中华内分泌代谢杂志最新文献

{"title":"Shared decision making for elective abdominal aortic aneurysm surgery.","authors":"Michael Swart, Robert McCarthy","doi":"10.7861/clinmed.2019-0352","DOIUrl":"10.7861/clinmed.2019-0352","url":null,"abstract":"<p><p>Decisions on how and when to treat an abdominal aortic aneurysm involve a number of clinicians; interventional radiologists and vascular surgeons assess the technical ability to repair the aneurysm. Patients' fitness and past medical history is assessed to estimate their short- and long-term survival with or without surgery. Most importantly the patients' personal preference for treatment must be identified. Getting a patient to share what matters most to them requires shared decision making.</p>","PeriodicalId":10120,"journal":{"name":"中华内分泌代谢杂志","volume":"35 1","pages":"473-477"},"PeriodicalIF":4.4,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77891054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild sustained physiological hyperglycemia impairs hepatic insulin sensitivity in healthy individuals with normal glucose tolerance","authors":"Yichao Wei, Yu Hu","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.017","url":null,"abstract":"Previous studies have shown that chronic hyperglycemia exacerbates skeletal muscle insulin resistance and worsens β-cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity stays unclear. This paper is the Chinese translation of \" Mild physiologic hyperglycemia induces hepatic insulin resistance in healthy normal glucose-tolerant participants\" , published on \" Journal of Clinical Endocrinology & Metabolism\" [Tripathy D, Merovci A, Basu R, et al. J Clin Endocrinol Metab, 2019, 104(7): 2842-2850] after obtaining the copyright of the original journal. This study examined the effect of sustained physiologic hyperglycemia on endogenous glucose production(EGP) in 16 healthy individuals with three-step hyperinsulinemic euglycemic clamp. The results showed that sustained physiologic hyperglycemia for only 48 hours increased the rate of basal hepatic glucose production and induced hepatic insulin resistance in healthy persons with normal glucose tolerance, indicating the role of glucotoxicity in the increase of hepatic glucose production in type 2 diabetes. \u0000 \u0000Key words: \u0000Hyperglycemia; Insulin resistance; Normal glucose tolerance","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"893-897"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46352319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment options for patients with recurrent Graves hyperthyroidism after anti-thyroid drug treatment","authors":"Meng Liu, Jia Liu, Guang Wang","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.019","url":null,"abstract":"Graves′ disease (GD) is the most common cause of hyperthyroidism, and its treatment includes anti-thyroid drugs (ATD), radioactive iodine therapy (RAI), and surgical treatment. ATD is the first choice for GD treatment in China, but the high recurrence rate limits its widely clinical application. The therapeutic strategy for patients with recurrent hyperthyroidism after ATD treatment is still controversial. \u0000 \u0000Key words: \u0000Hyperthyroidism; Graves′ disease; Anti-thyroid drugs; Recurrence","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"903-906"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47723925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to the patient with pancytopenia secondary to panhypopituitarism after craniopharyngioma surgery","authors":"Xiaoyang Shi, Kai Zhang, Yanfang Wang, S. Ma, Junpeng Yang, Lu Yu, Zhigang Zhao, Huijuan Yuan","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.013","url":null,"abstract":"Craniopharyngioma is the most common benign intracranial tumor in children. The major post-operative complication is dysfunction of pituitary, which can result in many complicate clinical manifestations with hormonal deficiencies. Normochromic anemia has been reported as a common hematologic abnormality. However, pancytopenia is rarely reported so far. Here we described a 21-year-old inpatient with the main complaint of nasal bleeding, who received craniopharyngioma surgery 9 years ago. Laboratory tests showed pancytopenia secondary to panhypopituitarism. This paper aims to increase the awareness of this disease and accumulate clinical experiences for the clinicians. \u0000 \u0000Key words: \u0000Craniopharyngioma; Hypopituitarism; Pancytopenia","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"878-881"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42773560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum CTRP6 level and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus","authors":"Jiaoyang Li, Min Liu, Xiaoyan Qi, Ya-Di Wang, Li Ran, Tao Hong, Jing Yang, Gebo Wen, Jianghua Liu, Xinhua Xiao","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.006","url":null,"abstract":"Objective \u0000To explore the relationship between serum C1q and tumor necrosis factor related protein 6(CTRP6) level and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus (T2DM). \u0000 \u0000 \u0000Methods \u0000A total of 167 patients with newly diagnosed T2DM in the outpatient department of our hospital were recruited from April 2016 to March 2017 and 165 subjects with normal glucose tolerance were used as the control group. The concentrations of CTRP6, interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor α (TNF-α) were determined by ELISA. \u0000 \u0000 \u0000Results \u0000Circulating CTRP6 level was significantly higher in T2DM group than that in control group [(652.54±132.57) vs (521.28±119.93)μg/L, P<0.01] after adjusting age and body mass index (BMI). Overweight/obese subjects revealed higher CTRP6 levels compared with those in lean individuals. In addition, circulating CTRP6 level was positively correlated with BMI, waist circumference, fasting plasma glucose, postprandial 2h plasma glucose, HbA1C, fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride (TG), IL-6, MCP-1, highly sensitive C-reactive protein (hs-CRP), and TNF-α, while it was inversely correlated with high-density lipoprotein-cholesterol(P<0.01). Multivariate linear regression analysis showed that TG, HOMA-IR, and IL-6 were independent factors for CTRP6 level. After adjusting for potential confounders, CTRP6 remained an independent risk factor for T2DM. Trend test showed that the increase in CTRP6 level was significantly linear with the occurrence of T2DM. The analysis of receiver operating characteristic curves revealed that the area under the curve for circulating CTRP6 to predict T2DM was 0.730. \u0000 \u0000 \u0000Conclusions \u0000CTRP6 may be associated with insulin resistance. \u0000 \u0000 \u0000Key words: \u0000C1q/TNF-related protein-6; Diabetes mellitus, type 2; Inflammation; Insulin resistance","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"843-847"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47954787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of insulin resistance and β-cell function with macrosomia among pregnant women with gestational diabetes mellitus","authors":"Ming-Wei Zhao, Guanghui Li","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.007","url":null,"abstract":"Objective \u0000To investigate the associations of insulin resistance and β-cell function with macrosomia among pregnant women with gestational diabetes mellitus (GDM). \u0000 \u0000 \u0000Methods \u0000Totally 165 women with GDM were enrolled from January 2017 to June 2017 in the Nutrition Clinic of Beijing Obstetrics and Gynecology Hospitals of Capital Medical University, and they were followed-up until delivery. These GDM women were divided into macrosomia group (birth weight≥4 000 g) and control group (birth weight 2 500-3 999 g) according to their infants′ birth weight. Homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) were estimated. Multivariable logistic regression was conducted to analyze the risk factors of macrosomia. \u0000 \u0000 \u0000Results \u0000Compared to control group, macrosomia group had higher gestational weeks and body mass index (BMI) before pregnancy, gestational weight gain, fasting plasma glucose levels during both 24-28 and 28-32 weeks of gestation, and HOMA-IR. Multivariable logistic regression showed that the risk of macrosomia was associated with BMI before pregnancy (OR=1.41, 95%CI 1.14-1.75, P<0.01), gestational weight gain (OR=1.50, 95%CI 1.26-1.79, P<0.01) and fasting blood glucose during the 28-32 week period of gestation (OR=6.56, 95%CI 1.15-37.27, P<0.05). In addition, BMI before pregnancy was positively correlated to birth weight (r=0.21, P<0.01), HOMA-IR(r=0.46, P<0.01), and HOMA-β(r=0.26, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Fasting plasma glucose levels during 28-32 weeks of gestation are associated with the risk of giving birth to macrosomia in pregnant women with GDM independent of maternal BMI before pregnancy as well as gestational weight gain. \u0000 \u0000 \u0000Key words: \u0000Gestational diabetes mellitus; Insulin resistance; Islet β-cell function; Macrosomia","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"848-852"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49035302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential expression of long non-coding RNAs in peripheral blood of type 2 diabetic patients","authors":"Xuan Zhu, Pan Zhang, P. Lou, Yang-guang Du, Ting-jun Liu, C. Qiao, Z. Dong, Peipei Chen, Ting Li","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.008","url":null,"abstract":"Objective \u0000To screen and verify the differential expression profiles of long non-coding RNAs(LncRNAs) in peripheral blood of patients with type 2 diabetes mellitus(T2DM), to identify the potential molecular specific markers of early T2DM. \u0000 \u0000 \u0000Methods \u0000The blood samples of 4 type 2 diabetic patients and 4 normal control subjects were collected for microarray analysis. Then six candidate markers of LncRNAs screened from the differential expression profile were tested by qRT-PCR among the subjects (80 cases in the T2DM group and 50 cases in the control group). The possibility of these LncRNAs as molecular diagnostic markers was analyzed, and finally two of them were carried out by receiver operating characteristic (ROC) analysis. \u0000 \u0000 \u0000Results \u0000Compared with control subjects, there were differentially expressed 133 LncRNAs in type 2 diabetic patients, among which 5 were up-regulated with the maximum up-regulated fold 3.29 and 128 were down-regulated with the maximum down-regulated fold 8.99. Six down-regulated LncRNAs were selected for validation and revealed a similar result to that of microarray.The expressions of two LncRNAs(NONHSAT160746 and NONHSAT140069) in peripheral blood of diabetic patients were significantly lower than those of control subjects (P<0.01). The areas under the ROC curve of the two LncRNAs were 0.734 and 0.703, respectively(P<0.01). \u0000 \u0000 \u0000Conclusion \u0000LncRNAs NONHSAT160746 and LncRNAs NONHSAT140069 are the potential molecular specific markers for the diagnosis of diabetes mellitus. \u0000 \u0000 \u0000Key words: \u0000Diabetes mellitus, type 2; Long non-coding RNAs; Microarray analysis; Biological markers","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"853-858"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44367682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the study of familial glucocorticoid deficiency","authors":"Ai-Lin Luo, Zhi-fang Wang, Xia-lian Li","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.016","url":null,"abstract":"Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive disease characterized by a single cortisol deficiency and normal aldosterone and renin levels, reported by Shepard et al. in 1959 for the first time. The onset age of FGD may be early or later, from neonatal to adult. The clinical manifestations vary due to the different age at onset. The clinical identification was difficult and would be prone to misdiagnosis because the disease may have many similarities with primary adrenal insufficiency (PAI) caused by other reasons. \u0000 \u0000Key words: \u0000Familial glucocorticoid deficiency; Gene mutations","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"888-892"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69807916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardizing the management of fine needle aspiration for thyroid nodules","authors":"Xiaoyun Liu, Shu-hang Xu, Hongxun Wu, Y. Zhang, Jiandong Bao, Chao Liu, Tao Yang, Jian Wang","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.001","url":null,"abstract":"Thyroid nodules are very common in the clinical practice. Fine needle aspiration (FNA) is a major method for the diagnosis of thyroid nodules. This review tried to cover the definition, current status, clinical significance, indications, contraindications, ultrasound evaluation, as well as preparations, steps, molecular diagnosis, cytology diagnosis, and possible pitfalls of this technique. Our purpose is trying to make this procedure universalized and standardized in order to serve more patients by providing clinicians with some helpful references and advices. \u0000 \u0000Key words: \u0000Thyroid nodule; Fine needle aspiration; Technique; Standardization","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"819-824"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42719638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addison disease as presenting manifestation of one patient with adrenoleukodystrophy and identification of a novel ABCD1 gene mutation","authors":"Yue Zhou, B. Dong, Xiang Wang, Zhuang Geng, Yajing Huang, Yangang Wang","doi":"10.3760/CMA.J.ISSN.1000-6699.2019.10.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1000-6699.2019.10.003","url":null,"abstract":"Objective \u0000To identify the clinical manifestations, imaging findings, and genetic mutation characteristics in a rare case of adrenoleukodystrophy(ALD)with adrenocortical dysfunction(Addison′s disease)as the first manifestation. \u0000 \u0000 \u0000Methods \u0000The clinical data of the proband and his family members were comprehensively collected, and ABCDl gene sequencing was meticulously performed for the proband and his mother using high-throughput sequencing method. \u0000 \u0000 \u0000Results \u0000The patient presented with systematical skin pigmentation accompanied by fatigue in early stage, arose stroke-like episodes manifested as a sudden loss of consciousness and incontinence induced by high fever, and followed by progressive unclear speech, unstable walking and worsening vision. Serum very long-chain fatty acid(VLCFA)concentration increased over normal range. The brain MRI showed an abnormal signal of the symmetric distribution of the bilateral corpus callosum. A new c. 874_876del GAG hemizygous variation in the patient′s ABCD1 gene was detected, while his mother had a nucleotide heterozygous variation to this site . \u0000 \u0000 \u0000Conclusion \u0000The diagnosis of ALD requires a combination of clinical manifestations, imaging examination, and serum VLCFA level measurement, while the detection of ABCD1 gene mutations is considered to be the most reliable approach. \u0000 \u0000 \u0000Key words: \u0000Adrenaleukodystrophy; Adrenal insufficiency; Addison disease; ABCD1 gene","PeriodicalId":10120,"journal":{"name":"Chinese Journal of Endocrinology and Metabolism","volume":"35 1","pages":"829-833"},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45524665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}