Personalized Medicine Universe最新文献_第9页

Safety and efficacy of a dietary supplement containing functional food ingredients for erectile dysfunction 含有功能性食品成分的膳食补充剂治疗勃起功能障碍的安全性和有效性

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.03.002

Seika Kamohara M.D., Ph.D , Masakatsu Kageyama , Satoshi Sunayama M.D., Ph.D , Kozo Denpo Ph.D

{"title":"Safety and efficacy of a dietary supplement containing functional food ingredients for erectile dysfunction","authors":"Seika Kamohara M.D., Ph.D , Masakatsu Kageyama , Satoshi Sunayama M.D., Ph.D , Kozo Denpo Ph.D","doi":"10.1016/j.pmu.2014.03.002","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.03.002","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Functional food<span> ingredients are widely used for erectile dysfunction. We conducted 2 clinical studies to evaluate the safety and efficacy of a commercialized dietary supplement containing </span></span><span><em>Panax </em><em>ginseng</em></span> C.A. Meyer extract, <em>Lepidium meyenii</em> root extract, yeast extract, egg white peptide, <em>Mucuna pruriens</em><span> extract, black ginger extract, polyphenol, </span><span>l</span>-arginine, <span>l</span>-carnitine, coenzyme Q<sub>10</sub><span>, vitamin E, black pepper extract, and zinc.</span></p></div><div><h3>Methods</h3><p><span>In the first study, after providing informed consent, 15 healthy men (mean age, 35.3 ± 1.9 years) participated. A dietary supplement, EDiSON was administered for 8 weeks. Adverse events were recorded daily. In the second study, 14 men diagnosed with mild-to-moderate erectile dysfunction participated in an 8-week randomized, double-blind, placebo-controlled study. They were assigned to the dietary supplement group (</span><em>n</em> = 8) or the placebo group (<em>n</em><span> = 6). The primary outcome was the quality of life, as assessed by the International Index of Erectile Function-5 (IIEF-5) questionnaire.</span></p></div><div><h3>Results</h3><p>All patients completed the studies. In the first study, the intake of the dietary supplement was not associated with any adverse events. In the second study, the intake of the supplement was associated with significant improvement of the IIEF-5 score at 4 weeks and at 8 weeks of the trial, compared to the baseline.</p></div><div><h3>Conclusion</h3><p><span>Our initial findings support the safety of the EDiSON dietary supplement. The results from the randomized, double blind, placebo-controlled trial support the use of the EDiSON dietary supplement for the treatment of mild-to-moderate erectile dysfunction. This study was registered at </span><span>http://www.umin.ac.jp</span><svg><path></path></svg>, as UMIN000009405.</p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 38-41"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Personalized medicine-based strategy for prostate cancer 针对前列腺癌的个性化医疗策略

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/J.PMU.2014.03.007

A. Gotoh

引用次数: 4

Role of mitochondrial DNA changes in prostate cancer progression 线粒体DNA变化在前列腺癌进展中的作用

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.03.005

Masahiro Higuchi Ph.D., Ara Kim, Cody C. Cook, Sara Prior, Akinobu Gotoh

引用次数: 0

Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder 用猴头草化合物治疗后神经认知障碍的显著改善:复发性抑郁症的一个案例研究

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.02.004

Kazutoyo Inanaga MD, PhD

引用次数: 13

Improvement of refractory schizophrenia on using Amyloban®3399 extracted from Hericium erinaceum 猴头菌提取物Amyloban®3399对难治性精神分裂症的改善作用

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.04.002

Kazutoyo Inanaga , Taketoshi Matsuki , Yoshio Hoaki , Koji Miki , Akira Shigemoto , Susumu Hirota , Nobuhiro Mori , Nobuyuki Hattori

引用次数: 4

Improvement of refractory schizophrenia on using Amyloban®3399 extracted from Hericium erinaceum 猴头菌提取物Amyloban®3399对难治性精神分裂症的改善作用

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/J.PMU.2014.04.002

K. Inanaga, Taketoshi Matsuki, Y. Hoaki, K. Miki, A. Shigemoto, Susumu Hirota, N. Mori, N. Hattori

引用次数: 4

Serum concentrations of diterpenoid alkaloids after oral administration of powdered processed aconite root 口服炮制附子粉末后血清二萜生物碱浓度的变化

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.04.001

Hajime Nakae , Yuji Fujita , Shigeatsu Endo

引用次数: 1

Emerging histopathological prognostic biomarkers in hepatocellular carcinomas 新出现的肝细胞癌组织病理学预后生物标志物

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/J.PMU.2014.03.006

K. Yorita, Akinobu Ohno, H. Kataoka

引用次数: 1

Role of mitochondrial DNA changes in prostate cancer progression 线粒体DNA变化在前列腺癌进展中的作用

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/J.PMU.2014.03.005

M. Higuchi, A. Kim, C. C. Cook, Sara E. Prior, A. Gotoh

引用次数: 0

Syncope 晕厥

Personalized Medicine Universe Pub Date : 2014-07-01 DOI: 10.1016/j.pmu.2014.02.001

Howard J. Kline

{"title":"Syncope","authors":"Howard J. Kline","doi":"10.1016/j.pmu.2014.02.001","DOIUrl":"https://doi.org/10.1016/j.pmu.2014.02.001","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Syncope is a common clinical problem characterized by a transient, spontaneously self-terminating loss of consciousness with complete and prompt recovery, the cause of which is insufficiency of cerebral blood flow creating generalized anoxia, most commonly due to a transient fall of </span>systemic arterial pressure<span> to levels below those tolerated by the cerebrovascular autoregulation<span><span> mechanism. A thorough evaluation of the underlying cause of syncope is warranted in all patients to precisely diagnose the underlying mechanism or cause in order to provide the appropriate treatment of syncope since it is challenging for many reasons. The purpose of this review on syncope is to provide a thorough differential diagnosis as to the underlying cardiac and non-cardiac causes with methods of assessment of the specific causes. Knowledge of the specific cause, especially in the setting of structural heart disease or primary electrical cardiac disease, has an increased incidence of sudden death and overall mortality. It is also important to establish whether or not syncope is due to </span>orthostatic hypotension<span> since it is associated with a twofold increased mortality, whereas those individuals with neurally mediated syncope have an excellent prognosis.</span></span></span></p></div>","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"3 ","pages":"Pages 4-10"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pmu.2014.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90131468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0