中华医学美学美容杂志最新文献_第4页

Effectiveness of circumvertical mastopexy with internal shaping using inferior dermal-glandular flap for correction of breast ptosis 下皮腺瓣内整形术矫正乳房下垂的效果

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-10-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.05.012

Y. Lang, Bi Li, Jian-Xun Ma, Y. Xia, Jie Zhang

{"title":"Effectiveness of circumvertical mastopexy with internal shaping using inferior dermal-glandular flap for correction of breast ptosis","authors":"Y. Lang, Bi Li, Jian-Xun Ma, Y. Xia, Jie Zhang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.05.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.05.012","url":null,"abstract":"Objective \u0000To evaluate the clinical effect of circumvertical mastopexy with internal shaping using inferior dermal-glandular flap for correction of breast ptosis. \u0000 \u0000 \u0000Methods \u0000From April 2010 to November 2017, 33 cases of breast ptosis were treated in our department. The patients required nipple elevation of 3-6 cm and had unpleasing result after circumareolar mastopexy were treated with the technique of circumvertical lift with breast suspension and internal shaping with inferior dermal-glandular flap which pedicle was on the inframammary crease and tack technique for removing excessive skin precisely. \u0000 \u0000 \u0000Results \u000033 cases had their drainage tubes removed at the 2~3 days and suture removed at the 12~14 days postoperatively. All had primary healing of incision and no complications such as necrosis of NAC and dehiscence of incision occurred. Elastic bra was asked to wear for three to six months and then stable shape was achieved. Follow-up lasted for 6-60 months. All cases were satisfied with their new breast shape. \u0000 \u0000 \u0000Conclusions \u0000Circumvertical mastopexy with internal shaping using inferior dermal-glandular flap is a simple and effective method with relatively short scar and good shape for correction of the medium grade breast ptosis. \u0000 \u0000 \u0000Key words: \u0000Mammaplasty; Breast ptosis; Mastopexy; Circumvertical incision; Tack technique","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"392-395"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41413774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curative effect of autologous platelet rich plasma on facial acne scars 自体富血小板血浆治疗面部痤疮瘢痕疗效观察

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-10-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.05.018

Huili Wang, Liangshuo Hu, D. Jiang, Q. Tan

{"title":"Curative effect of autologous platelet rich plasma on facial acne scars","authors":"Huili Wang, Liangshuo Hu, D. Jiang, Q. Tan","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.05.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.05.018","url":null,"abstract":"Objective \u0000To compare the efficacy and safety of two administration modes of autologous platelet-rich plasma (PRP), intradermal injection (ID) and microneedle technique in the treatment of facial post acne scars. \u0000 \u0000 \u0000Methods \u0000From March 2017 to March 2018, 32 patients (8 male, 14 female) with facial acne scars were included. They were randomly divided into two groups (group A and group B) and both underwent splitface therapy. Each group was randomly divided into two subgroups. Group A was administered by microneedle + PRP (A1) on one side and by microneedle + saline (A2) on the other. In group B, one cheek was treated with ID PRP (B1) and the other received ID saline (B2). Each patient received overall 3 treatments per session with 28 days intervals. Patients were followed-up six months after their last treatment and clinical evaluation was assessed by 2 independent plastic surgeons and patients themself. \u0000 \u0000 \u0000Results \u0000The results were obvious difference between each group. The score of evaluation by physicians and patients in A1 group (2.565±0.504) point showed significantly better results compared with other groups. B1 group (1.820±0.592) point was significantly higher than B2 group (1.345±0.483) point (P 0.05). The total effective rate in A1 group was 100%, which was higher than B1 group (43.75%), A2 group (81.25%) and B2 group (25%), with statistical significance (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The current study introduces the combination of autologous PRP and microneedle technique as an effective and safe modality in the treatment of facial post acne scars with short recovery time and easy operation. Any concerns of immunogenic reactions or disease transfer are eliminated because PRP is prepared from autologous blood. Therefore, the method is suitable to be widely used in clinic. \u0000 \u0000 \u0000Key words: \u0000Platelet-rich plasma; Acne vulgaris; Cicatrix; Atrophy; Microneedle acupuncture therapy","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"414-417"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45240380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of perforator flap with preserved Choke vessel area in repairing the defect induced by tumor removal 保留喉管区穿支皮瓣修复肿瘤切除后缺损的效果

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-10-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.05.004

Jiayun Hong, Daojiang Yu, W. Su, Wen-ya Han, Lijun Wu, Wenyuan Yu, Xiaoyun Wang

{"title":"Effect of perforator flap with preserved Choke vessel area in repairing the defect induced by tumor removal","authors":"Jiayun Hong, Daojiang Yu, W. Su, Wen-ya Han, Lijun Wu, Wenyuan Yu, Xiaoyun Wang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.05.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.05.004","url":null,"abstract":"Objective \u0000To explore the clinical significance of protection \" Choke vessel area\" in the application of perforator flap to repair large defect of trunk after tumor resection. \u0000 \u0000 \u0000Methods \u0000A total of 62 patients (38 males and 24 females, aged from 19 to 79 years) from the Department of Plastic Surgery, Second Affiliated Hospital of Suzhou University underwent reconstructive surgery for large area defects of the trunk from March 2012 to January 2016. The perforator flap was designed according to the perforator location detected by Doppler before surgery. The flaps were harvested on the pedicle of perforators and dissected on the deep layer of deep fascia (including part of the myolemma). The areas of flap ranged from 5.0 cm × 10.0 cm to 19.0 cm × 22.0 cm. The donor site was sutured directly or local flap was transferred to repair. \u0000 \u0000 \u0000Results \u0000Flaps survived well in 59 of the 62 cases. The tip of flap was necrotic and healed after dressing change in 1 diabetic patient. The distal part of flap was necrotic on cuticular layer and healed after dressing change in another patient with scrotal defect. One patient had flap necrosis 10 days after operation and was repaired twice. The results were satisfied after following-up from 3 months to 2 years for 17 cases and from 6 months to 2 years for 25 cases. Fibrosarcoma protuberant and squamous cell carcinoma recurred in 1 case each, but the function and appearance were satisfactory after primary repair. \u0000 \u0000 \u0000Conclusions \u0000The procedure of preserving Choke vessel area can improve the blood supply of perforator flap and obtain larger survival area and survival quality. It is worthy of clinical application. \u0000 \u0000 \u0000Key words: \u0000Neoplasms; Defects; Body surface area; Free-style perforate flap; Choke vessel; Survival quality","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"364-367"},"PeriodicalIF":0.0,"publicationDate":"2019-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46801308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of different storage media on the activity of human adipose-derived stem cell 不同储存介质对人脂肪干细胞活性的影响

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-10-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.05.011

Yin-Di Wu

引用次数: 0

Application of 3D reconstruction and simulation in rhinoplasty 三维重建与仿真在鼻整形术中的应用

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.014

Yang Wang, H. Cui

{"title":"Application of 3D reconstruction and simulation in rhinoplasty","authors":"Yang Wang, H. Cui","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.014","url":null,"abstract":"Objective \u0000To provide useful reference for the pre-operative design and operation by 3D reconstruction and simulation techniques in rhinoplasty. \u0000 \u0000 \u0000Methods \u0000From October 2016 to March 2017, the laser scanning and 3D reconstruction were performed on 25 patients before operations. The facial morphology and the simulated effect were ontained. All patients were female and they were 18 to 39 years old. The average age was 26 years old. The outline and form were normal. We discussed with patients to confirm the ideal nasal 3D simulated effect. In the process of operation, we were guided by the data of soft measures and 3D printing model. \u0000 \u0000 \u0000Results \u0000Among 25 patients who werefollowed up postoperatively. We got intuitive, accurate 3D reconstruction graphs and simulated surgery procedures in all cases. Being applied to actual surgery procedure, 23 patients were satisfactory with postoperational results. Two patient＇s nasal tip dropped. We were satisfied with the results after repair. \u0000 \u0000 \u0000Conclusions \u00003D reconstruction and simulation techniques improve surgical precision and operation planning selection, which is a good aided method in rhinoplasty. \u0000 \u0000 \u0000Key words: \u0000Rhinoplasty; Printing, three-dimensional; Computer simulation; 3D printing technology; Laser scanning","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"306-308"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43432432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous costal cartilage for nasal tip surgery: report of 86 cases 自体肋软骨用于鼻尖手术86例报告

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.006

An-tang Liu, Yuxin Qian, Hao Hu, W. Meng, Yong Xu, Hui Wang, Ying-fan Zhang, Yao-zhong Zhao

{"title":"Autologous costal cartilage for nasal tip surgery: report of 86 cases","authors":"An-tang Liu, Yuxin Qian, Hao Hu, W. Meng, Yong Xu, Hui Wang, Ying-fan Zhang, Yao-zhong Zhao","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.006","url":null,"abstract":"Objective \u0000To present our experience and techniques with the use of autologous costal cartilage grafts in Asian rhinoplasty, and to report the surgical results and complications in 86 consecutive rhinoplasty cases. \u0000 \u0000 \u0000Methods \u0000All operations were performed by the first author (Liu AT) with open approach, costal cartilages and perichondrium were used to reconstruct the nasal tip projection according to the tripod theory in rhinoplasty, after removing the previous injection material, L-shaped implant or hypertrophic scar tissue in the tip. Medical charts and operative records were reviewed retrospectively to summary the complications. Nasal dorsum augmentation was done by costal cartilage or I-shaped allograft, sometimes with anterior sheath of rectus abdominis. Patients＇ subjective satisfaction of the postoperative nasal appearance was self-evaluated with grading (1 worse, 2 no change, 3 improved, and 4 much improved). \u0000 \u0000 \u0000Results \u0000From September 2015 to March 2017, 86 patients underwent rhinoplasty at our hospital. The postoperative follow-up duration was 6 to 20 months. Overall, functional and aesthetic outcome was satisfactory in most patients, and the mean score by the patients＇ self-evaluation was 3.3±0.6. Graft exposure, mobility, or significant resorption, pneumothorax or significant donor-site pain were not observed. \u0000 \u0000 \u0000Conclusions \u0000Even with minimal complications and morbidities, autologous costal cartilage grafts in Asian rhinoplasty is a versatile and reliable graft material for nasal tip surgery in severe short or saddle nose, contracted nose due to previous L-shaped augmentation and revision rhinoplasty in which the septal cartilage has already been harvested. \u0000 \u0000 \u0000Key words: \u0000Autologous costal cartilage; Nasal tip plasty; Nasal dorsum augmentation; Revision rhinoplasty; Saddle nose","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"280-283"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41710046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial effect of cod-derived polypeptides (CDPs) on wound healing in a rat model of skin incisions 鳕鱼衍生多肽（CDPs）对大鼠皮肤切口模型伤口愈合的有益作用

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.021

W. Yi

{"title":"Beneficial effect of cod-derived polypeptides (CDPs) on wound healing in a rat model of skin incisions","authors":"W. Yi","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.021","url":null,"abstract":"Objective \u0000To investigate the wound-healing process in a rat model of skin full-thickness incisions and to detect related possible mechanism. \u0000 \u0000 \u0000Methods \u0000Twenty-four female rats were selected and the dorsal skin of rats was used as the experimental area. A cutaneous excision (6 mm diameter) was made on the back of each animal, close to the cervical area. The dorsal skin of every rat was allocated to three groups which were treated with physiological saline, human recombinant epidermal growth factor (rhEGF), and CDPs, respectively. After making a rat model of skin incisions, we observed the wound healing process, took photos of the wounds under a digital microscope, and use sulfuric graph paper to record the size of every wound. At the 3rd, 6th, 9th, 12th day after modeling, 6 rats were killed, and mRNA expression of K10, K14, and EGF was detected in the skin tissues using a RT-PCR technique. \u0000 \u0000 \u0000Results \u0000At the 6th and 12th day after modeling, there were significant differences between the experimental group and the blank control group (P<0.05). The gene expression of EGF, K-14 in the third day and that of EGF, K-10 and K-14 in the 6th and 12th day were up-regulated compared with control group, and there were significant differences between them (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000CDPs have a beneficial effect on the acceleration of skin wound healing, possibly due to increasing keratinocyte proliferation and up-regulating the expression of K10, K14 and EGF genes. \u0000 \u0000 \u0000Key words: \u0000Keratin-10; Keratin-14; Epidermal growth factor; Cod-derived polypeptides; Wound healing","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"330-334"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41926759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes of facial volume maintenance rate after single autologous fat grafted for repaired progressive facial hemiatrophy 单一自体脂肪移植修复进行性面部半萎缩后面部体积维持率的变化

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.013

Jun-Quan Chen, Binghang Li, Jianjian Lu, Jiajie Xu, Chao Zhang, Fang Xie, Liya Yang, Lu Yang, Shuyuan Li, L. Teng

{"title":"Changes of facial volume maintenance rate after single autologous fat grafted for repaired progressive facial hemiatrophy","authors":"Jun-Quan Chen, Binghang Li, Jianjian Lu, Jiajie Xu, Chao Zhang, Fang Xie, Liya Yang, Lu Yang, Shuyuan Li, L. Teng","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.013","url":null,"abstract":"Objective \u0000To measure the change of facial volume maintenance rate after autologous fat grafted for repaired progressive facial hemiatrophy by using three-dimensional digital technology. \u0000 \u0000 \u0000Methods \u00003D scanner was used to acquire facial data in 10 patients with progressive facial hemiatrophy before operation; Mimics 17.0 software was used to reconstruce patients＇ facial 3D model and to calculate the volume of facial tissue defect; autologous fat was grafted to repair facial deformity. The facial volume maintenance rate was calculated in all the patients 3 months and 6 months after operation. \u0000 \u0000 \u0000Results \u0000We had performed facial 3D data acquisition and facial repaired with autologus fat grafted in 10 patients; patients＇ facial morphology was improved. The mean facial volume maintenance rate was (35.80±3.44)% in 3 months and (27.82±3.80)% 6 months after surgery. \u0000 \u0000 \u0000Conclusions \u0000The mean facial volume maintenance rate in postoperative 3 months is inferior to that in 6 months in single autologous fat grafted for repairing progressive facial hemiatrophy. \u0000 \u0000 \u0000Key words: \u0000Facial Hemiatrophy; Autografts; Printing, three-dimensional; Autologous fat grafted; Facial volume maintenance rate; Progressive facial hemiatrophy","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"302-305"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46338249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical skills for female frontotemporal hairline reconstruction 女性额颞发际线重建的手术技巧

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.009

Xiang Xie, Dong Li, Hong-Yu Xue, Hongbin Xie, Hongsen Bi

{"title":"Surgical skills for female frontotemporal hairline reconstruction","authors":"Xiang Xie, Dong Li, Hong-Yu Xue, Hongbin Xie, Hongsen Bi","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.009","url":null,"abstract":"Objective \u0000To explore the operative method and skill for female frontotemporal hairline reconstruction. \u0000 \u0000 \u0000Methods \u0000From October 2010 to October 2016, 120 female patients were performed with the hairline reconstruction. The follicular units were arranged irregularly, 40-55 FUs/cm2, with 30°-45° angle from the forehead skin and 15°-20° angle from the temporal skin. The finest hairs were selected and arranged in hairline margin. \u0000 \u0000 \u0000Results \u0000All the patients were followed up for 10-24 months. 95 patients were very satisfied, 25 patients were satisfied, and no patients were unsatisfied. 9 patients complained low density in the middle of the hairline and they had another surgery to improve the density. 3 patients＇s hairline was regular, and another graft was done to correct the unnatural appearance. 6 patients＇s hairs of the hairline margin were thick, but no further treatment was done. 1 patient underwent hair transplantation again, because of the still high hairline. 6 patients＇s transplanted hairs appeared curly, and the curly degree was decreased after 1-2 years. The density of the transplanted hair was (44.7±8.1) FU/cm2. The density of 9 cases who complained low density in the middle of the hairline, was (36.9±3.1) FU/cm2. The hair diameter of the hairline edge was (57.5±13.5) μm. The hair diameter of 6 cases who felt the hair thick was (70.2±5.1) μm. The angle of hair and the frontal skin was (40.2±8.5)°, The angle of hair and the temporal skin was (18.2±4.7)°. \u0000 \u0000 \u0000Conclusions \u0000In female frontotemporal hairline reconstruction, nature hairline is created by irregular arrangement of hairs, proper density and angle and exact arrangement of different diameter hairs. \u0000 \u0000 \u0000Key words: \u0000Hair; Transplantation, autologous; Forehead; Women; Hair line","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"289-292"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70000895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of tacrolimus in treating vitiligo on the secretion of local chemokine 他克莫司治疗白癜风对局部趋化因子分泌的影响

Chinese Journal of Medical Aesthetics and Cosmetology Pub Date : 2019-08-15 DOI: 10.3760/CMA.J.ISSN.1671-0290.2019.04.019

Yongping Xu, Miao-ni Zhou, R. Jin, Wen Xu, A. Xu

{"title":"Effects of tacrolimus in treating vitiligo on the secretion of local chemokine","authors":"Yongping Xu, Miao-ni Zhou, R. Jin, Wen Xu, A. Xu","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.04.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.04.019","url":null,"abstract":"Objective \u0000To analyze the abnormalities of local chemokines in patients with vitiligo and to explore the effect of tacrolimus on the secretion of chemokines in keratinocytes. \u0000 \u0000 \u0000Methods \u0000Blister fluids of 50 patients with vitiligo were collected, including lesion areas and normal areas. Luminex was used to analyze the concentration of local chemokines in patients with vitiligo to determine whether the chemokines were closely related to vitiligo. The effect of tacrolimus on chemokine secretion of was analyzed by Western blot in HaCaT cells. \u0000 \u0000 \u0000Results \u0000By Luminex analysis of blister fluid, it was found that CXCL9 and CXCL10 were significantly higher in the leukoplakia of vitiligo, and there was a significant difference, compared with the blister fluid in the normal site (P<0.01). IFN-γ significantly stimulated the keratinocyte cell line HaCat to express CXCL9 and CXCL10. After pretreatment of HaCaT cells with 20 mg tacrolimus, the expression of CXCL9 and CXCL10 was significantly decreased, compared with the blank control (P<0.01). \u0000 \u0000 \u0000Conclusions \u0000The leukoplakia chemokines CXCL9 and CXCL10 are highly expressed in vitiligo patients. The tacrolimus can significantly reduce the expression of CXCL9 and CXCL10 in keratinocytes under stress, and it therefore plays a therapeutic role in vitiligo. \u0000 \u0000 \u0000Key words: \u0000Vitiligo; Tacrolimus; Chemokine CXCL9; Chemokine CXCL10; HaCaT cells","PeriodicalId":10094,"journal":{"name":"Chinese Journal of Medical Aesthetics and Cosmetology","volume":"25 1","pages":"322-325"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44621546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0