The Chemical Engineering Journal and the Biochemical Engineering Journal最新文献_第10页

Application of neural networks to lysine production 神经网络在赖氨酸生产中的应用

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03090-4

Y.-H. Zhu, T. Rajalahti, S. Linko

引用次数: 20

Optimum operating conditions in closed-system industrial acetifiers (batch operation): a study by computer simulation 封闭系统工业活化剂(批量操作)的最佳操作条件:计算机模拟研究

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(95)03069-7

M. Macías, I. Caro, D. Cantero

{"title":"Optimum operating conditions in closed-system industrial acetifiers (batch operation): a study by computer simulation","authors":"M. Macías, I. Caro, D. Cantero","doi":"10.1016/0923-0467(95)03069-7","DOIUrl":"10.1016/0923-0467(95)03069-7","url":null,"abstract":"<div>This work studies the optimum operating conditions in theoretical industrial acetifiers using computer simulation techniques. The fundamental part of the simulator is a global model for the growth of Acetobacter aceti in submerged culture compiled from the literature. The model is based on an expression which brings together a function for the specific rate of growth and another function for the specific rate of death, which reflects the combined influences of acetic acid, ethanol and oxygen. The kinetic parameters of the model are refitted by non-linear least-squares-type techniques, using data obtained from laboratory and industrial experimentation.The optimum operating conditions have been calculated for two types of batch process: those with constant concentrations of dissolved oxygen and those with a constant rate of oxygen transfer to the fermentation medium. In both cases, the influence on the evolution of the process of different initial concentration levels of ethanol, acetic acid, biomass, dissolved oxygen and KLa has been studied.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 3","pages":"Pages 183-191"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(95)03069-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78493329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hydrodynamical interactions between particles and liquid flows in biochemical applications 生物化学应用中颗粒与液体流动之间的流体动力学相互作用

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03086-2

P.J.C. Caulet , R.G.J.M. van der Lans, K.Ch.A.M. Luyben

{"title":"Hydrodynamical interactions between particles and liquid flows in biochemical applications","authors":"P.J.C. Caulet , R.G.J.M. van der Lans, K.Ch.A.M. Luyben","doi":"10.1016/0923-0467(96)03086-2","DOIUrl":"10.1016/0923-0467(96)03086-2","url":null,"abstract":"<div>The interactions between a turbulent flow field and discrete particles have numerous applications in biochemical engineering. On the one hand, flows have a strong influence on the particle motion, from which consequences for heat and mass transfer, mixing or even damage to particles are derived. On the other hand, the presence of the discontinuous (solid) phase is regarded as altering the turbulent field (two-way coupling). At present, no fully explained mechanism of this turbulence alteration is offered in the literature. However, the two-way coupling can no longer be considered when the particle concentration becomes sufficiently high. The dominant mechanism affecting the flow is then the particle—particle interaction. Until now, no clear definition of a demarcation between hydrodynamic (fluid—particle interaction) and viscous (particle—particle interaction) influences in liquid—solid or liquid—solid—gas systems has been given in the literature.In this paper we present first a description of the forces acting on a particle in a flow and the most relevant parameters linked to the response of a particle to turbulent stimulations. Some illustrations are given for common biochemical applications. The second part is concerned with the action of the particles on the turbulence, the main trends observed and their significance in such applications being focused on. It is also demonstrated here that the transition between the hydrodynamic and the viscous regimes is located between 20% and 30% in solid volume concentration.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 3","pages":"Pages 193-206"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(96)03086-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80146002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The vortex wave membrane bioreactor: hydrodynamics and mass transfer 涡旋波膜生物反应器:流体力学与传质

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03087-4

H.R. Millward, B.J. Bellhouse, I.J. Sobey

{"title":"The vortex wave membrane bioreactor: hydrodynamics and mass transfer","authors":"H.R. Millward, B.J. Bellhouse, I.J. Sobey","doi":"10.1016/0923-0467(96)03087-4","DOIUrl":"10.1016/0923-0467(96)03087-4","url":null,"abstract":"<div>An experimental study of a membrane bioreactor has investigated the dynamics of the vortex wave as an effective aeration technique for application in high density mammalian cell culture. Gas transfer membranes have been employed in order to eliminate the potentially lethal gas3-liquid interface found in stirred tank and bubble columns. The diffusion-limited features of oxygen transfer through a membrane have been overcome by harnessing the excellent mixing characteristics of oscillatory flow and vortex formation.The crucial hydrodynamic features of the vortex wave, in a relatively wide channel, have been classified in terms of deflector spacing, Reynolds number and Strouhal number. The dynamic gassing-in of oxygen from a gas phase, across the membrane, to a liquid phase has allowed us to quantify the mass transfer characteristics in terms of the Sherwood number. Significant mass transfer enhancement has been achieved under laminar flow conditions, without a major increase in power dissipation. The Sherwood number has been found to be dependent on both the Reynolds number and the Strouhal number. The Reynolds analogy has been employed to calculate shear rates. The low shear rates (about 300 s{sut-1}) and maximum theoretical hybridoma cell densities (about 1.0 sx 10{su9} cells ml{sut-1}) indicate that the vortex wave design may be an effective alternative to traditional bioreactors.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 3","pages":"Pages 175-181"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(96)03087-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78035632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Determination of yield and maintenance coefficients in citric acid production by Aspergillus niger 黑曲霉产柠檬酸产量及维持系数的测定

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03088-6

Liliana Krzystek, Pawel Gluszcz, Stanislaw Ledakowicz

{"title":"Determination of yield and maintenance coefficients in citric acid production by Aspergillus niger","authors":"Liliana Krzystek, Pawel Gluszcz, Stanislaw Ledakowicz","doi":"10.1016/0923-0467(96)03088-6","DOIUrl":"10.1016/0923-0467(96)03088-6","url":null,"abstract":"<div>One method for economic planning and management of production processes is a balance of substrate mass and energy it contains. Theoretical assumptions and practical applications of mass and energy balances in the process of citric acid production by Aspergillus niger are discussed in the study.In the calculation of biomass and product yields as well as the maintenance coefficients mechanistic values such as true biomass and citric acid yields YmaxATP,X(P) on ATP and specific ATP consumption mATP due to maintenance processes were used. A set of limitations imposed on theoretical and true yield coefficients in the linear growth equation is also presented.The experimental measurements were performed in an air-lift bioreactor of 220 dm3 operating capacity, with external circulation loop. The sole carbon source for the cultivation of A. niger was sucrose at an initial concentration of 100 g l−1.The experimentally obtained yield coefficients relative to cell growth and citric acid production have reached 96% and 83% respectively of real maximum theoretical values. Calculated true biomass and citric acid yield coefficients were closely correlated with the values from the balance analysis of stoichiometric equations. Calculated value of specific maintenance requirements mATP was 0.015 mol ATP [mol C(dry mass)]−1 h−1.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 3","pages":"Pages 215-222"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(96)03088-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80436327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Comparative evaluation of hydrodynamic and gas—liquid mass transfer characteristics in bubble column and airlift slurry reactors 气泡塔与气升浆体反应器流体动力及气液传质特性的比较评价

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03085-0

K.H. Choi, Y. Chisti, M. Moo-Young

{"title":"Comparative evaluation of hydrodynamic and gas—liquid mass transfer characteristics in bubble column and airlift slurry reactors","authors":"K.H. Choi, Y. Chisti, M. Moo-Young","doi":"10.1016/0923-0467(96)03085-0","DOIUrl":"10.1016/0923-0467(96)03085-0","url":null,"abstract":"<div>Three pneumatically agitated reactors — a bubble column and two airlift devices — with identical rectangular cross-sections (0.456 m × 0.153 m), working heights (1.64 m) and equivalent gas sparging arrangements were compared in terms of the hydrodynamic and oxygen transfer performance. The two airlift reactors had identical riser-to-downcomer cross-sectional area ratios of 1.0, but differed in being sparged either in the central draft-tube or in the peripheral risers. The reactors produced comparable overall gas holdups for otherwise identical conditions in air—water or air—water—glass bead (0.069 mm particle diameter, 0%–5% (v/v) solids loading) systems. For the airlifts, irrespective of the sparging configuration or the solids loading, the same linear equation could relate the riser and the downcomer gas holdups. The velocity of the induced liquid circulation was not affected by solids loading, but the central draft-tube sparged design produced consistently higher velocities than did sparging in peripheral tubes. The bubble column had the poorest mixing performance. Complete suspension of solids occurred in all reactors in the range of superficial air velocities (0.01–0.08 m s−1) tested; however, the distribution of solids was non-uniform in the bubble column. The airlift devices achieved homogeneous distribution. The oxygen transfer capability of the three reactors was comparable, with the bubble column performing slightly better.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 3","pages":"Pages 223-229"},"PeriodicalIF":0.0,"publicationDate":"1996-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(96)03085-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85523062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Editor's Note 编者按

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)80025-X

ProfessorColin Webb

引用次数: 0

Distribution equilibrium of penicillin G between water and organic solutions of Amberlite LA-2 青霉素G在安培石LA-2水溶液中的分布平衡

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(96)03089-8

Ruey-Shin Juang, Yuh-Sheng Lin

引用次数: 6

Dynamic liquid holdup and oxygen mass transfer in a cocurrent upflow bioreactor with small packing at low Reynolds numbers 低雷诺数下小填料共流上流式生物反应器的动态液含率和氧传质

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-06-01 DOI: 10.1016/0923-0467(95)03068-9

F.M. Samb, M. Deront, N. Adler, P. Péringer

引用次数: 10

Effectiveness factor for a hollow-fiber biofilm reactor at maximum substrate consumption 最大底物消耗时中空纤维生物膜反应器的有效系数

The Chemical Engineering Journal and the Biochemical Engineering Journal Pub Date : 1996-05-01 DOI: 10.1016/0923-0467(95)03066-2

Abdurrahman Tanyolaç, Haluk Beyenal

{"title":"Effectiveness factor for a hollow-fiber biofilm reactor at maximum substrate consumption","authors":"Abdurrahman Tanyolaç, Haluk Beyenal","doi":"10.1016/0923-0467(95)03066-2","DOIUrl":"10.1016/0923-0467(95)03066-2","url":null,"abstract":"<div>In this work, a model was proposed to evaluate the effectiveness factor of a hollow-fiber biofilm reactor (HFBR) for optimum biofilm densities, to achieve a maximum substrate consumption rate. The effectiveness factor was calculated for selected lumen concentrations using a cell-density-dependent effective diffusion coefficient, Monod biokinetics adapted for maintenance, and a minimum substrate concentration concept for biofilm activity in the model, a different approach from that in the literature. The solution of the continuity equation revealed an optimum biofilm density and active biofilm thickness, corresponding to a maximum substrate consumption rate within the biofilm. The optimum biofilm density decreased with increasing lumen substrate concentrations, while the maximum substrate consumption rate and active biofilm thickness parabolically increased, as experimentally observed in the literature. Meanwhile, an interesting descending trend of the effectiveness factor at optimum biofilm density was observed at low lumen substrate concentration and biofilm thickness values for different radial flow rates.</div>","PeriodicalId":101226,"journal":{"name":"The Chemical Engineering Journal and the Biochemical Engineering Journal","volume":"62 2","pages":"Pages 149-154"},"PeriodicalIF":0.0,"publicationDate":"1996-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-0467(95)03066-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89093724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11