Veterinary Vaccine最新文献_第2页

Development of a baculovirus-derived chimeric virus-like particles against QX-type avian infectious bronchitis and H9N2 avian influenza 杆状病毒衍生嵌合病毒样颗粒抗qx型禽传染性支气管炎和H9N2禽流感的研制

Veterinary Vaccine Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI: 10.1016/j.vetvac.2025.100119

Bingchen Qiao , Qi Meng , Ni Zhao , Zihe Gao , Yusen Tian , Xifeng Hu , Chenfeng Jiang , Xiaofei Song , Jihui Ping

{"title":"Development of a baculovirus-derived chimeric virus-like particles against QX-type avian infectious bronchitis and H9N2 avian influenza","authors":"Bingchen Qiao , Qi Meng , Ni Zhao , Zihe Gao , Yusen Tian , Xifeng Hu , Chenfeng Jiang , Xiaofei Song , Jihui Ping","doi":"10.1016/j.vetvac.2025.100119","DOIUrl":"10.1016/j.vetvac.2025.100119","url":null,"abstract":"<div><div>Currently, the spread of H9N2 avian influenza virus (AIV) and avian infectious bronchitis virus (IBV) is one of the major predicaments facing the poultry industry. Virus-like particles (VLPs)-based vaccine, as one of the most promising alternative to traditional vaccines, provides new perspectives for the prevention of poultry diseases. Here, we generated a chimeric VLPs (VLPs) vaccine against both AIV and IBV by using baculovirus/insect cell expression system, and evaluated its efficacy in chickens. The VLPs is composed of three proteins: HA, M1, and rS. The HA and M1 proteins were derived from the H9N2 AIV A/chicken/Anhui/LH99/2017 (AH/99, H9N2), while rS was composed of the S1 subunit of the QX-type IBV CK/CH/JS/CZ211063 (CZ211063, GI-19) protein and the transmembrane domain (TM) and cytoplasmic tail domain (CTD) of the H9N2 AIV HA protein. Subcutaneous immunization with the VLPs vaccine induced a robust humoral immune responses, providing complete protection against H9N2 AIV in chickens. Furthermore, challenge experiments with QX-type IBV indicated that VLPs vaccine immunization significantly inhibited viral replication in the trachea, lung, and kidney, and suppressed viral shedding in the throat and cloaca. Additionally, histopathological analysis revealed that the VLPs vaccine effectively mitigated QX-type IBV-induced tissue damages in the respiratory and renal systems. Collectively, these results suggest that the VLPs vaccine developed in this study is a promising vaccine candidate for the avian influenza and infectious bronchitis control, and highlight the potential of VLP-based vaccines as a viable alternative to traditional egg-dependent vaccines in the prevention of poultry diseases.</div></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"4 2","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccination protocols according to World Small Animal Veterinary Association guidelines: a critical review of its implementation in Brazil 根据世界小动物兽医协会准则的疫苗接种方案：对其在巴西实施情况的重要审查

Veterinary Vaccine Pub Date : 2025-06-01 Epub Date: 2025-06-11 DOI: 10.1016/j.vetvac.2025.100120

Amanda de Jesus Fonseca, Jordana Dantas Rodrigues Reis, Marcus Vinicius de Aragão Batista

{"title":"Vaccination protocols according to World Small Animal Veterinary Association guidelines: a critical review of its implementation in Brazil","authors":"Amanda de Jesus Fonseca, Jordana Dantas Rodrigues Reis, Marcus Vinicius de Aragão Batista","doi":"10.1016/j.vetvac.2025.100120","DOIUrl":"10.1016/j.vetvac.2025.100120","url":null,"abstract":"<div><div>Vaccines are an important tool to help control and eradicate human and animal diseases worldwide. Given the complexity and unpredictability of immune responses in certain situations, the World Small Animal Veterinary Association (WSAVA) published guidelines to improve immunization of small animals. Therefore, this review aims to discuss these guidelines, which guide the three-yearly revaccination in small animals, as opposed to the annual booster, use of monovalent vaccines, and replacement of revaccination with serological tests, when possible, in addition to suggesting changes to the vaccination schedule for puppies. By reviewing articles and publications on small animal vaccination, the rationale for the guidelines was discussed. Considering the social and economic divergences between developed countries, where the guidelines are currently applied, and emerging and underdeveloped countries, the difficulties of the guidelines’ implementation in Brazil were assessed. The guidelines have current foundations, and vaccinating with multipurpose vaccines more frequently may increase the chances of adverse reactions in small animals. However, the country still presents difficulties in implementing the guidelines in their entirety, in addition to the challenges involving abandoned animals, the unavailability of monovalent vaccines and serological tests accessible to the poorest population limits the adherence of guardians and professionals to the WSAVA guidelines.</div></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"4 2","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum antibody titers against distemper, parvovirus and infectious hepatitis in dogs from Central Spain 西班牙中部犬犬瘟热、细小病毒和传染性肝炎血清抗体滴度

Veterinary Vaccine Pub Date : 2025-06-01 Epub Date: 2025-03-01 DOI: 10.1016/j.vetvac.2025.100107

Jose L. Blanco , Elena Parra , Silvia Rubies , Gustavo Ortiz-Diez , Marta E. Garcia

{"title":"Serum antibody titers against distemper, parvovirus and infectious hepatitis in dogs from Central Spain","authors":"Jose L. Blanco , Elena Parra , Silvia Rubies , Gustavo Ortiz-Diez , Marta E. Garcia","doi":"10.1016/j.vetvac.2025.100107","DOIUrl":"10.1016/j.vetvac.2025.100107","url":null,"abstract":"<div><div>A canine population's immune resistance to canine distemper virus (CDV), canine parvovirus (CPV), and infectious hepatitis virus (CAV-1) was evaluated. In this study, a total of 112 sera were analyzed. Animals were considered as vaccinated if, in the last two years, they had received at least one dose of a vaccine that provides joint protection against CDV, CPV, and CAV-1. Animals that had never received any dose of these vaccines were designated as non-vaccinated. CDV, CPV, and CAV-1 antibodies were detected via a modified solid-phase enzyme-linked immunosorbent assay (ELISA), which detects IgG antibody levels in sera and provides semi-quantitative results in <30 min. In total, 41.1 % of the dogs had been vaccinated, and 58.9 % of dogs were designated as non-vaccinated. Overall, 90.2 %, 92.0 %, and 78.6 % of the tested dogs had positive results for the presence of IgG antibodies against CPV, CDV, and CAV-1, respectively. CPV antibodies were present in 87.9 % (58/66) of the vaccinated and 93.5 % (43/46) of the non-vaccinated dogs, while CDV antibodies were present in 95.5 % (63/66) of the vaccinated and 87.0 % (40/46) of the non-vaccinated dogs. Finally, CAV-1 antibodies were present in 84.8 % (56/66) of the vaccinated and of 69.6 % (32/46) the non-vaccinated dogs.</div></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"4 2","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rabies vaccines: Journey from classical to modern era 狂犬疫苗：从古典到现代的旅程

Veterinary Vaccine Pub Date : 2025-03-01 Epub Date: 2025-01-30 DOI: 10.1016/j.vetvac.2025.100105

Bushra Khan , Nidhi Shrivastava , Naheed Parveen Sheikh , Pramod Kumar Singh , Hem Chandra Jha , Hamendra Singh Parmar

{"title":"Rabies vaccines: Journey from classical to modern era","authors":"Bushra Khan , Nidhi Shrivastava , Naheed Parveen Sheikh , Pramod Kumar Singh , Hem Chandra Jha , Hamendra Singh Parmar","doi":"10.1016/j.vetvac.2025.100105","DOIUrl":"10.1016/j.vetvac.2025.100105","url":null,"abstract":"<div><div>Rabies, caused by the neurotropic rabies virus, remains a significant public health concern worldwide. It remains a deadly zoonotic disease with a near 100 % fatality rate once clinical symptoms manifest, causing about 59,000 deaths annually, of which 59.6 % occur in Asia and 36.4 % in Africa. Dog-mediated rabies accounts for over 99 % of human cases. This review provides a comprehensive overview of rabies, covering its epidemiology, pathogenesis, Etiology, and developments in rabies vaccines. Once the virus enters the body through the bite of an infected animal it travels via peripheral nerves to the central nervous system, leading to fatal encephalitis if left untreated. Vaccination of domestic animals plays a pivotal role in preventing transmission to humans. Post-exposure prophylaxis (PEP) remains the cornerstone of rabies prevention in individuals exposed to potentially infected animals, comprising rabies vaccine and Rabies immunoglobulin administration. Advances in molecular virology have shed light on the pathogenesis of rabies, revealing the intricate interactions between the virus and the host immune system. Despite decades of research, treatment options for established rabies infection remain limited, emphasizing the importance of preventive measures. Experimental therapies, including monoclonal antibodies and novel antiviral agents, promise to improve outcomes in rabies patients. Regardless of the established efficacy of rabies vaccines, challenges remain in ensuring widespread accessibility and coverage, particularly in resource-limited regions. Strategies to enhance pre-exposure prophylaxis with affordable vaccine delivery are essential for achieving global rabies control and elimination goals, underscoring the need for sustained surveillance, vaccination, and public awareness efforts. Continued research into the virology and immunology of rabies is essential for the development of novel interventions to combat this deadly disease.</div></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"4 1","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The past, present and future of duck plague virus vaccines 鸭瘟病毒疫苗的过去、现在和未来

Veterinary Vaccine Pub Date : 2025-03-01 Epub Date: 2025-01-03 DOI: 10.1016/j.vetvac.2025.100104

Linjiang Yang , Mingshu Wang , Zhishuang Yang , Anchun Cheng

引用次数: 0

Efficacy of intranasal vaccines containing bovine corona virus or bovine respiratory syncytial virus and parainfluenza virus type 3 in young calves with or without maternally derived antibodies 含有牛冠状病毒或牛呼吸道合胞病毒和3型副流感病毒的鼻内疫苗对具有或不具有母源抗体的小牛的疗效

Veterinary Vaccine Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.vetvac.2025.100106

Piet Nuijten, Birgit Makoschey, Elias Salem, Mark van Rooij, Geert Vertenten

引用次数: 0

Progress on the poxvirus vaccine 痘病毒疫苗的进展情况

Veterinary Vaccine Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1016/j.vetvac.2024.100092

Mengmeng Zhao , Miaomiao Zhang , Limei Qin, Han Gao, Keshan Zhang

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Vaccine delivery: Overcoming the challenges of vaccinating livestock and wildlife 提供疫苗：克服为牲畜和野生动物接种疫苗的挑战

Veterinary Vaccine Pub Date : 2024-12-01 Epub Date: 2024-11-28 DOI: 10.1016/j.vetvac.2024.100093

Freya A. Russell , Dietmar W. Hutmacher , Tim R. Dargaville , Kenneth W. Beagley

引用次数: 0

Immunization of mice with delayed lysis Salmonella expressing PCV2b Cap protein enhanced mucosal and innate immunity and reduced viral load 用表达 PCV2b Cap 蛋白的延迟裂解沙门氏菌免疫小鼠，可增强粘膜和先天免疫力，降低病毒载量

Veterinary Vaccine Pub Date : 2024-09-01 Epub Date: 2024-06-04 DOI: 10.1016/j.vetvac.2024.100069

Gerui Zhang , Yuanyu Shen , Zipeng Wang , Guijuan Hao , Fangkun Wang

{"title":"Immunization of mice with delayed lysis Salmonella expressing PCV2b Cap protein enhanced mucosal and innate immunity and reduced viral load","authors":"Gerui Zhang , Yuanyu Shen , Zipeng Wang , Guijuan Hao , Fangkun Wang","doi":"10.1016/j.vetvac.2024.100069","DOIUrl":"10.1016/j.vetvac.2024.100069","url":null,"abstract":"<div><p>Porcine circovirus type 2 (PCV2) has been recognized as a critical pathogen associated with numerous porcine circovirus-related diseases. Immunization is commonly regarded as the most efficient method to combat PCV2 infection. The virus's main antigen is the Cap protein, which is encoded by the ORF2 gene. In this investigation, we cloned the PCV2 Cap gene into the pYA3681 plasmid and subsequently electrotransferred it into the delayed lysis <em>Salmonella</em> strain χ11802, ultimately generating the χ11802 (pYA3681-Cap) vaccine candidate strain. We assessed the levels of sIgA and IgG specific to the Cap protein in mice, revealing that their mucosal and humoral immunity had been activated by χ11802 (pYA3681-Cap). The result was a substantial elevation in antibody levels, and a notable reduction in viral load in the immunized group compared to the unvaccinated group. Furthermore, the study revealed a significant decrease in the viral load in the lungs, liver, and spleen of mice inoculated with χ11802 (pYA3681-Cap), in comparison to both the empty carrier group and the phosphate buffered saline control group. This study further investigated the lytic effect of the delayed lysis vaccine vector. The χ11802 (pYA3681-EGFP) strain was undetectable 10 days post-challenge, indicating that the vaccine strain can effectively release the carried exogenous antigen and prevent the residual vaccine strain from spreading and causing pollution in the environment. A successful construction of the χ11802 (pYA3681-Cap) strain expressing the PCV2 Cap protein was executed in this study. To summarize, our study suggests that PCV2-Cap, when expressed in the delayed lysis <em>Salmonella</em> strain χ11802, could serve as a safe and economically efficient candidate PCV2 vaccine.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"3 3","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772535924000167/pdfft?md5=cde184ecc5a42509cbec406f9faf1182&pid=1-s2.0-S2772535924000167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of period supplementation of Saccharomyces boulardii in humoral immune response of sheep immunized with recombinant chimera of Paeniclostridium sordellii 定期补充布拉氏酵母菌对重组索氏梭菌嵌合体免疫绵羊体液免疫反应的影响

Veterinary Vaccine Pub Date : 2024-09-01 Epub Date: 2024-08-22 DOI: 10.1016/j.vetvac.2024.100081

Pâmela Aristimuno Sedrez , Rafael Rodrigues Rodrigues , Vitória Sequeira Gonçalves , Vitória Muller , Neida Conrad , Fabrício Rochedo Conceição , Fábio Pereira Leivas Leite

{"title":"Effect of period supplementation of Saccharomyces boulardii in humoral immune response of sheep immunized with recombinant chimera of Paeniclostridium sordellii","authors":"Pâmela Aristimuno Sedrez , Rafael Rodrigues Rodrigues , Vitória Sequeira Gonçalves , Vitória Muller , Neida Conrad , Fabrício Rochedo Conceição , Fábio Pereira Leivas Leite","doi":"10.1016/j.vetvac.2024.100081","DOIUrl":"10.1016/j.vetvac.2024.100081","url":null,"abstract":"<div><p><em>Saccharomyces boulardii</em> has emerged as a promising probiotic agent in bolstering the immune system. In vaccinology, its application can be explored to optimize vaccine efficacy by augmenting host immune response and consequently enhancing the immunogenicity of antigenic formulations. However, it is imperative to conduct further research to comprehend the effectiveness of this probiotic in novel vaccines targeting significant pathogens affecting animal health. Hence, this study investigated the effects of a short (3 - 5 days) or continuously (56 days) <em>S. boulardii</em> supplementation (3 × 10<sup>8</sup> CFU/mL) on the adaptive immunity of sheep immunized with a recombinant antigen against <em>Paeniclostridium sordellii</em> (rAPS). Four immunized groups (G1-G4) were evaluated, varying the regimen of <em>S. boulardii</em> supplementation. Elevated levels of anti-rAPS IgG immunoglobulins were detected in all vaccinated animals. Daily supplementation with <em>S. boulardii</em> (G1) resulted in higher IgG levels, reaching antibody titers of up to 25,600, which were 16 times higher than those observed in not supplemented group (G4) and 4 times higher than in the group supplemented for 3 days (G3) or 5 days (G2) before each immunization. These findings demonstrate that <em>S. boulardii</em> can enhance vaccine-induced immune responses against <em>P. sordellii</em>, particularly IgG-mediated immune responses in sheep. The possibility of a short supplementation for 5–3 days is a very important finding for animal husbandry, considering the supplementation and supply management cost.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"3 3","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772535924000283/pdfft?md5=9f501b1c6f5504af40326ce334e3ec3c&pid=1-s2.0-S2772535924000283-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0