MATERIALS & DESIGN最新文献

Fluorine-programmed molecular chain engineering enables continuous and flexible apatite fibers with tunable surface topography 氟编程分子链工程使连续和灵活的磷灰石纤维具有可调的表面形貌

MATERIALS & DESIGN Pub Date : 2026-07-17 DOI: 10.1016/j.matdes.2026.116603

Shan Zhang, Pan-dong Lin, Xiao Gui-yong, Ming Xie, Ya-hao Geng, Zhigang Song, Tianhao Wu, Guo-chao Gu, Xiang-hai An, Shengyun Huang, Dong-sheng Zhang, Yu‐peng Lu

引用次数: 0

NIR-II fluorescence imaging of bone using synergistic targeting nanoprobes for precise diagnosis of skeletal disorders 使用协同靶向纳米探针的NIR-II骨荧光成像用于骨骼疾病的精确诊断

MATERIALS & DESIGN Pub Date : 2026-07-01 DOI: 10.1016/j.matdes.2026.116557

Ajing Wu, Wenxuan Wang, Liu R, Huifang Hao, Xiaochun Zheng, Mingxin Zhao, Haonan Chen, Yanchun Ma, Weiwei Kang, Ruiping Zhang

{"title":"NIR-II fluorescence imaging of bone using synergistic targeting nanoprobes for precise diagnosis of skeletal disorders","authors":"Ajing Wu, Wenxuan Wang, Liu R, Huifang Hao, Xiaochun Zheng, Mingxin Zhao, Haonan Chen, Yanchun Ma, Weiwei Kang, Ruiping Zhang","doi":"10.1016/j.matdes.2026.116557","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.116557","url":null,"abstract":"Early diagnosis of bone-related diseases remains a critical clinical challenge, attributable to persistent limitations in imaging accuracy and safety. While near-infrared Region II (NIR-II) imaging confers substantial advantages for deep-tissue visualization, its clinical translation is hampered by the inadequate targeting specificity of conventional contrast agents. Here, we developed Au-Ag@Apo-Tf/3-Az (AA@TFN), a synergistic targeting gold–silver nanocluster probe engineered with glutathione and azide functionalities, which achieved bone-specific enrichment via a hierarchical three-level targeting mechanism. AA@TFN first anchored to hydroxyapatite in the bone matrix through glutathione carboxyl-mediated chelation, then targeted transferrin receptors highly expressed in bone marrow, and finally endured macrophage-mediated uptake facilitated by azide-enhanced bone affinity. A synergistic targeting strategy enabled real-time, high-resolution NIR-II imaging across the complete skeleton, with enhanced probe enrichment at lesion sites driven by microenvironmental changes. AA@TFN enabled visualization of synovial inflammation in rheumatoid arthritis models and millimeter‑scale microlesions in multiple myeloma models. Furthermore, the probe exhibited excellent biocompatibility and favorable safety profiles, underscoring its strong translational potential. A versatile platform was established for the diagnosis of bone diseases and non-invasive monitoring of therapeutic efficacy.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"1 1","pages":"116557-116557"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148394250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An oral carrier-free nanodrug’s synergistic mechanisms analyzed in silico and in experiment: assembly ability, pH tolerance capability, mucus layer permeability 一种口服无载体纳米药物的协同机制的硅和实验分析：组装能力，pH耐受性，黏液层渗透性

MATERIALS & DESIGN Pub Date : 2026-06-10 DOI: 10.1016/j.matdes.2026.116381

Minfang Feng, Xingxing Dai, B. Y. Li, Yumei Yan, Xinhui Peng, Rui Li, Yueyang Xie, Guoqing Li, Xinyuan Shi

{"title":"An oral carrier-free nanodrug’s synergistic mechanisms analyzed in silico and in experiment: assembly ability, pH tolerance capability, mucus layer permeability","authors":"Minfang Feng, Xingxing Dai, B. Y. Li, Yumei Yan, Xinhui Peng, Rui Li, Yueyang Xie, Guoqing Li, Xinyuan Shi","doi":"10.1016/j.matdes.2026.116381","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.116381","url":null,"abstract":"Despite their promising potential as simplified and highly efficient therapeutic platforms, carrier-free nanodrugs remain limited by an incomplete explanation of the molecular mechanisms that govern their co-assembly, structural stability, and biological interactions. This knowledge gap impedes rational guidance for preliminary drug selection in carrier-free nanodrug development, especially for oral administration, where navigating the complex gastrointestinal environment is a major barrier to absorption. Here, a glycyrrhizic acid-baicalin nanodrug (GBN) was chosen as representative carrier-free nanodrug model. It exhibits emergent properties including the enhanced efficacy and effective oral delivery by overcoming gastrointestinal barriers. Experimental characterization and molecular simulations revealed that GBN exhibited stable pharmaceutical properties, and its greater thermodynamic and kinetic stability than self-assembly endowed it with potent assembly ability and sustained assembly ability at different pH levels. An integrated computational framework combining gastrointestinal pH-response modeling with a mesoscopic intestinal mucus model was also established and further enabled quantitative assessment of GBN stability and mucus permeability. Overall, this study established a comprehensive simulation-experiment framework for evaluating the assembly ability and oral delivery mechanisms of carrier-free nanodrugs, expecting to provide a comprehensive analysis for evaluating the assembly ability and oral delivery mechanisms of nanodrugs.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"267 1","pages":"116381-116381"},"PeriodicalIF":0.0,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Load-bearing, macroporous cultivation substrate for vertical agriculture: enabled by freeze–thaw processing and green waste–incorporated PVA–agarose composites 用于垂直农业的承重大孔栽培基质：通过冻融处理和绿色废物掺入的聚乙烯醇-琼脂糖复合材料

MATERIALS & DESIGN Pub Date : 2026-06-06 DOI: 10.1016/j.matdes.2026.116347

Wenzhong Cui, M Zhang, Ruohan Li, Zhiyong Qi, Wanlai Zhou

{"title":"Load-bearing, macroporous cultivation substrate for vertical agriculture: enabled by freeze–thaw processing and green waste–incorporated PVA–agarose composites","authors":"Wenzhong Cui, M Zhang, Ruohan Li, Zhiyong Qi, Wanlai Zhou","doi":"10.1016/j.matdes.2026.116347","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.116347","url":null,"abstract":"The scalability and resilience of vertical agriculture are constrained by the lack of substrates that simultaneously bear mechanical loading, preserve pore connectivity, and maintain a balanced rhizosphere microenvironment. This work develops a load-bearing macroporous substrate through a crosslinker-free freeze–thaw strategy combined with green waste valorization, fabricating physically crosslinked polyvinyl alcohol–agarose composites. The eco-friendly composite exhibits exceptional stability, retaining over 95% of its volumetric integrity under vertical loading. Synergized by freeze–thaw processing and green waste fillers, a hierarchical pore structure is established, with 78% of pores ranging from 0.2 to 50 μm, coordinating water retention (saturated water content >80%) and gas exchange while sustaining rhizosphere oxygen above 19%. Lettuce cultivation confirms significantly improved plant growth. By integrating green waste valorization, low-energy fabrication, and system-oriented design, this study provides a high-performance substrate for vertical agriculture and extends the design paradigm of biomass-based functional composites","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"267 1","pages":"116347-116347"},"PeriodicalIF":0.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of curcumin-borneol hybrids for rheumatoid arthritis pathological intervention via AKT/mTOR/HIF-1α pathway modulation 通过AKT/mTOR/HIF-1α通路调控的姜黄素-冰片复合物对类风湿关节炎病理干预的合理设计

MATERIALS & DESIGN Pub Date : 2026-05-11 DOI: 10.1016/j.matdes.2026.116214

Yue Peng, Cuiman Tang, Mingcong Niu, Tianyi Xu, Qingyu Meng, Xinran Li, Rongheng Ma, Huimin Yu

引用次数: 0

Self-Assembling Tetramethylpyrazine-Glycyrrhizic acid hydrogel inhibits microglial pyroptosis in spinal cord injury via the NETs/cGAS/STING pathway 自组装四甲基吡嗪-甘草酸水凝胶通过NETs/cGAS/STING途径抑制脊髓损伤小胶质细胞焦亡

MATERIALS & DESIGN Pub Date : 2026-05-10 DOI: 10.1016/j.matdes.2026.116192

Gang Liu, Jiashu YUE, Huizhong Bai, Zhenzhen Pei, Yu Jiang, Zhanglin Yang, Qinzhe Liu, Li Liu, Ruiqin Yu, Caixia Zhang, Jinyu Li, Xiaohong Mu, Yuhong Liu

引用次数: 0

UCNPs@Ce6-based Near-Infrared photodynamic therapy triggers mitophagy-related apoptosis in esophageal squamous cell carcinoma UCNPs@Ce6-based近红外光动力疗法引发食管鳞状细胞癌中有丝分裂相关的细胞凋亡

MATERIALS & DESIGN Pub Date : 2026-05-08 DOI: 10.1016/j.matdes.2026.116193

Wenqing Chen, Xiaohui Lin, Tianmei Zhang, Yu Luo, Zhimei Huang, Danlei Chen, Xingwu Zheng, Jian Wen

{"title":"UCNPs@Ce6-based Near-Infrared photodynamic therapy triggers mitophagy-related apoptosis in esophageal squamous cell carcinoma","authors":"Wenqing Chen, Xiaohui Lin, Tianmei Zhang, Yu Luo, Zhimei Huang, Danlei Chen, Xingwu Zheng, Jian Wen","doi":"10.1016/j.matdes.2026.116193","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.116193","url":null,"abstract":"• This rare earth up-conversion nanoparticle platform overcomes the characteristic of Er 3+ that its highest fluorescence emission peak is at 540 nm under 980 nm laser excitation, with the highest fluorescence emission peak near 660 nm for better exciting Ce6. • It is confirmed for the first time that the chlorin e6-loaded up-conversion nanoparticle platform has excellent biocompatibility and efficient tumor-targeting ability in esophageal squamous cell carcinoma cells. • Chlorin e6-loaded up-conversion nanoparticle platform has a dual regulatory function. First, its combination with photodynamic therapy activates mitochondrial apoptosis and mitochondrial autophagy related to reactive oxygen species. Second, this nanoplatform itself may suppress the inflammatory pathway by activating autophagy. Chlorin e6 (Ce6), an efficient photosensitizer, suffers from poor biocompatibility, and lanthanide-doped upconversion nanoparticles (UCNPs) possess unique optical properties, yet their roles in esophageal squamous cell carcinoma (ESCC) remain unclear. In this study, Ce6-loaded UCNPs (UCNPs@Ce6) with a core–shell-shell structure was designed and synthesized to overcome the limitation of conventional photodynamic therapy (PDT) that relies on shallow-penetrating light. In vitro, UCNPs@Ce6-PDT selectively inhibited ESCC cells without affecting normal esophageal epithelial cells. Mechanistically, PDT induced mitochondrial dysfunction, mitophagy, and apoptosis via the reactive oxygen species (ROS)-mitochondrial pathway, whereas UCNPs@Ce6 alone activated autophagy and inhibited pyroptosis/necroptosis-related inflammation. In vivo, the fluorescence image-guided tumor therapy achieved tumor growth inhibition (73.72% ± 2.88%) without obvious toxicity. Collectively, this nanoplatform provides a safe and effective strategy for targeted therapy of ESCC by combining PDT-triggered mitophagy-related apoptosis with autophagy-mediated anti-inflammatory responses.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"266 1","pages":"116193-116193"},"PeriodicalIF":0.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147966989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-hydrogelated structured sensors of high-performances for degradable bioelectronics 用于可降解生物电子学的高性能生物凝胶结构传感器

MATERIALS & DESIGN Pub Date : 2026-05-05 DOI: 10.1016/j.matdes.2026.116177

Kang Ma, Hao Lyu, Yì Wáng, Yuxing Wang, Haoran Wu, Dandan Dai, Shihang Wang, Ruiqi Liu, Yuxing Wang, Dingyi Pan, Deqing Mei, Chengchen Guo, Kai Tao

{"title":"Bio-hydrogelated structured sensors of high-performances for degradable bioelectronics","authors":"Kang Ma, Hao Lyu, Yì Wáng, Yuxing Wang, Haoran Wu, Dandan Dai, Shihang Wang, Ruiqi Liu, Yuxing Wang, Dingyi Pan, Deqing Mei, Chengchen Guo, Kai Tao","doi":"10.1016/j.matdes.2026.116177","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.116177","url":null,"abstract":"• Proteinic hydrogelation enables biocompatible and biodegradable implantable bioelectronics. • Interlocking sawtooth structure amplifies pressure-to-strain conversion for high sensitivity. • Molecular self-assembly combining with mechanical design allows development of practical bio-devices. Compared with state-of-the-art polymeric counterparts, proteinic self-assemblies may bridge the gap between device performances and biocompatibility/biodegradability requirement, showing promising potentials in implantable bioelectronic scenarios. Nevertheless, stochastic behaviors due to lack of structural design severely restrict the reliability of proteinic sensors, along with hindering their miniaturization for in vivo applications. Herein, proteinic hydrogelation-based structured implantable sensors of intrinsic biodegradability with enhanced stability and sensing behaviours are engineered. Upon enzymatic crosslinking, the bio-hydrogels can boost mechanical elasticity and lead to minimal swelling side-effects for bioelectronics. Followingly, an interlocking sawtooth structure is designed to convert external loading into tensile strain, based on which a miniaturized implantable tactile sensor of high-performances is developed, showing an ultrahigh sensitivity integrated with fast dynamic responses, high resolutions towards varied amplitudes, frequencies and types, as well as reliable repeatability and intrinsic biodegradability. Our findings exemplify the feasibility of developing bio-hydrogelated structured sensors as biodegradable bioelectronics","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"266 1","pages":"116177-116177"},"PeriodicalIF":0.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147967111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STAT3-Mediated wound repair Enabled by a Carrier-Free GA/GLA@Zn supramolecular hydrogel for treating MRSA-Infected skin wounds 无载体GA/GLA@Zn超分子水凝胶治疗mrsa感染的皮肤伤口

MATERIALS & DESIGN Pub Date : 2026-03-31 DOI: 10.1016/j.matdes.2026.115948

Weimei Wang, Ping Feng, Ruigang Zhou, Yun-Hee Han, Weilong Peng, Ruonan Bo, Mingjiang Liu, Jingbo Yu, Jingui Li

{"title":"STAT3-Mediated wound repair Enabled by a Carrier-Free GA/GLA@Zn supramolecular hydrogel for treating MRSA-Infected skin wounds","authors":"Weimei Wang, Ping Feng, Ruigang Zhou, Yun-Hee Han, Weilong Peng, Ruonan Bo, Mingjiang Liu, Jingbo Yu, Jingui Li","doi":"10.1016/j.matdes.2026.115948","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115948","url":null,"abstract":"• A carrier-free supramolecular hydrogel is developed for infected wound healing. • GA/GLA@Zn exhibits potent anti-MRSA, anti-inflammatory and antioxidant activities. • STAT3 is a key molecular target validated by simulations and in vivo assays. • GA/GLA@Zn accelerates angiogenesis and tissue regeneration via the STAT3 axis. Drug-resistant bacterial infection severely impedes skin wound healing, highlighting the urgent need for effective non-antibiotic therapies. Herein, we develop a carrier-free injectable supramolecular hydrogel (GA-GLA@Zn) through the co-assembly of gallic acid (GA) and glycyrrhizic acid (GLA) reinforced by Zn 2+ coordination. The hydrogel exhibits excellent injectability, mechanical stability, and sustained Zn 2+ release, providing a functional platform for infected wound treatment. GA-GLA@Zn shows potent antibacterial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) by disrupting bacterial membranes, while maintaining favorable biocompatibility and blood compatibility. In vitro studies demonstrate effective reactive oxygen species scavenging, suppression of inflammatory responses, and promotion of fibroblast proliferation and migration. In a MRSA-infected full-thickness wound model, GA-GLA@Zn markedly accelerates wound closure, reduces bacterial burden, alleviates excessive inflammation, and enhances collagen deposition and tissue remodeling. Mechanistically, integrated network pharmacology and molecular simulations identify signal transducer and activator of transcription 3 (STAT3) as a key molecular target of GA and GLA. In vivo results further reveal activation of STAT3 signaling and its downstream effectors Cyclin D1 and SOCS3, accompanied by enhanced angiogenesis via the HIF-1α/VEGF pathway. Overall, this study elucidates a STAT3-centered mechanism and highlights GA-GLA@Zn as a promising antibiotic-free strategy for treating drug-resistant infected wounds.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"265 1","pages":"115948-115948"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vacuum-engineered living probiotics deliver superoxide dismutase to reprogram redox and microbiota networks for gut–immune–brain restoration in chronic inflammatory bowel disease 真空工程活益生菌提供超氧化物歧化酶，重编程氧化还原和微生物群网络，用于慢性炎症性肠病的肠道-免疫-脑恢复

MATERIALS & DESIGN Pub Date : 2026-03-10 DOI: 10.1016/j.matdes.2026.115762

Shenghao Zhang, Haoran Zou, Jiahui Ma, Jia Yi, Runchao Tao, Rongbing Chen, Hanbing Wang, Li Luo, Xiaofei Hong, Wei Wu, Qinsi Yang, Da Sun, Lilei Zhuang

{"title":"Vacuum-engineered living probiotics deliver superoxide dismutase to reprogram redox and microbiota networks for gut–immune–brain restoration in chronic inflammatory bowel disease","authors":"Shenghao Zhang, Haoran Zou, Jiahui Ma, Jia Yi, Runchao Tao, Rongbing Chen, Hanbing Wang, Li Luo, Xiaofei Hong, Wei Wu, Qinsi Yang, Da Sun, Lilei Zhuang","doi":"10.1016/j.matdes.2026.115762","DOIUrl":"https://doi.org/10.1016/j.matdes.2026.115762","url":null,"abstract":"• Vacuum processing loads antioxidant enzyme inside a mucus-adapted probiotic carrier. • Construct survives gastric transit and releases active enzyme in the intestine. • Therapy reduces oxidative stress and mucosal inflammation in zebrafish colitis. • Microbiota remodeling parallels recovery of anxiety behavior in colitis zebrafish. Inflammatory bowel disease (IBD) arises from oxidative stress, immune dysregulation, and microbial imbalance, and often extends to neuropsychiatric comorbidities via gut–immune–brain axis disruption. Here we present Akkermansia muciniphila engineered by vacuum-assisted intracellular loading of superoxide dismutase (SOD@AKK) as a living therapeutic for chronic IBD. Unlike free SOD, SOD@AKK withstood gastric stress and enabled sustained intestinal release of active enzyme. In a chronic zebrafish IBD model, SOD@AKK markedly reduced oxidative burden, suppressed pro-inflammatory cytokines, restored epithelial integrity, and rebalanced microbial communities. Notably, it also alleviated anxiety-like behavior, linking ecological and immunological repair to behavioral recovery. These findings establish SOD@AKK as a site-specific, multi-functional bio-intervention that integrates redox detoxification with microbiota reprogramming, offering a blueprint for next-generation microbiome-based therapeutics in IBD and related neuroimmune disorders.","PeriodicalId":101318,"journal":{"name":"MATERIALS & DESIGN","volume":"264 1","pages":"115762-115762"},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0