Revista de Psiquiatría y Salud Mental (English Edition)最新文献

{"title":"Is intensive home-treatment a real alternative to classical hospitalization for managing acute psychiatric processes? Insights from clinical practice","authors":"Ana Martín-Blanco , Laura Calvo-Saiz , Jacopo Baccarin , Alba González-Fernández , Alejandro Keymer-Gausset , Sara Vieira-Costa , Núria Ribas-Fitó , Carles Garcia-Ribera","doi":"10.1016/j.rpsmen.2022.09.009","DOIUrl":"10.1016/j.rpsmen.2022.09.009","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 3","pages":"Pages 213-215"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10508729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of occupation on the incidence of vascular dementia: A 12-year follow-up cohort study","authors":"Ana Cristina Gracia-Rebled ,&nbsp;Raúl Lopez-Anton ,&nbsp;Concepción Tomás ,&nbsp;Elena Lobo ,&nbsp;Guillermo Marcos ,&nbsp;Antonio Lobo ,&nbsp;Javier Santabárbara","doi":"10.1016/j.rpsmen.2022.09.007","DOIUrl":"10.1016/j.rpsmen.2022.09.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Vascular dementia (DV) is the second cause of dementia with 15.8-20% of cases. Previous studies of the effect of occupation in DV do not show conclusive results, therefore, the objective was to analyze if the type of occupation can vary the risk of developing DV in those older than 55 years.</p></div><div><h3>Material and methods</h3><p><span><span>In the ZARADEMP project, a community sample of 4,803 individuals were followed longitudinally in four waves. The occupation was classified following the National Classification of Occupations (CNO-11) and the International Standard Classification of Occupations (ISCO-08). Different standardized instruments were used: the medical and psychiatric histories (History and Aetiology Schedule) and other risk factors (Mini-Mental Status Examination, </span>Geriatric Mental State-AGECAT). For this study, we calculated incidence rates, incidence rate ratios and hazard ratios in multivariate </span>Cox regression models, stratified by gender. For this study, we included 3,883 participants.</p></div><div><h3>Results</h3><p>In women, the risk of DV was doubled in <em>Blue-collar</em> workers, with a moderate effect (Cohen’s d<!--> <!-->=<!--> <!-->0.54) and multiplying by 2.7 in <em>Homeworks</em> respect to <em>White Collar</em> with a moderate effect (Cohen's d<!--> <!-->=<!--> <!-->0.77), although they did not reach statistical significance. We did not observe the effect of occupation on the risk of DV in men.</p></div><div><h3>Conclusions</h3><p>We have found a moderate but non-significant effect between occupation and DV risk in women. We found no effect of occupation on the risk of VD in males while other clinical factors (age, diabetes or body mass index) presented a clearer effect than the occupation.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 3","pages":"Pages 185-195"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33512348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ECT: A decision to decrease risks during COVID-19 pandemic","authors":"Miguel Martinez-Roig,&nbsp;Jose Alfonso Arilla-Aguilella,&nbsp;Maria Carmen Bono-Ariño,&nbsp;Raquel Rolando-Urbizu,&nbsp;Argia Arriola-Segura","doi":"10.1016/j.rpsmen.2021.04.002","DOIUrl":"10.1016/j.rpsmen.2021.04.002","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 137-139"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9331886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Another Godot who is still not coming: More on biomarkers for depression","authors":"Milena Čukić ,&nbsp;Danka Savić","doi":"10.1016/j.rpsmen.2022.07.005","DOIUrl":"10.1016/j.rpsmen.2022.07.005","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 153-154"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in urgent care for patients with an eating disorder during the COVID-19 pandemic in a Spanish province","authors":"María Irigoyen-Otiñano ,&nbsp;Ana González-Pinto ,&nbsp;Vicent Llorca-Bofí ,&nbsp;Marina Adrados-Pérez ,&nbsp;Laura Arenas-Pijoan ,&nbsp;Giovanni Torterolo ,&nbsp;Marta Sánchez-Cazalilla ,&nbsp;Esther Buil ,&nbsp;Eugènia Nicolau-Subires ,&nbsp;Carla Albert-Porcar ,&nbsp;Lucía Ibarra-Pertusa ,&nbsp;Margarita Puigdevall-Ruestes","doi":"10.1016/j.rpsmen.2022.07.002","DOIUrl":"10.1016/j.rpsmen.2022.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>The COVID-19 pandemic has had a great impact on people's mental health. Patients with eating disorders (ED) are also highly sensitive to the pandemic situation due to their physical and mental health. The objective of this study is to evaluate the impact that the COVID-19 pandemic may have had on the reasons for the urgent care of patients with an eating disorder, comparing the reasons for care with those from a previous period.</p></div><div><h3>Method</h3><p>We compared the visits to the emergency room and their characteristics before and after the pandemic of patients with an eating disorder in the province of Lleida. Information regarding sociodemographic status, reason for consultation, diagnosis, characteristics of suicidal behaviour, and other data were obtained from the electronic medical records.</p></div><div><h3>Results</h3><p>Within the total emergency attendances, eating disorders increased from 1.7% in the pre-pandemic period to 3.1% during the pandemic (<em>p</em> <!-->=<!--> <!-->0.030). Regarding the reason for consultation, a change in the pattern is observed, decreasing consultations for anxious decompensation (<em>p</em> <!-->&lt;<!--> <!-->0.001) and increasing suicidal behaviour (<em>p</em> <!-->=<!--> <!-->0.016) and behavioural disorder (<em>p</em> <!-->=<!--> <!-->0.022).</p></div><div><h3>Conclusions</h3><p>In our study we ascertained an increase in urgent care given to patients with an eating disorder during the two states of alarm, while consultations for anxiety symptoms decreased notably. However, care for suicidal behaviour increased, especially in women with comorbidity of personality disorders and who were unemployed.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 142-146"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9589717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 mortality and its relationship with internet searches on mental health during the first year of pandemic","authors":"Juan Antonio Becerra-García,&nbsp;Teresa Sánchez-Gutiérrez,&nbsp;Sara Barbeito Resa,&nbsp;Ana Calvo Calvo","doi":"10.1016/j.rpsmen.2022.06.002","DOIUrl":"10.1016/j.rpsmen.2022.06.002","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 140-142"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the effectiveness of electroconvulsive therapy through the determination of anaesthetic depth. Preliminary results","authors":"Òscar Alcoverro-Fortuny ,&nbsp;Ferran Viñas Usan ,&nbsp;Carmen Elena Sanabria ,&nbsp;José Emilio Rojo Rodes","doi":"10.1016/j.rpsmen.2021.07.004","DOIUrl":"10.1016/j.rpsmen.2021.07.004","url":null,"abstract":"","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 151-153"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT-1 knockdown in infralimbic cortex","authors":"M. Neus Fullana ,&nbsp;Verónica Paz ,&nbsp;Francesc Artigas ,&nbsp;Analia Bortolozzi","doi":"10.1016/j.rpsmen.2022.06.008","DOIUrl":"10.1016/j.rpsmen.2022.06.008","url":null,"abstract":"<div><h3>Objective</h3><p>Recently, we reported on a new MDD-like mouse model based on a regionally selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex (IL) which evokes widespread changes in mouse brain associated with the typical alterations found in MDD patients. To further characterize this new MDD-like mouse model, here we examine some transcriptional elements of glutamatergic/GABAergic neurotransmission and neuroplasticity in forebrain regions in the GLT-1 knockdown mice. Furthermore, we assess the acute ketamine effects on these transcriptional processes.</p></div><div><h3>Material and methods</h3><p>We used a small interfering RNA (siRNA) pool targeting GLT-1 mRNA to disrupt the GLT-1 transcription in mouse IL. Histological assays were performed to examine postsynaptic density protein-95 (PSD95), neuritin (NRN), glutamine acid descarboxilase-65 (GAD65), and GLT-1 mRNA expression in IL and hippocampus.</p></div><div><h3>Results</h3><p>Knockdown of GLT-1 in mouse IL leads to decreased expression of PSD95<span> and NRN neuroplasticity mRNAs in IL and hippocampus, which was reversed by an acute dose of ketamine antidepressant. Likewise, a single dose of ketamine also increased the mRNA levels of GAD65 and GLT-1 in IL of GLT-1 knockdown mice, reaching the basal values of control mice.</span></p></div><div><h3>Conclusions</h3><p>The glutamatergic neuronal hyperactivity and deficits in the GABA system resulting from siRNA-induced astroglial glutamate transporter knockdown in IL can compromise the integrity/plasticity of neurocircuits affected in MDD. Suitable depressive-like animal models to address the neurobiological changes in MDD are an unmet need and the development of the GLAST/GLT-1 knockdown mouse model may represent a better option to understand the rapid-acting antidepressant effects of ketamine.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 94-100"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40607497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The KDM6B mutation: Phenotype and clinical characteristics—Report of a case","authors":"Inmaculada Insa Pineda ,&nbsp;Cristina Luz Gómez González","doi":"10.1016/j.rpsmen.2022.06.005","DOIUrl":"10.1016/j.rpsmen.2022.06.005","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Alterations in the genes of lysine methylation as Lysine-specific demethylase 6B (KDM6B) have been associated with multiple neurodevelopmental disorders. Until now, there are few cases in the literature attributed to KDM6B mutations. This gap may be due to the fact that the </span>exome sequencing technique is still being implemented in routine clinical practice.</p></div><div><h3>Material and methods</h3><p>A case is presented with its clinical and phenotypic characteristics. The sequence exome analysis was done with the Nimblegen SeqCap EZ MedExome capture kit<!--> <!-->+<!--> <span>mtDNA 47Mb. The psychopathological approach from mental health was carried out through individual and family interviews, the Conner's questionnaires, ADHD rating scale, as well as the psychometry.</span></p></div><div><h3>Results</h3><p>A frameshift variant in the KDM6B gene related to neurodevelopmental disorders with facial and body dysmorphia was obtained. The case was oriented as a neurodevelopmental disorder secondary to a genetic alteration and a comorbid Attention Deficit Hyperactivity Disorder (ADHD).</p></div><div><h3>Conclusions</h3><p>The clinical peculiarities shared by patients identified with the KDM6B mutation, raises the need to recognize it as a particular entity. The possibility of applying the exome sequencing<span> technique to patients with syndromic phenotype and developmental impairment may clarify its etiopathogenesis. It is highly probable that the complexity of these cases requires an approach by a multidisciplinary team that includes genetics, neurology<span> and psychiatry, among other specialties. The coordinated approach is essential to have a comprehensive vision of the case.</span></span></p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 88-93"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40526634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies","authors":"Pau Soldevila-Matías ,&nbsp;Anton Albajes-Eizagirre ,&nbsp;Joaquim Radua ,&nbsp;Gracián García-Martí ,&nbsp;José M. Rubio ,&nbsp;Diana Tordesillas-Gutierrez ,&nbsp;Inmaculada Fuentes-Durá ,&nbsp;Aleix Solanes ,&nbsp;Lydia Fortea ,&nbsp;Dominic Oliver ,&nbsp;Julio Sanjuán","doi":"10.1016/j.rpsmen.2022.06.004","DOIUrl":"10.1016/j.rpsmen.2022.06.004","url":null,"abstract":"<div><h3>Introduction</h3><p>The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP.</p></div><div><h3>Methods</h3><p>Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines.</p></div><div><h3>Results</h3><p>Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolateral prefrontal cortex (6 studies), frontal lobe (8 studies), cingulate (6 studies) and insula (5 studies). The meta-analysis showed statistically significant hypoactivation in the left anterior insula, precuneus and bilateral striatum.</p></div><div><h3>Conclusions</h3><p>While the studies tend to highlight frontal hypoactivation during cognitive tasks in FEP, our meta-analytic results show that the left precuneus and insula primarily display aberrant activation in FEP that may be associated with salience attribution to external stimuli and related to deficits in perception and regulation.</p></div>","PeriodicalId":101104,"journal":{"name":"Revista de Psiquiatría y Salud Mental (English Edition)","volume":"15 2","pages":"Pages 101-116"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40509368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}