Pharmaceutical Science Advances最新文献_第3页

The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer SPP1在骨质疏松、骨关节炎和癌症中的重要作用

Pharmaceutical Science Advances Pub Date : 2025-05-07 DOI: 10.1016/j.pscia.2025.100074

Yaru Qu , Shuixian Li , Huiyuan Luo , Junnan Li , Tong Wang , Xiuzhen Han

{"title":"The crucial role of SPP1 in osteoporosis, osteoarthritis, and cancer","authors":"Yaru Qu , Shuixian Li , Huiyuan Luo , Junnan Li , Tong Wang , Xiuzhen Han","doi":"10.1016/j.pscia.2025.100074","DOIUrl":"10.1016/j.pscia.2025.100074","url":null,"abstract":"<div><div>Osteopontin (OPN), also known as secreted phosphoprotein 1(SPP1), is a highly glycosylated and phosphorylated acidic protein, which is a multifunctional glycoprotein expressed in numerous cell types. SPP1 is involved in the attachment of osteoclasts to mineralized bone matrix, inflammatory reaction, cell recruitment, and tissue repair, and plays an important role in bone formation, fibrosis, immune diseases, and cancer. The role of SPP1 in osteoporosis, osteoarthritis and cancer is multi-faceted. While it holds potential therapeutic value, it also presents certain limitations. This review integrates the molecular structural characteristics of SPP1, including isoform variants and post-translational modifications, with its pathophysiological functions. It highlights the regulatory roles of SPP1 in these diseases: maintaining the dynamic balance between bone resorption and formation in osteoporosis, promoting cartilage degeneration and inflammation in osteoarthritis, and driving tumor progression in cancer through the activation of pathways such as PI3K/AKT/mTOR. Furthermore, SPP1 regulates tumor-associated macrophages and fibroblasts within the tumor microenvironment, thereby facilitating immune evasion and metastasis. The article also underscores the potential value of precisely modulating SPP1 activity in the treatment of osteoporosis and osteoarthritis and suggests a combined therapeutic strategy targeting SPP1, offering novel insights into overcoming the limitations of single-target cancer therapies.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GLDC interacts with VPS34 to inhibit tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma GLDC与VPS34相互作用抑制肝癌的肿瘤发生和上皮-间质转化

Pharmaceutical Science Advances Pub Date : 2025-04-25 DOI: 10.1016/j.pscia.2025.100072

Zan Song , Hao Dong , Kailing Zhang , Bingke Qiao , Leilei Li , Zhicheng Zhang , Zhili Fan , Jing Li , Yu Li , Mengfei Liu , Ying Liu , Xinyu Gu , Tao Zhang

{"title":"GLDC interacts with VPS34 to inhibit tumorigenesis and epithelial-mesenchymal transition in hepatocellular carcinoma","authors":"Zan Song , Hao Dong , Kailing Zhang , Bingke Qiao , Leilei Li , Zhicheng Zhang , Zhili Fan , Jing Li , Yu Li , Mengfei Liu , Ying Liu , Xinyu Gu , Tao Zhang","doi":"10.1016/j.pscia.2025.100072","DOIUrl":"10.1016/j.pscia.2025.100072","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancer with high mortality and limited therapeutic strategy. Glycine decarboxylase (GLDC) is the key limiting enzyme in glycine breakdown metabolism and acts as oncogene or tumor suppressor to impact tumor onset and progression in a context dependent manner. However, the underlying mechanism of GLDC on autophagy and progression is largely unexplored in HCC. Here, we showed that GLDC overexpression inhibited cell proliferation, cell migration and promoted cell senescence and autophagy in HCC. Intriguingly, induced GLDC remarkably attenuated epithelial-mesenchymal transition (EMT) progress and tumor growth <em>in vitro</em> and <em>in vivo</em>. Mechanically, we demonstrated that GLDC upregulated VPS34 protein and enhanced its interaction with VPS34, thus promoting the association of VPS34 with Beclin1/ATG14 complex and autophagy induction in HCC. Importantly, GLDC acetylation at K514 promoted interaction of GLDC-VPS34, whereas GLDC acetylation-dead mutant K514R abolished their binding. Furthermore, GLDC protein was decreased in HCC tissues compared with para-tumor tissues and reduced GLDC was significantly correlated with poor prognosis of patients. In conclusion, we unveil the key regulatory role of GLDC in autophagy and HCC progression through VPS34 and provide a potential strategy for HCC therapy.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of glutarimide-containing polyketides: Structures, bioactivities and their biosynthesis 含戊二酰亚胺多酮类化合物的研究进展：结构、生物活性及其生物合成

Pharmaceutical Science Advances Pub Date : 2025-04-23 DOI: 10.1016/j.pscia.2025.100071

Yanrong Shi , Chunhua Lu , Yuemao Shen

{"title":"Research progress of glutarimide-containing polyketides: Structures, bioactivities and their biosynthesis","authors":"Yanrong Shi , Chunhua Lu , Yuemao Shen","doi":"10.1016/j.pscia.2025.100071","DOIUrl":"10.1016/j.pscia.2025.100071","url":null,"abstract":"<div><div>Glutarimide-containing polyketides (GPs) are an important class of natural products with antifungal, antibacterial, antitumor and other biological activities. Generally, the structures have a six-membered ring of glutarimide (also known as 2,6-piperidinedione) and a polyketide side chain or a ring of varying lengths attached at C4 such as cycloheximide, 9-methylstreptimidone and migrastatin. Currently, at least 65 natural glutarimide antibiotics have been isolated and identified. The novel biosynthetic mechanism of the <em>trans</em>-AT PKS and multifaceted modes of action have promoted the progressive exploration of glutarimide-containing products. However, the related information on the aspects of new structure discovery, biological activity and biosynthesis of GPs is still not available. This review summarizes the current research from the aspects of new structure discovery, biological activity and biosynthesis, aiming to provide a reference for in-depth products mining and structure-activity relationship research. Special emphasis is placed on their potential as drug leads, particularly in cancer therapy, and the role of modern analytical techniques in their discovery and characterization.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100071"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial potentials and challenges of paracetamol: A comprehensive reassessment based on database reports 扑热息痛的抗菌潜力和挑战：基于数据库报告的综合再评估

Pharmaceutical Science Advances Pub Date : 2025-04-09 DOI: 10.1016/j.pscia.2025.100070

Muhammad Torequl Islam , Raihan Chowdhury , Md. Shimul Bhuia , Md. Sakib Al Hasan , Md. Showkot Akbor , Fardin Farhad , Carolina Bandeira Domiciano , Davi Antas e Silva , Henrique D.M. Coutinho

{"title":"Antimicrobial potentials and challenges of paracetamol: A comprehensive reassessment based on database reports","authors":"Muhammad Torequl Islam , Raihan Chowdhury , Md. Shimul Bhuia , Md. Sakib Al Hasan , Md. Showkot Akbor , Fardin Farhad , Carolina Bandeira Domiciano , Davi Antas e Silva , Henrique D.M. Coutinho","doi":"10.1016/j.pscia.2025.100070","DOIUrl":"10.1016/j.pscia.2025.100070","url":null,"abstract":"<div><div>Paracetamol (PMCL) is an analgesic-antipyretic drug. It is frequently used as an over-the-counter (OTC) drug in many countries around the world, especially for headaches, mild pain, and fever. Knowing its toxic effects on the nervous and hepatic systems, it has been combined with the psychoactive drug caffeine. However, PMCL's antipyretic action during fevers caused by various pathogens might be due to its antimicrobial power. Therefore, we have a question about whether PMCL can be used as an OTC medication or not. This review aimed to summarize the antimicrobial activity, facts behind it, possible action mechanisms, and causes of resistance growth, along with the antimicrobial and toxicological impacts of its metabolites, derived products, and combination products, on the basis of database reports. Numerous pieces of evidence suggest that both PMCL and caffeine have broad-spectrum antimicrobial effects. PMCL is evidently effective against gram-positive and gram-negative bacteria, fungi, viruses, and protozoa. Its major toxic metabolite, <em>N</em>-acetyl-p-benzoquinone imine (NAPQI), also has antimicrobial potential. Despite its antimicrobial effects, PMCL has contributed to antimicrobial resistance. In conclusion, according to the findings from database reports, PMCL is not only an analgesic-antipyretic drug, but it also has broad-spectrum antimicrobial potential against many pathogenic gram-positive and gram-negative bacteria and fungi as well as some viruses and protozoa. The use of PMCL as an OTC medication might bring a dangerous health issue in the future among the population, for example, growing microbial resistance and harmful toxicological impacts in different organs in humans.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100070"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microdynamic flowability for early API characterisation: A case study on Palbociclib 早期API表征的微动力流动性：帕博西尼的案例研究

Pharmaceutical Science Advances Pub Date : 2025-03-14 DOI: 10.1016/j.pscia.2025.100069

David Blanco , Nicolas Pätzmann , Pablo García-Triñanes

引用次数: 0

Nasal powder formulation employing microenvironmental pH-modifier for rapid absorption of mirtazapine 采用微环境ph改性剂快速吸收米氮平的鼻粉配方

Pharmaceutical Science Advances Pub Date : 2025-03-10 DOI: 10.1016/j.pscia.2025.100068

Kohei Yamada , Tsubasa Kihara , Kaori Shinsato , Hirofumi Yasui , Michihiro Shino , Hideyuki Sato , Satomi Onoue

{"title":"Nasal powder formulation employing microenvironmental pH-modifier for rapid absorption of mirtazapine","authors":"Kohei Yamada , Tsubasa Kihara , Kaori Shinsato , Hirofumi Yasui , Michihiro Shino , Hideyuki Sato , Satomi Onoue","doi":"10.1016/j.pscia.2025.100068","DOIUrl":"10.1016/j.pscia.2025.100068","url":null,"abstract":"<div><div>Antidepressant mirtazapine (MRZ) has been drawing attention in the management of delirium. However, oral use of MRZ could have drawbacks in onset of actions and ease of administration by caregivers. This study was the first attempt to develop nasal powder formulation (NP), an easily-administered formulation, of MRZ containing a microenvironmental pH-modifier for rapid dissolution and absorption. Ten mixtures of MRZ and counterions were tested in terms of the supersaturation level and stability to select a favorable pH-modifier. NP of MRZ (NP/MRZ) with the selected counterion was prepared by jet milling and characterized regarding physicochemical properties and pharmacokinetic (PK) behaviors after intranasal administration to rabbits. In phosphate buffer solution (PBS, pH5.6), glutamic acid (Glu) showed 10.7-fold supersaturation of MRZ, with the value being the highest among the ten counterions tested. The addition of Glu led to no significant change in the photostability or chemical stability of MRZ compared with crystalline MRZ. NP/MRZ with Glu (NP/MRZ-E) consisted of microcrystals of MRZ and Glu attached to lactose carriers, and over 93% of MRZ was emitted from a capsule in Jetlizer™. Both NP/MRZ-E and NP/MRZ exhibited enhanced dissolution in PBS compared with crystalline MRZ, and more rapid dissolution was observed for NP/MRZ-E. In rabbits, a crushed MRZ tablet (3 mg-MRZ/kg, <em>p.o.</em>) exhibited a time to maximum plasma concentration (<em>T</em><sub>max</sub>) and bioavailability (BA) of 72 min and 10%, respectively. NP/MRZ-E (0.3 mg-MRZ/kg, <em>i.n.</em>) showed <em>T</em><sub>max</sub> of <5 min with BA of 93%, and this result might be due to rapid dissolution/permeation in nasal mucosa and avoidance of the hepatic first-pass effect. In conclusion, NP employing a microenvironmental pH-modifier would be a promising dosage form of MRZ to offer rapid nasal absorption.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanodispersion of lutein with use of metastable polymorph for improved dissolution and oral absorption 利用可蜕变多晶体对叶黄素进行纳米分散，以提高溶解度和口服吸收率

Pharmaceutical Science Advances Pub Date : 2025-03-04 DOI: 10.1016/j.pscia.2025.100067

Kodai Ueno, Monami Sugihara, Tetsuya Matsushita, Kohei Yamada, Hideyuki Sato, Satomi Onoue

{"title":"Nanodispersion of lutein with use of metastable polymorph for improved dissolution and oral absorption","authors":"Kodai Ueno, Monami Sugihara, Tetsuya Matsushita, Kohei Yamada, Hideyuki Sato, Satomi Onoue","doi":"10.1016/j.pscia.2025.100067","DOIUrl":"10.1016/j.pscia.2025.100067","url":null,"abstract":"<div><div>Lutein (LT) is an attractive nutrient for eye health, although it has low water solubility and poor oral absorption. The present study aimed to develop a novel nanodispersion (ND) of LT using a metastable polymorph, offering improved oral absorption of LT. A metastable crystalline form of LT (LT-II) and hydroxypropyl cellulose were subjected to wet-milling followed by freeze-drying to obtain the ND of LT-II (ND/LT-II), and its physicochemical, photochemical, and pharmacokinetic properties of LT samples were evaluated. The mean particle size of LT-II in ND/LT-II was 354 nm, and there was no significant change in the crystalline form of LT-II, even after wet milling and freeze-drying. LT generated significant amounts of superoxide anions upon exposure to pseudo-sunlight (250 W/m<sup>2</sup>), indicating high photoreactivity. After irradiation with pseudo-sunlight (250 W/m<sup>2</sup>, 30 min), the percentages of LT remaining in the LT solution, amorphous LT, and ND/LT-II were 75, 79, and 92%, respectively. LT-II dissolved slightly faster than the stable crystalline form of LT (LT-I) in the dissolution media. ND/LT-II further improved the dissolution property of LT-II, and the dissolved amount of LT was 137- and 7.2-fold higher than that of LT-I and LT-II, respectively, at 2 h after dispersion in water. After administration of LT samples (100 mg-LT/kg), systemic exposure to LT in the LT-I and LT-II was negligible, whereas a marked improvement in oral absorption was observed in the ND/LT-II groups. Thus, applying ND technology to LT-II may improve oral absorption, and thus the nutrient function of LT.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of tadalafil-loaded hydrogel: An in-vivo evaluation of wound healing activity 他达拉非负载水凝胶的制备和表征：伤口愈合活性的体内评估

Pharmaceutical Science Advances Pub Date : 2025-02-25 DOI: 10.1016/j.pscia.2025.100066

Anita Sadat Haji Seyed Javadi Pajouhi , Amir Larki-Harcheghani , Mojdeh Mohammadi , Sajjad Makhdoomi , Alireza Nourian , Katayoun Derakhshandeh

{"title":"Preparation and characterization of tadalafil-loaded hydrogel: An in-vivo evaluation of wound healing activity","authors":"Anita Sadat Haji Seyed Javadi Pajouhi , Amir Larki-Harcheghani , Mojdeh Mohammadi , Sajjad Makhdoomi , Alireza Nourian , Katayoun Derakhshandeh","doi":"10.1016/j.pscia.2025.100066","DOIUrl":"10.1016/j.pscia.2025.100066","url":null,"abstract":"<div><div>Tadalafil (TD) is a phosphodiesterase type 5 (PDE-5) inhibitor that has gained attention for its wound healing properties. In this study, a TD-loaded hydrogel was prepared and characterized, and its wound-healing efficacy was evaluated. After preparing the TD hydrogel, its physicochemical properties such as viscosity, pH, drug-loading capacity (DL%), <em>in vitro</em> release behavior, and stability were characterized. Moreover, <em>in vivo</em> studies were performed to evaluate hydroxyproline (HP) and the wound healing efficacy of 1, 1.5, 3% (w/w) TD hydrogels in New Zealand rabbits. Histopathological analysis was also performed using hematoxylin and eosin (H&E) staining. We successfully prepared a TD hydrogel with high stability. The results of the <em>in vivo</em> experiments on full-thickness wounds showed that the 1.5% TD hydrogel with a pH of 5.81 ± 0.421, viscosity of 12,435 ± 63, drug-loading capacity of 91.73 ± 1.482%, and drug release rate of 88% was superior to other formulations when HP level was increased, which decreased the time required for wound healing; this was corroborated by the histological analysis. Thus, the TD hydrogel formulation prepared in this study is a promising topical therapeutic agent for wound healing.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Garcioligantone J and K, a pair of epimeric caged-polyprenylated xanthonoids from Garcinia Oligantha, inhibit the growth of lung cancer cells through ER stress-mediated apoptosis Garcioligantone J和K是一对来自于Garcinia Oligantha的笼状聚戊烯基黄嘌呤类化合物，它们通过内质网应激介导的凋亡抑制肺癌细胞的生长

Pharmaceutical Science Advances Pub Date : 2025-02-21 DOI: 10.1016/j.pscia.2025.100065

Lingyu Li , Hao Zheng , Qingying Liu , Dongmei Ren

{"title":"Garcioligantone J and K, a pair of epimeric caged-polyprenylated xanthonoids from Garcinia Oligantha, inhibit the growth of lung cancer cells through ER stress-mediated apoptosis","authors":"Lingyu Li , Hao Zheng , Qingying Liu , Dongmei Ren","doi":"10.1016/j.pscia.2025.100065","DOIUrl":"10.1016/j.pscia.2025.100065","url":null,"abstract":"<div><div>Garcioligantone J and K (GLJ and GLK) are a pair of isomers isolated from <em>Garcinia Oligantha</em> Merr. Herein, we described the structure elucidation including the absolute configurations of GLJ and GLK, explored and compared their anti-cancerous effects and underlying mechanism in A549 and NCI-H292 cells. The results indicated that GLJ and GLK are two isomers with different configuration at C-12, they inhibited cell proliferation and induced apoptosis in two lung cancer cell lines with almost the same extent. The induction of apoptosis by GLJ and GLK was demonstrated by DAPI and annexin-V-FITC/PI staining. Further investigation revealed increased Bax/Bcl-2 ratio, cleaved caspase-3, caspase-9 and PARP, loss of mitochondrial membrane potential (MMP) in cells, indicating that GLJ and GLK induced mitochondrial apoptosis. Increased GRP78, p-eIF2α and GADD153 manifested that endoplasmic reticulum (ER) stress was induced by GLJ and GLK. Meanwhile, upregulated reactive oxygen species (ROS) level was found and GLJ and GLK-induced ER stress and apoptosis could be attenuated by ROS scavenger NAC. Apoptosis induced by GLJ and GLK also could be alleviated by ER stress inhibitor 4-PBA. These showed that GLJ and GLK-induced apoptosis was mediated by ER stress relied on ROS generation. The efficacy of GLJ and GLK on lung cancer cell proliferation was further demonstrated in a zebrafish xenograft model. Collectively, the absolute configurations of GLJ and GLK were identified and they exerted lethal effects on lung cancer cells to the same extent via ROS-ER stress-mitochondrial apoptosis signaling, suggesting that GLJ and GLK might be used as potential modulating agents in lung cancer treatments.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-walled carbon nanotubes sensors: Preparation and bio-application advances 单壁碳纳米管传感器的制备及其生物应用进展

Pharmaceutical Science Advances Pub Date : 2025-02-16 DOI: 10.1016/j.pscia.2025.100064

Xiaotong Chen , Difan Wang , Wenshuo Ding , Hengchang Zang, Lian Li

{"title":"Single-walled carbon nanotubes sensors: Preparation and bio-application advances","authors":"Xiaotong Chen , Difan Wang , Wenshuo Ding , Hengchang Zang, Lian Li","doi":"10.1016/j.pscia.2025.100064","DOIUrl":"10.1016/j.pscia.2025.100064","url":null,"abstract":"<div><div>Molecular recognition and detection are the main concerns in the field of biological analysis because they can be affected by various factors. Single-walled carbon nanotube (SWCNTs)-based optical biosensors have been applied in this field owing to their high sensitivity, good fluorescence stability, and tissue transparency. Purification of single-chiral SWCNTs and surface functionalization of SWCNTs are effective strategies for achieving real-time monitoring and high-throughput screening of biological analytes. Combining these technologies with microfluidic platforms and machine learning algorithms further broadens the application areas of sensors and enhances their analytical performance and usefulness in complex biological systems. Therefore, this review first discusses the preparation methods for single-chiral SWCNTs in recent years and introduces covalent and non-covalent functionalization techniques for SWCNTs, including oligonucleotide chains, peptides, and surfactant modifications. Subsequently, we systematically evaluate the applications of functionalized SWCNT biosensors for recognizing small molecules, including gas phase composition, neurotransmitters, and reactive oxygen species. These biosensors have been shown to have high sensitivity and specificity in the detection of a wide range of small molecules, offering a wide range of possibilities for analyzing volatile organic compounds, signaling molecules, and reactive oxygen species within biological systems, and providing new ways of gaining insights into the complex mechanisms of disease progression. Finally, we have analyzed the ability of SWCNT biosensors to recognize biomolecules in various categories, including proteins, nucleic acids, and lipids. Using these sensors for clinical disease diagnosis improves the accuracy and timeliness of diagnosis and opens up new ways to improve patients' prognosis and quality of life. We believe that SWCNT biosensors have great potential for future development in biomedicine.</div></div>","PeriodicalId":101012,"journal":{"name":"Pharmaceutical Science Advances","volume":"3 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0