.</p><p><strong>Conclusions: </strong>We are the first to report the differential gene expression in patients with obesity-related HOHF and reveal the various pathophysiologic mechanisms underlying the disease. Further research is needed to determine the role of cellular function and maintenance, inflammation, and iron homeostasis in obesity-related HOHF.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"5 4","pages":"201-212"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spencer C. Lacy, Menhel Kinno, Cara Joyce, Mingxi D. Yu
{"title":"Direct Oral Anticoagulants in Patients With Cardiac Amyloidosis: A Systematic Review and Meta-Analysis","authors":"Spencer C. Lacy, Menhel Kinno, Cara Joyce, Mingxi D. Yu","doi":"10.36628/ijhf.2023.0031","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0031","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136305659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Choon Tan, Yong Hao Yeo, Jia Wei Tham, Jian Liang Tan, Hee Kong Fong, Bryan E-Xin Tan, Kwan S Lee, Justin Z Lee
{"title":"Adverse Events in Total Artificial Heart for End-Stage Heart Failure: Insight From the Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE)","authors":"Min Choon Tan, Yong Hao Yeo, Jia Wei Tham, Jian Liang Tan, Hee Kong Fong, Bryan E-Xin Tan, Kwan S Lee, Justin Z Lee","doi":"10.36628/ijhf.2023.0020","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0020","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136305663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Min Gyu Kong, Inki Moon, Hye-Sun Seo, Jon Suh, Jah Yeon Choi, Jin Oh Na, Eung Ju Kim
{"title":"Home Bioelectrical Impedance Analysis Management System in Patients With Heart Failure: Rationale and Study Design","authors":"Min Gyu Kong, Inki Moon, Hye-Sun Seo, Jon Suh, Jah Yeon Choi, Jin Oh Na, Eung Ju Kim","doi":"10.36628/ijhf.2023.0018","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0018","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"203 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135699549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}