Biophysics and physicobiology最新文献_第2页

Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium. 利用多能干细胞衍生的造血内皮对体外人体内皮细胞向造血细胞转变进行实时成像。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-03-22 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s015

Yuriko Yoneda, Hisaya Kato, Yoshiro Maezawa, Koutaro Yokote, Mio Nakanishi

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引用次数: 0

Editorial: Singularity Biology and Beyond. 社论：奇点生物学及其他

IF 1.6

Biophysics and physicobiology Pub Date : 2024-03-15 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s013

Takeharu Nagai

引用次数: 0

Model systems for discovering evolutionary singularity of bilaterian physiological regulation: lessons from studies on simple/primitive flatworms. 发现两栖动物生理调节进化奇异性的模式系统：从简单/原始扁形虫研究中汲取的教训。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-03-02 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s012

Shunsuke Mori, Aoshi Kobayashi, Hirotaka Sakamoto, Mayuko Hamada, Tatsuya Sakamoto, Ryo Nakamura

引用次数: 0

Visualizing Singularity Phenomenon. 奇点现象可视化。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-22 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s011

Tomonobu M Watanabe, Tsuyoshi Shiina

引用次数: 0

Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system. 利用荧光计时器揭示 T 细胞动态：从 Tocky 系统获得的启示。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-16 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s010

Masahiro Ono

{"title":"Unraveling T-cell dynamics using fluorescent timer: Insights from the Tocky system.","authors":"Masahiro Ono","doi":"10.2142/biophysico.bppb-v21.s010","DOIUrl":"10.2142/biophysico.bppb-v21.s010","url":null,"abstract":"Understanding the temporal dynamics of T-cell transcription is crucial for insights into immune cell function and development. In this study, we show the features of the Timer-of-Cell-Kinetics-and-Activity (Tocky) system, which enables analysis of temporal dynamics of cell activities and differentiation, leveraging Fluorescent Timer protein, which spontaneously changes its emission spectrum from blue to red fluorescence in known kinetics, as reporters. The current study examines the properties of the Tocky system, highlighting the Timer-Angle approach, which is a core algorithm of Tocky analysis and converts Timer Blue and Red fluorescence into Timer Angle and Intensity by trigonometric transformation. Importantly, Tocky analyzes time-related events within individual cells by the two phases of measurements, distinguishing between (1) the temporal sequence of cellular activities and differentiation within the time domain, and (2) the transcription frequency within the frequency domain. The transition from time measurement to frequency analysis, particularly at the Persistent locus that bridges these domains, highlights that system's unique property in what is measured and analyzed by Tocky. Intriguingly, the sustained transcriptional activities observed in cells at the Persistent locus may have unique biological features as demonstrated in activated regulatory T-cells (Treg) and pathogenic T-cells, respectively, using Foxp3-Tocky and Nr4a3-Tocky models. In conclusion, the Tocky system can provide crucial data for advancing our understanding of T-cell dynamics and function.","PeriodicalId":101323,"journal":{"name":"Biophysics and physicobiology","volume":"21 Supplemental","pages":"e211010"},"PeriodicalIF":1.6,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromophore-assisted light inactivation of target proteins for singularity biology. 用于奇异生物学的色团辅助光灭活目标蛋白质。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-15 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s009

Hisashi Shidara, Susumu Jitsuki, Kiwamu Takemoto

引用次数: 0

Research on the molecular mechanism of singularity phenomenon in neurological disorders. 研究神经系统疾病中奇异现象的分子机制。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-15 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s008

Hiroko Bannai, Akihiko Takashima, Yoshiyuki Soeda, Hideaki Yoshimura, Gen Matsumoto, Naruhiko Sahara, Michio Hiroshima, Mitsuru Hattori, Takeharu Nagai

引用次数: 0

Elucidating molecular and cellular mechanisms of singularity phenomena in immunology. 阐明免疫学中奇异现象的分子和细胞机制。

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-14 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s007

Taku Okazaki, Tomoya Katakai

引用次数: 0

Holistic concepts in GPCR dynamics. GPCR 动态的整体概念。

Biophysics and physicobiology Pub Date : 2024-02-10 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.0011

Kota Katayama, Ryoji Suno

引用次数: 0

A battle between two biological singularities: Immune response vs. cancer. 两个生物奇点之间的较量：免疫反应与癌症

IF 1.6

Biophysics and physicobiology Pub Date : 2024-02-09 eCollection Date: 2024-01-01 DOI: 10.2142/biophysico.bppb-v21.s006

Tomoya Katakai, Taku Okazaki

{"title":"A battle between two biological singularities: Immune response vs. cancer.","authors":"Tomoya Katakai, Taku Okazaki","doi":"10.2142/biophysico.bppb-v21.s006","DOIUrl":"10.2142/biophysico.bppb-v21.s006","url":null,"abstract":"In a post-growth multicellular organism, the phenomenon in which a small number of rare cells can be the starting point for inducing a dramatic change in the entire system is considered a \"biological singularity.\" The immune response and cancer can be regarded as singularity phenomena in mammals, but their nature is fundamentally different. The immune response is considered a \"programmed\" singularity, whereas cancer is an \"unprogrammed\" singularity. These two systems perpetually engage in a cycle of attack and defense within the organism. The outcome is depending on the wining system, which determines whether the individual experiences a state resembling light or darkness. However, the overall mechanism of the competition remains unclear and is expected to be elucidated with future innovations in bioimaging technologies. Immune checkpoint blockade therapy is a means by which the two singularity balances can be artificially manipulated; therefore, mechanistic insight is necessary for cancer treatment strategies. Altogether, these findings provide a different perspective crucial for understanding the behavior of dynamic cell populations in multicellular organisms.","PeriodicalId":101323,"journal":{"name":"Biophysics and physicobiology","volume":"21 Supplemental","pages":"e211006"},"PeriodicalIF":1.6,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0