Biomedica : revista del Instituto Nacional de Salud最新文献

{"title":"Strong antibody reactivity to HIV-1 synthetic peptides in seropositive indigenous Warao people","authors":"Isabel Durango, Sandra Losada, Henry Bermúdez, Julián Villalba, Yoneira Sulbaran, Rossana C Jaspe, Jacobus H De Waard, Héctor R Rangel, Óscar O Noya, Flor H Pujol","doi":"10.7705/biomedica.7510","DOIUrl":"10.7705/biomedica.7510","url":null,"abstract":"<p><strong>Introduction: </strong>Previous studies have described an epidemic of HIV-1 in the indigenous Warao population living in the Orinoco Delta, Venezuela. The Warao face extraordinary challenges amid of their ongoing HIV-1 epidemic, the highest reported HIV-1 prevalence in indigenous groups (9.6%) in South America.</p><p><strong>Objective: </strong>To investigate the antibody reactivity to HIV-1 synthetic peptides in seropositive individuals, with a particular focus on the indigenous Warao population from Venezuela.</p><p><strong>Materials and methods: </strong>The HIV-1 Pol region from infected patients' isolates was amplified, sequenced, and analyzed using phylogenetic tools. Custom-designed synthetic peptides were derived from conserved regions of HIV-1 glycoproteins 41 and 120, based on reference sequences. Multiple antigen blot assays were used to evaluate the presence of antibodies against synthetic peptides.</p><p><strong>Results: </strong>The most frequent HIV-1 subtype was B, the most common in Venezuela, although some individuals were infected with subtype A1. Distinct patterns of reactivity to synthetic peptides were observed between the sera of the general population and the Warao population; the sera of the latter exhibited a high intensity of peptide recognition.</p><p><strong>Conclusions: </strong>The use of synthetic peptides, coupled with the robust performance of multiple antigen blot assays, enriches our understanding of antibody responses in different HIV-1-infected populations.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"267-276"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onychomadesis secondary to mouth, hand, and foot disease: Case report","authors":"Rodolfo Arredondo-Nontol, Miriam Arredondo-Nontol, Luis Castillo-Peña, Edward Andrés Vertiz, Gaby Lourdes Gómez, Narcisa Reto","doi":"10.7705/biomedica.7171","DOIUrl":"https://doi.org/10.7705/biomedica.7171","url":null,"abstract":"<p><p>This case is about a previously healthy five-year-old girl who presented with hand, foot, and mouth disease, and subsequently developed onychomadesis one month later, with detachment of the nail plates on both fingers and toes. However, the condition resolved spontaneously.\u0000After hand, foot, and mouth disease, she exhibited nail bed elevation at the proximal región of the nails on the second and third fingers of both hands. This elevation was painless, without bleeding, and later involved all toes. The condition resolved spontaneously over the following three months, with new, healthy nail growth.\u0000In Latin America, onychomadesis is a rare complication of hand, foot, and mouth disease in our region and is associated with atypical forms of the disease, indicating altered host response to common infections with coxsackie viruses. Reporting such cases is essential to understand these benign and self-limited variations, prevent misdiagnoses, and inform parents appropriately.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"190-196"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocardiosis: A case series and literature review","authors":"José Camilo Álvarez-Rodríguez, Carlos A Solórzano-Ramos, Viviana López-Ramírez, Luisa Torres-Rubio, Ana Ovalle-Gómez, Jersson Camilo Sánchez-Gámez, Cindy L Beltrán-Endo, María J López-Mora, Julio C Gómez-Rincón, Cristian L Cubides-Cruz, Rose M Jaramillo-Calle, Vanessa Correa-Forero, Nidia Gabriela Cristina García, Sonia Isabel Cuervo-Maldonado","doi":"10.7705/biomedica.7486","DOIUrl":"https://doi.org/10.7705/biomedica.7486","url":null,"abstract":"<p><p>Nocardiosis is caused by a branched Gram-positive bacillus that affects mostly immunosuppressed patients. The clinical manifestations can be localized or disseminated, and the treatment depends on the affected organs, the severity of the disease, and the susceptibility profile.\u0000Nocardiosis should be considered in the differential diagnosis of localized or disseminated abscesses in immunosuppressed patients. Early clinical suspicion would allow the start of empirical treatment, prompt microbiological research, and may positively impact survival.\u0000We present a case series of 14 patients with infection by Nocardia spp. who attended different health institutions in Bogotá between January 2008 and November 2023. The clinical microbiology laboratory provided information on demographic, clinical, and laboratory variables.\u0000Fourteen patients were analyzed, with an average age of 49.8 years (30 to 72 years); 10 were men, and nine had a diagnosis involving immunosuppression: six had cancer and three had other underlying immunosuppression. Diabetes and hypertension were the most common comorbidities. The infection was chronic in 10 patients; the organs involved were the brain and lungs in 7 cases. Nocardia species’ was identified in five subjects; one of the patients presented infection with Cryptococcus spp. Nocardiosis treatment was prolonged and included trimethoprim-sulfamethoxazole in 12 cases; four patients died.\u0000Infection by Nocardia spp. is primarily opportunistic, presents unique clinical and microbiological aspects, and is a differential diagnosis of localized or systemic abscesses in immunosuppressed patients. Clinical suspicion allows a careful approach in terms of diagnosis, and initiation of empiric antibiotic treatment can positively impact survival.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"197-214"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma underdiagnosis in children: A school-based screening in a low socioeconomic status population.","authors":"Dayan Crispin-Cruz, Alejandro Casas-Herrera, Camilo Rojas-Báez, Carlos Torres-Duque, Mauricio González-García","doi":"10.7705/biomedica.7138","DOIUrl":"https://doi.org/10.7705/biomedica.7138","url":null,"abstract":"<p><strong>Introduction: </strong>International asthma management and prevention recommendations emphasize the importance of early and accurate diagnosis and adequate disease control. However, these aspects remain a serious concern, especially in children with low socioeconomic status.</p><p><strong>Objective: </strong>To describe asthma prevalence, underdiagnosis, severity, and control among children with low socioeconomic status in Bogotá, Colombia.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional study using the International Study of Asthma and Allergies Questionnaire in children aged 7-11 in two public schools. The children with affirmative answers in the questionnaire were evaluated clinically and functionally at the mobile health care unit. Asthma prevalence, underdiagnosis, control level, severity, and patients' quality of life were assessed with validated instruments.</p><p><strong>Results: </strong>We screened 920 schoolchildren with an age of 9.5 ± 1.1; 186 were evaluated clinically and functionally by spirometry, and 122 of them were diagnosed with asthma (17.2%). Underdiagnosis was 68%. Most patients had moderate and severe asthma, and 90% were cases of not well or very poorly controlled asthma.</p><p><strong>Conclusions: </strong>Screening children in school settings is a suitable strategy for detecting asthma and reducing underdiagnosis in communities with low socioeconomic status and limited access to health care services. The asthma underdiagnosis and poor disease control were high.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"277-285"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic burden of premature death due to suicide in Colombia between 2005 and 2021","authors":"Jean Carlo Pineda-Lozano, Diana Patricia Díaz-Jiménez, Carlos Castañeda-Orjuela","doi":"10.7705/biomedica.7623","DOIUrl":"https://doi.org/10.7705/biomedica.7623","url":null,"abstract":"<p><strong>Introduction: </strong>Suicide is a public health problem with significant social and economic consequences. In Colombia, suicide affects mostly young people.</p><p><strong>Objective: </strong>To estimate the years of life potentially lost and the economic burden associated with suicide in Colombia between 2005 and 2021.</p><p><strong>Material and methods: </strong>We conducted a retrospective study to estimate the years of life potentially lost and the economic burden related to suicide from the perspective of society. We modified the human capital method and considered two scenarios. Information on suicide mortality and economic variables was collected from official sources, and indirect costs due to premature mortality were calculated. The costs are expressed in 2021 US dollars, considering the average of the 2021 representative market rate (COP $3,743).</p><p><strong>Results: </strong>Between 2005 and 2021, 40,157 deaths by suicide were recorded in Colombia, mainly in young men between 15 and 29 years old. These deaths represented 2,104,731 years of life potentially lost. The total economic costs associated with suicide ranged from USD $4.21 billions to USD $7.1 billions in the two scenarios considered, with an average annual cost between USD $247.6 and USD $422.2 millions in each case. The most densely populated departments had the highest accumulated costs by population rates. Vaupés, Amazonas, and Quindío had the highest costs per thousand inhabitants.</p><p><strong>Conclusions: </strong>It is necessary to address suicide in Colombia from a comprehensive and multidimensional perspective, investing in mental health programs and preventive approaches to reduce the economic burden and social impact. The results offer valuable information to design suicide prevention policies and strategies and highlight the importance of targeting specific population groups and regions.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"215-227"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene variants, oxidative stress and inflammation in Colombian populations","authors":"Dayan Nicole Banguera, Lizeth Giovanna Mejía, Diana Ramírez-Montano, Marcela Perenguez-Verdugo, Andrés Castillo","doi":"10.7705/biomedica.7220","DOIUrl":"10.7705/biomedica.7220","url":null,"abstract":"<p><p>Introduction. Oxidative stress and inflammation are biological processes crucial in developing chronic inflammatory diseases.\u0000Objective. This study aimed to identify the ancestry components and mitochondrial haplogroups of individuals from various regions of Colombia. We also compared relative frequencies of gen variants potentially associated with oxidative stress response and inflammation.\u0000Materials and methods. A structural genomic analysis was conducted on five genomes and 58 exomes from individuals across different regions of Colombia. Genetic ancestry components and mitochondrial haplogroups were evaluated with specific molecular markers. Additionally, we compared the frequencies of gene variants related to oxidative stress and inflammation.\u0000Results. Two main ancestry groups were identified: one group exhibited a predominantly African ancestry, having mitochondrial haplogroups L1, L2, L3, B2, and D1; the other group showed predominantly European and East Asian ancestry, having mitochondrial haplogroups H2, U2, B2, A2, C, D1, and D4. Furthermore, non-Afro-Colombian individuals revealed a higher frequency of the variants rs2458236 in the dual oxidase 1 gene (DUOX1), rs2536512 in superoxide dismutase 3 gene (SOD3), rs4073 in interleukin 8 gene (IL-8), and rs1143627 and rs1143634 in interleukin 1 beta gene (IL-1β).\u0000Conclusion. This study highlights significant differences in the allele frequencies of gene variants associated with oxidative stress and inflammation. These differences correspond to the primary genetic ancestry components of the individuals studied.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"244-266"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric psoriasis: A descriptive, retrospective and multicenter study in Colombia","authors":"Mauricio Torres, Juliana Flórez, María Salomé Páez, Ángela María Londoño, Paola Cárdenas, Mariela Tavera, Mónica Paola Novoa, Carolina Cortés, Rosángela Casanova","doi":"10.7705/biomedica.7638","DOIUrl":"10.7705/biomedica.7638","url":null,"abstract":"<p><strong>Introduction: </strong>Pediatric psoriasis has a prevalence ranging from 0.5 to 4.1%. It is more common in females, and the predominant type is the vulgar or plaque. It has been associated with comorbidities such as obesity and metabolic syndrome or even with a family history of psoriasis.</p><p><strong>Objective: </strong>To describe the epidemiological and clinical characteristics of pediatric patients diagnosed with psoriasis attending pediatric dermatology consultations with dermatologists who are members of the Asociación Colombiana de Dermatología from January 2017 to June 2022.</p><p><strong>Material and methods: </strong>We conducted a descriptive, retrospective, and multicenter study. We describe the prevalence, clinical characteristics, diagnostic methods, personal and family history, and treatments for patients with pediatric psoriasis. Stata 13™ software was used for data analysis.</p><p><strong>Results: </strong>From 26,870 patients, 146 were diagnosed with psoriasis (0.54%), with a femaleto-male ratio of 1.5:1 and a median age of onset of eight years. The most common variant was vulgar psoriasis (72.6%), followed by guttate psoriasis (6.85%), and the scalp was the most frequently affected location (55.48%). The most common comorbidities were obesity and Crohn’s disease (5.5% each). Family history included 39 cases of psoriasis, 16 diabetes mellitus, and 7 dyslipidemia. Seventy-eight percent of the cases were classified as mild according to the Psoriasis Area Severity Index (PASI); 65% received topical treatment, and 18% received systemic treatment. Sixty-five percent received topical treatment, while systemic treatment and phototherapy was used in 19% and 2.7%, respectively. When using combined treatment (6%) received topical and systemic modalities, 1.3% used topical with phototherapy, and 0.68% received all treatments.</p><p><strong>Conclusion: </strong>In the evaluated population, the most frequent variant of pediatric psoriasis was the vulgar type with mild severity. Most patients with this clinical presentation received opical treatment. The association with other systemic diseases implies the need for further studies.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"310-320"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malaria after liver transplantation: Report of two cases and a review of published cases.","authors":"Andrés Fernando Rodríguez-Gutiérrez, Isabel Cristina Ramírez-Sánchez","doi":"10.7705/biomedica.7433","DOIUrl":"10.7705/biomedica.7433","url":null,"abstract":"<p><p>Malaria is a tropical disease that is rarely reported in liver transplant recipients. However, some cases have been documented around the world and here we report two. Case 1. A 54-year-old male attended the emergency room 30 days after liver transplantation due to malaise, fever, chills, thrombocytopenia, and anemia. Plasmodium vivax was detected in the blood smear, and the patient was treated with artemether/lumefantrine, achieving resolution of the parasitemia. Neither chloroquine nor primaquine were prescribed because they were unavailable in the country. Two months later, the patient returned to the emergency room with the same symptoms and was diagnosed with a relapse of malaria caused by P. vivax. The patient received successful treatment with chloroquine and primaquine, which were already available. Given that the liver donor came from a malaria-endemic area, the infection was probably of donor origin, likely by hypnozoites present in the allograft. Case 2. A 58-year-old woman living in a malaria-endemic region attended the emergency service with fever, malaise, arthralgia, cytopenias, and hypertransaminasemia six months after undergoing a liver transplant. P. vivax was detected in the blood smear, so treatment with chloroquine and primaquine was started. After treatment, the blood smear was negative, and the patient was discharged.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"180-189"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic critical appraisal of GRADE recommendations for prostate cancer staging","authors":"Dayana Sáenz, Ana Marcela Torres, Rodrigo Pardo, Wilfredo Donoso","doi":"10.7705/biomedica.7653","DOIUrl":"https://doi.org/10.7705/biomedica.7653","url":null,"abstract":"<p><strong>Introduction: </strong>Prostate cancer staging is necessary to determine tumor extent. In recent years, new and more accurate imaging modalities that could provide a better framework for patient management have emerged. They are currently incorporated into the prostate cancer guideline recommendations. Clinical practice guidelines are important for implementing clinical research findings and high-quality evidence-based recommendations.</p><p><strong>Objective: </strong>To review and evaluate the quality of evidence underpinning the categorization of prostate cancer staging guidelines using the AGREE II tool.</p><p><strong>Material and methods: </strong>Systematic searches were performed on the PubMed, BiGG, and Epistemonikos databases. In addition, repositories and clinical practice guidelines websites were hand searched to identify GRADE recommendations for prostate cancer staging published in the last five years. The quality of clinical practice guidelines was assessed using the AGREE II tool. Recommendations and the certainty of evidence were also summarized.</p><p><strong>Results: </strong>Seven guidelines that met the selection criteria were included. A narrative analysis of the staging recommendations and evidence mapping was performed. The AGREE II domain “clarity of presentation” had the highest score (mean = 71.59%), whereas “applicability” had the lowest score (mean = 45.15%). Five guidelines met the proposed AGREE II cutoff scores and provided staging and diagnostic recommendations.</p><p><strong>Conclusions: </strong>Significant heterogeneity was observed in the methodological quality of the guidelines included, along with common deficits regarding applicability and stakeholder involvement. Thus, more rigorous and high-quality guidelines need to be developed to facilitate their implementation by clinicians in daily practice.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"286-296"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental fluorosis in volcanic areas: Analysis of associated factors in a Colombian school population","authors":"Yeimy Tatiana Ortega, Angye Paola Salcedo, Rafaela Reis da Silva, Bruno Gutiérrez, Johana Alejandra Moreno","doi":"10.7705/biomedica.7337","DOIUrl":"10.7705/biomedica.7337","url":null,"abstract":"<p><p>Introduction. Dental fluorosis is an endemic problem in southern Colombia, especially due to its proximity to volcanic areas and the composition of their waters.\u0000Objective. To identify the prevalence and factors associated with the development of dental fluorosis in the school population of the municipality of La Cruz, Nariño.\u0000Materials and methods. We conducted a cross-sectional observational study that included clinical and sociodemographic variables and data about habits, diet, and dental fluorosis knowledge. To collect the information, we used a questionnaire completed by the parents or guardians and a clinical evaluation –previously standardized by the researchers– of schoolchildren between 8 and 12 years from two educational institutions. A descriptive statistical analysis was performed with proportions and measures of central tendency. The multivariate analysis used a negative binomial regression with rate ratios and 95% confidence intervals.\u0000Results. We included 116 participants with a mean age of 9.80 (SD = 1.38) years and a mean of the Dean’s index of 2.36 (SD = 0.86). A higher Dean’s index was associated with older age (p < 0.003), brand of salt (p < 0.007), higher consumption of legumes (p < 0.001), cereals (p < 0.038), and fish (p < 0.025), and lower consumption of red meat (p < 0.017).\u0000Conclusion. Dental fluorosis is a multifactorial problem that requires different approaches according to the territories and their particularities and public health measures to control its high prevalence.</p>","PeriodicalId":101322,"journal":{"name":"Biomedica : revista del Instituto Nacional de Salud","volume":"45 2","pages":"297-309"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}