{"title":"Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Are Beta-Blockers Still Relevant?","authors":"Junho Hyun","doi":"10.36628/ijhf.2024.0038","DOIUrl":"10.36628/ijhf.2024.0038","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jah Yeon Choi, Mi-Na Kim, Seongwoo Han, Sunki Lee, Myung Soo Park, Min Gyu Kong, Sung-Hea Kim, Yong-Hyun Kim, Sang-Ho Jo, Sungeun Kim, Seonghoon Choi, Jinsung Jeon, Jieun Lee, Byambakhand Battumur, Seong-Mi Park, Eung Ju Kim
{"title":"Rationale, Design, and Interim Observations of the Steady Movement With Innovating Leadership for Heart Failure (SMILE HF) Registry: A Multicenter Prospective Cohort Registry for Patients With Acute Heart Failure.","authors":"Jah Yeon Choi, Mi-Na Kim, Seongwoo Han, Sunki Lee, Myung Soo Park, Min Gyu Kong, Sung-Hea Kim, Yong-Hyun Kim, Sang-Ho Jo, Sungeun Kim, Seonghoon Choi, Jinsung Jeon, Jieun Lee, Byambakhand Battumur, Seong-Mi Park, Eung Ju Kim","doi":"10.36628/ijhf.2024.0014","DOIUrl":"10.36628/ijhf.2024.0014","url":null,"abstract":"<p><strong>Background and objectives: </strong>Heart failure (HF) is a leading cause of hospitalization and death worldwide. The Steady Movement with Innovating Leadership for Heart Failure (SMILE HF) aims to evaluate the clinical characteristics, management, hospital course, and long-term outcomes of patients hospitalized for acute HF in South Korea.</p><p><strong>Methods: </strong>This prospective, observational multicenter cohort study was conducted on consecutive patients hospitalized for acute HF in nine university hospitals since September 2019. Enrolment of 2000 patients should be completed in 2024, and follow-up is planned through 2025.</p><p><strong>Results: </strong>Interim analysis of 1,052 consecutive patients was performed to understand the baseline characteristics. The mean age was 69±15 years; 57.6% were male. The mean left ventricular ejection fraction was 39±15%. The prevalences of HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction were 50.9%, 15.3%, and 29.2%. Ischemic cardiomyopathy (CMP) was the most common etiology (32%), followed by tachycardia-induced CMP (12.8%) and idiopathic dilated CMP (9.5%). The prescription rate of angiotensin-converting enzyme inhibitor/angiotensin receptor blockers/angiotensin receptor/neprilysin inhibitor, beta-blockers, spironolactone, and sodium-glucose cotransporter-2 inhibitors at discharge were 76.8%, 66.5%, 50.0%, and 17.5%, respectively. The post-discharge 90-day mortality and readmission rates due to HF aggravation were 2.0% and 6.4%, respectively. Our analysis reveals the current state of acute HF in South Korea.</p><p><strong>Conclusions: </strong>Our interim analysis provides valuable insights into the clinical characteristics, management, and early outcomes of acute HF patients in South Korea, highlighting the current state and treatment patterns in this population.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"President's Message: 4 Pillars of Korean Society of Heart Failure.","authors":"Byung-Su Yoo","doi":"10.36628/ijhf.2024.0031","DOIUrl":"10.36628/ijhf.2024.0031","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Young In Kim, Min-Soo Ahn, Byung-Su Yoo, Jang-Young Kim, Jung-Woo Son, Young Jun Park, Sung Hwa Kim, Dae Ryong Kang, Hae-Young Lee, Seok-Min Kang, Myeong-Chan Cho
{"title":"Differences in the Effects of Beta-Blockers Depending on Heart Rate at Discharge in Patients With Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation.","authors":"Young In Kim, Min-Soo Ahn, Byung-Su Yoo, Jang-Young Kim, Jung-Woo Son, Young Jun Park, Sung Hwa Kim, Dae Ryong Kang, Hae-Young Lee, Seok-Min Kang, Myeong-Chan Cho","doi":"10.36628/ijhf.2023.0052","DOIUrl":"10.36628/ijhf.2023.0052","url":null,"abstract":"<p><strong>Background and objectives: </strong>Beta-blockers (BBs) improve prognosis in heart failure (HF), which is mediated by lowering heart rate (HR). However, HR has no prognostic implication in atrial fibrillation (AF) and also BBs have not been shown to improve prognosis in heart failure with preserved ejection fraction (HFpEF) with AF. This study assessed the prognostic implication of BB in HFpEF with AF according to discharge HR.</p><p><strong>Methods: </strong>From the Korean Acute Heart Failure Registry, 687 patients with HFpEF and AF were selected. Study subjects were divided into 4 groups based on 75 beats per minute (bpm) of HR at discharge and whether or not they were treated with BB at discharge.</p><p><strong>Results: </strong>Of the 687 patients with HFpEF and AF, 128 (36.1%) were in low HR group and 121 (36.4%) were in high HR group among those treated with BB at discharge. In high HR group, HR at discharge was significantly faster in BB non-users (85.5±9.1 bpm vs. 89.2±12.5 bpm, p=0.005). In the Cox model, BB did not improve 60-day rehospitalization (hazard ratio, 0.93; 95% confidence interval [95% CI], 0.35-2.47) or mortality (hazard ratio, 0.77; 95% CI, 0.22-2.74) in low HR group. However, in high HR group, BB treatment at discharge was associated with 82% reduced 60-day HF rehospitalization (hazard ratio, 0.18; 95% CI, 0.04-0.81), but not with mortality (hazard ratio, 0.77; 95% CI, 0.20-2.98).</p><p><strong>Conclusions: </strong>In HFpEF with AF, in patients with HR over 75 bpm at discharge, BB treatment at discharge was associated with a reduced 60-day rehospitalization rate.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yosef Manla, Obada Kholoki, Nizar Attallah, Feras Bader
{"title":"Causes of Hospitalization in Patients With Cardiorenal Syndrome Across the Spectrum of Ejection Fraction.","authors":"Yosef Manla, Obada Kholoki, Nizar Attallah, Feras Bader","doi":"10.36628/ijhf.2023.0065","DOIUrl":"10.36628/ijhf.2023.0065","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Heart Failure With Preserved Ejection Fraction and Frailty: From Young to Superaged Coexisting HFpEF and Frailty.","authors":"Amina Rakisheva, Anzhela Soloveva, Anastasia Shchendrygina, Ilya Giverts","doi":"10.36628/ijhf.2023.0064","DOIUrl":"10.36628/ijhf.2023.0064","url":null,"abstract":"<p><p>Being commonly diagnosed in elderly women and associated with comorbidities as well as ageing-related cardio-vascular changes, heart failure with preserved ejection fraction (HFpEF) has been recently considered as a distinct cardiogeriatric syndrome. Frailty is another frequent geriatric syndrome. HFpEF and frailty share common underlying mechanisms, often co-exist, and represent each other's risk factors. A threshold of 65 years old is usually used to screen patients for both frailty and HFpEF in research and clinical settings. However, both HFpEF and frailty are very heterogenous conditions that may develop at younger ages. In this review we aim to provide a broader overview on the coexistence of HFpEF and frailty throughout the lifetime. We hypothesize that HFpEF and frailty patients' profiles (young, elderly, superaged) represent a continuum of the common ageing process modified by cumulative exposure to risk factors resulting to a presentation of HFpEF and frailty at different ages. We believe, that suggested approach might stimulate assessment of frailty in HFpEF assessment and vice versa regardless of age and early implementation of targeted interventions. Future studies of pathophysiology, clinical features, and outcomes of frailty in HFpEF by age are needed.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Another, A Few Good Device for End Stage Heart Failure.","authors":"Jooyeon Lee, Jaewon Oh, Seok-Min Kang","doi":"10.36628/ijhf.2024.0023","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0023","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chan Joo Lee, Hokyou Lee, Minjae Yoon, Kyeong-Hyeon Chun, Min Gyu Kong, Mi-Hyang Jung, In-Cheol Kim, Jae Yeong Cho, Jeehoon Kang, Jin Joo Park, Hyeon Chang Kim, Dong-Ju Choi, Jungkuk Lee, Seok-Min Kang
{"title":"Heart Failure Statistics 2024 Update: A Report From the Korean Society of Heart Failure.","authors":"Chan Joo Lee, Hokyou Lee, Minjae Yoon, Kyeong-Hyeon Chun, Min Gyu Kong, Mi-Hyang Jung, In-Cheol Kim, Jae Yeong Cho, Jeehoon Kang, Jin Joo Park, Hyeon Chang Kim, Dong-Ju Choi, Jungkuk Lee, Seok-Min Kang","doi":"10.36628/ijhf.2024.0010","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0010","url":null,"abstract":"<p><strong>Background and objectives: </strong>The number of people with heart failure (HF) is increasing worldwide, and the social burden is increasing as HF has high mortality and morbidity. We aimed to provide updated trends on the epidemiology of HF in Korea to shape future social measures against HF.</p><p><strong>Methods: </strong>We used the National Health Information Database of the National Health Insurance Service to determine the prevalence, incidence, hospitalization rate, mortality rate, comorbidities, in-hospital mortality, and healthcare cost of patients with HF from 2002 to 2020 in Korea.</p><p><strong>Results: </strong>The prevalence of HF in the total Korean population rose from 0.77% in 2002 to 2.58% (1,326,886 people) in 2020. Although the age-standardized incidence of HF decreased over the past 18 years, the age-standardized prevalence increased. In 2020, the hospitalization rate for any cause in patients with HF was 1,166 per 100,000 persons, with a steady increase from 2002. In 2002, the HF mortality was 3.0 per 100,000 persons, which rose to 15.6 per 100,000 persons in 2020. While hospitalization rates and in-hospital mortality for patients with HF increased, the mortality rate for patients with HF did not (5.8% in 2020), and the one-year survival rate from the first diagnosis of HF improved. The total healthcare costs for patients with HF were approximately $2.4 billion in 2020, a 16-fold increase over the $0.15 billion in 2002.</p><p><strong>Conclusions: </strong>The study's results underscore the growing socioeconomic burden of HF in Korea, driven by an aging population and increasing HF prevalence.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Role of Vitamin D Deficiency Correction in Heart Failure Management: Insights and Prospects.","authors":"Hyung Yoon Kim","doi":"10.36628/ijhf.2024.0019","DOIUrl":"https://doi.org/10.36628/ijhf.2024.0019","url":null,"abstract":"","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristiana Vitale, Ilaria Spoletini, Giuseppe M C Rosano
{"title":"The Dual Burden of Frailty and Heart Failure.","authors":"Cristiana Vitale, Ilaria Spoletini, Giuseppe M C Rosano","doi":"10.36628/ijhf.2023.0057","DOIUrl":"10.36628/ijhf.2023.0057","url":null,"abstract":"<p><p>Frailty is highly prevalent among patients with heart failure (HF) and independently predicts adverse outcomes. However, optimal frailty definitions, assessments, and management in HF remain unclear. Frailty is common in HF, affecting up to 80% of patients depending on population characteristics. Even pre-frailty doubles mortality risk versus robust patients. Frailty worsens HF prognosis through systemic inflammation, neurohormonal changes, sarcopenia, and micronutrient deficiency. Simple screening tools like gait speed and grip strength predict outcomes but lack HF-specificity. Comprehensive geriatric assessment is ideal but not always feasible. Exercise, nutrition, poly-pharmacy management, and multidisciplinary care models can help stablize frailty components and improve patient-centred outcomes. Frailty frequently coexists with and exacerbates HF. Routine frailty screening should guide supportive interventions to optimize physical, cognitive, and psychosocial health. Further research on HF-specific frailty assessment tools and interventions is warranted to reduce this dual burden.</p>","PeriodicalId":101410,"journal":{"name":"International journal of heart failure","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}