Revista de Psiquiatría y Salud Mental (English Edition)最新文献

{"title":"Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic","authors":"Joaquim Radua , Lydia Fortea , Edith Pomarol-Clotet , Eduard Vieta , Miquel Àngel Fullana , Aleix Solanes","doi":"10.1016/j.rpsmen.2022.07.003","DOIUrl":"10.1016/j.rpsmen.2022.07.003","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 147-149"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient drop in the neutrophil count during COVID-19 regardless of clozapine treatment in patients with mental illness","authors":"Gabriel Vallecillo , Josep Marti-Bonany , Maria José Robles , Joan Ramón Fortuny , Fernando Lana , Victor Pérez","doi":"10.1016/j.rpsmen.2022.06.006","DOIUrl":"10.1016/j.rpsmen.2022.06.006","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 134-137"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal abnormalities, executive dysfunction and symptoms severity are modulated by COMT Val158Met polymorphism in first episode psychosis","authors":"Elisa Rodríguez-Toscano ,&nbsp;Kenia Martínez ,&nbsp;David Fraguas ,&nbsp;Joost Janssen ,&nbsp;Laura Pina-Camacho ,&nbsp;Bárbara Arias ,&nbsp;Eduard Vieta ,&nbsp;Gisela Mezquida ,&nbsp;Silvia Amoretti ,&nbsp;Miguel Bernardo ,&nbsp;Josefina Castro-Fornieles ,&nbsp;Manuel Jesús Cuesta-Zorita ,&nbsp;Antonio Lobo ,&nbsp;Ana González-Pinto ,&nbsp;Iluminada Corripio Collado ,&nbsp;Anna Mané ,&nbsp;Celso Arango ,&nbsp;Mara Parellada ,&nbsp;PEPs Group","doi":"10.1016/j.rpsmen.2022.07.001","DOIUrl":"https://doi.org/10.1016/j.rpsmen.2022.07.001","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Core dysfunctions proposed for psychotic disorders include prefrontal cortex (PFC) dopaminergic hypoactivity, executive function (EF) deficits and reduced gray matter in the PFC. The Val variant of </span><span><em>COMT</em></span> Val₁₅₈<span>Met polymorphism is associated with reduced dopaminergic signaling in the PFC. However, it is unclear how COMT Val</span>₁₅₈Met modulates PFC gray matter reduction, EF deficits and symptom severity at the time of the first psychotic episode.</p></div><div><h3>Methods</h3><p>The effect of COMT on both EF performance and prefrontal volume (PFC-VOL) was tested in 158 first episode psychosis (FEP) patients and 141 healthy controls (HC) matched for age (range 9–35 years), sex, ethnicity, handedness and COMT Val₁₅₈Met distribution. EF and PFC-VOL were compared between FEP and HC groups within each polymorphism status (Met/Met versus Val carriers) to assess whether COMT influenced diagnostic differences. Next, correlations between PFC-VOL and EF performance were computed, as well as between both variables and other clinical characteristics of interest (PANSS scores, PAS infancy and premorbid IQ) in the FEP sample.</p></div><div><h3>Results</h3><p>COMT influenced the diagnostic differences mainly in PFC-VOL, but also in EF performance. FEP-Val carriers showed lower EF scores and reduced PFC-VOL compared to the HC group but also poorer EF performance than FEP Met/Met. Poorer EF performance was associated with smaller PFC-VOL, and both were related to increased severity of negative symptoms, poorer premorbid adjustment, and lower estimated premorbid IQ in FEP patients.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that COMT Val₁₅₈Met polymorphism might contribute to PFC-VOL reductions, executive dysfunctions and symptom severity in FEP patients.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 74-87"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90012169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging correlates of insight in non-affective psychosis: A systematic review and meta-analysis","authors":"Pau Soldevila-Matías ,&nbsp;Georgios Schoretsanitis ,&nbsp;Diana Tordesillas-Gutierrez ,&nbsp;Manuel J. Cuesta ,&nbsp;Renato de Filippis ,&nbsp;Rosa Ayesa-Arriola ,&nbsp;Carlos González-Vivas ,&nbsp;Esther Setién-Suero ,&nbsp;Norma Verdolini ,&nbsp;Julio Sanjuán ,&nbsp;Joaquim Radua ,&nbsp;Benedicto Crespo-Facorro","doi":"10.1016/j.rpsmen.2022.06.007","DOIUrl":"10.1016/j.rpsmen.2022.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>Neurological correlates of impaired insight in non-affective psychosis remain unclear. This study aimed to review and meta-analyze the studies assessing the grey matter volumetric correlates of impaired insight in non-affective psychosis.</p></div><div><h3>Methods</h3><p>This study consisted of a systematic review of 23 studies, and a meta-analysis with SDM-PSI of the 11 studies that were whole-brain and reported maps or peaks of correlation of studies investigating the grey matter volumetric correlates of insight assessments of non-affective psychosis, PubMed and OVID datasets were independently reviewed for articles reporting neuroimaging correlates of insight in non-affective psychosis. Quality assessment was realized following previous methodological approaches for the ABC quality assessment test of imaging studies, based on two main criteria: the statistical power and the multidimensional assessment of insight. Study peaks of correlation between grey matter volume and insight were used to recreate brain correlation maps.</p></div><div><h3>Results</h3><p>A total of 418 records were identified through database searching. Of these records, twenty-three magnetic resonance imaging (MRI) studies that used different insight scales were included. The quality of the evidence was high in 11 studies, moderate in nine, and low in three. Patients with reduced insight showed decreases in the frontal, temporal (specifically in superior temporal gyrus), precuneus, cingulate, insula, and occipital lobes cortical grey matter volume. The meta-analysis indicated a positive correlation between grey matter volume and insight in the right insula (i.e., the smaller the grey matter, the lower the insight).</p></div><div><h3>Conclusion</h3><p>Several brain areas might be involved in impaired insight in patients with non-affective psychoses. The methodologies employed, such as the applied insight scales, may have contributed to the considerable discrepancies in the findings.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 117-133"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discontinuation of maintenance electroconvulsive therapy: Lessons learned from the COVID-19 pandemic","authors":"Erika Martínez-Amorós ,&nbsp;Pilar Serra ,&nbsp;Adriana Bassa ,&nbsp;Diego J. Palao ,&nbsp;Narcís Cardoner","doi":"10.1016/j.rpsmen.2022.07.004","DOIUrl":"10.1016/j.rpsmen.2022.07.004","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 154-155"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striatal volumes as potential biomarkers in Eating Disorders: A pilot study","authors":"Rosa M. Molina-Ruiz ,&nbsp;Jeffrey C.L. Looi ,&nbsp;Mark Walterfang ,&nbsp;Tomás García-Saiz ,&nbsp;Fiona A. Wilkes ,&nbsp;Lena L. Liu ,&nbsp;Dennis Velakoulis ,&nbsp;Jose Luis Carrasco Perera ,&nbsp;Marina Diaz-Marsa","doi":"10.1016/j.rpsmen.2022.06.003","DOIUrl":"10.1016/j.rpsmen.2022.06.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Differences in bulimic and impulsive behaviours in Eating Disorders (ED) have been associated with cortico-striatal circuit dysfunction at a neurobiological level. We sought to investigate neo-striatal volume as a biomarker in ED subgroups as well as the possible relationship with trauma history.</p></div><div><h3>Material and methods</h3><p>We studied 24 female patients: Anorexia Nervosa AN (<em>n</em> <!-->=<!--> <!-->8), Bulimia Nervosa BN (<em>n</em> <!-->=<!--> <!-->9), comorbid ED with borderline personality disorder (EDc; <em>n</em> <!-->=<!--> <!-->7), and a group of Healthy Controls (<em>n</em> <!-->=<!--> <span>19). Binge eating behaviours and impulsivity scales were used to characterize our sample as well as Trauma Questionnaires and Magnetic resonance imaging (MRI) volumetric manual measurements of caudate and putamen nuclei (striatum).</span></p></div><div><h3>Results</h3><p>Our preliminary results showed a significantly larger left putaminal volume in AN compared to the other three groups [C (<em>p</em> <!-->=<!--> <!-->0.008), BN (<em>p</em> <!-->&lt;<!--> <!-->.001) and EDc (<em>p</em> <!-->=<!--> <!-->.001)] and a smaller right putaminal volume in EDc compared to controls (<em>p</em> <!-->=<!--> <!-->.045) and AN (<em>p</em> <!-->=<!--> <!-->.039).</p><p>Some negative correlations were found between bilateral putaminal volumes and self-reported general and early traumatization scores.</p></div><div><h3>Conclusion</h3><p>This pilot study suggested that striatal volumes might differentiate AN from BN and EDc at a neurobiological level with implications for treatment strategies. Larger scale studies should be carried out that allow replication of these data.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 65-73"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making the most of biomarkers in psychiatry","authors":"Benedicto Crespo-Facorro","doi":"10.1016/j.rpsmen.2022.06.009","DOIUrl":"10.1016/j.rpsmen.2022.06.009","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 63-64"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the epidemiological studies of suicide in Spain conclusive?","authors":"Maite Santurtún ,&nbsp;Ana García Blanco","doi":"10.1016/j.rpsmen.2022.06.001","DOIUrl":"10.1016/j.rpsmen.2022.06.001","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 150-151"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirror image study (10 years of follow-up and 10 of standard pre-treatment) of psychiatric hospitalizations of patients with severe schizophrenia treated in a community-based, case-managed programme","authors":"Silvia Díaz-Fernández ,&nbsp;Danny Francisco Frías-Ortiz ,&nbsp;Juan José Fernández-Miranda","doi":"10.1016/j.rpsmen.2022.01.002","DOIUrl":"10.1016/j.rpsmen.2022.01.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To determine the psychiatric hospitalizations of patients with severe schizophrenia before (standard treatment in mental health centres) and during treatment in a comprehensive, community-based, case-managed programme, as well as the role played by antipsychotic medication (oral or long-acting injectable).</p></div><div><h3>Methods</h3><p>Observational, mirror image study of ten years of follow-up and ten retrospectives (‘pre-treatment’: standard), of patients with severe schizophrenia in a community-based programme, with pharmacological and psychosocial integrated treatment and intensive case management (N = 344). Reasons for discharge from the programme and psychiatric hospital admissions (and whether they were involuntary) were recorded ten years before and during treatment, as well as the antipsychotic medication prescribed.</p></div><div><h3>Results</h3><p>The retention achieved in the programme was high: after 10 years only 12.2% of the patients were voluntary discharges vs 84.3% on previous standard treatment. The number of patients with hospital admissions, and number of admissions due to relapses decreased drastically after entering the programme (<em>P</em> &lt; .0001), as well the involuntary admissions (<em>P</em> &lt; .001). Being on long-acting injectable antipsychotic medication was related with these results (<em>P</em> &lt; .0001).</p></div><div><h3>Conclusions</h3><p>Treatment of patients with severe schizophrenia in a comprehensive, community-based and case-managed programme achieved high retention rates, and was effective in drastically reducing psychiatric hospitalizations compared to the previous standard treatment in mental health units. Undergoing treatment with long-acting injectable antipsychotics was clearly linked to these outcomes.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 1","pages":"Pages 47-53"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173505022000024/pdfft?md5=b27bbc6a6b1fcb4e58de528ef8f00db5&pid=1-s2.0-S2173505022000024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39875556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative Symptoms: A Brief Story and Advances in Spain","authors":"William T. Carpenter Jr","doi":"10.1016/j.rpsmen.2022.02.001","DOIUrl":"https://doi.org/10.1016/j.rpsmen.2022.02.001","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 1","pages":"Pages 1-2"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2173505022000097/pdfft?md5=ef12ff6397450dcdb12c22142be69eb3&pid=1-s2.0-S2173505022000097-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91992894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}