ChemPhotoChem最新文献_第8页

BOPHY Derivatives as Phototherapeutic Agents for the Photodynamic Inactivation of Microorganisms 作为光动力灭活微生物的光治疗剂的 BOPHY 衍生物

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-07-03 DOI: 10.1002/cptc.202400077

Claudia Chávez Hernández, Yohana B. Palacios, Edwin J. Gonzalez Lopez, Maribel Lopez, Edgardo N. Durantini, Andrés M. Durantini, Maximiliano L. Agazzi, Daniel A. Heredia

{"title":"BOPHY Derivatives as Phototherapeutic Agents for the Photodynamic Inactivation of Microorganisms","authors":"Claudia Chávez Hernández, Yohana B. Palacios, Edwin J. Gonzalez Lopez, Maribel Lopez, Edgardo N. Durantini, Andrés M. Durantini, Maximiliano L. Agazzi, Daniel A. Heredia","doi":"10.1002/cptc.202400077","DOIUrl":"10.1002/cptc.202400077","url":null,"abstract":"The improvement of photodynamic inactivation (PDI) significantly depends on the development of new families of photosensitizers (PSs). In this sense, three BOPHY derivatives (BP, BP-Br and BP-I) were synthetized, studied, and compared to assess their antimicrobial photodynamic properties. BP is an interesting fluorescent probe for cell imaging, while the halogenated analogs (BP-Br and BP-I) are excellent oxygen photosensitizing agents. BP compound presented a fluorescence quantum yield close unity and showed no reactive oxygen species (ROS) production. In contrast, BP-I did not show emission properties but exhibited a high production of ROS through both photodynamic mechanisms, generating singlet oxygen (type II) and superoxide radical anion (type I) under aerobic light irradiation. BP-Br presented an adequate balance between ROS production and emission properties. The photokilling action and the binding to bacterial cells of these macrocycles were evaluated in vitro against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli bacteria. Our results demonstrated that the halogenated BOPHY derivatives were effective PSs in inactivating MRSA using shorter irradiation periods. In addition, the antimicrobial action sensitized by these BOPHYs was potentiated by adding KI. The combination of halogenated BOPHY and KI led to a complete elimination of both Gram-positive and Gram-negative bacteria. Hence, BP-Br and BP-I prove to be potent broad-spectrum antimicrobial PSs. To the best of our knowledge, this is the first time that BOPHY derivatives have been applied to photokill pathogenic microorganisms.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoisomerization of Azobenzene Induced Generation of Hydrazobenzene Mediated by Diboron Ester 二硼酯介导的偶氮苯光异构化诱导肼的生成

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-07-02 DOI: 10.1002/cptc.202400085

Xinluo Song, Lingfeng Yin, Subin Hao, Yanqi Chen, Cheng Ma, Ming-De Li, Li Dang

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Theoretical and Experimental Evaluation of the Electronic Relaxation Mechanisms of 2-Pyrimidinone: The Primary UVA Absorbing Moiety of the DNA and RNA (6–4) Photolesion 2-Primidinone 电子弛豫机制的理论和实验评估：DNA 和 RNA (6-4) 光子的主要 UVA 吸收分子

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-07-01 DOI: 10.1002/cptc.202400070

Dr. Danillo Valverde, Dr. Sean J. Hoehn, Eduardo D. Koyanagui, Dr. Sarah E. Krul, Prof. Carlos E. Crespo-Hernández, Prof. Antonio Carlos Borin

{"title":"Theoretical and Experimental Evaluation of the Electronic Relaxation Mechanisms of 2-Pyrimidinone: The Primary UVA Absorbing Moiety of the DNA and RNA (6–4) Photolesion","authors":"Dr. Danillo Valverde, Dr. Sean J. Hoehn, Eduardo D. Koyanagui, Dr. Sarah E. Krul, Prof. Carlos E. Crespo-Hernández, Prof. Antonio Carlos Borin","doi":"10.1002/cptc.202400070","DOIUrl":"10.1002/cptc.202400070","url":null,"abstract":"The (6–4) photolesion is a key photodamage that occurs when two adjacent pyrimidine bases in a DNA strand bond together. To better understand how the absorption of UVB and UVA radiation by the 2-pyrimidinone moiety in a (6–4) lesion can damage DNA, it is important to study the electronic deactivation mechanism of its 2-pyrimidinone chromophore. This study employs theoretical (MS-CASPT2/cc-pVDZ level) and experimental (steady state and femtosecond broadband spectroscopic) methods to elucidate the photochemical relaxation mechanisms of 2-(1H)-pyrimidinone and 1-methyl-2-(1H)-pyrimidinone in aqueous solution (pH 7.4). In short, excitation at 320 nm leads to the population of the S1 1(ππ*) state with excess vibrational energy, which relaxes to the S1 1(ππ*) minimum in one picosecond or less. A trifurcation event in the S1 1(ππ*) minimum ensued, leading to radiative and nonradiative decay of the population to the ground state or the population of the long-lived and reactive T1 3(ππ*) state in hundreds of picoseconds. Collectively, the theoretical and experimental results support the idea that in DNA and RNA, the T1 3(ππ*) state of the 2-pyrimidinone moiety in the (6–4) lesion can further participate in photosensitized chemical reactions increasing DNA and RNA damage.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cptc.202400070","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141524063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Photothermal Effect and Fenton-Like Oxidation for Synergistic Removal of Fluoroquinolones Antibiotics under Near-Neutral Conditions 近中性条件下协同去除氟喹诺酮类抗生素的光热效应和芬顿类氧化作用

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-07-01 DOI: 10.1002/cptc.202400103

Lanya Jiao, Dr. Jiao Meng, Shujun Wang, Prof. Xuan Sun

引用次数: 0

Covalent Organic Frameworks: Synthesis and Applications for Photocatalysis 共价有机框架：光催化的合成与应用

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-27 DOI: 10.1002/cptc.202400131

Misbah Shahid, Dr. Aziz ur Rehman, Dr. Tayyaba Najam, Dr. Hammad Majeed, Dr. Marwan Shalash, Dr. Salah M. El-Bahy, Dr. Muhammad Sufyan Javed, Dr. Syed Shoaib Ahmad Shah, Dr. Muhammad Altaf Nazir

{"title":"Covalent Organic Frameworks: Synthesis and Applications for Photocatalysis","authors":"Misbah Shahid, Dr. Aziz ur Rehman, Dr. Tayyaba Najam, Dr. Hammad Majeed, Dr. Marwan Shalash, Dr. Salah M. El-Bahy, Dr. Muhammad Sufyan Javed, Dr. Syed Shoaib Ahmad Shah, Dr. Muhammad Altaf Nazir","doi":"10.1002/cptc.202400131","DOIUrl":"10.1002/cptc.202400131","url":null,"abstract":"Covalent organic frameworks (COFs), newly developed materials, exhibit considerable promise in the field of catalysis. COFs exhibit captivating catalytic characteristics, including thermal and chemical stability, customizable porosities, and the ability to place active sites flexibly with tunable functions. To establish a connection between structure and activity, this paper provides a thorough justification of the planned creation of covalent organic frameworks for photocatalysis, encompassing H2 production, carbon dioxide reduction, pollutants reduction and transformation of organic substances. We have investigated the catalytic sites that are active within covalent organic frameworks, encompassing the metals, molecular catalysts, and catalyst with single atom (SACs); the reactive skeleton/linkages; and the reactive pendant groups. This exploration aims to establish the benefits of using COF-based catalysts compared to traditional catalysts. Despite the new advantages, numerous difficulties have also been noted with regard to the future. The objective of this review is to make it easier to design COF-based composite materials for practical uses.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insight into Spectral Properties and Solvatochromic Behavior of [b]-Fused BODIPYs: Experimental and Computational Study 洞察 [b]-Fused BODIPYs 的光谱特性和溶色行为：实验和计算研究

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-26 DOI: 10.1002/cptc.202400074

Dr. Ksenia V. Ksenofontova, Artyom Yu. Shagurin, Evgeniy E. Molchanov, Dr. Alexander A. Ksenofontov, Dmitrii A. Sbytov, Yana E. Kalyamanova, Prof. Elena A. Danilova, Dr. Yuriy S. Marfin

{"title":"Insight into Spectral Properties and Solvatochromic Behavior of [b]-Fused BODIPYs: Experimental and Computational Study","authors":"Dr. Ksenia V. Ksenofontova, Artyom Yu. Shagurin, Evgeniy E. Molchanov, Dr. Alexander A. Ksenofontov, Dmitrii A. Sbytov, Yana E. Kalyamanova, Prof. Elena A. Danilova, Dr. Yuriy S. Marfin","doi":"10.1002/cptc.202400074","DOIUrl":"10.1002/cptc.202400074","url":null,"abstract":"Two π-extended derivatives of boron-dipyrromethene (BODIPY) – unsymmetrical benzo[b]-fused BODIPY 1 and symmetrical naptho[b]-fused BODIPY 2 – were synthesized. Spectroscopic and photophysical properties of the synthesized fluorescent dyes were investigated in various organic media. Both BODIPY 1 and BODIPY 2 distinguished by bathochromically shifted absorption and emission bands compared to their non-fused derivatives, while possessing green (526–543 nm) and red (664–708 nm) absorbance and fluorescence, respectively. Spectral characteristics of the investigated fluorescent dyes were found to be weakly depended on solvent polarizability in case of BODIPY 1 and greatly influenced by both solvent polarizability and dipolarity in case of BODIPY 2. Quantum chemical calculations were used to clarify the relationships between geometry/electronic structure and spectral properties/solvatochromic behavior of BODIPY 1 and BODIPY 2.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141523916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Efficacy of Photocaged β-Lapachone in Bacillus subtilis Biofilms 光笼化β-拉帕醌在枯草芽孢杆菌生物膜中的抗菌功效

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-26 DOI: 10.1002/cptc.202400164

Elyse Hudson, Christabel Faylinn, Ivonne R. Lopez-Miranda, Joshua N. Milstein, Dr. Andrew A. Beharry

{"title":"Antimicrobial Efficacy of Photocaged β-Lapachone in Bacillus subtilis Biofilms","authors":"Elyse Hudson, Christabel Faylinn, Ivonne R. Lopez-Miranda, Joshua N. Milstein, Dr. Andrew A. Beharry","doi":"10.1002/cptc.202400164","DOIUrl":"10.1002/cptc.202400164","url":null,"abstract":"With the rise of antibiotic resistance within clinical settings, combating the growth of microbial biofilms presents a unique challenge. Biofilm-inhabiting bacteria are embedded within a self-produced, protective matrix, which can reduce the efficacy of treatment. The naturally derived product β-lapachone is an appealing therapeutic agent that has been reported to inhibit biofilm growth. However, its off-target toxicity and poor metabolic stability pose a significant hurdle for its application in vivo. Using a photo-pharmacological approach via a coumarin-based photocage, the reactivity of β-lapachone can be tuned so it only becomes active once the photocage is removed. Here we report both the photo-uncaging efficiency and the effective inhibition concentration of photocaged β-lapachone within model Bacillus subtilis biofilms. Additionally, the mechanism of action is analyzed with results supporting catalase inhibition. This novel light-activatable anti-microbial has potential applications in medical settings to inhibit biofilm growth and provide synergistic treatment with traditional antibiotics.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cptc.202400164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141523915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of BiVO4@ NiCo2O3 Heterojunction to Promote Photocatalytic CO2 Reduction 构建 BiVO4@ NiCo2O3 异质结以促进光催化还原二氧化碳

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-26 DOI: 10.1002/cptc.202400152

Wenjie Fu, Guanhong Lu, Dr. Xiao Wang, Prof. Xiaofeng Xie, Prof. Jing Sun

引用次数: 0

Photocatalytic Functionalization of Alkenes Enabled by Polyfluoroaryl Migration 通过多氟芳基迁移实现烯烃的光催化功能化

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-19 DOI: 10.1002/cptc.202400159

Artem G. Savchenko, Mikhail O. Zubkov, Prof. Dr. Jinbo Hu, Prof. Dr. Alexander D. Dilman

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Photoelectrocatalytic Reduction of Nitrobenzene to Azobenzene by Using Ag Nanoparticles-Decorated Si Nanocone Arrays Photocathodes 使用银纳米颗粒装饰的硅纳米锥阵列光电阴极光电催化将硝基苯还原为偶氮苯

IF 3 4区化学

ChemPhotoChem Pub Date : 2024-06-11 DOI: 10.1002/cptc.202400099

Kai Zhang, Jiacheng Yu, Changzhou Ru, Dr. Lixuan Mu, Prof. Junjie Li, Prof. Wensheng Shi, Dr. Guangwei She

{"title":"Photoelectrocatalytic Reduction of Nitrobenzene to Azobenzene by Using Ag Nanoparticles-Decorated Si Nanocone Arrays Photocathodes","authors":"Kai Zhang, Jiacheng Yu, Changzhou Ru, Dr. Lixuan Mu, Prof. Junjie Li, Prof. Wensheng Shi, Dr. Guangwei She","doi":"10.1002/cptc.202400099","DOIUrl":"10.1002/cptc.202400099","url":null,"abstract":"Photoelectrocatalytic (PEC) reduction of nitrobenzene (NB) is an extremely promising technology for renewable energy utilization and conversion. PEC reduction of NB to produce higher-value azobenzene (AZB) instead of aniline (AN), which is now commonly reported, is not currently achievable. In this work, we fabricated Ag nanoparticles (AgNPs)-decorated silicon nanocone (SiNC) array photocathodes with which the PEC reduction of NB to azobenzene (AZB) was realized for the first time. The SiNC array structure constructed by cryogenic dry etching greatly improved the light absorption ability of the photoelectrode. Ag was chosen as the cocatalyst because of its larger potential difference for the NB reduction reaction and the competing side reaction hydrogen evolution reaction. The Schottky junction formed by AgNPs with Si facilitates the rapid extraction of photogenerated electrons to participate in the PEC reaction. Under the optimized conditions, the PEC reduction of NB was achieved with a conversion of more than 90 %, with the reduction products being mainly AZB (9 : 1 ratio of AZB to AN) as well as excellent stability. The present work provides a photoelectrode that highly selectively PEC reduction of NB to AZB, and also provides insights into the design and preparation of high-performance silicon-based photoelectrodes.","PeriodicalId":10108,"journal":{"name":"ChemPhotoChem","volume":"8 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0