MATERIALS & DESIGN最新文献

{"title":"Catechol-functionalized Chitosan/Polyvinyl alcohol hydrogel microneedles integrating multimodal antibacterial nanocomposites for enhanced wound healing","authors":"Wenrui Ma, Hengjun Zhang, Jiaqi Liu, Hanhua Xu, Xianling Dai, Man Shen, Junjie Fan, Yingchun Huang, Shuang Wang, Ruijie Ai, Linlin Liu, Jing Bao, Ming Chen","doi":"10.1016/j.matdes.2026.115811","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115811","url":null,"abstract":"• A hydrogel microneedle patch with PDT/PTT and sustained antimicrobial effects is proposed. • The patch maintains stable skin attachment and preserves antioxidant functionality. • The patch demonstrates potent antibacterial and biofilm eradication capabilities. • The patch promotes wound regeneration via single-treatment administration. Pathogenic bacterial infections, particularly antibiotic-resistant strains, severely impede wound healing, increasing patient pain and healthcare costs. Herein, we engineered a bioinspired, adhesive and near-infrared (NIR)-responsive hydrogel microneedles (MNs) patch for transdermal delivery of multifunctional antimicrobials to treat infected wound. The patch consisted of a mussel-mimetic hydrogel matrix of 3, 4-dihydroxyphenylacetic acid-modified chitosan and poly (vinyl alcohol) (DLC/PVA). The DLC/PVA hydrogel MNs were loaded with engineered antimicrobial nanocomposites (SAMnPor@TA/Ag-HA), featuring NIR-activatable manganese porphyrin assemblies (SAMnPor), ultrasmall tannic acid-chelated silver (TA/Ag) nanoparticles, and a protective hyaluronic acid (HA) outer layer. These organic–inorganic nanocomposites conferred the DLC/PVA MNs with multimodal antibacterial activity driven by photodynamic, photothermal and metalloantimicrobial effects, including rapid disinfection under NIR irradiation and sustained antibacterial activity in the absence of light. In mouse bacterial-infected wound models, a single administration of the DLC/PVA MNs patch exerted superior antimicrobial efficacy and wound healing ability, highlighting its great potential in combating bacterial infections and promoting tissue regeneration. Compared with common hyaluronic acid methacrylated (HAMA) MNs, the DLC/PVA MNs exhibited appropriate tissue adhesion and remarkable antioxidant activity due to the integration of mussel-derived catechol groups. This study offers a promising long-term wound care strategy by integrating advanced antibacterial nanocomposites within a polysaccharide-based microneedle platform.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"264 1","pages":"115811-115811"},"PeriodicalIF":0.0,"publicationDate":"2026-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a dual-layer microneedle drug delivery system based on “chemotherapy-immunity-anti-inflammatory” for melanoma research","authors":"Lina Sun, Huahua Li, Chunyu Zhao, Zhou Shu, Mengting Xu, Y Wang, Lili Yue, Yining Zhang, Xinying Lu, Yanjie Guo, S Du, Xinran Wang, Jie Bai","doi":"10.1016/j.matdes.2026.115559","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115559","url":null,"abstract":"• Localized melanoma treatment offers distinct advantages. • The microneedle delivery system exhibits a dual synergistic effect of cell wall disruption and drug release. • Combining Traditional Chinese Medicine Components with Chemotherapy Drugs to Enhance Efficacy and Reduce Toxicity. • Nucleus-shell nanomedicines enable tiered treatment combining chemotherapy, immunotherapy, and anti-inflammatory effects. Melanoma, the most lethal skin disease with steadily rising incidence rates, demands safer, more precise, and intelligently effective combination therapies. By utilizing traditional Chinese medicine polysaccharides as the microneedle matrix, we developed dual-layer microneedles incorporating multi-core–shell structured nanoparticles and anti-inflammatory immune nanoparticles loaded with both chemical and herbal components. These dual-layer microneedles demonstrate superior synergistic antitumor and anti-inflammatory effects both in vivo and in vitro. Following local administration, they achieve a 95.6% inhibition rate against melanoma, effectively inhibiting tumor growth and invasion. They significantly enhance the activation and immune function of tumor-targeting T cells, increase the proportion of CD8 + T cells, and simultaneously activate innate immune functions in immune organs. This approach boosts the proportion of immune T cells and NK cells in the spleen, promotes T cell secretion of TNF-α to achieve anti-tumor immune activation, and enhances systemic anti-inflammatory immune responses. Simultaneously, it reduces drug concentration in non-targeted areas, minimizing systemic toxicity and side effects. This achieves a tiered drug delivery effect combining “chemotherapy-immunotherapy-anti-inflammation,” realizing a three-pronged synergistic anti-tumor effect through “break the skin barrier −drug release-immune coordination.” It provides a reference for developing new formulations for microneedle local administration and topical anti-tumor preparations.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"262 1","pages":"115559-115559"},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone substrate topography modulates fibroblast-to-myofibroblast transition through Filamin A-mediated TGFβ/Smad signaling pathway","authors":"Ruolan Liu, Xiaohua Shi, Dafang Yu, Yujie Lan, Y J Huang, Zichen Yang, Cheng Chen, Yao Chen, Linbo Jin, Dongli Fan, Z. M. Lei","doi":"10.1016/j.matdes.2026.115508","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115508","url":null,"abstract":"• Microgroove surface topography of PDMS inhibits fibroblast-myofibroblast transition by modulating Filamin A and TGFβ/Smad signaling pathways. • Silicone Substrate Topography reduces fibrosis markers, including Filamin A, TGFβ1, Smad2/3, and α-SMA, suggesting potential for preventing capsular contracture • Multi-omics analysis identifies key proteins and metabolites involved in cytoskeletal remodeling and collagen synthesis, supporting optimized material design for soft tissue repair. Capsular contracture, a prevalent complication of polydimethylsiloxane (PDMS) implants, severely compromises patients’ quality of life. While surface morphology is recognized as a PDMS-related factor influencing capsular contracture, the precise mechanism by which this physical alteration affects intracellular signaling remains unclear. In this study, we developed smooth PDMS and bionic microgrooved surfaces PDMS. Through in vitro cell experiments, in vivo implantation, and multi-omics analysis, we investigated how surface microstructures modulate fibroblast transformation. Results demonstrated that microgrooved PDMS significantly inhibited fibroblast-mediated transformation (FMT) and downregulated expression of filamentous protein A (FLNA), TGFβ1, Smad2/3, and α-SMA. These findings indicate that PDMS exerts anti-fibrotic effects by regulating the FLNA-mediated TGFβ/Smad signaling pathway, thereby disrupting cytoskeletal remodeling and extracellular matrix accumulation. Multi-omics analysis further identified differential expression proteins and metabolites involved in cytoskeletal dynamics, collagen synthesis, and metabolic pathways. In conclusion, the PDMS surface substrate morphology critically regulates fibroblast transformation by modulating the cytoskeleton and signaling pathways, providing a theoretical basis for optimizing the design of soft tissue repair materials.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"262 1","pages":"115508-115508"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutathione-scavenging ferroptotic nanoamplifiers strengthen tumour therapy through sonodynamic/photothermal-triggered GPX4 inhibition and lipid peroxidation","authors":"Wenting Zhang, Xiangyong Meng, Shouda Gao, Xue Han, Yafei Lin, Xuening Zhang, Yueyang Yao, Xi Zhu, Juan Feng, Yang Zhang","doi":"10.1016/j.matdes.2026.115502","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115502","url":null,"abstract":"• In this study, we achieved bimetallic synergy to overcome ferroptosis resistance during therapy, which is primarily caused by intracellular regulatory abnormalities, such as enhanced glutathione biosynthesis. • Sonodynamic therapy is introduced to mediate reactive oxygen species generation, which not only reduces tumour thermoresistance but also significantly enhances the therapeutic efficacy of photothermal therapy. • It provides preclinical evidence for the utility of iridium-based nanomaterials in inducing ferroptotic cell death, expanding the toolbox of nanotherapeutics for refractory prostate cancer. Ferroptosis-based therapeutic strategies hold promise for overcoming the limitations of conventional therapies in modulating cell-death pathways, offering novel avenues for treating tumours that exhibit poor responsiveness to standard approaches. However, intrinsic regulatory mechanisms in tumour cells induce therapeutic resistance, severely impeding the antitumour efficacy of ferroptosis-inducing therapies. In this study, IrO x @TCPP-Cu nanomaterials were developed to enable dual-metal catalytic reduction of GSH and to mediate ferroptosis through sonodynamic and photothermal therapy (SDT/PTT) for the treatment of prostate cancer.The underlying mechanism is as follows: IrO x decomposes to generate oxygen, which enhances the sonodynamic activity of TCPP-Cu and promotes continuous production of singlet oxygen ( 1 O 2 ), leading to the accumulation of lipid peroxides (LPO)..Concurrently, IrO x -mediated PTT inhibits the System-Xc − pathway, leading to reduced expression of glutathione peroxidase 4 (GPX4). Furthermore, the redox cycling between Ir 4+ /Ir 3+ and Cu 2+ /Cu + depletes the intracellular GSH, thereby suppressing GPX4 activity. The burst of reactive oxygen species (ROS) induced by SDT overcomes the PTT-associated thermal resistance, thus enhancing the overall therapeutic efficacy. This cascaded effect disrupts ROS-GPX4 homeostasis, resulting in irreversible LPO accumulation and ultimately triggering ferroptotic cell death. Collectively, the Ir-based nanoclusters developed in this study represent a highly promising strategy for cancer ferroptosis therapy.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"262 1","pages":"115502-115502"},"PeriodicalIF":0.0,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunomodulatory Sr2+-crosslinked hydrogel with antibacterial, antioxidant, and anti-inflammatory activities for accelerated skin wound healing","authors":"Qingxi Meng, Qingcong Wei, Weiwei Zhang, Qing Wu, Yuqin Jiang, Zhiguo Hu, Yuqin Zhang, Qigang Wang","doi":"10.1016/j.matdes.2026.115497","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115497","url":null,"abstract":"• Sr 2+ -crosslinked alginate/carboxymethyl chitosan-based hydrogel promotes skin wound healing. • The hydrogel effectively induces macrophage polarization towards M2 phenotype. • The hydrogel exhibits excellent antibacterial and radical scavenging properties. • The hydrogel suppresses inflammation, promotes angiogenesis, and re-epithelization. Bacterial infection and persistent inflammation significantly impair skin wound healing. To address these problems, a multifunctional hydrogel biomaterial featuring immunomodulatory characteristics is desirable in wound management. Here, an M2 macrophage-polarized hydrogel exhibiting antibacterial, antioxidant, and anti-inflammatory functions was fabricated by simply mixing sodium alginate, carboxymethyl chitosan, 4-formylphenylboronic acid, naringin, and Sr 2+ . Sr 2+ and naringin are effectively loaded into gel networks via coordination reactions and borate esters, respectively. Carboxymethyl chitosan and naringin endowed the hydrogel with excellent antibacterial properties. Naringin also effectively scavenges radicals, thus alleviating oxidative stress. The hydrogel also promotes the reprogramming of macrophages from the M1 phenotype (pro-inflammatory) to the M2 phenotype (anti-inflammatory), collectively downregulating the level of pro-inflammatory TNF-α and MPO and upregulates anti-inflammatory IL-10 levels. Additionally, the hydrogel exhibits appropriate mechanical, tissue adhesive, and hemostatic properties. In view of combined therapeutic effects including killing bacteria, scavenging radicals, and macrophage polarization, the hydrogel can alleviate inflammation, promote angiogenesis, and collagen deposition, thereby promoting cutaneous repair in a murine full-thickness excisional wound model. It provides an innovative strategy to facilely prepare multifunctional hydrogel dressing materials with immunomodulatory properties for treating other complex wounds.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"262 1","pages":"115497-115497"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodegradable tetrasulfide bonds incorporated mesoporous polyamidoamine nanoplatform for enhancing antitumor efficiency via photothermal enhanced GSH depletion","authors":"Xiuhua Lin, Suhua Jiang, Siting Zhang, Huaqin Zhang, Xin Lin, Jiaping Lin, Zhizong Shen","doi":"10.1016/j.matdes.2025.115406","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115406","url":null,"abstract":"• Mesoporous polydopamine doped with tetrasulfide bonds were fabricated for the first time. • It has satisfactory photothermal conversion efficiency and effective intracellular GSH consumption. • Potent PTT and ROS generation were achieved for in vitro and in vivo tumor cell killing. Owing to the heat resistance of heat shock proteins that trigger cellular antioxidants like glutathione (GSH), it is challenging to simultaneously inhibit the spread and metastasis of tumor nodules and prevent tumor recurrence using conventional photothermal therapy (PTT). In this research, for incorporation of PTT and GSH depletion, we utilized mesoporous polydopamine nanospheres doped with GSH-responsive tetrasulfide bonds (referred to as gMPDA) for the synergistic suppression of lung cancer cells. By incorporating Arg-Gly-Asp (RGD) peptides onto the surface (forming gMPDA-RGD), the stability and tumor-targeting specificity of this biodegradable nanoplatforms were markedly improved. In vitro studies testified that these innovative nanotherapeutics displayed an impressive photothermal conversion efficiency (η = 52.33 %) and efficient consumption of intracellular GSH, leading to the collapse of the PDA based nanoframe. Notably, the disruption of redox balance post-808 nm laser irradiation led to effective PTT and reactive oxygen species (ROS) production. Importantly, gMPDA-RGD manifested a strong tumor-targeting ability in lung tumor-bearing Balb/C mice under fluorescent imaging. The synergistic treatments led to complete elimination of tumor cells when exposed to 808 nm laser irradiation. This study underscored the potential of gMPDA-RGD as a potent nanomedicine for the synergistic therapy of PTT and GSH depletion in clinical malignant tumor.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"261 1","pages":"115406-115406"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic nanoplatform potentiates STING-immunotherapy by coordinated delivery of chemotherapeutic and innate immune agonist","authors":"Hongpeng Duan, Zhiyuan Chen, Xinyue Wang, Bei Zhang, Liangbo Guo, Wenhao Lv, Zhenbin Xu, Shaosheng Wu, Fan Yu, Difan Wang, Weijing Zhang, Yifan Lian, Shengmin Zhang","doi":"10.1016/j.matdes.2025.115372","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115372","url":null,"abstract":"Assembly of tumor cell membrane–cloaked PEG–PLGA@DOX/R848 and schematic of dual cGAS–STING/TLR7/8 activation to remodel the tumor immune microenvironment and potentiate chemo-immunotherapy in TNBC. Triple-negative breast cancer (TNBC) lacks effective targeted therapies, with outcomes limited by an immunosuppressive tumor microenvironment. We developed a tumor cell membrane–cloaked PEG-PLGA nanoplatform that co-delivers doxorubicin (DOX) and the Toll-like receptor 7/8 agonist R848. DOX-induced cytosolic DNA activates the cGAS–STING axis, while R848 engages TLR7/8–MyD88–NF-κB/IRF7 in antigen-presenting cells; their convergence potentiates type-I interferon signaling and immunogenic cell death, repolarizing macrophages from M2 to M1 and promoting effector and memory T-cell responses. In orthotopic and metastatic TNBC models, the platform suppressed tumor growth with favorable tolerability, supporting translational chemoimmunotherapy. • Biomimetic membrane coating confers enhanced tumor targeting and efficient intracellular delivery. • pH-responsive co-release of doxorubicin and a TLR7/8 agonist elicits synergistic tumor cell killing. • Coordinated activation of the cGAS–STING and TLR–MyD88 pathways amplifies type I interferon signaling and antitumor immune responses. An immunosuppressive tumor microenvironment is a major barrier to effective chemoimmunotherapy. In this work, a cancer cell membrane–coated PEG–PLGA nanoparticle system was constructed to co-deliver doxorubicin and the TLR7/8 agonist R848 for coordinated immune activation. The resulting core–shell nanomaterial exhibited pH-responsive behavior and enhanced tumor cellular uptake. In vitro studies showed that treatment induced robust activation of innate immune signaling, including a 2.3-fold increase in IFN-β secretion mediated by the cGAS–STING–IRF3 pathway, together with activation of MyD88–NF-κB signaling. These effects were accompanied by synergistic cytotoxicity (CI < 1), macrophage repolarization toward an M1 phenotype, as reflected by an increase in the IL-12/IL-10 ratio from approximately 0.7 to >3.2, and a pronounced Th1-biased immune response. In orthotopic and experimental metastatic triple-negative breast cancer models, the membrane-coated nanoparticles achieved approximately 75 % inhibition of primary tumor growth and a 95 % reduction in lung metastatic burden, without detectable systemic toxicity. These results demonstrate that biomimetic membrane–assisted co-delivery enables synchronized activation of cytosolic and endosomal innate immune pathways, providing an effective strategy for remodeling the tumor immune microenvironment and enhancing chemoimmunotherapeutic efficacy","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"261 1","pages":"115372-115372"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction for pH-responsive and bone-targeted osteoporosis therapy","authors":"Peng Luo, Jiaming Fu, Xiaowei Yang, Fengbo Mo, Yanlong Zhong, Qi Lai, Shaorong Huang, Xiaoyong Zhang, Bin Zhang, Yen Wei","doi":"10.1016/j.matdes.2025.115291","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115291","url":null,"abstract":"• Construction of hyperbranched polyglycerol-based curcumin prodrug via phenol-yne click reaction. • HPGCA can self-assemble into water dispersible nanoparticles. • HPGCA shows pH-dependent drug release and bone-targeting capability. • HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN. Osteoporosis is one of the most common chronic metabolic diseases that mainly caused by an imbalance in bone homeostasis. Considered its severe concurrent disorders, osteoporosis has become a global health issue, however, the anti-osteoporosis medications available in clinical practice are confronted with challenges such as high costs, adverse side effects, and limited efficacy. Herein, we reported construction of pH-responsive and bone-targeting nanomedicine (termed HPGCA) via click conjugation of alkyne functionalized hyperbranched polyglycerol (HPG) with curcumin (Cur) and alendronate (ALN) for the first time. We demonstrated that HPGCA exhibit superior water dispersibility, small particle size, and pH-dependent drug release behavior. Results from biological assays indicated that HPGCA displayed desirable bone-targeting capability, strong anti-osteoporosis efficacy, good hemocompatibility, and negligible adverse effects. More importantly, HPGCA showed better anti-osteoporosis efficacy than both free Cur and ALN according results from micro-CT and TRAP staining. The synergistic osteoporosis therapeutic efficacy would be explained by targeting delivering HPGCA to bone tissues and in-situ releasing cargos under acidic environment. Therefore, considered the above aspects, we believe that the innovative nanomedicine is promising for osteoporosis therapy in clinic and will provide new insights for full realization anti-osteoporotic properties of natural compounds.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"261 1","pages":"115291-115291"},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 3D-printed composite scaffold with sequential release of graphene oxide/hydroxyapatite synergistically enhances angiogenesis-osteogenesis for bone defect repair","authors":"Chunchun Li, C. Lyu, Yangfan Ding, Ziying Feng, Jiahua Zhu, Yichen Zhao, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Dong Su, Pengfei Cai, Xiumei Mo, Liang Song","doi":"10.1016/j.matdes.2025.115273","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115273","url":null,"abstract":"","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115273-115273"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spider silk-inspired dual-crosslinked bioadhesive for wet tissue adhesion","authors":"You Ran, Sibei Tao, Weimin Wu, Jiahe Zhao, Yuyang He, Qi Xing, Zixiong Wang, Jun Luo, Jianshu Li, J. Li, Siying Tao, Jiaojiao Yang","doi":"10.1016/j.matdes.2025.115269","DOIUrl":"https://doi.org/10.1016/j.matdes.2025.115269","url":null,"abstract":"• A dual-crosslinked hydrogel adhesive enables robust adhesion in wet tissue environments. • Inspired by spider silk architecture, the design overcomes the mechanical weakness of catechol-based hydrogels. • The wet adhesion strength is enhanced by over 100 % compared to traditional hydrogels, reaching 60.13 kPa; wound closure rate improved by 20 %. • The structure–property relationship of the hydrogel system is systematically elucidated, with insights into the underlying microscopic mechanisms. Clinical applications urgently require hydrogel-based bioadhesives with strong wet adhesion. Catechol-based hydrogels, inspired by mussel adhesion mechanisms, have previously demonstrated excellent wet adhesive performance. However, their intrinsically amorphous polymer chains and loose three-dimensional networks result in poor overall mechanical strength, which constrains further improvement of wet adhesion. In contrast, spider silk derives its outstanding mechanical properties from a unique hierarchical structure of interlaced β-sheet nanocrystalline and amorphous domains. Drawing inspiration from spider silk, we developed a biomimetic dual-crosslinked hydrogel (pTS). In this design, the β-sheets of silk fibroin (SF) mimic crystalline domains, while covalent bonds in poly(tannic acid) (pTA) and hydrogen bonds with SF emulate amorphous regions. This architecture yields a dual-crosslinked network with hydrogen bond-mediated physical and covalent bond-driven chemical crosslinks. By introducing tannic acid (TA) self-polymerization as a tunable parameter, we elucidated how the degree of polymerization regulates the hydrogel’s mechanical and adhesive properties. Notably, the pTS hydrogel exhibited markedly enhanced wet adhesion strength—more than twice that of the conventional TS hydrogel counterparts—reaching 60.13 kPa. In vivo, pTS accelerated wound closure, significantly increasing the healing rate by nearly 20 % over the control group. This work proposes a biomimetic strategy for engineering high-performance wet bioadhesives.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"260 1","pages":"115269-115269"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}