Personalized Medicine Universe最新文献

{"title":"Safety and efficacy of a dietary supplement containing functional food ingredients for erectile dysfunction","authors":"Seika Kamohara M.D., Ph.D ,&nbsp;Masakatsu Kageyama ,&nbsp;Satoshi Sunayama M.D., Ph.D ,&nbsp;Kozo Denpo Ph.D","doi":"10.1016/j.pmu.2014.03.002","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.03.002","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Functional food<span> ingredients are widely used for erectile dysfunction. We conducted 2 clinical studies to evaluate the safety and efficacy of a commercialized dietary supplement containing </span></span><span><em>Panax </em><em>ginseng</em></span> C.A. Meyer extract, <em>Lepidium meyenii</em> root extract, yeast extract, egg white peptide, <em>Mucuna pruriens</em><span> extract, black ginger extract, polyphenol, </span><span>l</span>-arginine, <span>l</span>-carnitine, coenzyme Q₁₀<span>, vitamin E, black pepper extract, and zinc.</span></p></div><div><h3>Methods</h3><p><span>In the first study, after providing informed consent, 15 healthy men (mean age, 35.3 ± 1.9 years) participated. A dietary supplement, EDiSON was administered for 8 weeks. Adverse events were recorded daily. In the second study, 14 men diagnosed with mild-to-moderate erectile dysfunction participated in an 8-week randomized, double-blind, placebo-controlled study. They were assigned to the dietary supplement group (</span><em>n</em> = 8) or the placebo group (<em>n</em><span> = 6). The primary outcome was the quality of life, as assessed by the International Index of Erectile Function-5 (IIEF-5) questionnaire.</span></p></div><div><h3>Results</h3><p>All patients completed the studies. In the first study, the intake of the dietary supplement was not associated with any adverse events. In the second study, the intake of the supplement was associated with significant improvement of the IIEF-5 score at 4 weeks and at 8 weeks of the trial, compared to the baseline.</p></div><div><h3>Conclusion</h3><p><span>Our initial findings support the safety of the EDiSON dietary supplement. The results from the randomized, double blind, placebo-controlled trial support the use of the EDiSON dietary supplement for the treatment of mild-to-moderate erectile dysfunction. This study was registered at </span><span>http://www.umin.ac.jp</span><svg><path></path></svg>, as UMIN000009405.</p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 38-41"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mitochondrial DNA changes in prostate cancer progression","authors":"Masahiro Higuchi Ph.D.,&nbsp;Ara Kim,&nbsp;Cody C. Cook,&nbsp;Sara Prior,&nbsp;Akinobu Gotoh","doi":"10.1016/j.pmu.2014.03.005","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.03.005","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 57-58"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90131465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder","authors":"Kazutoyo Inanaga MD, PhD","doi":"10.1016/j.pmu.2014.02.004","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.02.004","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 46-48"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90131466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of refractory schizophrenia on using Amyloban®3399 extracted from Hericium erinaceum","authors":"Kazutoyo Inanaga ,&nbsp;Taketoshi Matsuki ,&nbsp;Yoshio Hoaki ,&nbsp;Koji Miki ,&nbsp;Akira Shigemoto ,&nbsp;Susumu Hirota ,&nbsp;Nobuhiro Mori ,&nbsp;Nobuyuki Hattori","doi":"10.1016/j.pmu.2014.04.002","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.04.002","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 49-53"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90131467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ethics of personalized medicine","authors":"Jack Kushner MD, MGA, FACS, FICS, FAANS, HDG","doi":"10.1016/j.pmu.2014.03.001","DOIUrl":"10.1016/j.pmu.2014.03.001","url":null,"abstract":"<div><p>Personalized medicine is that branch of medicine whereby a patient's treatment and prognosis are based on his genes. Recent genetic research explains the variations and similarities between humans, their diseases, and their responses to various treatments. Because governments and universities have not set strict standards, there are numerous tests and kits available to detect genetic problems. But are these kits accurate? The validity of some biomarkers is suspect.</p><p>The ethics of personalized medicine became an issue when some laboratory tests resulted in women incorrectly having been told that they have a high risk of breast or ovarian cancer when they did not. Ethical issues are not confined to the utilization of genetic information, but can be raised with the acquisition of human material for the advancement of knowledge. Whose genes are these? Who owns your DNA?</p><p>In the US, patients are given prenatal genetic advice upon which they can decide for themselves how to proceed. But in Russia, patients have no choice. The state makes most decisions. Selective breeding would be unacceptable in western countries.</p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 42-45"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88682212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum concentrations of diterpenoid alkaloids after oral administration of powdered processed aconite root","authors":"Hajime Nakae ,&nbsp;Yuji Fujita ,&nbsp;Shigeatsu Endo","doi":"10.1016/j.pmu.2014.04.001","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.04.001","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 54-56"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of refractory schizophrenia on using Amyloban®3399 extracted from Hericium erinaceum","authors":"K. Inanaga, Taketoshi Matsuki, Y. Hoaki, K. Miki, A. Shigemoto, Susumu Hirota, N. Mori, N. Hattori","doi":"10.1016/J.PMU.2014.04.002","DOIUrl":"https://doi.org/10.1016/J.PMU.2014.04.002","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"20 1","pages":"49-53"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85286210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging histopathological prognostic biomarkers in hepatocellular carcinomas","authors":"K. Yorita, Akinobu Ohno, H. Kataoka","doi":"10.1016/J.PMU.2014.03.006","DOIUrl":"https://doi.org/10.1016/J.PMU.2014.03.006","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"134 1","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89513720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of mitochondrial DNA changes in prostate cancer progression","authors":"M. Higuchi, A. Kim, C. C. Cook, Sara E. Prior, A. Gotoh","doi":"10.1016/J.PMU.2014.03.005","DOIUrl":"https://doi.org/10.1016/J.PMU.2014.03.005","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"1 1","pages":"57-58"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73139524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the business of genetic testing","authors":"Hirohiko Matsumoto M.D., Ph.D","doi":"10.1016/j.pmu.2014.05.001","DOIUrl":"10.1016/j.pmu.2014.05.001","url":null,"abstract":"","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 59-60"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83659404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}