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Maternal cerebral centralization of blood flow in pregnant women with specific gestational hypertension 特殊妊娠期高血压孕妇的母体脑血流集中
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.03.003
Glaucimeire Marquez Franco , Waldemar Naves do Amaral
{"title":"Maternal cerebral centralization of blood flow in pregnant women with specific gestational hypertension","authors":"Glaucimeire Marquez Franco ,&nbsp;Waldemar Naves do Amaral","doi":"10.1016/j.recli.2015.03.003","DOIUrl":"10.1016/j.recli.2015.03.003","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the occurrence of maternal brain centralization in pregnant women with specific gestational hypertension; to establish normal values of the ratio of the uterine artery with (mean and standard deviation) ophthalmic artery; to compare the ratio of uterine to the ophthalmic artery with normal and abnormal groups; and to establish the Receiver Operator Curve (ROC) for diagnosis of patients with specific hypertensive disease of pregnancy.</p></div><div><h3>Methods</h3><p>To achieve the proposed objectives a case–control study was carried out where the sample consisted of 178 pregnant patients divided into two groups. The control group included pregnant 83 pregnant normotensive women; a case group included 95 patients with clinical and laboratory diagnoses of specific gestational hypertension.</p></div><div><h3>Results</h3><p>Patients with preeclampsia had lower values than the patients who had eclampsia. The Doppler parameters that were statistically significant were those of the ratio of uterine artery with the ophthalmic artery (AU/AO) and vice versa. A comparison between the normal curve systole–diastole and the respective cut-off point was performed. A ROC is shown in the cut-off considering the systolic velocity, the diastolic velocity, the systole/diastole relation, and the index of resistance of the ophthalmic artery.</p></div><div><h3>Conclusion</h3><p>The maternal centralization in high risk pregnancies was observed when specific gestational hypertension is real. The normal curve has a mean and standard deviation of the relative Doppler of the uterine artery to the ophthalmic artery systolic/diastolic ratio was 0.43<!--> <!-->±<!--> <!-->0.16 for normal pregnant patients. Comparing the group of patients with normal pathological group of patients there was a statistically significant difference between them considering the relation of Doppler uterine artery with ophthalmic artery. The cut-off point was more sensitive, verified by ROC, which defines maternal brain centralization in patients with specific gestational hypertension as 0.57 for the Doppler systolic/diastolic ratio of the uterine artery compared with the ophthalmic artery, with 78% sensitivity and 13% false positive.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 19-24"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133678377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using ultrasound and Doppler ultrasound to assess vascular changes in pre-eclampsia and eclampsia: a systematic review 应用超声和多普勒超声评估子痫前期和子痫的血管改变:一项系统综述
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.04.002
Glaucimeire Marquez Franco , Marianne de Oliveira Falco , Waldemar Naves do Amaral
{"title":"Using ultrasound and Doppler ultrasound to assess vascular changes in pre-eclampsia and eclampsia: a systematic review","authors":"Glaucimeire Marquez Franco ,&nbsp;Marianne de Oliveira Falco ,&nbsp;Waldemar Naves do Amaral","doi":"10.1016/j.recli.2015.04.002","DOIUrl":"10.1016/j.recli.2015.04.002","url":null,"abstract":"<div><h3>Objectives</h3><p>This systematic review aimed to evaluate whether Doppler ultrasound of the ophthalmic artery and uterine artery, and ultrasound of flow-mediated dilation of the brachial artery, can be used to effectively assess vascular function in pregnant women without disease or other complications with pre-eclampsia and eclampsia to establish the most appropriate method for evaluating these diseases.</p></div><div><h3>Methods</h3><p>Two databases were searched for relevant articles: the National Library of Medicine (PubMed) and the Virtual Health Library. Articles published between 1989 and 2014 about Doppler ultrasound of the ophthalmic artery were retrieved; all articles published from 2000 to 2014 about using ultrasound to assess flow-mediated dilation of the brachial artery were retrieved; and for Doppler ultrasound of the uterine artery, only articles published between January 2013 and March 2014 were retrieved because the literature in this area is extensive.</p></div><div><h3>Results</h3><p>A total of 260 articles were retrieved; 32 were eligible for inclusion. There were 16 articles on using Doppler ultrasound to evaluate the ophthalmic artery and eight about using it to assess the uterine artery, and eight articles evaluated the use of ultrasound to assess flow-mediated dilation of the brachial artery.</p></div><div><h3>Conclusions</h3><p>Doppler ultrasound is useful in diagnosing pre-eclampsia and eclampsia in pregnant women; the use of this technique makes early intervention feasible, and thereby improves prognosis; and it reduces the morbidity and mortality of pregnant women and their newborns.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 33-41"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125143812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hirsutismo pós‐menopausa: caso clínico raro de hipertecose ovárica
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.03.004
Sílvia Fernandes, Ana Maçães, Filipa Nunes, Fernanda Geraldes, Fernanda Águas
{"title":"Hirsutismo pós‐menopausa: caso clínico raro de hipertecose ovárica","authors":"Sílvia Fernandes,&nbsp;Ana Maçães,&nbsp;Filipa Nunes,&nbsp;Fernanda Geraldes,&nbsp;Fernanda Águas","doi":"10.1016/j.recli.2015.03.004","DOIUrl":"10.1016/j.recli.2015.03.004","url":null,"abstract":"<div><p>Mild clinical signs of hyperandrogenism such as hirsutism may arise during the menopausal transition as part of the aging process. However, development of virilization may be interpreted as the presence a specific source of androgen excess.</p><p>66 year‐old menopausal woman, with a record of progressive hirsutism since menopausal age (50 years‐old) exacerbated over the past year. Episodes of metrorrhagia were not valued by the patient. Physical examination showed deepening of voice, frontotemporal alopecia, hirsutism in face, trunk and limbs and hypertrophy of the clitoris.</p><p>A transvaginal ultrasound revealed a thickened endometrium and enlarged ovaries considering her age and analytical study showed an increase of total testosterone (225ng/dL). No changes were detected at computerized tomography of adrenals and cerebral magnetic resonance. Performed an hysteroscopy with removal of endometrial polyp, associated to simple endometrial hyperplasia without atypia. The histological diagnosis after hysterectomy and bilateral salpingo‐oophorectomy, revealed a ovarian hyperthecosis. Six months after surgery it was observed a testosterone within the normal range, marked hirsutism reduction and alopecia improvement.</p><p>Diagnosis of hyperandrogenism in postmenopausal is a challenging task. Imaging techniques do not always reveal the source of excess androgens. The ovarian hyperthecosis treatment effectively improves hirsutism and reduces the risk of hormone‐dependent tumors.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 42-46"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114933151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Atualização das estimativas da magnitude do aborto induzido, taxas por mil mulheres e razões por 100 nascimentos vivos do aborto induzido por faixa etária e grandes regiões. Brasil, 1995 a 2013 按年龄组和主要区域分列的人工流产规模、每千名妇女的比率和每100名活产人工流产的比率的最新估计数。巴西,1995年至2013年
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.05.003
Mario Francisco Giani Monteiro , Leila Adesse , Jefferson Drezett
{"title":"Atualização das estimativas da magnitude do aborto induzido, taxas por mil mulheres e razões por 100 nascimentos vivos do aborto induzido por faixa etária e grandes regiões. Brasil, 1995 a 2013","authors":"Mario Francisco Giani Monteiro ,&nbsp;Leila Adesse ,&nbsp;Jefferson Drezett","doi":"10.1016/j.recli.2015.05.003","DOIUrl":"10.1016/j.recli.2015.05.003","url":null,"abstract":"<div><h3>Introduction</h3><p>Estimates of induced abortion in Brazil were inaccurate until the early 1990, varying between 300 million and 3.3 million clandestine abortions. In 2000, were estimated 22.3 abortions induced by 1000 women in Brazil, using the methodology proposed by the Alan Guttmacher Institute.</p></div><div><h3>Objective</h3><p>Update estimates of induced abortion in Brazil during the period of 1995 to 2013.</p></div><div><h3>Method</h3><p>The primary data source was the number of hospitalizations for abortion registered in the Hospital Information System of the Unified Health System, disaggregated by region and age group. The number of induced abortions has been estimated by interval upper limit, multiplying by five the number of hospitalizations, and by lower bound, by multiplying by four the number of hospitalizations. It was considered under percentage record of 12.5% and the proportion of miscarriages of 25%.</p></div><div><h3>Results</h3><p>Between 1995 and 2013, the hospitalizations of women from 10 to 49 years by complications from abortion decreased by 27% and the estimate of the annual number of induced abortions declined 26%. It was observed decline of upper limit of induced abortion ratio of 27/1000 women for 16/1000. The same was noticed for the lower bound of 21/12/1000 to 1000. In the two regions with the highest number of hospitalizations for complications of abortion, Northeast and Southeast, showed significant reduction in the number of cases of 35% and 27% respectively. Found a great reduction in the risk of induced abortion, of 43% between 15 and 29 years, 49% between 20 and 29 years old, 26% between 30 and 39 years and 50% of 40 to 49 years. The estimation of induced abortions decreased from 864,628 to 687,347 (lower limit), and from 1,086,708 to 865,160 (upper limit).</p></div><div><h3>Conclusion</h3><p>Both the reason of abortion per 100 live births and the rate of induced abortions per thousand women aged 15 to 49 years in Brazil showed decrease in the studied period.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 11-18"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.05.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114058496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Metastização uterina de carcinoma mamário – Relato de caso 乳腺癌子宫转移-病例报告
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.04.006
Sílvia Couto , Carla Antunes , Ana Cristina Vilhena , Luís Canelas , Ana Oliveira
{"title":"Metastização uterina de carcinoma mamário – Relato de caso","authors":"Sílvia Couto ,&nbsp;Carla Antunes ,&nbsp;Ana Cristina Vilhena ,&nbsp;Luís Canelas ,&nbsp;Ana Oliveira","doi":"10.1016/j.recli.2015.04.006","DOIUrl":"10.1016/j.recli.2015.04.006","url":null,"abstract":"<div><p>Metastatic disease involving the uterus is rare. Typically it is the ovaries that are involved and the primary tumor is usually the breast or the gastrointestinal tract.</p></div><div><h3>Case report</h3><p>We describe a case of metastatic breast carcinoma involving the uterus in a patient who had had a bilateral mastectomy due to invasive carcinoma NOS more than thirty years ago. Histological assessment of the hysteroscopy biopsy specimen including immunohistochemistry staining confirmed the breast carcinoma as the primary lesion, however it was classified as lobular carcinoma. The patient refused surgery or other invasive procedures, having complied nevertheless to follow up with clinical and ultrasound evaluation.</p></div><div><h3>Conclusion</h3><p>Metastatic breast disease to the feminine genital tract is more frequently due to lobular invasive carcinoma. We present a case of uterine metastization of invasive lobular carcinoma more than thirty years since the primary tumor, which was classified as invasive carcinoma NOS and confirmed by histological revision. It is of great importance to give the pathologist the correct information about the patient, namely of any oncologic background, so differential diagnosis can be made.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 47-50"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131342883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A quem interessa o Estatuto da Família? 谁关心家庭地位?
Reprodu??o & Climatério Pub Date : 2015-01-01 DOI: 10.1016/j.recli.2015.06.002
Jefferson Drezett
{"title":"A quem interessa o Estatuto da Família?","authors":"Jefferson Drezett","doi":"10.1016/j.recli.2015.06.002","DOIUrl":"10.1016/j.recli.2015.06.002","url":null,"abstract":"","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"30 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126731956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Segurança do uso da cabergolina na embriogênese e na gestação 卡麦角林在胚胎发生和妊娠中的安全性
Reprodu??o & Climatério Pub Date : 2014-09-01 DOI: 10.1016/j.recli.2015.03.001
Heloisa Carvalho de Morais , Aline Pinheiro Custódio , Eduardo Camelo de Castro , Waldemar Naves do Amaral , Eliane Souza Cruz , Sander Antônio Pereira da Silva
{"title":"Segurança do uso da cabergolina na embriogênese e na gestação","authors":"Heloisa Carvalho de Morais ,&nbsp;Aline Pinheiro Custódio ,&nbsp;Eduardo Camelo de Castro ,&nbsp;Waldemar Naves do Amaral ,&nbsp;Eliane Souza Cruz ,&nbsp;Sander Antônio Pereira da Silva","doi":"10.1016/j.recli.2015.03.001","DOIUrl":"https://doi.org/10.1016/j.recli.2015.03.001","url":null,"abstract":"<div><p>Cabergoline is a dopaminergic agonist and exhibits a suppression effect on prolactin. It is used to treat hyperprolactinemia in infertile patients and to prevent the ovarian hyperstimulation syndrome in vitro fertilization cycles.</p></div><div><h3>Objetive</h3><p>A systematic review on the literature looking for studies that evaluate the safety use of Cabergoline in the embryogenesis and in pregnancy.</p></div><div><h3>Method</h3><p>Systematic review of articles published in last 23 years that try to establish the relationship between the use of Cabergoline in the gestational period with a possible teratogenic effect. The papers were available in the following scientific databases: Medline, Lilacs e Scielo. The key words used were cabergoline, pregnancy and teratogen.</p></div><div><h3>Results</h3><p>Twelve articles published from 1994 to 2013 were selected. It has been found that 800 pregnant women were exposed to cabergoline. Most of the papers analysed showed that the cabergoline is a safety alternative for theconceptus and for the pregnancy outcome. Its use did not increase the risk of fetal malformation, miscarriage and premature birth.</p></div><div><h3>Conclusion</h3><p>Data regarding the use of cabergoline during pregnancy have become increasingly consistent, and most articles have demonstrated the reliability and safety of this drug.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"29 3","pages":"Pages 130-135"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92150196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anomalias fetais graves incompatíveis com a vida: devemos perguntar ao Gato de Cheshire qual caminho seguir? 与生命不相容的严重胎儿异常:我们应该问柴郡猫该走哪条路?
Reprodu??o & Climatério Pub Date : 2014-09-01 DOI: 10.1016/j.recli.2015.05.001
Jefferson Drezett
{"title":"Anomalias fetais graves incompatíveis com a vida: devemos perguntar ao Gato de Cheshire qual caminho seguir?","authors":"Jefferson Drezett","doi":"10.1016/j.recli.2015.05.001","DOIUrl":"https://doi.org/10.1016/j.recli.2015.05.001","url":null,"abstract":"","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"29 3","pages":"Pages 85-87"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92150197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Papel local dos androgênios no desenvolvimento de folículos pré‐antrais de primatas não humanos cultivados individualmente em matriz tridimensional 雄性激素在三维基质中单独培养的非人类灵长类窦前卵泡发育中的局部作用
Reprodu??o & Climatério Pub Date : 2014-09-01 DOI: 10.1016/j.recli.2015.05.002
Jhenifer Kliemchen Rodrigues , Paula Andrea de Albuquerque Salles Navarro , Mary Beth Zelinski , Richard L. Stouffer , Jing Xu
{"title":"Papel local dos androgênios no desenvolvimento de folículos pré‐antrais de primatas não humanos cultivados individualmente em matriz tridimensional","authors":"Jhenifer Kliemchen Rodrigues ,&nbsp;Paula Andrea de Albuquerque Salles Navarro ,&nbsp;Mary Beth Zelinski ,&nbsp;Richard L. Stouffer ,&nbsp;Jing Xu","doi":"10.1016/j.recli.2015.05.002","DOIUrl":"https://doi.org/10.1016/j.recli.2015.05.002","url":null,"abstract":"<div><h3>Objectives</h3><p>To evaluate the effects of ablation of steroid production and the role of testosterone and dihydrotestosterone in the development of secondary follicles of nonhuman primates (<em>Macaca mulatta</em>) in 3<!--> <!-->D matrix.</p></div><div><h3>Methods</h3><p>The ovarian cortex (n<!--> <!-->=<!--> <!-->8 adult females) was diced and secondary follicles were isolated and cultured individually for 40 days on alginate matrix. Experiment 1: Ablation of steroid production with use of trilostane (TRL) and testosterone replacement. Follicles of 4 animals were assigned to 4 groups: control (vehicle), TRL (TRL from the start of culture), Low testosterone (T) (TRL testosterone and 10<!--> <!-->ng/mL), high T (TRL testosterone and 50<!--> <!-->ng/mL); Experiment 2: Ablation of steroid production with use of trilostane (TRL) and replacement of dihydrotestosterone (DHT). Follicles of 4 animals were assigned to 4 groups: control (vehicle), TRL (TRL from the start of culture), DHT (DHT 50<!--> <!-->ng/mL), DHT<!--> <!-->+<!--> <!-->TRL (TRL and DHT 50<!--> <!-->ng/mL). It were analyzed: survival, growth, antrum formation, steroid hormone production, and degree of maturation and quality of oocytes.</p></div><div><h3>Results</h3><p>The percentage of surviving follicles in culture, growth and antrum formation was lower in the presence of TRL in all experiments, compared with the control group. Replacement of T and DHT in the presence of TRL, recovered survival, growth, antrum formation, hormone production, and the quality and maturity of oocytes comparable to the control group. DHT added to standard maturation media promoted an increase in the percentage of survival follicles and antrum formation compared to the control group.</p></div><div><h3>Conclusions</h3><p>This study provided evidence of the role of androgens since the beginning of folliculogenesis in primates, reinforcing the existence of molecular mechanisms regulating androgenic activity, and new interactions between androgens and steroid hormones. Our findings show that T and DHT can recover survival, growth, antrum formation, hormone production and oocyte viability of in vitro cultured preantral follicles exposed to ablation of steroid production. DHT added to standard maturation media promoted an increase in the percentage of follicle survival and antrum formation compared to the control group, opening perspectives to evaluate whether this androgen supplementation could improve follicular development in vitro. The knowledge obtained contribute to a understanding of the dynamics of folliculogenesis in primates, still poorly understood, and assists in identifying the optimal conditions for growing follicle, which may in future be applied to assist cancer patients who wish to preserve their future fertility</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"29 3","pages":"Pages 93-104"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92107186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Misoprostol for induction of second trimester abortion in pregnancies resulting from sexual violence: effectiveness analysis of a protocol applied in the Brazilian public health service 米索前列醇用于诱导因性暴力导致的妊娠中期流产:对巴西公共卫生服务部门适用的一项议定书的有效性分析
Reprodu??o & Climatério Pub Date : 2014-09-01 DOI: 10.1016/j.recli.2015.04.001
Jefferson Drezett , Maria Misrelma Moura Bessa , Daniela Pedroso , Ana Cristina Fernandes Silva , Luiz Henrique Gebrim , Raquel Molina de Vasconcellos , Luiz Carlos de Abreu
{"title":"Misoprostol for induction of second trimester abortion in pregnancies resulting from sexual violence: effectiveness analysis of a protocol applied in the Brazilian public health service","authors":"Jefferson Drezett ,&nbsp;Maria Misrelma Moura Bessa ,&nbsp;Daniela Pedroso ,&nbsp;Ana Cristina Fernandes Silva ,&nbsp;Luiz Henrique Gebrim ,&nbsp;Raquel Molina de Vasconcellos ,&nbsp;Luiz Carlos de Abreu","doi":"10.1016/j.recli.2015.04.001","DOIUrl":"https://doi.org/10.1016/j.recli.2015.04.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the effectiveness of misoprostol protocol on abortion of pregnancies resulting from sexual violence.</p></div><div><h3>Method</h3><p>Retrospective study with a convenience sample of 253 patients with pregnancy between 13 and 22 weeks of pregnancy who underwent legal abortion in the Hospital Pérola Byington, São Paulo, Brazil, between January 2008 and December 2014. Doses of misoprostol 400<!--> <!-->μg (13–17 weeks of gestation) and 200<!--> <!-->μg (18–22 weeks of gestation) were administered vaginally every 12<!--> <!-->h. The dose was doubled after two doses of no response and maintained for up to four days. In the absence of fetal expulsion, a second cycle of misoprostol was conducted after a 72-h pause. The failure of misoprostol was considered complete after two cycles without fetal elimination. The outcome was complete or incomplete fetal expulsion, evaluated in number of days and misoprostol dose required for abortion. Data were entered in Microsoft Excel 2010 program.</p></div><div><h3>Results</h3><p>The age ranged from 11 to 44 years of age, average 22.6<!--> <!-->±<!--> <!-->8.2 years of age, with the mean gestational age of 16.8<!--> <!-->±<!--> <!-->2.6 weeks. Abortion occurred in 248 cases (98.0%) with an average of 1468.8<!--> <!-->μg of misoprostol. The analysis of the dispersion of the total dose of misoprostol indicates no significant change with increasing gestational age (<em>y</em> <!-->=<!--> <!-->0.9475<em>x</em> <!-->+<!--> <!-->1453) (<em>R</em><sup>2</sup> <!-->=<!--> <!-->0.0001). The average induction time was 2.3 days and in 81.8% of the cases abortion occurred in the first 72<!--> <!-->h. Excessive and immediate uterine bleeding after fetal elimination was observed in 2.6% of the cases.</p></div><div><h3>Conclusion</h3><p>Misoprostol protocol used was effective and safe for second trimester abortion in pregnancy resulting from sexual violence.</p></div>","PeriodicalId":101073,"journal":{"name":"Reprodu??o & Climatério","volume":"29 3","pages":"Pages 105-111"},"PeriodicalIF":0.0,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.recli.2015.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92107184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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