Molecular Brain Research最新文献

{"title":"Co-expression of the 5-HT3B subunit with the 5-HT3A receptor reduces alcohol sensitivity","authors":"Volodya Hayrapetyan,&nbsp;Monica Jenschke,&nbsp;Glenn H. Dillon,&nbsp;Tina K. Machu","doi":"10.1016/j.molbrainres.2005.09.011","DOIUrl":"10.1016/j.molbrainres.2005.09.011","url":null,"abstract":"<div><p>Allosteric modulation of mouse 5-Hydroxytryptamine_3A (5-HT_3A) and 5-HT_3A/B<span> receptor function by ethanol and trichloroethanol (TCEt) was assessed in HEK293 cells with whole cell patch-clamp electrophysiological recordings. Ethanol enhanced 5-HT</span>_3A receptor function, but had no effect on mouse 5-HT_3A/B receptor mediated currents. The enhancing action of trichloroethanol (TCEt) on mouse 5-HT_3A/B receptor function was much less than that observed in the mouse 5-HT_3A receptor. Where alcohol-induced increases in peak amplitude were observed, the slope of the 20–80% rising phase of current onset was also enhanced, suggesting that increases in activation rate may be one mechanism through which alcohols enhance function of the 5-HT₃ receptors.</p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 2","pages":"Pages 146-150"},"PeriodicalIF":0.0,"publicationDate":"2005-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25663619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum","authors":"Vincent A. Funari ,&nbsp;Victoria L.M. Herrera ,&nbsp;Daniel Freeman ,&nbsp;Dean R. Tolan","doi":"10.1016/j.molbrainres.2005.09.019","DOIUrl":"10.1016/j.molbrainres.2005.09.019","url":null,"abstract":"<div><p><span><span><span><span>Since 1967, fructose has become the primary commercial sweetener in the food industry. Large amounts of fructose can be toxic and have been correlated with atherosclerosis, malabsorption, hyperuricemia, lactic acidosis, and cataracts. To understand the deleterious and critical role(s) fructose plays in normal metabolism, it is essential to know how and where fructose is metabolized. The fructose transporter, </span>GLUT5<span><span>, and the specialized enzymes ketohexokinase, </span>aldolase, and triokinase comprise the well-defined fructose-specific metabolic pathway found in liver, kidney, and small intestine. It is estimated that 50–70% of ingested fructose is metabolized in these tissues; where and how the remaining 30–50% is metabolized is not well defined. Prediction of tissues capable of metabolizing fructose via this pathway was done using </span></span>expressed sequence tags (ESTs) in Unigene and a gene-specific virtual </span>northern blot<span> (VNB) algorithm. Unigene and VNB combined correctly predicted the expression of the genes required for fructose metabolism in liver, kidney, and small intestine. Both methods indicated brain, breast, lymphocytes, muscle, placenta, and stomach additionally express this set of genes. Expression of the genes for GLUT5 (</span></span><em>glut5</em>) and ketohexokinase (<em>khk</em><span>) in neurons was validated by immunohistochemistry<span> and RNA in situ hybridization, respectively. Using stringent controls, clear expression of </span></span><em>glut5</em> and <em>khk</em><span> was localized to Purkinje cells in the cerebellum. Cerebellum was used to oxidize fructose to carbon dioxide. Together, these data suggest that these neurons in the brain are able to utilize fructose as a carbon source.</span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 2","pages":"Pages 115-122"},"PeriodicalIF":0.0,"publicationDate":"2005-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25670418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different expression role among glutamate transporters in rat retinal glial cells under various culture conditions","authors":"Mitsuhiro Imasawa,&nbsp;Kenji Kashiwagi,&nbsp;Yoko Iizuka,&nbsp;Mayumi Tanaka,&nbsp;Shigeo Tsukahara","doi":"10.1016/j.molbrainres.2005.08.010","DOIUrl":"10.1016/j.molbrainres.2005.08.010","url":null,"abstract":"<div><p><span>Using cultured rat retinal glial cells, the changes in the expression of </span>glutamate<span><span><span> transporters (GLTs) under such conditions as the degree of confluence of the cells, hypoxia, glutamate loading, and potassium loading, were assessed. After the retinal glial cells were isolated from 3-day-old Sprague–Dawley rats, GLAST, GLT-1, and EAAC1 mRNA expression was confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and their protein expression was confirmed by </span>Western blot analysis<span> and immunostaining. Changes in the expression of the GLTs at 6 h after passage and at confluence, during culture in 5% oxygen, during glutamate loading and during potassium loading were assessed using real-time PCR. Although the GLAST mRNA expression was increased during glutamate and potassium loading, no changes in the expression were observed during hypoxia and at confluence. By contrast, the GLT-1 mRNA expression was increased during hypoxia and at confluence, but not during glutamate and potassium loading, and the EAAC1 mRNA expression was not changed only during glutamate loading. The expression of EAAC1 in the cultured retinal glial cells was confirmed. The expression of the GLTs varied according to the environment and the type of load suggests that the involvement of the GLTs in </span></span>retinal physiology and pathology varies depending on the subtype.</span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.08.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25685408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLUK6-deficient mice","authors":"Dong-ho Youn ,&nbsp;Nana Voitenko ,&nbsp;Gabor Gerber ,&nbsp;Yun-kyung Park,&nbsp;Jan Galik ,&nbsp;Mirjana Randić","doi":"10.1016/j.molbrainres.2005.09.004","DOIUrl":"10.1016/j.molbrainres.2005.09.004","url":null,"abstract":"<div><p><span>Functional kainate receptors<span> are expressed in the spinal cord substantia gelatinosa region, and their activation contributes to bi-directional regulation of excitatory synaptic transmission at primary afferent synapses with spinal cord substantia gelatinosa neurons. However, no study has reported a role(s) for kainate receptor subtypes in long-term synaptic plasticity phenomena in this region. Using gene-targeted mice lacking glutamate receptor 5 (GLU</span></span>_K5) or GLU_K6 subunit, we here show that GLU_K6 subunit, but not GLU_K5<span> subunit, is involved in the induction of long-term potentiation of excitatory postsynaptic potentials, evoked by two different protocols: (1) high-frequency primary afferent stimulation (100 Hz, 3 s) and (2) low-frequency spike-timing stimulation (1 Hz, 200 pulses). In addition, GLU</span>_K6 subunit plays an important role in the expression of kainate-induced Ca²⁺<span> transients in the substantia gelatinosa. On the other hand, genetic deletion of GLU</span>_K5 or GLU_K6 subunit does not prevent the induction of long-term depression. These results indicate that unique expression of kainate receptors subunits is important in regulating spinal synaptic plasticity and thereby processing of sensory information, including pain.</p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 9-18"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25630436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway","authors":"Manuel DeCastro,&nbsp;Bistra B. Nankova,&nbsp;Parul Shah,&nbsp;Pranav Patel,&nbsp;Pradeep V. Mally,&nbsp;Ravi Mishra,&nbsp;Edmund F. La Gamma","doi":"10.1016/j.molbrainres.2005.09.002","DOIUrl":"10.1016/j.molbrainres.2005.09.002","url":null,"abstract":"<div><p><span><span>Multiple intracellular and extracellular regulatory factors affect transcription of the tyrosine hydroxylase (TH) gene encoding the rate-limiting enzyme in the </span>biosynthesis<span><span><span><span> of the neurotransmitters dopamine, </span>norepinephrine and epinephrine. </span>Short chain fatty acids<span> like butyrate<span><span> are known to alter TH gene expression, but the mechanism of action is unknown. In this report, transient transfection assays identified the proximal TH promoter to contain sufficient genetic information to confer butyrate responsiveness to a reporter gene. Deletion studies and gel shift analyses revealed that the promoter region spanning the cAMP response element is an absolute requirement for </span>transcriptional activation<span> by butyrate. The branched short chain fatty acid valproate is used for seizure control in humans. Significantly, it has a similar aliphatic structure to butyrate, and it was found to have similar effects on TH in PC12 cells. Site-directed mutagenesis indicated that the effects of both fatty acids were mediated through the canonical CRE. Butyrate treatment also resulted in CREB phosphorylation without changing CREB protein levels. The increased phosphorylation of CREB correlated with accumulation of TH mRNA. The </span></span></span></span>adenylate cyclase<span> inhibitor dideoxyadenosine blocked both CREB phosphorylation and accumulation of TH mRNA. The data are consistent with the conclusion that butyrate induces post-translational modifications of pre-existing CREB molecules in a cAMP/PKA-dependent manner to alter TH transcription. These results support the role of butyrate as a novel exogenous regulatory factor in TH gene expression. Our data delineate a molecular mechanism through which diet-derived environmental signals (e.g. butyrate) can modulate </span></span></span>catecholaminergic<span> systems by affecting TH gene transcription.</span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 28-38"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25630435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of two rat mas-related genes in a model of neuropathic pain","authors":"Eric L. Gustafson ,&nbsp;Maureen Maguire ,&nbsp;Marilena Campanella ,&nbsp;Glauco Tarozzo ,&nbsp;Yuping Jia ,&nbsp;Xiao-Wei Dong ,&nbsp;Maureen Laverty ,&nbsp;Nicholas Murgolo ,&nbsp;Tony Priestley ,&nbsp;Angelo Reggiani ,&nbsp;Frederick Monsma ,&nbsp;Massimo Beltramo","doi":"10.1016/j.molbrainres.2005.09.014","DOIUrl":"10.1016/j.molbrainres.2005.09.014","url":null,"abstract":"<div><p>The <em>mas</em><span><span><span>-related gene (Mrg) family is a large family of G-protein-coupled receptors which are variable in number depending on species. The so-called sensory-neuron-specific receptors (SNSRs) make up a subset of the Mrg family, and several of these have been implicated in nociceptive processes. To verify their specific localization in sensory ganglia, we have determined the expression patterns of two of them, rMrgA and rMrgC, in a panel of rat tissues. The quantitative PCR results in the rat tissue panel indicate that, while several non-neuronal tissues contain significant levels of mRNA for both receptors, these two receptors are most highly expressed in dorsal root ganglia and trigeminal ganglia. Given this, we have examined the effects of spinal nerve ligation (SNL) on the expression of these genes. Peripheral neuropathy induced by ligation of spinal nerves at L5 and L6 resulted in a pronounced mechanical </span>allodynia<span>. These behavioral changes in tactile sensitivity were accompanied by significant decreases (10- to 100-fold) in the mRNA expression of both rMrgA and rMrgC exclusively in the L5 and L6 dorsal root ganglia ipsilateral to the SNL. In situ hybridization studies demonstrated that this decrease did not result from neuronal loss but rather from a reduction in the hybridization signals for rMrgC over small-to-medium diameter L5 and L6 dorsal root ganglia neurons. While the functional implications of the altered regulation of rMrgA and rMrgC in </span></span>neuropathic pain models remain unclear, the results suggest that therapeutics targeting these receptors may have limited utility.</span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 58-64"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25657224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural steroid hormone receptor gene expression in pregnant rats","authors":"Phyllis E. Mann,&nbsp;Jessica A. Babb","doi":"10.1016/j.molbrainres.2005.09.001","DOIUrl":"10.1016/j.molbrainres.2005.09.001","url":null,"abstract":"<div><p><span><span><span><span>Estrogen and </span>progesterone<span> play important roles during pregnancy in stimulating the onset of maternal behavior at parturition. The status of receptor expression<span><span> of these hormones during pregnancy in neural regions that regulate maternal behavior is unclear. The objective of the present study is to characterize changes in neural gene expression of the estrogen receptors α and β (ERα and ERβ) and the </span>progesterone receptor (PR) during the latter part of pregnancy. Brains from primigravid Sprague–Dawley rats were collected on days 15 and 21 of pregnancy. Micropunches of the </span></span></span>olfactory bulb<span> (OB), medial preoptic area (MPOA), bed nucleus of the </span></span>stria terminalis<span> (BnST), hypothalamus (HYP), medial amygdala (MeA), and the temporal cortex (TCx) were analyzed by real-time RT-PCR (Taqman™) for levels of gene expression. No changes in either ERα or ERβ mRNA levels were detected in any brain region between days 15 and 21 of pregnancy: however, the MPOA had higher levels of both ERα and ERβ than other brain regions. Progesterone receptor mRNA levels, in contrast, declined significantly in the MPOA, HYP, and TCx, between days 15 and 21 of pregnancy (</span></span><em>P</em> &lt; 0.05). In addition, the levels of PR mRNA were significantly higher in the HYP and TCx compared to both the OB and MeA. These data indicate that there is a downregulation of PR prepartum and suggest that this decrease may play a role in the disinhibition of maternal behavior at parturition.</p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 39-46"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25660240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expressions of cytokines and chemokines in the dorsal motor nucleus of the vagus nerve after right vagotomy","authors":"Jun Feng Ji,&nbsp;S. Thameem Dheen,&nbsp;S. Dinesh Kumar,&nbsp;Bei Ping He,&nbsp;Samuel Sam Wah Tay","doi":"10.1016/j.molbrainres.2005.09.017","DOIUrl":"10.1016/j.molbrainres.2005.09.017","url":null,"abstract":"<div><p><span>The aim of this study was to investigate the expression of cytokines, tumor necrosis factor alpha<span><span> (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6) and transforming growth factor-beta 1 (TGF-β1) and chemokines, fractalkine, </span>monocyte chemoattractant protein 1<span><span> (MCP-1) and stromal cell-derived factor 1 (SDF-1) in the dorsal motor nucleus of the vagus nerve (DMV) after right vagotomy. Results showed that the </span>immunoreactivities<span> of IL-1β, IL-6, TGF-β1, fractalkine and MCP-1 were upregulated in the DMV at 14 days and the upregulation persisted at least until 28 days following right vagotomy. Quantification analysis revealed significant increases in the number of their immunopositive cells in the right DMV at 14 and 28 days after right vagotomy. Moreover, the upregulation of TNF-α immunoreactivity and significantly increased number of TNF-α-immunopositive cells were observed in the injured DMV at 7 and 14 days, and the increase in SDF-1-immunopositive cells at 14 days, after right vagotomy. Real time RT-PCR analysis showed the significant increase in the mRNA expression of IL-1β, fractalkine and MCP-1 at 7 days, and the upregulation of TNF-α mRNA expression at 1 day after vagotomy. However, the peak increase in TGF-β1 mRNA expression was observed at 1 day and the significant increase persisted at least until 14 days following right vagotomy. Double immunofluorescence analysis showed co-localization of lectin, a marker for microglia with CX</span></span></span></span>₃<span><span>CR1 but not with IL-1β at 14 days following right vagotomy. This study suggests that cytokines and chemokines involved in neuroprotection and neurodestruction could be activated in the axotomized DMV. However, it warrants further investigation to understand the neurodestructive and </span>neuroprotective mechanisms that determine the fate of the vagal motoneurons after vagotomy.</span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 47-57"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25668361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Research Young Investigator Awards","authors":"","doi":"10.1016/S0169-328X(05)00422-5","DOIUrl":"https://doi.org/10.1016/S0169-328X(05)00422-5","url":null,"abstract":"","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Page v"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0169-328X(05)00422-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137407037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine phosphorylation of the N-methyl-d-aspartate receptor is enhanced in synaptic membrane fractions of the adult rat hippocampus","authors":"Susan M. Goebel ,&nbsp;Rachel M. Alvestad ,&nbsp;Steven J. Coultrap ,&nbsp;Michael D. Browning","doi":"10.1016/j.molbrainres.2005.09.012","DOIUrl":"10.1016/j.molbrainres.2005.09.012","url":null,"abstract":"<div><p>Hippocampal <em>N</em>-methyl-<span>d</span><span><span>-aspartate receptors (NMDARs) contribute to the expression of certain types of synaptic plasticity, such as long-term potentiation (LTP). It is well documented that tyrosine kinases increase NMDAR phosphorylation and potentiate NMDAR function. However, it is unclear how these phosphorylation changes result in enhanced NMDAR activity. We previously reported that NMDAR surface expression can be increased by LTP-inducing stimulation via tyrosine kinase-dependent mechanisms in the adult hippocampus [D.R. Grosshans, D.A. Clayton, S.J. Coultrap, M.D. Browning, Nat. Neurosci., 5 (2002) 27–33]. We therefore hypothesized that </span>tyrosine phosphorylation<span><span> of the NMDAR may enhance the trafficking of the receptor to the synaptic membrane. Here, we show that the </span>stoichiometry<span><span> of NR2A and NR2B tyrosine phosphorylation is significantly higher in synaptosomal membranes than intracellular microsomal/light membranes. Interestingly, NR2B tyrosine-1472, but not NR1 serine-896 or -897, phosphorylation is significantly higher in synaptosomal membranes than intracellular microsomal/light membranes. Furthermore, treatment of hippocampal slices with either a tyrosine phosphatase inhibitor or a </span>tyrosine kinase inhibitor alters NMDAR tyrosine phosphorylation and produces a corresponding change in the concentration of NMDARs in the synaptosomal membrane fraction. Taken together, these data support the hypothesis that tyrosine phosphorylation may enhance NMDAR activity by increasing the number of NMDARs at the synaptic membrane.</span></span></span></p></div>","PeriodicalId":100932,"journal":{"name":"Molecular Brain Research","volume":"142 1","pages":"Pages 65-79"},"PeriodicalIF":0.0,"publicationDate":"2005-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.molbrainres.2005.09.012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25663620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}