Seung-Mok Lee, Hae-Young Lee, Shin Hye Yoo, Hyun-Jai Cho, Jong-Chan Youn, Seong-Mi Park, Jin-Ok Jeong, Min-Seok Kim, Chi Young Shim, Jin Joo Park, Kye Hun Kim, Eung Ju Kim, Jeong Hoon Yang, Jae Yeong Cho, Sang-Ho Jo, Kyung-Kuk Hwang, Ju-Hee Lee, In-Cheol Kim, Gi Beom Kim, Jung Hyun Choi, Sung-Hee Shin, Wook-Jin Chung, Seok-Min Kang, Myeong Chan Cho, Dae-Gyun Park, Byung-Su Yoo
{"title":"Palliative Care and Hospice for Heart Failure Patients: Position Statement From the Korean Society of Heart Failure.","authors":"Seung-Mok Lee, Hae-Young Lee, Shin Hye Yoo, Hyun-Jai Cho, Jong-Chan Youn, Seong-Mi Park, Jin-Ok Jeong, Min-Seok Kim, Chi Young Shim, Jin Joo Park, Kye Hun Kim, Eung Ju Kim, Jeong Hoon Yang, Jae Yeong Cho, Sang-Ho Jo, Kyung-Kuk Hwang, Ju-Hee Lee, In-Cheol Kim, Gi Beom Kim, Jung Hyun Choi, Sung-Hee Shin, Wook-Jin Chung, Seok-Min Kang, Myeong Chan Cho, Dae-Gyun Park, Byung-Su Yoo","doi":"10.36628/ijhf.2024.0069","DOIUrl":"10.36628/ijhf.2024.0069","url":null,"abstract":"<p><p>Heart failure (HF) is a major cause of mortality and morbidity in South Korea, imposing substantial physical, emotional, and financial burdens on patients and society. Despite the high burden of symptom and complex care needs of HF patients, palliative care and hospice services remain underutilized in South Korea due to cultural, institutional, and knowledge-related barriers. This position statement from the Korean Society of Heart Failure emphasizes the need for integrating palliative and hospice care into HF management to improve quality of life and support holistic care for patients and their families. By clarifying the role of palliative care in HF and proposing practical referral criteria, this position statement aims to bridge the gap between HF and palliative care services in South Korea, ultimately improving patient-centered outcomes and aligning treatment with the goals and values of HF patients.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"7 1","pages":"32-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Increasing Readmissions of HFpEF and the Burden They Cause.","authors":"Moojun Kim, Chan Joo Lee","doi":"10.36628/ijhf.2025.0001","DOIUrl":"10.36628/ijhf.2025.0001","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"7 1","pages":"30-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aino Vesikansa, Juha Mehtälä, Sarah Smith, Anna Kirjavainen, Johanna Huupponen, Niina Säävuori, Katariina Pitkänen, Heikki Ukkonen
{"title":"Worsening Heart Failure and Medication Use in HFrEF: A Finnish Retrospective Registry Study and Patient Survey.","authors":"Aino Vesikansa, Juha Mehtälä, Sarah Smith, Anna Kirjavainen, Johanna Huupponen, Niina Säävuori, Katariina Pitkänen, Heikki Ukkonen","doi":"10.36628/ijhf.2024.0028","DOIUrl":"10.36628/ijhf.2024.0028","url":null,"abstract":"<p><strong>Background and objectives: </strong>Understanding worsening heart failure events (WHFEs) and clinical practices in the real world is essential in heart failure (HF) management. The primary objective of this single-center, retrospective, observational study, including a patient survey, was to characterize WHFEs and associated factors during the first year after the incident HF diagnosis in Finnish patients. Secondly, implementation and adherence to guideline-directed medical therapy (GDMT) and mortality during the whole follow-up were assessed.</p><p><strong>Methods: </strong>Incident HF patients (International Classification of Diseases, 10th Revision: I50) with reduced ejection fraction (HFrEF; <40%) were identified between 2013-2019 from the hospital data lake of Southwest Finland. Clinical characteristics, healthcare resource utilization, medication prescriptions and purchases, and deaths were collected from hospital records and national registers between 2011-2021. A survey was linked with register data for a subgroup of patients. Associations between explanatory factors, WHFEs, and mortality were studied using logistic and Cox regression models.</p><p><strong>Results: </strong>Among 570 HFrEF patients, 23% (n=133) experienced a WHFE within the first year after the incident diagnosis. During this 1-year period, 85% used angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, 90% beta-blockers, and 44% mineralocorticoid receptor antagonists, and >80% of patients were adherent to these medications. WHFEs were associated with higher risk of mortality (hazard ratio [HR], 1.82; 95% confidence interval [CI], 1.31-2.53; p<0.001), whereas adherence was associated with a lower risk of WHFEs (odds ratio, 0.31; 95% CI, 0.20-0.48; p<0.001) and mortality (HR, 0.66; 95% CI, 0.47-0.94; p=0.021) in multivariate models. Quality of life was lower in patients with (n=47) than without WHFEs (n=100).</p><p><strong>Conclusions: </strong>Improving adherence is crucial for mitigating adverse outcomes in HF.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"7 1","pages":"6-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mind the Gap: Bridging Guideline Recommendations and Real-World Practice in Heart Failure Management.","authors":"So Ree Kim, Dong-Hyuk Cho","doi":"10.36628/ijhf.2025.0002","DOIUrl":"10.36628/ijhf.2025.0002","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"7 1","pages":"19-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predictors and Trends of 30-day Readmissions in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insight From the National Readmission Database.","authors":"Sean DeAngelo, Rohan Gajjar, Gianfranco Bittar-Carlini, Badri Aryal, Bhannu Pinnam, Sharan Malkani, Ufuk Vardar, Yasmeen Golzar","doi":"10.36628/ijhf.2024.0041","DOIUrl":"10.36628/ijhf.2024.0041","url":null,"abstract":"<p><strong>Background and objectives: </strong>Hospital readmissions serve as a significant negative prognostic indicator and have a considerable impact on healthcare utilization among individuals diagnosed with heart failure with preserved ejection fraction (HFpEF). For our study, we aimed to elucidate predictors and trends of HFpEF readmissions within a 30-day period.</p><p><strong>Methods: </strong>The Healthcare Cost and Utilization Project National Readmission Database (NRD) was queried between 2016-2020 to study the 30-day all-cause hospital readmission rate, predictors, duration of hospital stay, and the overall cost of hospitalization. Multivariate/univariate logistic and linear regression analysis were used to analyze the outcomes and adjust for possible confounders.</p><p><strong>Results: </strong>A total of 3,831,156 index hospitalizations for acute decompensated HFpEF were identified between the years 2016-2020, of which 673,844 (18.4%) patients were readmitted within 30 days. The 30-day all-cause readmissions increased significantly from 17.4% to 19.9% (p<0.001) in the 5-year trend analysis. The most common cardiovascular cause for readmission was hypertensive heart disease with chronic kidney disease stage 1-4 (13.2%). Independent predictors associated with increased rate of readmissions were patients that left against medical advice (adjusted odds ratio [aOR], 2.06; 95% confidence interval [CI], 1.99-2.14; p<0.001), cirrhosis (aOR, 1.33; 95% CI, 1.30-1.36; p<0.001), and chronic obstructive pulmonary disease (aOR, 1.27; 95% CI, 1.25-1.29; p<0.001).</p><p><strong>Conclusions: </strong>Nearly 1 in 5 patients with acute decompensated HFpEF were readmitted within 30 days (2016-2020), with readmissions rising over time. Identifying at-risk patients is crucial to reducing readmissions and costs.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"7 1","pages":"21-29"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11791174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of the Novel Sodium-Dependent Glucose Cotransporter 2 Inhibitor, Enavogliflozin, on Cardiac Reverse Remodeling in Heart Failure Patients With Type 2 Diabetes Mellitus: A Case Series.","authors":"Taeil Yang, Youngwoo Jang, Wook-Jin Chung","doi":"10.36628/ijhf.2024.0018","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0018","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 4","pages":"176-178"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adequacy of Ambulatory Hemodynamic Assessments for Reducing All-Cause Mortality in Individuals With Heart Failure.","authors":"Reza Tabrizchi","doi":"10.36628/ijhf.2024.0021","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0021","url":null,"abstract":"<p><p>Heart failure (HF) as a syndrome which is <i>normally</i> associated with significant reduction of cardiac output has evolved to include conditions such those of moderate and preserved ejection fraction. While the prevalence of HF in the population is increasing, it is not HF with reduced ejection fraction that is driving the trajectory upward for mortality. There is some evidence to suggest that a better understanding of the pathophysiology, novel pharmacological strategies, devices, as well as remote monitoring of the hemodynamics seem to account for a reduction in the cardiovascular mortality and re-hospitalization in some cohorts with HF. However, the all-cause mortality associated with HF has not been reduced significantly by the current interventions. To explore the potential approaches needed for the strategies and avenues to reduce all-cause mortality in patients with HF, it would be helpful to evaluate the evidence in the literature directed at the care of patients with chronic/acute decompensated HF. It is evident that ambulatory measurements of pressures and volume are pivotal in a better management of HF but unless the interventions extend to an improvement in the renal function, the chances of reducing all-cause mortality seems modest. Therefore, future directions of interventions must not only be directed at close monitoring of pressures and volume simultaneously in HF patients but also at improving renal function. Moreover, it is clear that venous congestion plays a detrimental role in the deterioration of renal function and until measures are in place to reduce it, all-cause mortality will not decrease.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 4","pages":"149-158"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jae-Hyeong Park, Mijoo Kim, Jin Joo Park, Jun-Bean Park, Goo-Yeong Cho
{"title":"Prognostic Role of RVGLS/PASP Ratio, a New Echocardiographic Parameter of the Right Ventricle-Pulmonary Artery Coupling, in Patients With Acute Heart Failure.","authors":"Jae-Hyeong Park, Mijoo Kim, Jin Joo Park, Jun-Bean Park, Goo-Yeong Cho","doi":"10.36628/ijhf.2024.0048","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0048","url":null,"abstract":"<p><strong>Background and objectives: </strong>Few studies have addressed the predictive implications of right ventricular (RV) and pulmonary arterial (PA) coupling as assessed by echocardiography in patients with acute heart failure (AHF). This study aimed to ascertain the prognostic importance of RV-PA coupling in AHF cases and discern any divergence in its prognostic efficacy based on different heart failure (HF) phenotypes.</p><p><strong>Methods: </strong>We evaluated RV-PA coupling by measuring the ratio of right ventricular global longitudinal strain (RVGLS) to pulmonary arterial systolic pressure (PASP), termed the RVGLS/PASP ratio, and assessed its prognostic role using the STrain for Risk Assessment and Therapeutic Strategies in Patients with Acute Heart Failure registry.</p><p><strong>Results: </strong>From an AHF registry of 4312 patients, we analyzed the RVGLS/PASP ratio in 2,865 patients (1,449 men; age, 71.1±13.5 years). At a median follow-up of 35.0 months, 1,199 (41.8%) patients died. Remarkably, PASP (hazard ratio [HR], 1.012; p<0.001), RVGLS (HR, 1.019; p<0.001), and the RVGLS/PASP ratio (HR, 2.426; p<0.001) were statistically significant predictors of all-cause mortality in the univariate analysis. The RVGLS/PASP ratio was a significant predictor of all-cause mortality in all the HF phenotypes, including HF with reduced ejection fraction (HR, 2.124; p=0.002), HF with mildly reduced ejection fraction (HR, 2.733; p=0.021), and HF with preserved ejection fraction (HR, 2.134; p=0.006). Multivariate analysis after adjusting for clinical and echocardiographic variables revealed that the RVGLS/PASP ratio ≤0.32 was associated with a 36% increase in all-cause mortality (HR, 1.365; p<0.001).</p><p><strong>Conclusions: </strong>Impaired RV-PA coupling, defined as an RVGLS/PASP ratio (≤0.32) was associated with an increased risk of mortality in patients with AHF across all HF phenotypes.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT03513653.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 4","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sang Gune K Yoo, Mohammed O Ahmed, Nancy K Sweitzer
{"title":"Current and Future of Heart Failure Care in Asia.","authors":"Sang Gune K Yoo, Mohammed O Ahmed, Nancy K Sweitzer","doi":"10.36628/ijhf.2024.0033","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0033","url":null,"abstract":"<p><p>Heart failure (HF) is a significant global health concern, particularly in Asia, where over half of the world's population resides. Despite advances in treatment, the burden of HF is expected to rise in the region due to the aging population and an increase in non-communicable diseases associated with HF risk. This narrative review examines the current state of HF in Asia, highlighting differences in treatment utilization, underrepresentation of Asian individuals in clinical trials, emerging therapies, and implementation strategies, including the potential use of polypills and the need for expanded HF training opportunities for healthcare providers.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":"6 4","pages":"141-148"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}