Mild sustained physiological hyperglycemia impairs hepatic insulin sensitivity in healthy individuals with normal glucose tolerance

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2019-10-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2019.10.017

Yichao Wei, Yu Hu

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Abstract

Previous studies have shown that chronic hyperglycemia exacerbates skeletal muscle insulin resistance and worsens β-cell function. However, the effect of sustained physiologic hyperglycemia on hepatic insulin sensitivity stays unclear. This paper is the Chinese translation of " Mild physiologic hyperglycemia induces hepatic insulin resistance in healthy normal glucose-tolerant participants" , published on " Journal of Clinical Endocrinology & Metabolism" [Tripathy D, Merovci A, Basu R, et al. J Clin Endocrinol Metab, 2019, 104(7): 2842-2850] after obtaining the copyright of the original journal. This study examined the effect of sustained physiologic hyperglycemia on endogenous glucose production(EGP) in 16 healthy individuals with three-step hyperinsulinemic euglycemic clamp. The results showed that sustained physiologic hyperglycemia for only 48 hours increased the rate of basal hepatic glucose production and induced hepatic insulin resistance in healthy persons with normal glucose tolerance, indicating the role of glucotoxicity in the increase of hepatic glucose production in type 2 diabetes. Key words: Hyperglycemia; Insulin resistance; Normal glucose tolerance

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在葡萄糖耐量正常的健康个体中，轻度持续性生理性高血糖损害肝脏胰岛素敏感性

先前的研究表明，慢性高血糖会加剧骨骼肌胰岛素抵抗，并恶化β细胞功能。然而，持续的生理性高血糖对肝脏胰岛素敏感性的影响尚不清楚。本文是“轻度生理性高血糖诱导健康正常耐糖参与者肝胰岛素抵抗”的中文翻译，在获得原刊版权后发表在《临床内分泌学与代谢杂志》[Tropathy D，Merovci A，Basu R，et al.J Clin Endocrinol Metab，2019104（7）：2842-2850]上。本研究用三步高胰岛素-正常血糖钳夹检测了16名健康人持续生理性高血糖对内源性葡萄糖生成（EGP）的影响。结果表明，在糖耐量正常的健康人中，持续48小时的生理性高血糖增加了基础肝葡萄糖产生率，并诱导了肝胰岛素抵抗，这表明糖毒性在2型糖尿病肝葡萄糖产生增加中的作用。关键词：高血糖；胰岛素抵抗；正常葡萄糖耐量

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.