Biomedica : revista del Instituto Nacional de Salud最新文献

{"title":"[Chi o ji: precisión del lenguaje científico en español].","authors":"Biomédica Revista Del Instituto Nacional de Salud","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 2","pages":"333-334"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers to access to health services for people with orphan-rare diseases in Huila, Colombia","authors":"Ingrid Yolercy Troche, William González, Anyi Daniela Montealegre, Brayant Andrade","doi":"10.7705/biomedica.7991","DOIUrl":"10.7705/biomedica.7991","url":null,"abstract":"<p><p>Introduction. Despite the obligation to provide priority and timely care to people with orphan diseases, they continue to find barriers to health services.\u0000Objective. To determine access to health services barriers for people diagnosed with orphan or rare diseases.\u0000Materials and methods. We carried out a cross-sectional analytical study based on secondary data of 134 people reported with orphan or rare diseases in the department of Huila. Sociodemographic and clinical characterization and identification of barriers to access to health services at the geographic, economic, social, knowledge, cultural and health care levels were carried out. Statistical analysis was performed in Stata 15™ using measures of central tendency and association.\u0000Results. The median age was 15 years, 51.5% were male, 61.9% lived in urban areas, low income predominated, the most prevalent diagnosis was Guillain-Barré síndrome and 32.8% required hospitalization for complications of the disease. Living in rural areas presents a greater probability of having limited access to the center of care (OR = 10.7; 95% CI: 4.3-27) and lack of money for transportation (OR = 2.84; 95% CI: 1.26-6.52). Statistical association between subsidized regime and non-delivery of medicines (OR = 4.59; 95% CI: 1.44-19.17) was found.\u0000Conclusion. Participants face significant barriers to accessing health services associated with living in rural areas and their affiliation status.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 2","pages":"254-269"},"PeriodicalIF":0.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity of Listeria monocytogenes isolates in Colombia from 2010 until 2017 and comparison against the PulseNet regional surveillance network","authors":"Paula Lucía Díaz, Julieth Carolina Gamba, Diego Prada, Lucy Angeline Montaño, Edna Catering Rodríguez, Efraín Montilla-Escudero, Paloma Cuenca, Sandra Saavedra, Nathaly Rozo, Mónica Prieto, Claudia Martínez, Isabel Chinen","doi":"10.7705/biomedica.7863","DOIUrl":"10.7705/biomedica.7863","url":null,"abstract":"<p><p>Introduction. Listeriosis is a food-borne disease associated with Listeria monocytogenes, with high mortality in individuals with weakened immune systems. In Colombia, notification of the disease is not mandatory.\u0000Objective. To characterize phenotypically and genomically the clinical isolates of L. monocytogenes isolated from 2010 to 2017 in Colombia.\u0000Materials and methods. A total of 63 of the 443 isolates of L. monocytogenes were analyzed by laboratory surveillance of the Grupo de Microbiología at the Instituto Nacional de Salud. Antimicrobial susceptibility, serological test (O-H) antigens and PCR, pulsed-field gel electrophoresis (PFGE)-ApaI enzyme as well as whole genome sequencing (WGS) were performed. Fatalities attributed to L. monocytogenes were identified using SIVIGILA.\u0000Results. An estimated 50.73% of the isolates were females, in adults ≥ 15 years old (54%) and were recovered from blood cultures (58.7%), sensitive to penicillin and to trimethoprimsulfamethoxazole. Of the isolates, 77.8% were of the complex serogroup 4b-4d-4e; 42 patterns PFGE-ApaI were determined. Genomic sequencing of five isolates identified multilocus sequencing typing (MLST) ST1, ST2, ribosomal MLST (rMLST) 15992, 15983, 15959, 98481, clonal complex CC1, CC2, lineage I, and serotype 4b in silico. Virulence genes identified included pathogenicity island LIPI-1, LIPI-3 and internalins. Resistance genes included fosX, fosS-2, lin, norB and mprF. The plasmid J1776, and prophages vB_LmoS_293, LP_030_2, LP_030_3, A118 were identified. Global phylogenetic analysis identified that the closest sequences belonged to lineage I, and were from France, Chile, Perú and India.\u0000Conclusions. Strengthening epidemiological and laboratory surveillance would improve the control measures in public health.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"99-117"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small bowel perforation due to cytomegalovirus infection in a patient with HIV","authors":"Laurent Marcela Osorio, María José Herrera, Brayan Leonardo Bayona, Julio César Insignares, Diego Viasus","doi":"10.7705/biomedica.7439","DOIUrl":"10.7705/biomedica.7439","url":null,"abstract":"<p><p>Cytomegalovirus can cause disseminated or localized disease in people living with HIV with advanced immunosuppression, usually those with CD4+ T-lymphocyte cell counts <50 cells/mm3 who do not receive, complies, or does not respond to antiretroviral therapy.\u0000We report on the case of a patient living with HIV without antiretroviral therapy who was admitted to the emergency department for abdominal pain. During laparotomy, perforation of the ileum was found, requiring right hemicolectomy, ileotransverse anastomosis, and drainage due to fecaloid peritonitis. The report of histopathology documented multiple cytomegalic inclusions in stromal, epithelial, and endothelial cells, predominantly in the ileum, at the level of the perforation area. Although cytomegalovirus disease in the gastrointestinal tract is one of the most common complications of HIV, ileal perforation is an unusual manifestation with high mortality.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"16-21"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteremia by viridans group streptococci in children with leukemia: Epidemiology and variables associated with recurrence","authors":"María Emilia Padilla, Guadalupe Pérez, Vanesa Reijtman, Claudia Sarkis, Gabriela Belén Gonzáalez, Lourdes Ferreres, Sandra Gómez, Moira Taicz","doi":"10.7705/biomedica.8038","DOIUrl":"10.7705/biomedica.8038","url":null,"abstract":"<p><strong>Introduction: </strong>Infections caused by viridans group streptococci in pediatric oncology patients can be severe and are associated with high mortality.\u0000Objective. To describe the clinical, microbiological, and outcome characteristics of pediatric patients with viridans group streptococci bacteremia and acute leukemia in a highcomplexity hospital, and to identify variables associated with recurrence.</p><p><strong>Objective: </strong>To describe the clinical, microbiological, and outcome characteristics of pediatric patients with viridans group streptococci bacteremia and acute leukemia in a highcomplexity hospital, and to identify variables associated with recurrence.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study including patients aged 1 month to 18 years with acute leukemia and viridans group streptococci bacteremia between 2016 and 2022. Patients and episode characteristics were described, and a univariate analysis was performed comparing those with a single bacteremia episode to those with recurrent episodes.</p><p><strong>Results: </strong>A total of 108 episodes were identified, of which 85 (79%) were first or isolated episodes and 23 (21%) were recurrences. The median age was 68 months. Streptoccocus mitis and S. oralis were the most frequently identified species in both groups. Recurrent bacteremia was significantly associated with prior antibiotic use within the preceding 30 days, longer duration of prior antibiotic treatment, use of carbapenems, presence of acute gastroenteritis as the clinical focus of infection, and the consolidation phase of treatment.</p><p><strong>Conclusions: </strong>Viridans group streptococci bacteremia predominantly occurred in children with acute myeloid leukemia. Recurrence accounted for 21% of episodes and was associated with prior antibiotic exposure, gastroenteritis as the clinical focus, and the consolidation phase of chemotherapy.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"88-98"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From microscopy to metagenomics: Evolution and challenges in clinical microbiology","authors":"Marylin Hidalgo","doi":"10.7705/biomedica.8421","DOIUrl":"10.7705/biomedica.8421","url":null,"abstract":"","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"5-7"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13412273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual gastrointestinal histoplasmosis with jejunal perforation in a 57-year-old patient from Bogotá: Case report.","authors":"Diana-Marcela Gaviria-Delgado, Natalia Olaya, Laura Cristina Nocua-Báez","doi":"10.7705/biomedica.7959","DOIUrl":"10.7705/biomedica.7959","url":null,"abstract":"<p><p>Histoplasmosis is an endemic fungal infection caused by Histoplasma species. Disseminated forms, although rare, often involve the gastrointestinal tract and primarily affect immunocompromised patients. This article presents an unusual case of gastrointestinal histoplasmosis with jejunal perforation. A 57-year-old man presented with chronic abdominal pain, intermittent fever, cough, diaphoresis, nausea, and rapid weight loss. Findings on computed tomography scans showed thickening and malignant lesions in the intestine, further evaluated through laparotomy, in addition to pulmonary involvement. Jejunal perforation and septic shock were identified and treated with antibiotics. The clinical course was unfavorable, resulting in patient's death. Peritoneal liquid cultures and hemocultures were negative, but the biopsy histological analysis revealed the presence of intracellular yeasts compatible with Histoplasma spp. This case highlights the importance of considering invasive fungal infections in apparently immunocompetent critically ill patients and reassessing diagnostic methods to ensure timely and effective treatment.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"22-30"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13441454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTED: Brucella melitensis infection with osteoarticular involvement: First reported cases in Colombia. https://doi.org/10.7705/biomedica.8614","authors":"Ricardo Augusto Díaz, Isabel Cristina Ramírez-Sánchez, Daniel Montoya","doi":"10.7705/biomedica.7780","DOIUrl":"10.7705/biomedica.7780","url":null,"abstract":"<p><p>Brucellosis is the most common zoonosis in the world, with Brucella melitensis being the main isolated species. Despite this, only two cases of infection by this pathogen have been described in Colombia, none of them with osteoarticular involvement.\u0000We describe three cases of B. melitensis infection that debuted with spondylodiscitis, arthritis and myelitis, respectively, managed with combined antibiotic therapy and associated with surgical treatment, achieving clinical cure. This highlights the presence of B. melitensis in Colombia and raises the possibility of underdiagnosis of a species that before 2020 was considered absent in the country.\u0000\u0000Retracted publication in:\u0000\u0000Retracted article: Brucella melitensis infection with osteoarticular involvement: First reported cases in Colombia\u0000Category: Case Report\u0000Received: 29/11/2024\u0000Revised: 09/06/2025\u0000Accepted: 09/07/2025\u0000Online ahead of print: 11/07/2025\u0000Published: 07/06/2026\u0000Retracted: 11/08/2026\u0000\u0000Citation: Díaz RA, Ramírez-Sánchez IC, Montoya D. Brucella melitensis infection with osteoarticular involvement: First cases reported in Colombia. Biomédica. 2026;46(Suppl. 1):8-15. https://doi.org/10.7705/biomedica.8614.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"8-15"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13418323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of methicillin-resistant Staphylococcus aureus carriers in dental care staff: A systematic review and meta-analysis","authors":"Juana Patricia Sánchez-Villamil, Víctor Alfonso Morales-Peña, Juan Felipe Flórez-Joya","doi":"10.7705/biomedica.5794","DOIUrl":"10.7705/biomedica.5794","url":null,"abstract":"<p><strong>Introduction: </strong>Methicillin-resistant Staphylococcus aureus is a pathogen transmitted both in hospital and community settings. Although carriage among medical and nursing personnel has been widely studied, information regarding its presence among dental healthcare workers is limited.</p><p><strong>Objective: </strong>To estimate the prevalence of healthy methicillin-resistant S. aureus carriers among dental personnel.</p><p><strong>Materials and methods: </strong>We searched for articles in PubMed, ScienceDirect, Scopus, BVS, and Google Scholar in English, Portuguese, and Spanish. Three reviewers selected and extracted data from cross-sectional studies published up to December 2024. We assessed risk of bias using the Joanna Briggs Institute tool. We calculated pooled prevalence and conducted subgroup analyses using a random-effects model with maximum likelihood estimation in Stata 18.0™. The protocol was registered in PROSPERO (CRD42024563164).</p><p><strong>Results: </strong>We included 17 articles in the systematic review and six in the meta-analysis. The overall prevalence of nasal methicillin-resistant S. aureus carriage among dental personnel was 2.28% (95% CI: 0.78-6.4) in a combined sample of 1256 participants. Among dentists, prevalence was 3.63% (95% CI: 0.98-10.57); among dental assistants, 1.45% (95% CI: 0.11-11), and among dental students in clinical training, 2.0% (95% CI: 0.36-8.0). Differences between groups were not statistically significant (p = 0.87).</p><p><strong>Conclusions: </strong>Evidence on methicillin-resistant S. aureus carriage among dental personnel is scarce and lacks population representativeness. Although prevalence appears low, continued surveillance among all dental healthcare providers is recommended to monitor epidemiological transmission and associated risk factors.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"60-73"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Datos sintéticos de un modelo de datos común para las aplicaciones de inteligencia artificial en salud materna: reporte de experiencia en el contexto colombiano.","authors":"Ever Augusto Torres Silva","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"46 Sp. 1","pages":"152"},"PeriodicalIF":0.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}