TARGETS最新文献

筛选
英文 中文
Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system 孤儿g蛋白偶联受体在心血管系统中的新作用
TARGETS Pub Date : 2002-12-01 DOI: 10.1016/S1477-3627(02)02276-6
Sidath Katugampola , Anthony Davenport
{"title":"Emerging roles for orphan G-protein-coupled receptors in the cardiovascular system","authors":"Sidath Katugampola ,&nbsp;Anthony Davenport","doi":"10.1016/S1477-3627(02)02276-6","DOIUrl":"https://doi.org/10.1016/S1477-3627(02)02276-6","url":null,"abstract":"<div><p>Despite current drug therapies, including those that target enzymes, channels and known G-protein-coupled receptors (GPCRs), cardiovascular disease remains the major cause of ill health, which suggests that other transmitter systems might be involved in this disease. In humans, ∼175 genes have been predicted to encode ‘orphan’ GPCRs, where the endogenous ligand is not yet known. As a result of intensive screening using ‘reverse pharmacology’, an increasing number of orphan receptors are being paired with their cognate ligands, many of which are peptides. The existence of some of these peptides such as urotensin-II and relaxin had been known for some time but others, including ghrelin and apelin, represent novel sequences. The pharmacological characterization of these emerging peptide–receptor systems is a tantalising area of cardiovascular research, with the prospect of identifying new therapeutic targets.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 6","pages":"Pages 206-213"},"PeriodicalIF":0.0,"publicationDate":"2002-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02276-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91762246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Data integration standards in model organisms: from genotype to phenotype in the laboratory mouse 模式生物的数据整合标准:从实验室小鼠的基因型到表型
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02215-8
Carol J. Bult
{"title":"Data integration standards in model organisms: from genotype to phenotype in the laboratory mouse","authors":"Carol J. Bult","doi":"10.1016/S1477-3627(02)02215-8","DOIUrl":"10.1016/S1477-3627(02)02215-8","url":null,"abstract":"<div><p>The tremendous progress of the genome sequencing centers, combined with computational advances in algorithms for genome assembly and gene model prediction, provide the research community with valuable new resources in the form of complete, or nearly complete, genome sequences for a wide variety of organisms that serve as platforms to investigate biological systems. The challenge facing the bioinformatics community is how to integrate the rapidly emerging genomic data with experimental data, such as gene expression, protein interactions, cell processes and systems characteristics under select perturbations. Data integration is key to understanding at all levels because the process of integration brings together disparate types of data in formats that support effective data mining, pattern detection and hypothesis generation. Databases for model organisms are valuable sources of integrated data from the level of the genome to that of the phenotype. Databases for model organisms promote data integration through the development and implementation of nomenclature standards, controlled vocabularies and ontologies, that allow data different organisms to be compared and contrasted.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 163-168"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02215-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76883584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
News in brief 新闻简讯
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02262-6
V. Ashton
{"title":"News in brief","authors":"V. Ashton","doi":"10.1016/S1477-3627(02)02262-6","DOIUrl":"https://doi.org/10.1016/S1477-3627(02)02262-6","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 151-153"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02262-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137163638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards targeting signalling networks by functional phosphoproteomics 功能性磷蛋白组学靶向信号网络
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02217-1
Jasminka Godovac-Zimmermann , Larry R. Brown
{"title":"Towards targeting signalling networks by functional phosphoproteomics","authors":"Jasminka Godovac-Zimmermann ,&nbsp;Larry R. Brown","doi":"10.1016/S1477-3627(02)02217-1","DOIUrl":"10.1016/S1477-3627(02)02217-1","url":null,"abstract":"<div><p>We present the development of Proteo-Mode, an instrument for automated, high-throughput preparation of phosphoproteins for proteomics analysis of complex cellular signalling networks involving multiple, time-dependent protein phosphorylation events. Proteo-Mode automates all steps in the network analysis of phosphoproteins by proteomics method. This enables the integrated response of complex cellular signalling networks to be analyzed in normal and abnormal (disease) states and provides new perspectives in targeting and evaluation of the effects of therapeutic compounds on such networks.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 169-176"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02217-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79730536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Infectious link to Alzheimer's disease 阿尔茨海默病的传染因素
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02227-4
Martina Habeck (freelance writer)
{"title":"Infectious link to Alzheimer's disease","authors":"Martina Habeck (freelance writer)","doi":"10.1016/S1477-3627(02)02227-4","DOIUrl":"10.1016/S1477-3627(02)02227-4","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 147-148"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02227-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72996594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding anti-anxiety targets in fear mechanisms 在恐惧机制中寻找抗焦虑目标
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02226-2
Stephani Sutherland (freelance writer)
{"title":"Finding anti-anxiety targets in fear mechanisms","authors":"Stephani Sutherland (freelance writer)","doi":"10.1016/S1477-3627(02)02226-2","DOIUrl":"10.1016/S1477-3627(02)02226-2","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 149-151"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02226-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89261160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are genomic and proteomic technologies adding value to drug discovery? 基因组学和蛋白质组学技术是否为药物发现增加了价值?
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02224-9
Leodevico L. Ilag
{"title":"Are genomic and proteomic technologies adding value to drug discovery?","authors":"Leodevico L. Ilag","doi":"10.1016/S1477-3627(02)02224-9","DOIUrl":"10.1016/S1477-3627(02)02224-9","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 153-155"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02224-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"102423304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drugs from nonsense 新药来自废话
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02225-0
Lois Wingerson
{"title":"New drugs from nonsense","authors":"Lois Wingerson","doi":"10.1016/S1477-3627(02)02225-0","DOIUrl":"10.1016/S1477-3627(02)02225-0","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 148-149"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02225-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73249522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tired of the same old grind in the new genomics and proteomics era? 厌倦了在新的基因组学和蛋白质组学时代做同样的苦差事?
TARGETS Pub Date : 2002-11-01 DOI: 10.1016/S1477-3627(02)02228-6
Patricia E. Garrett , Feng Tao , Nathan Lawrence , Jay Ji , Richard T. Schumacher , Mark M. Manak
{"title":"Tired of the same old grind in the new genomics and proteomics era?","authors":"Patricia E. Garrett ,&nbsp;Feng Tao ,&nbsp;Nathan Lawrence ,&nbsp;Jay Ji ,&nbsp;Richard T. Schumacher ,&nbsp;Mark M. Manak","doi":"10.1016/S1477-3627(02)02228-6","DOIUrl":"10.1016/S1477-3627(02)02228-6","url":null,"abstract":"<div><p>New discoveries in life sciences depend on accurate analysis of biomolecules, which in turn depends on the extraction of high-quality molecules in high quantities from the tissues of plants, animals or microorganisms. The extraction process for hard-to-lyse cells and tissues has been a bottleneck in the path to discovery for many years. This review describes extraction methods currently in use, and compares them to a newly developed, automated process involving patented pressure cycling technology (PCT). The PCT sample preparation system (SPS) uses an instrument capable of rapid, temperature-controlled pressure cycling between ambient and high pressures, and single-use sample tubes containing a ram and a lysis disk. The quality and quantity of nucleic acid and protein prepared by the PCT SPS method are comparable to the older methods, whereas ease and safety of processing, reproducibility, speed and control are enhanced.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 5","pages":"Pages 156-162"},"PeriodicalIF":0.0,"publicationDate":"2002-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02228-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72571075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
News in brief 新闻简讯
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02233-X
Joanne Clough, Sheema Sheikh, Catherine Wild, Heather Yeomans
{"title":"News in brief","authors":"Joanne Clough,&nbsp;Sheema Sheikh,&nbsp;Catherine Wild,&nbsp;Heather Yeomans","doi":"10.1016/S1477-3627(02)02233-X","DOIUrl":"https://doi.org/10.1016/S1477-3627(02)02233-X","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 4","pages":"Pages 123-124"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02233-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136818305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信