Revista del Laboratorio Clínico最新文献_第2页

Papel central del laboratorio en el diagnóstico de un caso de infiltración de sistema nervioso central por mieloma múltiple refractario 实验室在诊断顽固性多发性骨髓瘤中枢神经系统浸润病例中的中心作用

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.01.002

Miguel Aliste , Alex Larruzea , Vicente Aguadero , Luz Muñoz , María Elena Ramila , Eugenio Berlanga

{"title":"Papel central del laboratorio en el diagnóstico de un caso de infiltración de sistema nervioso central por mieloma múltiple refractario","authors":"Miguel Aliste , Alex Larruzea , Vicente Aguadero , Luz Muñoz , María Elena Ramila , Eugenio Berlanga","doi":"10.1016/j.labcli.2019.01.002","DOIUrl":"10.1016/j.labcli.2019.01.002","url":null,"abstract":"<div><p>Leptomeningeal involvement in multiple myeloma is a rare and serious complication that usually occurs after relapses of the disease. To establish a correct diagnosis, it is necessary to demonstrate, by cytology, the presence of clonal plasma cells in the cerebrospinal fluid.</p><p>The clinical laboratory detected this complication in a patient diagnosed with refractory multiple myeloma after analysing a cerebrospinal fluid sample. The patient suffered from several neurological symptoms, such as faecal incontinence and lower limb mobility limitation. Pleocytosis and proteinorachia was initially observed, along with high levels of high-fluorescence cells, which are sometimes associated with malignant cells. The protein electrophoresis and immunofixation of the cerebrospinal fluid confirmed the presence of the monoclonal component, already detected in blood. After processing the sample by flow cytometry it was confirmed that there was infiltration of malignant plasma cells in the central nervous system.</p><p>This laboratory played a central and essential role in the diagnosis of this uncommon complication, by the combined use of protein electrophoresis, immunofixation, flow cytometry, and the haematology autoanalyser. This latter included the high fluorescence cells as a promising biomarker in the screening for the presence of tumour cells in biological fluids.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85282559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estudio de la ferropenia en el laboratorio clínico 临床实验室缺铁的研究

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.01.004

D. Pérez Surribas , A. Gella Concustell , E. Cruz Iglesias , S. Hermoso Durán , E. Urrechaga Igartua , M.J. Alcaide Martín , A. Merino González

引用次数: 2

Recomendaciones para el mantenimiento de equipos en el Laboratorio de Andrología y Embriología. Segunda parte. Equipos auxiliares 对男科和胚胎学实验室设备维护的建议。第二部分。辅助设备

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2018.06.003

María Isabel Jiménez García, Joan de Monserrat Vallvé, José Manuel Moreno Cebeira, Tamara Rodríguez Pérez, María Cristina Sánchez Pozo

引用次数: 0

El final de una época 一个时代的结束

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.09.001

Jesús Molano

引用次数: 0

Recomendaciones para el diseño e implementación de un programa de aseguramiento de la calidad de la fase preanalítica 对分析前阶段质量保证方案的设计和实施提出建议

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.01.003

Itziar Marzana Sanz, Mercedes Ibarz Escuer, María Antonia Llopis Diaz, Nuria Barba Meseguer, María Jesús Alsina Kirchner, Débora Martínez Espartosa, Montserrat Ventura Alemany, Isabel Garcia del Pino Castro, Marta Segovia Amaro, Juan José Puente Lanzarote, Josep María Bauça Roselló, Andrea Caballero Garralda, Carolina Gómez Gómez, Ana García Alvarez, Virtudes Álvarez Funes, Ruben Gomez-Rioja (Presidente)

{"title":"Recomendaciones para el diseño e implementación de un programa de aseguramiento de la calidad de la fase preanalítica","authors":"Itziar Marzana Sanz, Mercedes Ibarz Escuer, María Antonia Llopis Diaz, Nuria Barba Meseguer, María Jesús Alsina Kirchner, Débora Martínez Espartosa, Montserrat Ventura Alemany, Isabel Garcia del Pino Castro, Marta Segovia Amaro, Juan José Puente Lanzarote, Josep María Bauça Roselló, Andrea Caballero Garralda, Carolina Gómez Gómez, Ana García Alvarez, Virtudes Álvarez Funes, Ruben Gomez-Rioja (Presidente)","doi":"10.1016/j.labcli.2019.01.003","DOIUrl":"10.1016/j.labcli.2019.01.003","url":null,"abstract":"<div><p>The quality assurance of the pre-analytical phase is oriented towards two key aspects; the management of pre-analytical errors from the perspective of patient safety, and the improvement and harmonisation of procedures, based on the application of regulations and professional recommendations. Like the rest of the phases, it should include an internal quality assurance program, as well as the participation in external quality assurance programs.</p><p>The internal quality control should mainly be based on the identification of risks, systematic detection of errors, and establishment of indicators. The selection of indicators prioritising the impact on the patient, the way to detect and record errors in a systematic and easily exploitable manner, and also the variables used in the calculations, are important aspects to measure the effectiveness of improvement actions and to allow comparability between laboratories. In this sense, the external quality assurance programs of the pre-analytical phase based on the comparison of indicators are a useful tool for the design and implementation of a quality assurance program.</p><p>This document is intended as a support for each laboratory to select, implement, and evaluate its own indicators, according to the individual characteristics of its pre-analytical procedures, but without losing sight of the harmonisation between laboratories.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91510023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Estrategia para el diagnóstico de las dislipidemias. Recomendación 2018 血脂异常的诊断策略。建议2018年

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.03.001

Beatriz Candás Estébanez , Miguel Pocoví Mieras , Carlos Romero Román , Juan Carlos Vella Ramírez , Margarita Esteban Salán , María José Castro Castro , Enrique Rodríguez García , Teresa Arrobas Velilla , Pilar Calmarza , José Puzo Foncillas

{"title":"Estrategia para el diagnóstico de las dislipidemias. Recomendación 2018","authors":"Beatriz Candás Estébanez , Miguel Pocoví Mieras , Carlos Romero Román , Juan Carlos Vella Ramírez , Margarita Esteban Salán , María José Castro Castro , Enrique Rodríguez García , Teresa Arrobas Velilla , Pilar Calmarza , José Puzo Foncillas","doi":"10.1016/j.labcli.2019.03.001","DOIUrl":"10.1016/j.labcli.2019.03.001","url":null,"abstract":"<div><p>Dyslipidaemias are alterations in lipid metabolism that involve an excess, as well as a deficit, in lipid concentrations. These alterations are strongly associated with atherosclerosis, and it has been shown that its control reduces the incidence of episodes of ischaemic origin. Diagnosing dyslipidaemias from an aetiological point of view is very important, since the cardiovascular risk to which each one predisposes is different, and depends on the type of lipoprotein that is altered and its concentration. For this reason, it is very useful to have simple diagnostic algorithms that include the measurements of lipid metabolism that are available in most clinical laboratories in order to make the initial diagnosis of the type of dyslipidaemia. In the case of having the right diagnostic tools, identify it; and if not, to have the appropriate information to recommend the extension of the study in another centre with resources to establish the diagnosis</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.labcli.2019.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91361350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Medición del contenido de selenio en especímenes biológicos: aplicación en el laboratorio clínico 生物标本硒含量的测量:在临床实验室的应用

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2018.08.001

Aránzazu Anadón Ruiz , Irene Palazón Bru , María Teresa Llorente Ballesteros , M. Jesús Gaspar Blázquez

引用次数: 2

Anomalías de la diferenciación sexual: a propósito de un caso 性别分化异常:关于一个案例

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2018.09.004

Ángeles Sánchez Herrero, Amaya Hernando Espinilla, Cristina Esteller Beltrán

引用次数: 0

Hallazgo casual mediante array de polimorfismo de nucleótido simple. Síndrome de Warkany 通过单核苷酸多态性阵列偶然发现。Warkany综合征

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.03.003

Álvaro Gragera Martínez , Pilar Carrasco Salas , Ana Cía González , Rosario Mateos Checa , Raquel Tena , Antonio León Justel

{"title":"Hallazgo casual mediante array de polimorfismo de nucleótido simple. Síndrome de Warkany","authors":"Álvaro Gragera Martínez , Pilar Carrasco Salas , Ana Cía González , Rosario Mateos Checa , Raquel Tena , Antonio León Justel","doi":"10.1016/j.labcli.2019.03.003","DOIUrl":"10.1016/j.labcli.2019.03.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Chromosome 8 trisomy, known as Warkany syndrome, is a rare genetic disease that has a very variable phenotype. Its main clinical characteristic is intellectual disability, dysmorphic facies, and deep plantar folds. The case is presented of a 10-year-old patient with gargoyle-like facies, mental retardation, and joint stiffness. The initial study of the karyotype, in which 20 metaphases were analysed, was normal. A single nucleotide polymorphisms (SNPs) array was requested from the laboratory.</p></div><div><h3>Results</h3><p>A complete gain of chromosome 8 was detected, which was interpreted as a mosaic trisomy 8 of approximately 20%, and which was compatible with the clinical presentation of the patient.</p></div><div><h3>Discussion</h3><p>This case shows the limitations of the analysis of only 20 metaphases in the karyotype in patients with mosaic aneuploidies. In these cases it would be recommended to extend the study to at least 30 metaphases in order to detect mosaicisms in low proportion.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74117560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuevas medidas de diagnóstico eficiente en la hipersensibilidad alérgica al látex 乳胶过敏性超敏反应有效诊断的新措施

Revista del Laboratorio Clínico Pub Date : 2019-10-01 DOI: 10.1016/j.labcli.2019.03.002

Angel San Miguel Rodríguez , Angel San Miguel Hernández , Sara Martín Armentia , Alicia Armentia Medina , Jesus Pachon , Rosario Pastor , Patricia Cabrero Lobato

{"title":"Nuevas medidas de diagnóstico eficiente en la hipersensibilidad alérgica al látex","authors":"Angel San Miguel Rodríguez , Angel San Miguel Hernández , Sara Martín Armentia , Alicia Armentia Medina , Jesus Pachon , Rosario Pastor , Patricia Cabrero Lobato","doi":"10.1016/j.labcli.2019.03.002","DOIUrl":"10.1016/j.labcli.2019.03.002","url":null,"abstract":"<div><p>Latex allergy is an altered response of the body on contact with proteins found in natural rubber latex. The symptoms of allergic hypersensitivity to latex are quite similar to those of food allergy, with the gastrointestinal symptoms being less frequent and the cutaneous ones being more typical after the use of latex and nasal gloves and / or the asthma after the inhalation of the dust from latex gloves or balloons.</p><p>In the case of very sensitive patients it can cause severe allergic reactions if it comes in contact with mucous membranes or internal cavities. There is a paradox that the hospital environment is the most risky place, given the existing amount of latex in direct and indirect use.</p><p>People who are allergic to latex often have cross-allergic reactions, sometimes severe, after eating certain fruits and vegetables. The cross-reactions are due to the common allergens present in latex and in different foods.</p><p>It is important to use molecular allergen analysis to detect false latex diagnoses due to problems of cross-reactivity with fruit proteins. It is indicated how these new tests have replaced less accurate and efficient analyses, achieving a considerable saving of resources.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73421422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0