Revista Espa?ola de Enfermedades Metabólicas óseas最新文献

{"title":"","authors":"","doi":"10.1016/S1132-8460(08)75183-3","DOIUrl":"https://doi.org/10.1016/S1132-8460(08)75183-3","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 6","pages":"Pages 115-125"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)75183-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138401135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exostosis auriculares: una lesión del presente y del pasado","authors":"E. González Reimers , L. Lorenzo de la Peña , R. Sarmiento-Herrera , B. Pérez Piñero , M. Arnay de la Rosa","doi":"10.1016/S1132-8460(08)72491-7","DOIUrl":"10.1016/S1132-8460(08)72491-7","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 5","pages":"Pages 112-113"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72491-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129874650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genética de la osteoporosis posmenopáusica: nuevos conocimientos y nuevos conceptos sobre su relación con los polimorfismos genéticos en la ruta estrogénica","authors":"N. Mendoza ,&nbsp;F. Morón ,&nbsp;Á. Santalla","doi":"10.1016/S1132-8460(08)72490-5","DOIUrl":"10.1016/S1132-8460(08)72490-5","url":null,"abstract":"<div><p>La osteoporosis posmenopáusica es una enfermedad compleja, sujeta a fuertes influencias ambientales pero con una base genética no menos importante, tanto en la manera de adquisición como de pérdida de la masa ósea. El estudio genéticonos está permitiendo identificar a pacientes con riesgo de padecer enfermedades comunes como ésta, y en su evolución como herramienta clínica hemos pasado de la búsqueda de genes candidatos al análisis unilocus de sus polimorfismos genéticos y sus relaciones con determinados factores ambientales. El siguiente paso será analizar las posibles interacciones génicas y la relación entre los hallazgos genéticos y la respuesta a los tratamientos más comunes.</p></div><div><p>Postmenopausal osteoporosis is a complex disease, which is subject to strong environmental influences but with a no less important genetic basis, both in the manner of acquisition and loss of bone mass. Genetic studies are enabling us to identify patients at risk of suffering from common diseases like this, and in its evolution as a clinical tool we have advanced from the search for candidate genes to unilocus analysis of their genetic polymorphisms and their relationships with certain environmental factors. The next step will be to analyse possible gene interactions and the relationship between genetic findings and the response to the most common treatments.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 5","pages":"Pages 106-111"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72490-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114742662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estudio de las características de diferentes cánceres primitivos basado en las metástasis óseas","authors":"L.L. Rosselló Aubach ,&nbsp;L. Martín Guillén ,&nbsp;N. Montalà Palau ,&nbsp;M. Conde Seijas ,&nbsp;R. Torres Palou ,&nbsp;F. Pallisó Folch","doi":"10.1016/S1132-8460(08)72488-7","DOIUrl":"https://doi.org/10.1016/S1132-8460(08)72488-7","url":null,"abstract":"<div><p>Después de pulmón e hígado, el hueso es el lugar más frecuente de asentamiento de las metástasis durante la evolución de los diferentes tipos de tumores malignos. Nuestro objetivo ha sido conocer mediante un estudio retrospectivo monocéntrico las características clínicas, medios diagnósticos, tipo y localización de las lesiones metastásicas de un total de 183 pacientes en un período comprendido entre enero de 2001 hasta diciembre de 2006. La localización más frecuente del tumor primitivo fue la de pulmón con 50 casos, seguido del de próstata con 47, mama con 23 y vejiga urinaria con 16. En 10 casos no fue posibleencontrar el tumor primitivo. La prueba diagnóstica más utilizada fue la gammagrafía ósea (81%). Se realizó una biopsia en 26 casos y fue diagnóstica en un 90%. El asentamiento más frecuente de las metástasis óseas fue la columna vertebral (83 casos), y las vértebras D11, D12 y L1 fueron las más afectadas.</p></div><div><p>After lung and liver, bone is the most common site for establishment of metastases during the evolution of different cancer types. Our objective was to determine the clinical features, diagnostic tools, and the type and localization of metastasis in a retrospective, single-centre study conducted on 183 patients between January 2001 and December 2006. The lung was the most common site for primary tumours, followed by prostate and breast cancers. In 10 cases it was not possible to determine the origin. Bone scintigraphy was the most frequently used diagnostic method (81%). Bone biopsy was performed in 26 cases and was diagnostic for 90%. The spine, specifically vertebrae D11, D12 and L1, was the most common metastatic site, with 83 cases.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 5","pages":"Pages 94-98"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72488-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92341205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Características clínicas que pueden aumentar el riesgo de fractura en mujeres con osteoporosis. Subestudio osso (estudio observacional de osteoporosis grave)","authors":"E. Martín-Mola ,&nbsp;M.L. Rentero ,&nbsp;C. Garcés ,&nbsp;M. Casillas ,&nbsp;A. Carro ,&nbsp;A. Aragón ,&nbsp;I. Möller ,&nbsp;J. Rosas ,&nbsp;J. Zubieta ,&nbsp;M. de Haro ,&nbsp;P. Aguado","doi":"10.1016/S1132-8460(08)72489-9","DOIUrl":"https://doi.org/10.1016/S1132-8460(08)72489-9","url":null,"abstract":"<div><p>Las mujeres con osteoporosis establecida presentan un mayor riesgo de fracturas y un deterioro de su calidad de vida. El objetivo del estudio es determinar las características clínicas que pueden alertar a los médicos a la hora del diagnóstico. En el subestudio que aquí se presenta se obtuvieron grupos emparejados: uno con características asociadas al aumento del riesgo de fractura y un grupo control sin dichas características. Se compararon los factores de riesgo y la calidad de vida. En los 104 pares relacionados encontrados no se observaron diferencias en la mayoría de factores de riesgo de osteoporosis. Las escalas empleadas mostraron una reducción significativa de la calidad de vida en el grupo que presentaba cualquiera de los criterios de riesgo elevado de fracturas (p<!--> <!-->&lt;<!--> <!-->0,05). La presencia de fracturas múltiples o de antecedentes de respuesta inadecuada a fármacos para la osteoporosis está asociada con una peor calidad de vida.</p></div><div><p>Established osteoporosis in women is associated with a higher risk of fractures and poor quality of life. The objective of this study was to determine clinical features that could alert clinicians during diagnosis. Risk factors and quality of life were compared in paired groups. The first group presented clinical features related to increased risk of fracture, while the second, the control group, did not. Although 104 pairs were studied, no differences were found for the majority of osteoporosis risk factors. Nevertheless, the scales used showed a significant reduction in quality of life in the group that presented a higher fracture risk (P<!--> <!-->&lt;<!--> <!-->0.05). The existence of multiple fractures or a history of inadequate response to osteoporosis treatment is related to poorer quality of life.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 5","pages":"Pages 99-105"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72489-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92353134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factores predictivos del cumplimiento del tratamiento diario con raloxifeno y alendronato","authors":"C. Turbi ,&nbsp;M. Casillas ,&nbsp;M.A. Leal Muro ,&nbsp;S. García ,&nbsp;J. Tornero ,&nbsp;J.L. Calatayud Carretero","doi":"10.1016/S1132-8460(08)72487-5","DOIUrl":"10.1016/S1132-8460(08)72487-5","url":null,"abstract":"<div><p>El cumplimiento del tratamiento prescrito para la osteoporosis a menudo es inadecuado en la práctica clínica. El objetivo de este análisis fue evaluar los factores predictivos asociados con el cumplimiento del tratamiento diario con raloxifeno y alendronato en la práctica clínica. La influencia de diferentes factores se evaluó como un objetivo secundario en un estudio comparativo, abierto, multicéntrico, con un período de seguimiento de 12 meses. Se incluyeron 902 mujeres posmenopáusicas. Únicamente dos de las variables analizadas se mostraron como predictivas del cumplimiento terapéutico: el tratamiento prescrito (68,7% en las pacientes tratadas con raloxifeno frente al 54,0% en las tra -tadas con alendronato; p<!--> <!-->&lt;<!--> <!-->0,00019) y el tipo de especialidad médica (66,7% de aquellas tratadas por reumatólogos frente al 57,5% en las tratadas por traumatólogos; p<!--> <!-->&lt;<!--> <!-->0,0059). La especialidad del médico y la elección del tratamiento constituyen probablemente el enfoque principal para el problema del cumplimiento terapéutico.</p></div><div><p>Patient compliance to prescribed osteoporosis treatment is often poor in clinical practice and reasons for non-compliance are multifactorial. The aim of this analysis was to evaluate predictive factors associated with compliance to daily treatment with raloxifene and alendronate in clinical practice. The influence of different factors upon the degree of treatment compliance was evaluated as a secondary objective in a comparative, multicentre, open-label study with a 12-month follow-up period. Nine hundred and two postmenopausal women were included in the study. Only two of the variables were found to be predictive of treatment compliance: type of treatment (68,7% of patients administered raloxifene, versus 54,0% treated with alendronate; p<!--> <!-->&lt;<!--> <!-->0.00019) and the type of medical specialist attended (66,7% of the patients treated by rheumatologists, versus 57,5% treated by orthopaedic surgeons; p<!--> <!-->&lt;<!--> <!-->0.0059). The speciality of the physician and the selection of appropriate treatment for each patient are probably the primary approach to the issue of treatment compliance.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 5","pages":"Pages 87-93"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72487-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116993719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grado de conocimiento de la osteoporosis en mujeres posmenopáusicas","authors":"G. Graña ,&nbsp;R. Miguélez ,&nbsp;G. Herrero-Beaumont ,&nbsp;J.C. Acebes ,&nbsp;A. Torrijos ,&nbsp;C. Turbí ,&nbsp;M. Casillas","doi":"10.1016/S1132-8460(08)72482-6","DOIUrl":"10.1016/S1132-8460(08)72482-6","url":null,"abstract":"<div><p>En enfermedades asintomáticas como la osteoporosis es especialmente importante que las pacientes conozcan la enfermedad, sus tratamientos y las pautas de vida necesarias para prevenir de ese modo las posibles fracturas y sus consecuencias. En un estudio observacional, prospectivo, multicéntrico, comparativo y abierto de 12 meses de duración para evaluar el cumplimiento, como objetivo secundario del estudio se analizó el grado de conocimiento de la enfermedad mediante la prueba de Batalla, modificada para la osteoporosis. Los resultaron mostraron que, globalmente, el 49,3% de las pacientes tenía un conocimiento aceptable de la enfermedad, el 14,3% medianamente aceptable y en un 36,5% era inaceptable. Por tanto, si bien el grado de conocimiento de la osteoporosis en mujeres posmenopáusicas españolas fue aceptable, el conocimiento de esta enfermedad es todavía deficiente en más del 50%, por lo que es necesario continuar aumentando el conocimiento de la enfermedad en esta población.</p></div><div><p>In asymptomatic diseases such as osteoporosis, it is especially important for the patients to know about the disease, its treatment and the life guidelines necessary to prevent this method of possible fractures and their consequences. In an observational, prospective, multicenter, comparative and open label 12 month long study to evaluate compliance, as a secondary objective of the study, grade of knowledge of the disease was evaluated to study compliance using the Batalla test, modified for osteoporosis. The results showed that, overall, 49.3% of the patients had acceptable knowledge about the disease, 14.3% somewhat acceptable and 36.5% unacceptable knowledge. Thus, although the grade of knowledge on osteoporosis in postmenopausal Spanish women was accepted, knowledge on osteoporosis is still deficient in more than 50%. Thus, it is necessary to continue to increase knowledge about the disease in this population.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 4","pages":"Pages 71-75"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72482-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126815732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adecuación del manejo clínico de la osteoporosis a las guías de la SEIOMM. Estudio opinho-PC","authors":"A. Díez Pérez ,&nbsp;N. Guañabens Gay ,&nbsp;J. González Macías ,&nbsp;E. Jodar Gimeno ,&nbsp;M. Muñoz Torres ,&nbsp;E. Fuster Jensen ,&nbsp;En nombre del Grupo de Estudio Opinho-Pc","doi":"10.1016/S1132-8460(08)72480-2","DOIUrl":"10.1016/S1132-8460(08)72480-2","url":null,"abstract":"<div><h3>Objetivos</h3><p>Caracterizar el perfil clínico-demográfico y el manejo de la osteoporosis (OP) en Atención Primaria (AP) frente a las consultas hospitalarias (HO) y evaluar la adecuación del diagnóstico y el tratamiento (ADT) a las guías de la Sociedad Española de Investigación Ósea y Metabolismo Mineral (SEIOMM), 2001.</p></div><div><h3>Métodos</h3><p>Se trata de un estudio epidemiológico, transversal, multicéntrico de 407 pacientes (205 de AP/202 de HO) con OP.</p></div><div><h3>Resultados</h3><p>En las HO se observó mayor prevalencia de fracturas vertebrales previas al diagnóstico (24,4% en AP frente al 35,6% en HO; p<!--> <!-->=<!--> <!-->0,0132), mayor porcentaje de pacientes con OP secundaria y mayor grado de dependencia personal. Los pacientes en HO presentaron mayor uso de tratamiento hormonal sustitutivo (1,5% en AP frente al 5,4% en HO; p<!--> <!-->=<!--> <!-->0,0275) y suplementos de calcio y/o vitamina D (80,7% en AP frente al 93,0% en HO; p<!--> <!-->=<!--> <!-->0,0003). El cumplimiento terapéutico (CT) fue mayor en HO (3,4% frente al 10,6%, p<!--> <!-->=<!--> <!-->0,0074). La ADT a las guías de la SEIOMM fue elevada (&gt; 70%) en ambas consultas.</p></div><div><h3>Conclusiones</h3><p>Los pacientes con OP presentan más gravedad en HO. En ambos ámbitos hay un nivel alto de ADT, sin embargo, el CT es bajo.</p></div><div><h3>Objectives</h3><p>First, to characterize the clinical-demographical profile and therapeutic compliance of patients with osteoporosis (OP) in Primary Care (PC) and Hospitals (HO); second, to assess therapeutic and diagnosis compliance (TDC) of the SEIOMM guidelines, 2001.</p></div><div><h3>Methods</h3><p>Cross-sectional, epidemiological and multicenter study of 407 patients (205 PC/202 HO) with OP.</p></div><div><h3>Results</h3><p>In the hospital, a higher prevalence of vertebral fractures prior to the diagnosis (24.4% PC vs 35.6% HO, p<!--> <!-->=<!--> <!-->0.0132), higher percentage of patients with secondary OP and higher personal-dependence degree. HO patients showed more use of hormone replacement therapy (1.5% PC vs 5.4% HO, p<!--> <!-->=<!--> <!-->0.0275) and calcium supplement and/or vitamin D (80.7% PC vs 93.0% HO, p<!--> <!-->=<!--> <!-->0.0003). Treatment compliance (TC) was higher in HO (3.4% vs 10.6%, p<!--> <!-->=<!--> <!-->0.0074). TDC of SEIOMM guidelines was high (&gt; 70%) in both clinical settings.</p></div><div><h3>Conclusions</h3><p>HO OP patients show more severity. In both settings there is a high level of TDC. However, TC is low.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 4","pages":"Pages 59-65"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72480-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130562257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carta de presentación","authors":"M. Sosa Henríquez (Presidente de la SEIOMM)","doi":"10.1016/S1132-8460(08)72478-4","DOIUrl":"https://doi.org/10.1016/S1132-8460(08)72478-4","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 4","pages":"Page 54"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72478-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136556893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asociación de difosfonatos y vitamina D. ¿Avance terapéutico o argucia comercial?","authors":"I. Etxebarria Foronda","doi":"10.1016/S1132-8460(08)72485-1","DOIUrl":"10.1016/S1132-8460(08)72485-1","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 4","pages":"Pages 84-85"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)72485-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122319539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}