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Revue Fran?aise de Transfusion et Immuno-hématologie最新文献

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Investigation of monoclonal anti-glycophorin antibodies pH and temperature dependance, reactivity with enzyme treated cells and flow cytometry studies 单克隆抗糖蛋白抗体的pH和温度依赖性、与酶处理细胞的反应性及流式细胞术研究
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80119-3
H.H. Sonneborn, M. Ernst
{"title":"Investigation of monoclonal anti-glycophorin antibodies pH and temperature dependance, reactivity with enzyme treated cells and flow cytometry studies","authors":"H.H. Sonneborn,&nbsp;M. Ernst","doi":"10.1016/S0338-4535(88)80119-3","DOIUrl":"10.1016/S0338-4535(88)80119-3","url":null,"abstract":"<div><p>Monoclonal antibodies against antigens of the M/N blood group system have been shown to be dependent on the microenvironment concerning their specificity [1, 3]. Therefore all the workshop antibodies were first tested at different pH and temperatures to investigate their binding specificity. Concerning the binding specificity another important aspect is the reactivity with enzyme treated red blood cells using trypsin, chymotrypsin and neuraminidase [2]. These tests were performed with all antibodies, which were positive in the direct agglutination tests.</p><p>An interesting evaluation for epitope specificity is the analysis of reactivity including inhibition studies using flow cytometry [4]. Binding studies were performed with all workshop antibodies with M- and N-RBC whereas inhibition studies were done only with monoclonals showing anti-M specificity.</p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 333-344"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80119-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14195420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Serological and immunochemical characterization of « Lutheran-relatedmonoclonal antibodies 9 W 11, 9 W 13, 13 W 1 and 32 W 2 lutheran相关单克隆抗体9w11、9w13、13w1和32w2的血清学和免疫化学特性
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80138-7
J. Poole, A.H. Merry, E.J. Campbell
{"title":"Serological and immunochemical characterization of « Lutheran-relatedmonoclonal antibodies 9 W 11, 9 W 13, 13 W 1 and 32 W 2","authors":"J. Poole,&nbsp;A.H. Merry,&nbsp;E.J. Campbell","doi":"10.1016/S0338-4535(88)80138-7","DOIUrl":"10.1016/S0338-4535(88)80138-7","url":null,"abstract":"<div><p>Several examples of so called « Lutheran relatedmonoclonal antibodies have been described. With the exception of one anti-Lu<sup>b</sup> [10] they have all shown the same serological reactivity in being weak or negative with the dominant type of Lu(a-b-) cells. Two have the specificity AnWj [5, 3] and others [12, 14] have different, as yet undefined, specificities. By virtue of their positive reactivity with the recessive type of Lu(a-b-) the antigens defined by these antibodies are not thought to be controlled by genes at the Lutheran locus and are not therefore Lutheran system antigens. Their relationship with the Lutheran system remains at the phenotypic level ; the antigens are regulated by a gene, referred to as either In(Lu) or SYN-IB, which also regulates Lutheran and several unrelated antigens on some rare cells — commonly referred to as the dominant type of Lu(a-b-) — referred to throughout this report as Lu(a-b-)d.</p><p>The monoclonal antibodies described in this report have been characterised with regard to specificity, thermal and pH optima, ionic strength dependence, enzyme sensitivity and sensitivity to aminoethylisothioronium bromide (AET) and dithiothreitol (DTT). Immunoglobulin class and subclass have been determined and immunoblotting performed with culture supernatants 9 W 11, 9 W 13 and 13 W 1.</p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 453-461"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80138-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14275889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological characterization of 18 monoclonal antibodies directed against Rh, G and LW molecules 针对Rh、G和LW分子的18种单克隆抗体的免疫学特性
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80096-5
P.Y. Le Pennec, M.T. Klein, M. Le Besnerais, G. Tsikas, F. Champomier, D. Goossens, Ph. Rouger
{"title":"Immunological characterization of 18 monoclonal antibodies directed against Rh, G and LW molecules","authors":"P.Y. Le Pennec,&nbsp;M.T. Klein,&nbsp;M. Le Besnerais,&nbsp;G. Tsikas,&nbsp;F. Champomier,&nbsp;D. Goossens,&nbsp;Ph. Rouger","doi":"10.1016/S0338-4535(88)80096-5","DOIUrl":"10.1016/S0338-4535(88)80096-5","url":null,"abstract":"<div><p>In this work we studied 18 monoclonal antibodies (MAB<sub>s</sub>) of various specificities directed against Rh, G and LW molecules. These antibodies were tested by agglutination techniques using a panel of human red blood cells (RBC) of common and rare phenotypes in order to:</p><ul><li><span>1.</span><span><p>Confirm their specificity</p></span></li><li><span>2.</span><span><p>Investigate their reactivity with Rh variants</p></span></li><li><span>3.</span><span><p>Determine their titres using various techniques.</p></span></li></ul></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 123-131"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80096-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14276758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Kell related antibodies 凯尔相关抗体
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80128-4
G. Daniels
{"title":"Kell related antibodies","authors":"G. Daniels","doi":"10.1016/S0338-4535(88)80128-4","DOIUrl":"10.1016/S0338-4535(88)80128-4","url":null,"abstract":"<div><p>Five monoclonal antibodies were studied ; one human and 4 murines. The human antibody (26 W 12) was anti-K. One of the murine antibodies (20 W 4) was very similar to anti-K and the other 3 (9 W 12, 19 W 2, 20 W 3) recognised high frequency antigens related to the Kell system through their absence from K<sub>0</sub> cells.</p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 395-400"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80128-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14342218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Evaluation of monoclonal antibodies reacting with Kell system antigens 单克隆抗体与凯尔系统抗原反应的评价
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80131-4
H.H. Sonneborn, M. Ernst
{"title":"Evaluation of monoclonal antibodies reacting with Kell system antigens","authors":"H.H. Sonneborn,&nbsp;M. Ernst","doi":"10.1016/S0338-4535(88)80131-4","DOIUrl":"10.1016/S0338-4535(88)80131-4","url":null,"abstract":"<div><p>Until now there have been few reports on monoclonal antibodies reacting with antigens of the Kell system [2, 3, 4] and because of this only five monoclonal antibodies have been sent for investigation for this first workshop.</p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 411-415"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80131-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14342221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serological and biochemical characterization of monoclonal antibodies against red cell markers related to expression of lutheran blood group antigens 与路德血型抗原表达相关的红细胞标志物单克隆抗体的血清学和生化特性研究
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80133-8
M.J. Telen, A. Green, T. Young
{"title":"Serological and biochemical characterization of monoclonal antibodies against red cell markers related to expression of lutheran blood group antigens","authors":"M.J. Telen,&nbsp;A. Green,&nbsp;T. Young","doi":"10.1016/S0338-4535(88)80133-8","DOIUrl":"10.1016/S0338-4535(88)80133-8","url":null,"abstract":"<div><p>Monoclonal antibodies to erythrocyte membrane antigens have, prior to this investigation, led to identification of protein(s) which bear the Lu<sup>b</sup> antigen [4] as well as to increased understanding of the effects of the <em>in(Lu)</em> gene [7, 8, 9, 10], a gene which acts in an autosomal dominant fashion to down-regulate expression of all Lutheran antigens as well as numerous other antigens recognized by human and murine monoclonal antisera [1, 2, 5]. This study was therefore designed to determine what, if any, further contribution could be made using the four submitted workshop antibodies toward the understanding of the biochemistry of Lutheran antigens and the mechanism of action of the <em>In(Lu)</em></p></div>","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 421-428"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80133-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14342223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Human and murine anti-Rh monoclonal antibodies. A comparison of serological, immunochemical, cellular and functional activity 人和鼠抗rh单克隆抗体。血清学、免疫化学、细胞和功能活性的比较
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80104-1
B.M. Kumpel , K.A. Leader , G.D. Poole , J.E. Yendle , P.A. Judson
{"title":"Human and murine anti-Rh monoclonal antibodies. A comparison of serological, immunochemical, cellular and functional activity","authors":"B.M. Kumpel ,&nbsp;K.A. Leader ,&nbsp;G.D. Poole ,&nbsp;J.E. Yendle ,&nbsp;P.A. Judson","doi":"10.1016/S0338-4535(88)80104-1","DOIUrl":"10.1016/S0338-4535(88)80104-1","url":null,"abstract":"","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 187-201"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80104-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14276767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Results with the group 3 antibodies 结果为3组抗体
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80105-3
A.E.G. Kr. Von dem Borne
{"title":"Results with the group 3 antibodies","authors":"A.E.G. Kr. Von dem Borne","doi":"10.1016/S0338-4535(88)80105-3","DOIUrl":"10.1016/S0338-4535(88)80105-3","url":null,"abstract":"","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 203-208"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80105-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14276768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Report on monoclonal Rh antibodies serological and biochemical investigations 单克隆Rh抗体血清学和生化检查报告
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80106-5
C. Bloy , D. Blanchard , M. Huet , P. Hermand , J.L. Celton , J.P. Cartron
{"title":"Report on monoclonal Rh antibodies serological and biochemical investigations","authors":"C. Bloy ,&nbsp;D. Blanchard ,&nbsp;M. Huet ,&nbsp;P. Hermand ,&nbsp;J.L. Celton ,&nbsp;J.P. Cartron","doi":"10.1016/S0338-4535(88)80106-5","DOIUrl":"10.1016/S0338-4535(88)80106-5","url":null,"abstract":"","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 209-221"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80106-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14276769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Report on group 9 (« Band 3 ) antibodies 第9组(3带)抗体报告
Revue Fran?aise de Transfusion et Immuno-hématologie Pub Date : 1988-04-01 DOI: 10.1016/S0338-4535(88)80141-7
P.A. Judson , F.A. Spring , G. Mallinson , D.J. Anstee , S.F. Parsons
{"title":"Report on group 9 (« Band 3 ) antibodies","authors":"P.A. Judson ,&nbsp;F.A. Spring ,&nbsp;G. Mallinson ,&nbsp;D.J. Anstee ,&nbsp;S.F. Parsons","doi":"10.1016/S0338-4535(88)80141-7","DOIUrl":"10.1016/S0338-4535(88)80141-7","url":null,"abstract":"","PeriodicalId":101128,"journal":{"name":"Revue Fran?aise de Transfusion et Immuno-hématologie","volume":"31 2","pages":"Pages 471-475"},"PeriodicalIF":0.0,"publicationDate":"1988-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0338-4535(88)80141-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14195423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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