Anesthesia and pain medicine最新文献

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Neuromuscular blockade monitoring in pediatric patients. 儿科患者的神经肌肉阻滞监测。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.17085/apm.23158
Zehra Serpil Ustalar Ozgen
{"title":"Neuromuscular blockade monitoring in pediatric patients.","authors":"Zehra Serpil Ustalar Ozgen","doi":"10.17085/apm.23158","DOIUrl":"10.17085/apm.23158","url":null,"abstract":"<p><p>The administration of neuromuscular blocking agents (NMBAs), the cornerstone of pediatric anesthesia, facilitates intubation and muscle relaxation during surgery. However, NMBAs can also lead to serious complications including respiratory depression, residual paralysis, and prolonged recovery. Neuromuscular monitoring (NMM) in pediatric patients is therefore essential, as it is in adults, to ensure adequate paralysis during surgery and prompt recovery from NMBA-induced paralysis. This article aimed to provide a comprehensive overview of NMM in pediatric anesthesia including the various available methods, their advantages and disadvantages, and the importance of a standardized NMM approach.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 Suppl 1","pages":"S12-S24"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute tolerance to rocuronium -A case report. 对罗库溴铵的急性耐受性--病例报告。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.17085/apm.24064
Jong Ho Kim, Sang Joon Park, Youngsuk Kwon, Sung Mi Hwang, Hong Seuk Yang
{"title":"Acute tolerance to rocuronium -A case report.","authors":"Jong Ho Kim, Sang Joon Park, Youngsuk Kwon, Sung Mi Hwang, Hong Seuk Yang","doi":"10.17085/apm.24064","DOIUrl":"10.17085/apm.24064","url":null,"abstract":"<p><strong>Background: </strong>A booster dose can result in a similar reaction to the initial dose. Neuromuscular blocking agents (NMBAs) can produce a comparable reaction in the absence of specific pathophysiologic alterations.</p><p><strong>Case: </strong>An initial dose of rocuronium 40 mg was given to a male patient (50 years old, height 168 cm, weight 54 kg, body mass index 19.13 kg/m2) for anesthesia. The onset was usual, but the duration was brief. Two booster doses were administered at 20 min intervals, but recovery came quickly. So, acute tolerance was suspected. Muscle function was restored to greater than train-of-four ratio 0.75 while spontaneous aided breathing was maintained without the need of further NMBAs. Following the operation, sugammadex (1.85 mg/kg) was provided to prevent residual neuromuscular inhibition.</p><p><strong>Conclusions: </strong>Anesthetists must be able to suspect acute tolerance to NMBAs in patients with no unique medical history and have a plan to resolve it.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 4","pages":"333-338"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the effectiveness of subcostal transversus abdominis plane and rectus sheath blocks in postoperative analgesia in major open gynecological cancer surgeries: a prospective randomized study. 比较肋下腹横肌平面和直肠鞘阻滞在大型开放式妇科癌症手术术后镇痛中的效果:一项前瞻性随机研究。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-25 DOI: 10.17085/apm.24086
Duygu Akyol, Funda Gümüş Özcan
{"title":"Comparison of the effectiveness of subcostal transversus abdominis plane and rectus sheath blocks in postoperative analgesia in major open gynecological cancer surgeries: a prospective randomized study.","authors":"Duygu Akyol, Funda Gümüş Özcan","doi":"10.17085/apm.24086","DOIUrl":"10.17085/apm.24086","url":null,"abstract":"<p><strong>Background: </strong>The transversus abdominis plane block (TAPB) is frequently used for postoperative analgesia in abdominal surgery. However, it remains insufficient for analgesia during upper abdominal surgeries. Therefore, we compared the efficacy of the subcostal transversus abdominis plane block (STAPB) or rectus sheath block (RSB), in addition to the posterior transversus abdominis plane block (PTAPB), for postoperative analgesia in major gynecologic cancer surgeries.</p><p><strong>Methods: </strong>This prospective randomized study included 50 patients aged > 18 years (American Society of Anesthesiologists physical status II or III), who underwent gynecologic cancer surgery through a midline incision. All patients underwent PTAPB, STAPB, or RSB according to the randomization. The following parameters were recorded and compared: demographic data; intraoperative hemodynamic parameters; numeric rating scale (NRS) pain levels at the 1st, 6th, 12th, and 24th postoperative hours; opioid consumption; number of requests and boluses; adverse effects; surgical complications within 24 h.</p><p><strong>Results: </strong>Forty-seven patients were included in this study. In the STAPB group, postoperative 1, 12 and 24 h NRS values were lower; opioid consumption, opioid demand, and bolus numbers were lower during the postoperative 24 h as compared to RSB (P < 0.05). The intraoperative opioid and hemodynamic values were similar in both groups.</p><p><strong>Conclusions: </strong>STAPB in addition to PTAPB provides more effective analgesia than RSB for postoperative pain management in open gynecologic cancer surgeries.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 4","pages":"353-361"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sugammadex for our little ones: a brief narrative review. 为我们的小宝宝服用舒格迈地:简要回顾。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.17085/apm.24092
Soomin Lee, Woosuk Chung
{"title":"Sugammadex for our little ones: a brief narrative review.","authors":"Soomin Lee, Woosuk Chung","doi":"10.17085/apm.24092","DOIUrl":"10.17085/apm.24092","url":null,"abstract":"<p><p>Sugammadex, the first noncompetitive antagonist developed for the reversal of neuromuscular blockade (NMB), is one of the few drugs that has revolutionized anesthetic practice. However, the use of sugammadex for children between the ages of 2 and 17 years has only recently been approved and is currently not approved for children under the age of 2 years. Although the precision and reliability of reversal of NMB with sugammadex are of great benefit in pediatric anesthesia, several important questions remain regarding its use in our youngest patients. In this brief narrative review, we aim to provide an overview of the key considerations and potential challenges that anesthesiologists often face when using sugammadex in pediatric patients.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 4","pages":"269-279"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and accuracy of pediatric core temperature measurement using an esophageal probe inserted through the gastric lumen of a second-generation supraglottic airway device: a prospective observational study. 通过第二代声门上气道装置的胃腔插入食道探头测量小儿核心体温的可行性和准确性:一项前瞻性观察研究。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-28 DOI: 10.17085/apm.23150
Yeon-Ju Kim, Eundong Lee, Jaedo Lee, Hyungtae Kim, Won Uk Koh, Young-Jin Ro, Ha-Jung Kim
{"title":"Feasibility and accuracy of pediatric core temperature measurement using an esophageal probe inserted through the gastric lumen of a second-generation supraglottic airway device: a prospective observational study.","authors":"Yeon-Ju Kim, Eundong Lee, Jaedo Lee, Hyungtae Kim, Won Uk Koh, Young-Jin Ro, Ha-Jung Kim","doi":"10.17085/apm.23150","DOIUrl":"10.17085/apm.23150","url":null,"abstract":"<p><strong>Background: </strong>Accurate core temperature measurement in children is crucial; however, measuring esophageal temperature (TE) using a supraglottic airway device (SAD) can be challenging. Second-generation SADs, which have a gastric channel, can measure TE, and reduce gastric air volume. This study aimed to compare TE, measured using a probe inserted through the SAD gastric channel, with tympanic membrane (TTM) and forehead (TZHF) temperatures, measured using a zero-heat-flux cutaneous thermometer, with rectal temperature (TR).</p><p><strong>Methods: </strong>Temperature was recorded at 10-min intervals from 10 min after probe insertion until completion of surgery. We performed an equivalence test to evaluate whether the TE, TTM, and TZHF were equivalent to TR, with a margin of 0.3°C. Additionally, intraclass correlation coefficients (ICC) were calculated to assess the reliability of TE and TR at each time point.</p><p><strong>Results: </strong>We included 41 patients in the final analysis. In all patients, the esophageal probe was successfully inserted through the gastric channel of the SAD. When assessing agreement with TR as a reference, TE demonstrated equivalent results at all time points (P < 0.001 at 0, 10, 20, 30, and 40-min intervals and P = 0.018 at the 50-min interval), except at the completion of surgery (P = 0.697). TE also demonstrated good reliability with TR as a reference throughout the surgery (ICC > 0.75).</p><p><strong>Conclusions: </strong>In children with SAD insertion, TE can be accurately and feasibly measured through the SAD's gastric channel, making it suitable for routine application.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 Suppl 1","pages":"S105-S112"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing global recognition: our journey towards Emerging Sources Citation Index indexing. 提高全球认可度:我们的新兴资源引文索引索引之路。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.17085/apm.24128
Min Kyoung Kim, Hyun Kang
{"title":"Enhancing global recognition: our journey towards Emerging Sources Citation Index indexing.","authors":"Min Kyoung Kim, Hyun Kang","doi":"10.17085/apm.24128","DOIUrl":"10.17085/apm.24128","url":null,"abstract":"","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 4","pages":"267-268"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overall and linked blood pressure variabilities in the first 24 hours and mortality after spontaneous intracerebral hemorrhage: a retrospective study of 1,036 patients. 自发性脑内出血后最初 24 小时的总体血压变化和相关血压变化与死亡率:一项对 1,036 名患者进行的回顾性研究。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-10-31 DOI: 10.17085/apm.24039
Hangyul Cho, Taehoon Kim, Younsuk Lee, Dawoon Kim, Hansu Bae
{"title":"Overall and linked blood pressure variabilities in the first 24 hours and mortality after spontaneous intracerebral hemorrhage: a retrospective study of 1,036 patients.","authors":"Hangyul Cho, Taehoon Kim, Younsuk Lee, Dawoon Kim, Hansu Bae","doi":"10.17085/apm.24039","DOIUrl":"10.17085/apm.24039","url":null,"abstract":"<p><strong>Background: </strong>This study aims to establish the individual contributions of blood pressure variability (BPV) indexes, categorized into overall and linked variability, to mortality following intracerebral hemorrhage (ICH) by examining the risk factors.</p><p><strong>Methods: </strong>Patients with spontaneous ICH (n = 1,036) were identified with valid blood pressures (BP) from the first 24-h systolic BP records in the Medical Information Mart for Intensive Care IV version 2.2 database (MIMIC IV). Information on the baseline characteristics, including age, sex, initial Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS) scores, ICH location, Charlson comorbidity index score, and presence of diabetes with or without complications, were collected. Three indexes of BPV-range, standard deviation (SD), and generalized BPV (GBPV)-were calculated using the first 24-h systolic BPs. An automated stepwise variable-selection procedure was used to develop the final logistic model for predicting in-hospital mortality.</p><p><strong>Results: </strong>Out of 1,036 patients, 802 (77.4%) survived and were discharged after spontaneous ICH. Factors associated with mortality included age; male sex; ICH in the brainstem, ventricle, or multiple locations; low GCS score (< 9); high NIHSS score (> 20); and diabetes with complications. Mean systolic BP, SD, and GBPV were also linked to mortality. Higher GBPV notably increased the risk of in-hospital death, with an odds ratio of 3.21 (95% confidence interval, 2.10 to 4.97) for every + 10 mmHg/h change in GBPV.</p><p><strong>Conclusions: </strong>This study underscores the additional impact of GBPV, herein linked to BPV, on mortality following ICH, providing further insights into the management of blood pressure in the early stages of ICH treatment.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 4","pages":"302-309"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endotracheal intubation using a spiral endotracheal tube effectively reduces total tube handling time in children aged one month to six years using a McGrathTM video laryngoscope: a prospective randomized trial. 一项前瞻性随机试验:使用 McGrathTM 视频喉镜为 1 个月至 6 岁的儿童进行气管插管,使用螺旋气管导管可有效减少导管处理总时间。
Anesthesia and pain medicine Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.17085/apm.24018
Rahendra Rahendra, Fajar Sesario, Andi Ade Wijaya Ramlan, Raihanita Zahra, Christopher Kapuangan, Arif Hari Martono Marsaban, Aries Perdana
{"title":"Endotracheal intubation using a spiral endotracheal tube effectively reduces total tube handling time in children aged one month to six years using a McGrathTM video laryngoscope: a prospective randomized trial.","authors":"Rahendra Rahendra, Fajar Sesario, Andi Ade Wijaya Ramlan, Raihanita Zahra, Christopher Kapuangan, Arif Hari Martono Marsaban, Aries Perdana","doi":"10.17085/apm.24018","DOIUrl":"10.17085/apm.24018","url":null,"abstract":"<p><strong>Background: </strong>Airway management in children is challenging because of the smaller size, different proportions of anatomical structures compared to adults, and a higher risk of hypoxemia. Efforts to improve the efficiency of pediatric intubation can be made by manually twisting a spiral endotracheal tube (ETT) using a flexible stylet to manipulate its shape and angle.</p><p><strong>Methods: </strong>This controlled trial randomized fifty children aged one month to six years who underwent elective surgery under general anesthesia into two groups (spiral ETT [sETT] and no-stylet ETT/standard ETT). The sETT was formed by twisting the ETT using a handmade tool. The primary objective was to determine the effectiveness of the sETT compared to the standard ETT in reducing intubation time. Secondary objectives were ETT placement accuracy, first-attempt intubation success rate, and adverse effects.</p><p><strong>Results: </strong>The mean total tube handling time in the sETT group was significantly shorter compared to the no-stylet ETT group (sETT 16.8 ± 3.6 vs. standard ETT 18.8 ± 3.7 seconds; P = 0.049). sETT placement had a significantly greater central placement accuracy (odds ratio, 4.846; 95% confidence interval, 1.287-18.255; P = 0.015). However, first-attempt successful intubation rate (sETT 80% vs. standard ETT 64%, P = 0.208) and total intubation time (sETT: 46.5 ± 5.2 vs. standard ETT 48.4 ± 4.9 seconds; P = 0.205) were not significantly different. No adverse effects were observed for either ETT type.</p><p><strong>Conclusions: </strong>Spiral ETT effectively reduces total tube handling time and improves ETT placement accuracy in children using video laryngoscopy.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 Suppl 1","pages":"S113-S120"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educational perspectives in cardiothoracic anesthesia in the United States using a survey of educators and learners. 通过对教育者和学习者的调查了解美国心胸麻醉的教育前景。
Anesthesia and pain medicine Pub Date : 2024-07-01 Epub Date: 2024-07-23 DOI: 10.17085/apm.24011
Rushil Bose, Matthew Evers, Wai-Man Liu, Shannon Grap, Theodore J Cios
{"title":"Educational perspectives in cardiothoracic anesthesia in the United States using a survey of educators and learners.","authors":"Rushil Bose, Matthew Evers, Wai-Man Liu, Shannon Grap, Theodore J Cios","doi":"10.17085/apm.24011","DOIUrl":"10.17085/apm.24011","url":null,"abstract":"<p><strong>Background: </strong>Cardiothoracic anesthesiology training presents learners with unique challenges, procedural skills, and the management of high-intensity critical scenarios. An effective relationship between educator and learner can serve as the backbone for effective learning, which is crucial for the development of budding anesthesiologists. Strengthening this educational alliance between teachers and trainees involves understanding the educational values educators and learners find most important to their learning experiences. This study aimed to identify the key educational values related to cardiothoracic anesthesia for both learners and educators. By identifying these values in separate cohorts (learners and educators), the importance of various educational values can be examined and compared between the trainees and teachers.</p><p><strong>Methods: </strong>Two separate surveys (one for learners and one for teachers) were adapted from the Pratt and Collins Teaching Perspectives Inventory to establish the importance of various educational values related to cardiothoracic anesthesia. Surveys were sent to 165 Accreditation Council for Graduate Medical Education-accredited anesthesiology residency training programs in the United States to trainees (residents and cardiothoracic anesthesiology fellows) and educators (board-certified cardiothoracic anesthesiologists).</p><p><strong>Results: </strong>Analysis of survey results from 19 educators and 57 learners revealed no statistical differences across the two groups, except Q15: \"Let trainee perform critical technical steps\" (P value = 0.02).</p><p><strong>Conclusions: </strong>While learners and educators in cardiothoracic anesthesia hold similar values regarding cardiac anesthesia education, they differ in the degree to which critical technical steps should be performed by learners.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":" ","pages":"241-246"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regenerative therapy in geriatric patients with low back pain. 老年腰痛患者的再生疗法
Anesthesia and pain medicine Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI: 10.17085/apm.24069
Jeongsoo Kim, Kunjin Bae, Jeong Hwa Seo
{"title":"Regenerative therapy in geriatric patients with low back pain.","authors":"Jeongsoo Kim, Kunjin Bae, Jeong Hwa Seo","doi":"10.17085/apm.24069","DOIUrl":"10.17085/apm.24069","url":null,"abstract":"<p><p>Low back pain (LBP) is a prevalent and debilitating condition, particularly among older adults, with degenerative spinal disease being a major contributor. Regenerative therapy, which aims to repair and regenerate damaged spinal structures, has shown promise in providing long-term pain relief and functional improvement. This review focuses on the application and efficacy of regenerative therapies such as mesenchymal stem cells, platelet-rich plasma, and atelocollagen in older patients with LBP. Despite the potential benefits, there is a notable scarcity of studies specifically targeting the older population, and those available often have small sample sizes and limited age-related analyses. Our findings underscore the need for more comprehensive and well-designed clinical trials to evaluate the effectiveness of these therapies in older patients. Future research should prioritize larger age-specific studies to establish regenerative therapy as a viable and effective treatment option for LBP in the aging population.</p>","PeriodicalId":101360,"journal":{"name":"Anesthesia and pain medicine","volume":"19 3","pages":"185-193"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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