Polymer Chemistry最新文献

{"title":"Self-driving laboratory platform for many-objective self-optimisation of polymer nanoparticle synthesis with cloud-integrated machine learning and orthogonal online analytics†","authors":"Stephen T. Knox ,&nbsp;Kai E. Wu ,&nbsp;Nazrul Islam ,&nbsp;Roisin O'Connell ,&nbsp;Peter M. Pittaway ,&nbsp;Kudakwashe E. Chingono ,&nbsp;John Oyekan ,&nbsp;George Panoutsos ,&nbsp;Thomas W. Chamberlain ,&nbsp;Richard A. Bourne ,&nbsp;Nicholas J. Warren","doi":"10.1039/d5py00123d","DOIUrl":"10.1039/d5py00123d","url":null,"abstract":"<div><div>The application of artificial intelligence and machine learning is revolutionising the chemical industry, with the ability to automate and self-optimise reactions facilitating a step change in capability. Unlike small-molecules, polymer nanoparticles require navigation of a more complex parameter space to access the desired performance. In addition to the chemical reaction, it is desirable to optimise the polymer molecular weight distribution, particle size and polydispersity index. To solve this <em>many-objective</em> optimisation problem, a self-driving laboratory is constructed which synthesises and characterises polymer nanoparticles (incorporating NMR spectroscopy, gel permeation chromatography and dynamic light scattering). This facilitates the autonomous exploration of parameter space with programmable screens or AI driven optimisation campaigns <em>via</em> a cloud-based framework. The RAFT polymerisation of diacetone acrylamide mediated by a poly(dimethylacrylamide) macro-CTA was optimised to maximise monomer conversion, minimise molar mass dispersity, and target 80 nm particles with minimised polydispersity index. A full-factorial screen between 6- and 30-minutes residence time, between 68 and 80 °C and between 100 and 600 for the [monomer] : [CTA] ratio enabled mapping of the reaction space. This facilitated <em>in-silico</em> simulations using a range of algorithms – Thompson sampling efficient multi-objective optimisation (TSEMO), radial basis function neural network/reference vector evolutionary algorithm (RBFNN/RVEA) and multi objective particle swarm optimisation, hybridised with an evolutionary algorithm (EA-MOPSO), which were then applied to in-lab optimisations. This approach accounts for an unprecedented number of objectives for closed-loop optimisation of a synthetic polymerisation; and enabled the use of algorithms operated from different geographical locations to the reactor platform.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1355-1364"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/py/d5py00123d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoactive methylene blue-functionalized polymer for antimicrobial activation under red light†","authors":"Zeyu Shao ,&nbsp;Huanli Sun ,&nbsp;Edgar H. H. Wong","doi":"10.1039/d5py00068h","DOIUrl":"10.1039/d5py00068h","url":null,"abstract":"<div><div>This study presents the synthesis of a novel methylene blue acrylamide monomer and its incorporation into a diblock copolymer, , which exhibits potent antimicrobial activity against Gram-negative (<em>Escherichia coli</em>, <em>Pseudomonas aeruginosa</em>) and Gram-positive (<em>Staphylococcus aureus</em>) bacteria when photoirradiated under red light (<em>λ</em> = 630 nm). Mechanistic investigations revealed that singlet oxygen species, and not superoxides, are responsible for the antimicrobial activity, most likely by damaging cellular components such as proteins and DNA. The advantage of using red light as an external trigger because of its ability to penetrate skin and tissue is demonstrated here, where is still active against <em>E. coli</em> when irradiated through a cover of chicken skin. In terms of biocompatibility, is, significantly, 130 times more biocompatible than the original methylene blue dye. Overall, this study demonstrates the efficient modification of a red light-active photosensitiser into an antimicrobial macromolecule with improved biological properties for potential photodynamic applications in healthcare.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1373-1382"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/py/d5py00068h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chain folding of carbazole-donor containing polymers via a two-point interaction with naphthalene monoimide-based acceptors†","authors":"Arun Kumar Gayen ,&nbsp;S. Ramakrishnan","doi":"10.1039/d4py01234h","DOIUrl":"10.1039/d4py01234h","url":null,"abstract":"<div><div>Linear polymers carrying electron-rich dialkoxy-carbazole (DACBZ) units linked by flexible oligooxyethylene segments were induced into a zigzag folded state by an external folding agent, which carries two subunits: an electron-deficient dinitro-naphthalene monoimide (NMI(NO₂)₂) acceptor and an ammonium perchlorate unit. The ammonium unit of the folding agent interacts with the backbone oxyethylene segment and, in turn, brings two adjacent CBZ moieties on either side of the electron-deficient NMI(NO₂)₂ unit of the folding agent to induce a charge-transfer (CT) interaction; this two-point interaction was shown to be crucial for the stability of the pleated chain structure. An interesting, and potentially useful, feature of this system is the possibility to incorporate a pendant unit at the carbazole nitrogen (N) site; a variety of segments, such as linear, branched, or chiral alkyl chains, were installed to examine if the folding of the chain is influenced by the nature of the pendant segment. The formation of the pleated structure was studied by ¹H-NMR and UV-visible titration experiments; both these clearly revealed the presence of strong charge transfer (CT) interactions between the donor (D) and acceptor (A) units. The length of the spacer segment linking the NMI(NO₂)₂ acceptor unit and the ammonium group in the folding agent was varied, and it was seen that a 3-carbon spacer yielded the strongest cooperative interaction. To translate the folded conformation into the solid state, a solution of the donor polymer and the most efficient acceptor, taken in a 1 : 1 (D:A) ratio, was cast on a quartz plate. UV-visible studies of the film revealed the retention of the CT band; more importantly, immersing the film into an aqueous NaHCO₃ solution neutralized the ammonium group to generate the free amine. This caused an unexpected deepening of the colour, along with a hypsochromic shift of the CT band, suggesting that the free amine acceptor readjusts within the film to improve the CT interaction, exploiting the newly garnered freedom after de-coordination with the oligooxyethylene segment.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1345-1354"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of phenyl-substituted open-cage silsesquioxane-pendant polysiloxanes and their thermal and optical properties†","authors":"Miku Kosaka ,&nbsp;Kenji Kanaori ,&nbsp;Hiroaki Imoto ,&nbsp;Kensuke Naka","doi":"10.1039/d4py01460j","DOIUrl":"10.1039/d4py01460j","url":null,"abstract":"<div><div>We prepared phenyl-substituted corner-opened type polyhedral oligomeric silsesquioxanes (CO-POSSs) bearing tris(dimethoxysilyl)-groups with variable linker lengths at the opening vertex; that is, tris(dimethoxysilyl-ethyl-dimethylsiloxy)- and tris(dimethoxysilyl-propylthioethyl-dimethylsiloxy)-heptaphenyl-substituted CO-POSSs ( and ). Optically transparent free-standing films of phenyl-substituted open-cage silsesquioxane-pendant polysiloxanes () were prepared by optimizing the sol–gel reaction conditions for . Polycondensation of afforded an optically transparent and flexible phenyl-substituted CO-POSS-pendant polysiloxane film (). The polycondensations of and were fully completed even at 50 °C for 6 h under vacuum. ²⁹Si cross-polarization magic angle spinning (CP-MAS) NMR analysis suggests that the films included cyclotrisiloxane (D₃) and linear siloxane (D_linear) structures. The effects of the polysiloxane structures on the thermal and mechanical properties were studied. The highest temperature at which the sample lost 5 wt% of the original mass (<em>T</em>_d5) under N₂ (381 °C) was obtained for , even though it contained a flexible linker unit. The predominant linear siloxane structures may provide increase higher thermal stability. The UV-vis spectra of the resulting transparent films were mostly unchanged even after six days of exposure to UV irradiation in air. The present study shows that phenyl-substituted CO-POSS-pendant polysiloxanes represent alternative UV-resistant, optically transparent materials with higher heat resistance.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1365-1372"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/py/d4py01460j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and RAFT polymerisation of hydrophobic acrylamide monomers derived from plant oils†","authors":"Oliver J. Harris ,&nbsp;Peter Tollington ,&nbsp;Calum J. Greenhalgh ,&nbsp;Ryan R. Larder ,&nbsp;Helen Willcock ,&nbsp;Fiona L. Hatton","doi":"10.1039/d4py01100g","DOIUrl":"10.1039/d4py01100g","url":null,"abstract":"<div><div>Polymeric materials based on fatty acids (FAs) have a combination of characteristics (alkene groups, hydrophobicity, tuneable <em>T</em>_g) that give them great potential as renewable, high value materials. Here, we investigate the base catalysed transesterification of four different plant oils (high oleic sunflower, olive, hydrogenated coconut and hydrogenated rapeseed) with <em>N</em>-hydroxyethyl acrylamide. By conducting kinetics experiments, investigating potential side reactions and improving isolation of the target products, we were able to identify reactive impurities (radical inhibitors, unintended co-monomers) that were found to remain in the impure brine washed plant oil-based monomers (POBM). Kinetics experiments were then performed to investigate the RAFT polymerisation of these monomers. It was found that the more sustainable brine washing process was viable for the controlled radical polymerisation of the higher <em>k</em>_{p app} (saturated) monomers, however column purification was necessary for good control of unsaturated monomers. Polymers with values of <em>M</em>_n between 3000 and 12 000 g mol⁻¹ were synthesised and dependent on the FA source exhibited either amorphous or semi-crystalline behaviour (<em>T</em>_g values between −1 and 33 °C, <em>T</em>_m values between 48 and 66 °C). This work demonstrates the first example of RAFT polymerisation of acrylamide monomers derived from plant oils by a one step direct transesterification, opening the door for novel well-defined, functional bio-based polymers.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1321-1331"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/py/d4py01100g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acid-cleavable poly(oxazoline) surfactants†","authors":"Joseph A. Garcia ,&nbsp;Linglan Zhu ,&nbsp;Ashley Vergara Mendez ,&nbsp;Ellen M. Sletten","doi":"10.1039/d4py01166j","DOIUrl":"10.1039/d4py01166j","url":null,"abstract":"<div><div>The acidic tumor microenvironment and late endosomes present a promising target for stimuli-responsive nanotherapeutics. Acid-cleavable surfactants, particularly those with hydrazone linkages, offer enhanced stability outside the cell while enabling efficient intracellular payload release. Their acid-triggered cleavage and cationic byproducts facilitate endosomal escape, making them attractive for cancer nanomedicine. Herein, we report the synthesis of a new hydrazone-linked poly(oxazoline)-based diblock copolymer surfactant. This surfactant cleaves in a pH-dependent manner going from pH 7.4 down to pH 5.0, where after 21 h, 80% ± 3% of the hydrazone-linked polymer remained at pH 7.4 compared to 17% ± 2% at pH 5.0. We then demonstrate the ability of nanoemulsion encapsulated payloads to partition into cell membrane mimics only after cleavage of the surfactant. Through this system, we were able to increase the amount of payload release from 26% to 47% over 42 hours through pH changes. In all, this work demonstrates a viable route to create POx-based nanomaterials with controlled release capabilities in biologically relevant conditions and is a promising platform for advancing the endosomal escape and cancer targeting of nanomaterials.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1393-1399"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalable access to functional nylon 6 via ring-opening copolymerization of biobased δ-valerolactam with ε-caprolactam†","authors":"Yahui Mao ,&nbsp;Maosheng Li ,&nbsp;Youhua Tao","doi":"10.1039/d4py01406e","DOIUrl":"10.1039/d4py01406e","url":null,"abstract":"<div><div>Copolymerization of ε-caprolactam with functional lactam monomers was an effective strategy to introduce pendent substituents into nylon 6, which might endow these materials with improved processing properties, solubility, elasticity, and adhesion, while not compromising their inherent thermal and mechanical properties. However, the scalable synthesis of functional lactams remained extremely difficult due to their high raw material cost and/or cumbersome synthesis steps, making it difficult to meet the enormous market demand for nylon 6 materials. Herein, we introduced a new biobased δ-valerolactam monomer (3-(dimethylamino)-piperidone, ) derived from ornithine, which could efficiently copolymerize with ε-caprolactam to deliver functional nylon 6 polymers. Both monomer and copolymer synthesis proved straightforward and readily scalable. The resulting nylon 6 polymers exhibited comparable properties relative to their well-known commercial counterpart, including high thermal stability and crystallinity, suggesting that the incorporation of exerted minimal influence on the polymers’ inherent properties. Remarkably, the pendant dimethylamino group at the polyamide backbone could further convert into various functional structures by reacting with electrophiles, thereby providing a simple and versatile platform for the preparation of diverse functional nylon 6 materials towards broader applications.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1409-1417"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143486561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mixed-mode interpenetrating polymer networks from polymerizable eutectics†","authors":"Alexandra L. Mutch ,&nbsp;Stuart C. Thickett","doi":"10.1039/d4py01456a","DOIUrl":"10.1039/d4py01456a","url":null,"abstract":"<div><div>The preparation of interpenetrating polymer networks (IPNs) and semi-interpenetrating polymer networks (semi-IPNs) is reported <em>via</em> a solvent-free approach using a binary polymerizable eutectic. <em>N</em>-Isopropylacrylamide (NIPAM) and ε-caprolactone (CL) were mixed in various mole ratios to prepare viscous polymerizable liquids that were stable at room temperature, based on solid–liquid equilibrium phase diagrams from differential scanning calorimetry (DSC) data. The strong degree of association between NIPAM and CL within these mixtures was confirmed <em>via</em> 1D and 2D NMR spectroscopy. Using an appropriate UV photoinitiator and ring opening polymerization catalyst, the orthogonal polymerization (either in a sequential or simultaneous fashion) of each component within the eutectic was achieved, with enhanced reaction kinetics for the ring opening polymerization compared to a traditional solvent (DMSO). Through the incorporation of diacrylate and bis(carbonate) crosslinkers into the resin mixture, IPNs and semi-IPNs were realised in a one-pot two-step approach from polymerizable eutectics for the first time. These networks possessed thermoresponsive swelling behaviour in water, and retained their structural integrity in good solvents for both phases. This binary eutectic was also shown to be suitable as a resin for stereolithography 3D printing on a benchtop printer through the inclusion of a RAFT agent, achieving semi-IPN printed objects in a two-step approach.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1332-1344"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triblock architecture and PEG hydrophilic blocks enable efficient thermogelation of poly(2-phenyl-2-oxazine)-based worm-gels†","authors":"Anna-Lena Ziegler ,&nbsp;Andrew Kerr ,&nbsp;Florian T. Kaps ,&nbsp;Robert Luxenhofer","doi":"10.1039/d4py01345j","DOIUrl":"10.1039/d4py01345j","url":null,"abstract":"<div><div>Previously, the cooling-induced thermogelation of an amphiphilic ABA type triblock copolymer comprising a central poly(2-phenyl-2-oxazine) (pPheOzi) block flanked by hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks was reported. This process is based on an unusual, cooling-induced transition in polymer self-assembly from spherical to worm-like micelles, for which the PheOzi units are decisive. Here, we investigate this phenomenon further by introducing new variants of amphiphilic pPheOzi-based copolymers to explore the variability of the system. Changing the arrangement of the MeOx and PheOzi constitutional repeat units enables investigation of the influence of the polymer architecture on the thermogelation. We found that a triblock architecture is superior to diblock, gradient and star-like polymer architectures in terms of efficient order–order transition-based thermogelation. In addition, a coupling procedure based on copper-catalyzed azide–alkyne cycloaddition is presented that allows for a direct comparison of pMeOx and PEG as hydrophilic blocks in pPheOzi-based triblocks. Interestingly, PEG hydrophilic blocks also enable rapid worm-formation and show faster gelation as well as increased gel strength. Altogether, our findings provide basic design criteria for improved (pPheOzi-based) worm-gels. The introduced small library of pPheOzi-based copolymer variants can be used for further fundamental studies regarding thermo-responsive transitions in polymer self-assembly.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1383-1392"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/py/d4py01345j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"l-Phenylalanine monomer coacervation leads to well-controlled nanocrystal topochemical photo-RAFT polymerization†","authors":"Yuting Li ,&nbsp;Xiyu Wang ,&nbsp;Ying Cao ,&nbsp;Wenjing Niu ,&nbsp;Qing Zheng ,&nbsp;Xinhua Lu ,&nbsp;Yuanli Cai","doi":"10.1039/d4py01203h","DOIUrl":"10.1039/d4py01203h","url":null,"abstract":"<div><div>We describe the self-coacervation and nanocrystal topochemical photo-RAFT polymerization of ionic phenylalanine acrylamide. The charged monomer molecules undergo self-coacervation through nanoclustering, liquid–liquid phase separation, and crystallization within dense droplets in water at pH 7.0 and 25 °C, leading to ultrathin lamellar nanocrystal-containing droplets capable of well-controlled topochemical photo-RAFT polymerization. The reaction induces pathway-dependent self-assembly involving the one-dimensional (non)covalent polymerization of monomer nanoclusters into fibril bundles. Furthermore, monomer molecules within the crystal lattice undergo one-dimensional rearrangements guided by growing polymer segments, leading to the nanocrystal transition into perforated lamellar hollow sieves accompanied by decreased crystallinity, and followed by interfacial topochemical polymerization of monomer nanoclusters site-specifically along the newly activated sites of sieve edges, leading to sieve-centred parallel-growing fibrils. Further reaction leads to densely charged ultrathin fibril lamellae physically crosslinked by fibril network knots. Consequently, the well-controlled topochemical photo-RAFT polymerization up to &gt;98% conversion was achieved shortly in 1 h under ecofriendly ambient aqueous conditions. This work provides a robust platform of the solid-state topochemical polymerization with unprecedentedly high molecular weight controllability.</div></div>","PeriodicalId":100,"journal":{"name":"Polymer Chemistry","volume":"16 12","pages":"Pages 1400-1408"},"PeriodicalIF":4.1,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}