Personalized Medicine Universe最新文献

A case of adverse skin reactions to coronavirus disease 2019 vaccine successfully treated with eppikajutsuto 冠状病毒2019疫苗成功治疗皮肤不良反应一例

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2021006

Koumei Kameyama, H. Nakae, Yasuhito Irie

引用次数: 0

Airway stenting using Ultraflex for central airway stenosis due to lung cancer: A case report 使用Ultraflex支架治疗肺癌中央气道狭窄1例

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2022001

N. Yamashita, Mao Takayama, T. So, H. Shimokawa, Masatoshi Yamaoka, T. Yoshimatsu, T. Oyama, A. Gotoh

引用次数: 0

The role of regenerative invariant NKT cells in cancer immunotherapy for head and neck cancer 再生不变性NKT细胞在头颈癌免疫治疗中的作用

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2022004

S. Motohashi

引用次数: 1

Dendritic Cell and Natural Killer cell stability for immunotherapy after long-term cryopreservation 树突状细胞和自然杀伤细胞长期冷冻保存后免疫治疗的稳定性

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2022007

Emiko Fukushima, Minako Abe, Ayaka Nagami, Yasuha Nakaseko, Hazuki Yamajo, Hitomi Chibana, H. Abe

引用次数: 0

Cytokine-induced Neurogenesis for Alzheimer's Disease and Frontotemporal Dementia 细胞因子诱导的阿尔茨海默病和额颞叶痴呆的神经发生

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2022006

T. Shirasawa, Luis Carlos Aguilar Cobos

引用次数: 1

Japanese herbal kampo medicine individually contributes to alleviating side effects of cancer patients 日本草药甘坡药单独有助于减轻癌症患者的副作用

Personalized Medicine Universe Pub Date : 2022-11-01 DOI: 10.46459/pmu.2022002

Y. Uezono, K. Miyano, Miki Nonaka

引用次数: 0

Association analysis between adverse drug reactions to cytarabine therapy and single nucleotide polymorphisms in cytarabine metabolic genes in patients with hematopoietic tumor 造血肿瘤患者阿糖胞苷治疗不良反应与阿糖胞苷代谢基因单核苷酸多态性的相关性分析

Personalized Medicine Universe Pub Date : 2021-12-01 DOI: 10.46459/pmu.2021002

Hozumi Tashima, Yuka Endo, Naoto Okada, S. Nakamura, K. Kagawa, S. Fujii, H. Miki, K. Ishizawa, M. Abe, Youichi Sato

{"title":"Association analysis between adverse drug reactions to cytarabine therapy and single nucleotide polymorphisms in cytarabine metabolic genes in patients with hematopoietic tumor","authors":"Hozumi Tashima, Yuka Endo, Naoto Okada, S. Nakamura, K. Kagawa, S. Fujii, H. Miki, K. Ishizawa, M. Abe, Youichi Sato","doi":"10.46459/pmu.2021002","DOIUrl":"https://doi.org/10.46459/pmu.2021002","url":null,"abstract":"Purpose: Cytarabine arabinoside (Ara-C) is an anti-metabolite that is commonly used as a therapeutic agent for acute leukemia; however, it can cause adverse drug reactions, such as digestive disorders, rashes, and fever. Therefore, identification of gene markers that can accurately predict the development of adverse drug reactions is useful for selecting effective drugs for therapy. After entering the cells, Ara-C is metabolized to Ara-C triphosphate, which inhibits DNA synthesis and exhibits antitumor activity. Therefore, we conducted an association study between the adverse reactions to cytarabine therapy and single nucleotide polymorphisms (SNPs) in cytarabine metabolic genes. Methods: Among the patients treated with cytarabine at the Department of Hematology at Tokushima University Hospital, 46 patients provided informed consent and were included in this study. We selected 14 tag SNPs located in nine genes that are involved in the cytarabine metabolic pathway; these SNPs were genotyped using the polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) technique. Association analyses between adverse reactions to AraC therapy and SNPs were performed using logistic regression analysis. Results: The rs9394992 polymorphism in the SLC29A1 gene and rs3886768 polymorphism in the DCTD gene were associated with the development of rash after Ara-C therapy. The rs7277 polymorphism in the DCTD gene was associated with fever, and the rs16945930 polymorphism in the ABCC11 gene was associated with sore throat. Conclusions: Our findings suggest that SNPs in the Ara-C metabolic genes influence the development of adverse reactions to Ara-C, and the results suggest that these genes can be predictive of adverse reactions to Ara-C therapy.","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82147912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Algorithms using genome-wide association studies for prediction of effectiveness of biologics in rheumatoid arthritis 使用全基因组关联研究预测类风湿关节炎生物制剂有效性的算法

Personalized Medicine Universe Pub Date : 2020-10-31 DOI: 10.46459/pmu.2019019

Marowa Hashimoto, K. Funahashi, T. Maeda, A. Sagawa, T. Izumihara, Eisuke Shono, H. Matsuno, K. Fukuda, S. Hayashi, R. Kuroda, T. Matsubara

{"title":"Algorithms using genome-wide association studies for prediction of effectiveness of biologics in rheumatoid arthritis","authors":"Marowa Hashimoto, K. Funahashi, T. Maeda, A. Sagawa, T. Izumihara, Eisuke Shono, H. Matsuno, K. Fukuda, S. Hayashi, R. Kuroda, T. Matsubara","doi":"10.46459/pmu.2019019","DOIUrl":"https://doi.org/10.46459/pmu.2019019","url":null,"abstract":"Purpose: Two anti-TNF biologics, infliximab and etanercept, are extremely useful for inflammatory diseases such as rheumatoid arthritis (RA). However, approximately 20 to 30% of RA have been described as non-responders. Here, we analyzed the statistical relationships of whole genome single nucleotide polymorphisms (SNPs) with remission or low disease activity (LDA) among RA and developed algorithms using SNPs to predict effectiveness of these biologics. Methods: The total study subjects (first, second and validation population for each infliximab and etanercept) were 260 RA patients for infliximab and another 251 RA patients for etanercept. Effectiveness of infliximab and etanercept was assessed using DAS28-CRP. In first, second and the combined population, relationships of 277,339 SNPs with remission and LDA were analyzed using case-control analyses by Fisher’s exact tests for each infliximab and etanercept. We picked up SNPs (P < 0.05) from each first, second and combined population. Then, 10 SNPs with lower P value in the combined population were selected from common SNPs among the first, second and combined populations. We developed algorithms using the 10 SNPs to predict effectiveness of infliximab and etanercept. In the validation population, availability of the algorithms was evaluated. Results: Using combined infliximab-remission and LDA algorithms in the validation population, the accuracy was 90.4%. Using combined etanercept-remission and LDA algorithms in validation population, the accuracy was 76.8%. Conclusions: The combined use of our two algorithms using SNPs may be very useful in the prediction of remission or LDA before treatment with infliximab or etanercept.","PeriodicalId":101009,"journal":{"name":"Personalized Medicine Universe","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85593086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immune resilience in the age of COVID-19 and beyond– A Lifestyle Medicine approach COVID-19时代及以后的免疫复原力——一种生活方式医学方法

Personalized Medicine Universe Pub Date : 2020-10-31 DOI: 10.46459/pmu.2020012

Minako Abe, H. Abe

引用次数: 0

Effect of belt electrode skeletal muscle electrical stimulation on psychological stress 带电极骨骼肌电刺激对心理应激的影响

Personalized Medicine Universe Pub Date : 2020-10-31 DOI: 10.46459/pmu.2019020

Kouki Tomida, H. Nakae

引用次数: 0