The Journal of Trace Elements in Experimental Medicine最新文献

{"title":"Response†","authors":"John B. Vincent","doi":"10.1002/jtra.20009","DOIUrl":"https://doi.org/10.1002/jtra.20009","url":null,"abstract":"","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 4","pages":"295-297"},"PeriodicalIF":0.0,"publicationDate":"2004-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72333317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Society For Trace Element Research In Humans (ISTERH) Seventh International Conference, Bangkok, Thailand, November 7–12, 2004","authors":"","doi":"10.1002/jtra.20012","DOIUrl":"https://doi.org/10.1002/jtra.20012","url":null,"abstract":"","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 4","pages":"181-272"},"PeriodicalIF":0.0,"publicationDate":"2004-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72333316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and cord blood serum levels of zinc, copper, and iron in healthy pregnant Jordanian women","authors":"S.M. Awadallah, K.H. Abu-Elteen, A.Z. Elkarmi, S.H. Qaraein, N.M. Salem, M.S. Mubarak","doi":"10.1002/jtra.10032","DOIUrl":"https://doi.org/10.1002/jtra.10032","url":null,"abstract":"Altered plasma levels of zinc, copper, and iron during pregnancy are known to have profound effects on pregnant women and their neonates. The status of these elements is not known in pregnant women in Jordan. During the three trimesters of pregnancy, blood specimens were collected from 186 healthy pregnant women aged 1745 years and from cord blood of 92 of their neonates. The mean neonatal birth weight was 3.34 ± 0.44 kg. Maternal and cord blood serum levels of zinc, copper, and iron were determined by atomic absorption spectrophotometry, and hemoglobin concentration was determined by hematology cell counter. The results indicate significantly lower serum zinc levels and higher copper and iron levels in cord blood than in maternal blood. During the three trimesters of pregnancy, the serum levels of zinc and copper significantly decreased and increased, respectively, whereas the levels of serum iron were unchanged. Significant positive correlation was observed only between zinc levels of cord blood and birth weight. During third trimester, the mean serum levels of zinc and iron were significantly lower in anemic pregnant women (group I: Hb less than 11.0 g/ dL, n = 36) than that in nonanemic pregnant women (group II: Hb > or = 11.0 g/dL, n = 56). There was no noticeable difference between group I and group II regarding cord blood parameters on one hand and neonatal birth weight on the other hand. Similar significant positive correlation was observed between serum zinc levels of cord blood and birth weight in both groups. These results indicate that Jordanian women during pregnancy follow a well-balanced and adequate diet regime. J. Trace Elem. Exp. Med.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.10032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72359520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound load of copper and iron in the livers of pretreatment patients with Wilson's disease","authors":"Ai Harashima, Ai Hattori, Hisao Hayashi, Shinya Wakusawa, Atsuhiko Kusakabe, Yoshikazu Fujita, Minoru Tanaka, Motoyoshi Yano, Kentaro Yoshioka","doi":"10.1002/jtra.10054","DOIUrl":"https://doi.org/10.1002/jtra.10054","url":null,"abstract":"Ceruloplasmin is a major ferroxidase in sera, and people with hypoceruloplasminemia might have iron load complications. We used histochemical and X-ray microanalysis techniques on pretreatment liver specimens from five patients with Wilson's disease. Serum levels of ceruloplasmin and ferritin were determined before chelation therapy. All the patients showed hypoceruloplasminemia ranging from 15 to 160 mg/L. Histo-chemical copper was positively stained in four of the five patients. Copper deposits were clearly observed in the hepatocyte lysosomes of one patient. High serum ferritin levels ranging from 188 to 400 ng/mL were found. Histochemical iron was positive in the livers of two patients. Iron-specific X-rays were positive in the hepatocyte lysosomes of all the patients. These findings suggest that compound load of copper and iron is a fundamental finding in the liver of Wilson's disease with hypoceruloplasminemia. Copper cytotoxicity is a primary target for chelation therapy, and iron load, if hepatotoxic, should be treated by phlebotomy. J. Trace Elem. Exp. 17:65–73, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 1","pages":"65-73"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.10054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72359523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc deficiency and oxidative stress in brain: Magnetic resonance investigations in weanling rats","authors":"Rheal A. Towner, Christopher Appleby, Mark Levy, Tammy M. Bray","doi":"10.1002/jtra.20007","DOIUrl":"https://doi.org/10.1002/jtra.20007","url":null,"abstract":"In humans, zinc deficiency is characterized by a broad spectrum of neurological clinical syndromes. It is known that vesicular zinc-enriched areas of the brain, such as the hippocampus, are responsive to zinc deprivation, which may result in learning impairment. Recent findings show that zinc deficiency may cause alterations in neurochemical activity. In this study we used contrast-enhanced magnetic resonance imaging (MRI) to monitor disruptions to the blood–brain barrier (BBB) and image-guided MR spectroscopy to follow alterations in brain metabolites as a result of zinc-deficiency and/or hyperoxia-induced oxidative stress. Gadolinium-diethylaminetriaminopentaacetic acid, an extracellular T1 relaxation contrast agent, increases tissue water signal in the brain if the BBB is damaged. A significant increase in postcontrast T1-weighted MR image intensity was observed in the brain of zinc-deficient or hyperoxia-exposed rats, as well as zinc-deficient rats exposed only to hyperoxia when compared with zinc-adequate rats. From single-voxel image-guided MR spectroscopy results, significant decreases in the ratio of N-acetyl aspartate, a neuronal-specific compound, to total choline levels were found when comparing controls (zinc-adequate or zinc pair-fed) with zinc-deficiency or hyperoxia groups alone, and when zinc-deficiency was combined with hyperoxia. This study demonstrates the sensitivity of MR techniques in the ability to monitor the effect of zinc deficiency combined with oxidative stress on BBB permeability as well as detect alterations in brain metabolites. This will further aid in our understanding of the possible cellular and molecular mechanisms involved in zinc deficiency pathology associated with the brain. J. Trace Elem. Exp. Med. 17:161–174, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 3","pages":"161-174"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72360190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative quantative analysis of zinc, magnesium, and copper content in the scalp hair of healthy people and breast cancer patients","authors":"Eser Kilic,&nbsp;Asuman Demiroglu,&nbsp;Recep Saraymen,&nbsp;Engin Ok","doi":"10.1002/jtra.20006","DOIUrl":"https://doi.org/10.1002/jtra.20006","url":null,"abstract":"A quantitative elemental analysis of scalp hair of female breast cancer patients (n = 26) and female controls (n = 27) was used to study to find out correlation and possible changes, between breast cancer and healthy controls. Atomic absorption spectrophotometer analysis of the quantitative method was used to determine copper, magnesium, and zinc levels. There were no differences in magnesium concentrations (P > 0.05) in breast cancer patients and healthy subjects. However, comparison of mean elemental contents of the breast cancer patients with controls showed a significant enhancement of copper (P < 0.05) but declining trends for zinc (P < 0.05) in breast cancer patients. The usefulness and significance of element status in cancer patients should be discussed more detailed in the light of the most these recent data. J. Trace Elem. Exp. Med. 17:175–180, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 3","pages":"175-180"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72360191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-1α, tumor necrosis factor-α, and interleukin-12 secreted by zinc-induced murine macrophages in vivo and in vitro","authors":"M.D. Lastra,&nbsp;A.E. Aguilar,&nbsp;M.A. Cabañas,&nbsp;R. Hernandez,&nbsp;K. Humanez,&nbsp;R. Pastelin","doi":"10.1002/jtra.20003","DOIUrl":"https://doi.org/10.1002/jtra.20003","url":null,"abstract":"Oral treatment of zinc modulates cytokine secretion during the gestation, lactation, and weaning periods. We used a experimental mice model of zinc supplementation during the perinatal stages to study the effects of this ion over the production of interleukin IL-1α, IL-12, and tumor necrosis factor-alpha by peritoneal macrophages. In addition, we determined the gene expression of these cytokines. Zinc (500 mg/L) was orally administered to mice from gestation to lactation (6-week treatment, Zn+) and weaning (9-week treatment). The serum cytokines IL-1α and IL-12 were assayed in the offspring at 21 and 42 days after birth. Our results showed a significant (P < 0.01) increase in cytokine production in the Zn+ animals at the end of the lactation stage. There was a tendency for the IL-1 concentration to decrease at postweaning; nevertheless, IL-12 concentrations were increased in mice at 42 days of age (P < 0.001). The production of IL-1α, IL-12, and tumor necrosis factor-alpha in the macrophages supernatants in vitro followed the same tendencies (P < 0.001). Molecular analysis showed an increase of mRNA synthesis in all cases, from 4-fold to 6-fold, in the cytokines analyzed. Our results suggest that the increase in the proinflammatory cytokines as a result of zinc administration may potentiate Th1 cells response, which could lead to the increase of cytokine production in deficient newborns. J. Trace Elem. Exp. Med. 17:123–135, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 2","pages":"123-135"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72316861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green coconut water for intravenous use: Trace and minor element content","authors":"Georg A. Petroianu,&nbsp;Melita Kosanovic,&nbsp;Ibrahim Saad Shehatta,&nbsp;Bahaa Mahgoub,&nbsp;Ayman Saleh,&nbsp;Wolfgang H. Maleck","doi":"10.1002/jtra.20010","DOIUrl":"https://doi.org/10.1002/jtra.20010","url":null,"abstract":"Green coconut water (GCW; liquid endosperm) is sterile and has been used in the past in remote locations and/or during armed conflicts as a short-term intravenous hydration fluid. It is also conceivable to use GCW for total parenteral nutrition (TPN) under similar circumstances. Patients on TPN need elemental supplementation. Although data on the major elements (calcium, magnesium, potassium, sodium, and phosphorus) found in GCW are abundant, very limited information concerning trace and minor element content in GCW is available. The purpose of this study was to determine trace and minor element content in GCW. Major elements were arbitrarily defined as those with a GCW concentration in the mM range, as opposed to minor ones in the μM range and trace elements in the nM range. The values determined show the great variability typical for samples of plant origin. Under TPN conditions, GCW (1,000 mL/day) would be able to provide adequate supplementation of manganese (12 ± 5 μmol/L) and possibly zinc (6 ± 1 μmol/L) but not chromium (not detected, i.e., less than 9 nM/L) and copper (105 ± 100 nM/L). With respect to elements usually considered nonessential or even toxic, GCW compares favorably with commonly used TPN solutions, most notably for aluminium content (740 ± 360 nM/L) and cadmium (7 ± 4 nM/L). The levels of lead (150 ± 67 nmol/L) and barium (600 ± 300 nmol/L) were similar to those typically found in commercial TPN solutions. Those of strontium (8 ± 4 μmol/L) are higher but unlikely to be harmful. In conclusion, although GCW is not completely equivalent to high-tech (and high-cost) TPN solutions with trace element supplements, it still may provide sufficient support of at least some of the trace elements if used as a substitute. The GCW investigated by us is, at least, not toxic. However, our results for several trace elements are much lower than values previously reported in the literature, especially in coconuts from “polluted” areas. GCW from polluted soil might be easily toxic if used intravenously. J. Trace Elem. Exp. Med. 17:273–282, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 4","pages":"273-282"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72333315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride: A toxic or therapeutic agent in the treatment of osteoporosis?","authors":"Jan Aaseth,&nbsp;Mona Shimshi,&nbsp;J. Lester Gabrilove,&nbsp;Grethe Støa Birketvedt","doi":"10.1002/jtra.10051","DOIUrl":"https://doi.org/10.1002/jtra.10051","url":null,"abstract":"This article summarizes recent studies and is a review of the literature on the fluoride compounds and their influence on bone mineral mass. It is well known that fluoride is an important element for mineralization of body tissues. The use of topical and systemic fluoride for oral health has resulted in major reduction in dental caries, but fluoride also plays a role in bone health. Dieticians and other health professionals are advised to recommend adequate use of systemic and topical fluorides, especially in children and adolescents. Population studies as well as earlier studies of individuals exposed to fluorides indicate that doses above 30–40 mg daily can result in fluorosis, characterized by increased fracture risk. Numerous clinical studies have demonstrated increased bone mineral density in subjects treated with appropriate doses of fluoride. However, the clinical interpretation of these studies has been a matter of debate. Therapeutically, fluoride seems to be useful when the agent is started in the early stages of osteoporosis, especially in patients with intact trabecular bone. It is well established that fluoride can act as an effective stimulator of bone formation by the osteoblasts. Bisphosphonates, which can also increase bone density, act by inhibiting bone resorption by osteoclasts. As a result of this, owing to the tight paracrine association characterizing skeletal metabolism, bone formation is slowed down by the antiresorptive agents. It is of particular interest that great benefit in the treatment of osteoporoses is seen when adequate osteoblast-stimulating doses of fluorides are given in combination with antiresorptive medication, but further research is needed to substantiate this promising concept. J. Trace Elem. Exp. Med. 17:83–92, 2004. © 2004 Wiley-Liss, Inc.","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 2","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.10051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72316842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary chromium picolinate: Efficacy and safety †","authors":"Vijaya Juturu,&nbsp;James K. Komorowski","doi":"10.1002/jtra.20008","DOIUrl":"https://doi.org/10.1002/jtra.20008","url":null,"abstract":"","PeriodicalId":101243,"journal":{"name":"The Journal of Trace Elements in Experimental Medicine","volume":"17 4","pages":"291-293"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jtra.20008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72333019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}