Contact (Thousand Oaks (Ventura County, Calif.))最新文献_第3页

ER-LD Membrane Contact Sites: A Budding Area in the Pathogen Survival Strategy. ER-LD膜接触点：病原体生存策略中的萌芽区。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-12-18 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241304196

Rajendra Kumar Angara, Margaret F Sladek, Stacey D Gilk

引用次数: 0

Store-Operated Ca²⁺ Entry in Fibrosis and Tissue Remodeling. 储存操作的Ca2+进入纤维化和组织重塑。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241291374

Ahmed Emam Abdelnaby, Mohamed Trebak

{"title":"Store-Operated Ca2+ Entry in Fibrosis and Tissue Remodeling.","authors":"Ahmed Emam Abdelnaby, Mohamed Trebak","doi":"10.1177/25152564241291374","DOIUrl":"10.1177/25152564241291374","url":null,"abstract":"Fibrosis is a pathological condition characterized by excessive tissue deposition of extracellular matrix (ECM) components, leading to scarring and impaired function across multiple organ systems. This complex process is mediated by a dynamic interplay between cell types, including myofibroblasts, fibroblasts, immune cells, epithelial cells, and endothelial cells, each contributing distinctively through various signaling pathways. Critical to the regulatory mechanisms involved in fibrosis is store-operated calcium entry (SOCE), a calcium entry pathway into the cytosol active at the endoplasmic reticulum-plasma membrane contact sites and common to all cells. This review addresses the multifactorial nature of fibrosis with a focus on the pivotal roles of different cell types. We highlight the essential functions of myofibroblasts in ECM production, the transformation of fibroblasts, and the participation of immune cells in modulating the fibrotic landscape. We emphasize the contributions of SOCE in these different cell types to fibrosis, by exploring the involvement of SOCE in cellular functions such as proliferation, migration, secretion, and inflammatory responses. The examination of the cellular and molecular mechanisms of fibrosis and the role of SOCE in these mechanisms offers the potential of targeting SOCE as a therapeutic strategy for mitigating or reversing fibrosis.","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"7 ","pages":"25152564241291374"},"PeriodicalIF":0.0,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better Together: Interorganellar Communication in the Regulation of Proteostasis. 更好地团结在一起：蛋白稳态调控中的细胞间通信

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241272245

Andreas Kohler, Verena Kohler

引用次数: 0

Mitochondria, Peroxisomes and Beyond-How Dual Targeting Regulates Organelle Tethering. 线粒体、过氧物酶体及其他--双重靶向如何调控细胞器的系留。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-09-28 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241264254

Johannes Freitag, Thorsten Stehlik, Gert Bange

{"title":"Mitochondria, Peroxisomes and Beyond-How Dual Targeting Regulates Organelle Tethering.","authors":"Johannes Freitag, Thorsten Stehlik, Gert Bange","doi":"10.1177/25152564241264254","DOIUrl":"10.1177/25152564241264254","url":null,"abstract":"Eukaryotic cells feature distinct membrane-enclosed organelles such as mitochondria and peroxisomes, each playing vital roles in cellular function and organization. These organelles are linked at membrane contact sites, facilitating interorganellar molecule and ion exchange. Most contact-forming proteins identified to date are membrane proteins or membrane-associated proteins, which can form very stable contacts. Recent findings suggest additional mechanistically distinct tethering events that arise from dual protein targeting. Proteins bearing targeting signals for multiple organelles, such as an N-terminal signal for mitochondria and a C-terminal signal for peroxisomes, function as tethers, fostering contacts by engaging targeting factors at both organelles. A number of dually targeted membrane proteins can contribute to contact site formation and transit from one organelle to the other as well. These interactions may enable the fine-tuning of organelle proximity, hence, adapting connections to meet varying physiological demands.","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"7 ","pages":"25152564241264254"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to "Not so Rare: Diseases based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering". 不那么罕见：基于控制内质网-线粒体接触（MERC）系链的突变蛋白质的疾病》的勘误。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-09-24 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241276081

引用次数: 0

Getting to Grips with the Oxysterol-Binding Protein Family - a Forty Year Perspective. 掌握羟基甾醇结合蛋白家族--四十年的视角。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241273598

Vesa M Olkkonen, Elina Ikonen

{"title":"Getting to Grips with the Oxysterol-Binding Protein Family - a Forty Year Perspective.","authors":"Vesa M Olkkonen, Elina Ikonen","doi":"10.1177/25152564241273598","DOIUrl":"https://doi.org/10.1177/25152564241273598","url":null,"abstract":"This review discusses how research around the oxysterol-binding protein family has evolved. We briefly summarize how this protein family, designated OSBP-related (ORP) or OSBP-like (OSBPL) proteins, was discovered, how protein domains highly conserved among family members between taxa paved the way for understanding their mechanisms of action, and how insights into protein structural and functional features help to understand their versatility as lipid transporters. We also discuss questions and future avenues of research opened by these findings. The investigations on oxysterol-binding protein family serve as a real-life example of the notion that science often advances as a collective effort of multiple lines of enquiry, including serendipitous routes. While original articles invariably explain the motivation of the research undertaken in rational terms, the actual paths to findings may be less intentional. Fortunately, this does not reduce the impact of the discoveries made. Besides hopefully providing a useful account of ORP family proteins, we aim to convey this message.","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"7 ","pages":"25152564241273598"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11359446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances on Synaptotagmin-Like Mitochondrial-Lipid Binding Protein Domain Containing Lipid Transfer Proteins. 突触表蛋白-类线粒体-脂质结合蛋白结构域含脂质转移蛋白的最新研究进展。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241273646

Xuewen Hu, Yirui Cai, Wei-Ke Ji

引用次数: 0

Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering. 线粒体-内质网接触点（MERCs）作为线粒体相关膜（MAMs）的发现。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241261228

Tadashi Makio, Thomas Simmen

{"title":"Not So Rare: Diseases Based on Mutant Proteins Controlling Endoplasmic Reticulum-Mitochondria Contact (MERC) Tethering.","authors":"Tadashi Makio, Thomas Simmen","doi":"10.1177/25152564241261228","DOIUrl":"10.1177/25152564241261228","url":null,"abstract":"Mitochondria-endoplasmic reticulum contacts (MERCs), also called endoplasmic reticulum (ER)-mitochondria contact sites (ERMCS), are the membrane domains, where these two organelles exchange lipids, Ca2+ ions, and reactive oxygen species. This crosstalk is a major determinant of cell metabolism, since it allows the ER to control mitochondrial oxidative phosphorylation and the Krebs cycle, while conversely, it allows the mitochondria to provide sufficient ATP to control ER proteostasis. MERC metabolic signaling is under the control of tethers and a multitude of regulatory proteins. Many of these proteins have recently been discovered to give rise to rare diseases if their genes are mutated. Surprisingly, these diseases share important hallmarks and cause neurological defects, sometimes paired with, or replaced by skeletal muscle deficiency. Typical symptoms include developmental delay, intellectual disability, facial dysmorphism and ophthalmologic defects. Seizures, epilepsy, deafness, ataxia, or peripheral neuropathy can also occur upon mutation of a MERC protein. Given that most MERC tethers and regulatory proteins have secondary functions, some MERC protein-based diseases do not fit into this categorization. Typically, however, the proteins affected in those diseases have dominant functions unrelated to their roles in MERCs tethering or their regulation. We are discussing avenues to pharmacologically target genetic diseases leading to MERC defects, based on our novel insight that MERC defects lead to common characteristics in rare diseases. These shared characteristics of MERCs disorders raise the hope that they may allow for similar treatment options.","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"7 ","pages":"25152564241261228"},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141790883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spartin is a Lipid Transfer Protein That Facilitates Lipid Droplet Turnover. Spartin 是一种脂质转移蛋白，可促进脂滴的翻转。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-05-26 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241255782

Yaoyang Zhong, Tim P Levine

引用次数: 0

Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System. 接触肠道：肠道神经系统中的线粒体相关内质网膜。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2024-04-04 eCollection Date: 2024-01-01 DOI: 10.1177/25152564241244941

Jenny Greig, Giada Delfino, Pascal Derkinderen, Sébastien Paillusson

{"title":"Contacting the gut: Mitochondria-associated Endoplasmic Reticulum Membranes in the Enteric Nervous System.","authors":"Jenny Greig, Giada Delfino, Pascal Derkinderen, Sébastien Paillusson","doi":"10.1177/25152564241244941","DOIUrl":"https://doi.org/10.1177/25152564241244941","url":null,"abstract":"Changes in the connections between the endoplasmic reticulum (ER) and mitochondria, as well as alterations in mitochondria-associated ER membrane (MAM) signalling, have been documented in various neurodegenerative diseases affecting the brain. Despite the growing recognition of the significance of the gut-brain axis in neurodegenerative conditions, there has been no prior investigation into the biology of MAM within the enteric nervous system (ENS). Our recent research reveals, for the first time, the existence of connections between the ER and mitochondria within enteric neurons. Additionally, we observed alterations in the dynamics of these connections in the enteric neurons from a mouse model exhibiting age-related neurodegeneration. These findings provide the first detailed characterization of MAM in the ENS under physiological conditions and in a mouse model of age-associated neurodegeneration and shed new light on the potential role of enteric MAM in the context of neurodegenerative disorders.","PeriodicalId":101304,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"7 ","pages":"25152564241244941"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0