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Turning quantity into quality: novel quality assurance strategies for data produced by high-throughput genomics technologies 将数量转化为质量:高通量基因组技术产生的数据的新型质量保证策略
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02207-9
Hans Peter Fischer
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引用次数: 4
Finding the molecules to fuel chemogenomics 寻找分子来推动化学基因组学
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02206-7
Mark N. Namchuk
{"title":"Finding the molecules to fuel chemogenomics","authors":"Mark N. Namchuk","doi":"10.1016/S1477-3627(02)02206-7","DOIUrl":"10.1016/S1477-3627(02)02206-7","url":null,"abstract":"<div><p>Within the pharmaceutical industry, chemogenomics focuses on obtaining maximum benefit from the small molecules created in the drug-discovery process. Part of this discipline is the application of small-molecule inhibitors to aid in the characterization of the biological function of targets. The wider application of these approaches is hampered by a lack of reagents – that is, small molecules that have been thoroughly characterized and have appropriate potency and specificity for the target of interest. This review focuses on approaches used in the pharmaceutical industry to produce compounds for use in chemogenomics and on the challenges encountered in quickly characterizing their effects on biological activity.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 4","pages":"Pages 125-129"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02206-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77140519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
About drugs and airplanes: will better use of data and information pave the road to success? 关于药物和飞机:更好地利用数据和信息会为成功铺平道路吗?
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02211-0
Jack Elands
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引用次数: 0
Shimadzu scientist awarded Nobel Prize for Chemistry 岛津科学家获诺贝尔化学奖
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02229-8
Tetsuo Ichikawa
{"title":"Shimadzu scientist awarded Nobel Prize for Chemistry","authors":"Tetsuo Ichikawa","doi":"10.1016/S1477-3627(02)02229-8","DOIUrl":"10.1016/S1477-3627(02)02229-8","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 4","pages":"Page 122"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02229-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77367717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First genome study of anticarcinogen bears fruit 抗癌物质的首次基因组研究取得成果
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02210-9
Apoorva Mandavilli
{"title":"First genome study of anticarcinogen bears fruit","authors":"Apoorva Mandavilli","doi":"10.1016/S1477-3627(02)02210-9","DOIUrl":"10.1016/S1477-3627(02)02210-9","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 4","pages":"Page 121"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02210-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79598127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using mouse forward genetics to define novel target space 利用小鼠前向遗传学定义新的目标空间
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02208-0
Nancy A. Hong, Steve A. Kay, Richard J. Glynne
{"title":"Using mouse forward genetics to define novel target space","authors":"Nancy A. Hong,&nbsp;Steve A. Kay,&nbsp;Richard J. Glynne","doi":"10.1016/S1477-3627(02)02208-0","DOIUrl":"10.1016/S1477-3627(02)02208-0","url":null,"abstract":"<div><p>Rapid advances in genomics technologies have identified a wealth of new therapeutic targets, but typically these targets are weakly validated with only circumstantial evidence to link them to human disease. The next challenge is testing gene-to-disease connections in a relevant animal model, a time-consuming and uncertain process using conventional reverse-genetic approaches such as knockout and transgenic mice. By contrast, forward genetics proceeds by measuring a physiological process that is relevant to disease, then identifying the gene products that impinge on this process. This ‘phenotype-first’ approach solves the bottleneck of target validation by using clinically relevant assays in a mammalian whole-animal system as a discovery platform. As an unbiased approach to gene discovery and validation, forward genetics will identify novel drug targets and increase the success rate of drug development.</p></div>","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 4","pages":"Pages 130-138"},"PeriodicalIF":0.0,"publicationDate":"2002-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02208-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90869522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genzyme optimizes the universe 健赞优化宇宙
TARGETS Pub Date : 2002-10-01 DOI: 10.1016/S1477-3627(02)02219-5
Martina Habeck (freelance writer)
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引用次数: 0
Iceland's genome fits another piece in schizophrenia puzzle 冰岛的基因组解开了精神分裂症之谜的另一块拼图
TARGETS Pub Date : 2002-09-01 DOI: 10.1016/S1477-3627(02)02201-8
Katharine Pestell
{"title":"Iceland's genome fits another piece in schizophrenia puzzle","authors":"Katharine Pestell","doi":"10.1016/S1477-3627(02)02201-8","DOIUrl":"https://doi.org/10.1016/S1477-3627(02)02201-8","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 3","pages":"Pages 83-84"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02201-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
News in brief 新闻简讯
TARGETS Pub Date : 2002-09-01 DOI: 10.1016/S1477-3627(02)02238-9
Joanne Clough, Linsey Stapley, Heather Yeomans
{"title":"News in brief","authors":"Joanne Clough,&nbsp;Linsey Stapley,&nbsp;Heather Yeomans","doi":"10.1016/S1477-3627(02)02238-9","DOIUrl":"https://doi.org/10.1016/S1477-3627(02)02238-9","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 3","pages":"Pages 89-90"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02238-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aromatase and COX-2 in the anti-cancer loop 芳香化酶和COX-2在抗癌循环中的作用
TARGETS Pub Date : 2002-09-01 DOI: 10.1016/S1477-3627(02)02202-X
Paul Thacker (freelance writer)
{"title":"Aromatase and COX-2 in the anti-cancer loop","authors":"Paul Thacker (freelance writer)","doi":"10.1016/S1477-3627(02)02202-X","DOIUrl":"10.1016/S1477-3627(02)02202-X","url":null,"abstract":"","PeriodicalId":101208,"journal":{"name":"TARGETS","volume":"1 3","pages":"Pages 85-86"},"PeriodicalIF":0.0,"publicationDate":"2002-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1477-3627(02)02202-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79471986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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