中华老年多器官疾病杂志最新文献_第2页

Effect of anisodamine on lung edema after ischemia-reperfusion in rabbits: Effect of anisodamine on lung edema after ischemia-reperfusion in rabbits 山莨菪碱对兔缺血再灌注后肺水肿的影响:山莨菪碱对兔缺血再灌注后肺水肿的影响

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-10-27 DOI: 10.3724/SP.J.1264.2011.00015

Zhibo Jia, Gang Zhou, Li-Ping Wang, Hai Tian, Kaiyu Liu, Shu-lin Jiang

引用次数: 0

Progress of clinical research on stress hyperglycemia: Progress of clinical research on stress hyperglycemia 应激性高血糖临床研究进展:应激性高血糖临床研究进展

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-10-27 DOI: 10.3724/SP.J.1264.2011.00006

Yanzhao Guo, Zhang-rong Xu

引用次数: 1

Leflunomide and rheumatoid interstitial lung disease: Leflunomide and rheumatoid interstitial lung disease 来氟米特和类风湿间质性肺病:来氟米特和类风湿间质性肺病

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-10-27 DOI: 10.3724/SP.J.1264.2011.00021

R. Liu, Xiangyuan Liu

引用次数: 0

Recent advances in the diagnosis and treatment of non-pulmonary arterial hypertension pulmonary hypertension: Recent advances in the diagnosis and treatment of non-pulmonary arterial hypertension pulmonary hypertension 非肺动脉高压诊断与治疗的最新进展:非肺动脉高压诊断与治疗的最新进展

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-10-27 DOI: 10.3724/SP.J.1264.2011.00022

Yajuan Guo, Yushun Zhang, A. Ma

引用次数: 0

Effect of tirofiban on short-term prognosis of elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention 替罗非班对经皮冠状动脉介入治疗老年急性冠脉综合征患者短期预后的影响

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00011

Lu Cai-yi

{"title":"Effect of tirofiban on short-term prognosis of elderly patients with acute coronary syndrome undergoing percutaneous coronary intervention","authors":"Lu Cai-yi","doi":"10.3724/sp.j.1264.2011.00011","DOIUrl":"https://doi.org/10.3724/sp.j.1264.2011.00011","url":null,"abstract":"Objective To evaluate the effect of tirofiban on short-term prognosis of elderly patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention(PCI).Methods Totally 325 ACS patients were divided into two groups: Tirofiban group(n = 210) and control group(n= 115).All subjects underwent PCI with drug-eluting stents.Patients in tirofiban group received tirofiban,in addition to aspirin and clopidogrel.Patients in control group received oral administration of aspirin and clopi-dogrel only.The general data,the rate of thrombolysis in myocardial infarction(TIMI) grade 3 flow immediately after PCI,the in-stent thrombosis incidence,mild and severe bleeding rate,platelet decrease rate,mortality,and incidences of myocardial infarction (MI) and target vessel revascularization(TVR) at 30 days after PCI were compared between the two groups.Results The rate of TIMI grade 3 flow immediately after PCI was significantly higher in Tirofiban group than in control group(99.05%vs 94.78%,P0.05).The in-stent thrombosis incidence was lower in Tirofiban group than in control group(0.47%vs 3.47%,P0.01).The mortality and incidences of MI and TVR at 30 days after PCI were lower in Tirofiban group than in control group(0.00%vs 2.61%,0.47%vs 3.47%,and 0.47%vs 1.73%,P0.01).The mild bleeding rate was higher in Tirofiban group than in control group,with no significant difference(7.14%vs 4.35%,P0.05).The rates of severe bleeding and platelets decrease were not significantly different between the two groups(0.00%vs 0.00%,and 0.95%vs 0.87%,P0.05).Conclusion Tirofiban can improve the TIMI grade flow in elderly patients with ACS after PCI.It can also decrease the in-stent thrombosis incidence,mortality,and incidences of MI and TVR at 30 days after PCI,but do not increase the rates of severe bleeding and platelets decrease in these patients.So it can improve the short-term prognosis in elderly patients with ACS undergoing PCI.","PeriodicalId":10086,"journal":{"name":"Chinese Journal of Multiple Organ Diseases in the Elderly","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70071345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RASAL1 expression and ras activity with gastrointestinal tumors:a review 胃肠道肿瘤中RASAL1表达及ras活性的研究进展

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00020

L. Chengyu, Xie Honghu

引用次数: 0

Gastroscopy under electrocardiographic monitoring for elderly patients with coronary heart disease 老年冠心病患者心电图监护下的胃镜检查

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00013

Fu Wanfa

{"title":"Gastroscopy under electrocardiographic monitoring for elderly patients with coronary heart disease","authors":"Fu Wanfa","doi":"10.3724/sp.j.1264.2011.00013","DOIUrl":"https://doi.org/10.3724/sp.j.1264.2011.00013","url":null,"abstract":"Objective To assess the safety of esophageal and gastric endoscopy for elderly patients with coronary heart disease (CHD) by monitoring the changes of their vital signs during operation process.Methods A total of 60 patients over 60 years old accepting esophageal and gastric endoscopy were divided into CHD group(with mild ST-T change or history of angina or old myocardial infarction but without respiratory diseases) and control group(without heart diseases),with 30 in each group.The heart rate,blood pressure,oxygen saturation(SpO_2) and electrocardiogram during performance of esophageal and gastric endoscopy were compared between the two groups.Results Heart rate was significantly increased during operation in both groups(P0.05),and the variation in CHD group was greater than that in control group(P0.05).Blood pressure was also increased in both groups(P0.05) and there was no significant difference between two groups(P0.05).SpO_2 was significantly decreased in CHD group(P0.05) during operation but with no significant difference compared with control group(P0.05).Arrhythmia,but no dangerous arrhythmia, occurred in both groups during operation.In addition,there were 6 cases with ST-T changes in CHD group and all cases recovered to normal after operation.Conclusion With full preparation before operation and electrocardiographic monitoring if necessary during operation,esophageal and gastric endoscopy is safe for elderly patients with CHD.","PeriodicalId":10086,"journal":{"name":"Chinese Journal of Multiple Organ Diseases in the Elderly","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70071887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart rate variability in patients with vascular dementia 血管性痴呆患者的心率变异性

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00008

Yang Ruijie

{"title":"Heart rate variability in patients with vascular dementia","authors":"Yang Ruijie","doi":"10.3724/sp.j.1264.2011.00008","DOIUrl":"https://doi.org/10.3724/sp.j.1264.2011.00008","url":null,"abstract":"Objective To determine the roles of heart rate variability(HRV) in evaluating cardiac autonomic nerve function of patients with vascular dementia.Methods Totally 124 patients with vascular dementia and 102 control subjects received 24h dynamic Holter monitoring to perform frequency domain measures,time domain measures and non-linear analysis of HRV. The following HRV spectral parameters were considered:total frequency power(TF),low frequency power(LF),high frequency power(HF),standard diviation of normal-to-normal intervals(SDNN),square-root of mean squared differences of successive NN intervals(RMSS),and standard deviation of SDNN(SDSD).Poincare plot descriptors included vector angle index(VAI) and vector length index(VLI).Results The time domain measures(SDNN,RMSS,SDSD),frequency domain measures(TF,LF,HF),VAI and VLI were significantly lower in patients with vascular dementia than in control subjects[SDNN:(78±28) vs(129±30)ms,RMSS: (20±8) vs(24±8)ms,SDSD:(17±7) vs(22±8)ms,P0.01;TF:(1432±621) vs(1962±583) ms~2/Hz,LF:(934±347) vs (1309±371)ms~2/Hz,HF:(473±174) vs(601±247)ms~2/Hz,P0.01;VAI:(0.54±0.14) vs(0.67±0.13)ms,VLI:(154±19) vs(194±25)ms,P0.01].There were less patients who had Poincare scatter grams in shape of comet in patients with vascular dementia than in control subjects.Conclusion We recommend to perform HRV analysis,a noninvasive mehtod,for patients with vascular dementia to evaluate the cardiac autonomic nerve function.","PeriodicalId":10086,"journal":{"name":"Chinese Journal of Multiple Organ Diseases in the Elderly","volume":"31 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70071118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Function of isletβcells in non-diabetic population with hyperinsulinemia 非糖尿病高胰岛素血症人群胰岛β细胞的功能

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00002

T. Hui

{"title":"Function of isletβcells in non-diabetic population with hyperinsulinemia","authors":"T. Hui","doi":"10.3724/sp.j.1264.2011.00002","DOIUrl":"https://doi.org/10.3724/sp.j.1264.2011.00002","url":null,"abstract":"Objective To analyze the function of islet(3 cells in population who had normal glucose tolerance(NGT) or impaired glucose regulation(IGR) with hyperinsulinemia(HINS).Methods A total of 634 adults diagnosed as NGT or IGR with HINS by 75g oral glucose tolerance test(OGTT) were included for the analysis of the islet(3 cells function.Results In HINS group,homeostasis model insulin resistance index(HOMA-IR),⊿I_(120)/⊿G_(120),the first and second phase insulin secretion index were significantly higher than those in non-HINS group of non-diabetic population(P0.05),but insulin sensitive index(ISI)-Stumvoll and HOMA beta cells function index/insulin resistance(HBCI/IR) were significantly lower(P0.05).There was no significant difference in⊿I_(120)/⊿G_(120)/IR between the two groups(P0.05).In IGR with HINS group,HBCI,HBCI/IR,and the first and second phase insulin secretion index were significantly lower than those in NGT with HINS group(P0.05).There was no significant difference in HOMA-IR and ISI-Stumvoll between the two groups(P0.05).Conclusions Although the absolute insulin secretion is increasing in the NGT or IGR population with HINS,the isletβcells function decreases gradually.NGT or IGR with HINS are the transition state in the progress of diabetes mellitus,and the early detection and interference are strongly recommended.","PeriodicalId":10086,"journal":{"name":"Chinese Journal of Multiple Organ Diseases in the Elderly","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70070557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of telmisartan on the expression of matrix metalloproteinase-13 and its tissue inhibitor-1 and insulin resistance in nonalcoholic steatohepatitis rat model 替米沙坦对非酒精性脂肪性肝炎大鼠基质金属蛋白酶-13及其组织抑制剂-1表达及胰岛素抵抗的影响

Chinese Journal of Multiple Organ Diseases in the Elderly Pub Date : 2011-01-01 DOI: 10.3724/sp.j.1264.2011.00018

Liu Jiangkui, Shen Yi-hui

{"title":"Effects of telmisartan on the expression of matrix metalloproteinase-13 and its tissue inhibitor-1 and insulin resistance in nonalcoholic steatohepatitis rat model","authors":"Liu Jiangkui, Shen Yi-hui","doi":"10.3724/sp.j.1264.2011.00018","DOIUrl":"https://doi.org/10.3724/sp.j.1264.2011.00018","url":null,"abstract":"Objective To study the effects of telmisartan on matrix metalloproteinase-13(MMP-13) and tissue inhibitor of metallo- proteinase-1(TIMP-1) expressions and insulin resistance in rat model of nonalcoholic steatohepatitis(NASH).Methods Thirty male SD rats were randomized into normal control group,NASH model group and telmisartan intervention group.The rats were given standard food in normal control group,while high fat diet for 16 weeks in the other two groups to induce NASH.In telmisartan intervention group, telmisartan[5 mg/(kg·d)]was adminstrated intragastrically for 4 weeks since the 12th week.All animals were sacrificed at 16 weeks. Serum levels of alanine aminotransferase(ALT),aspartate transaminase(AST),fasting blood glucose(FBG) and fasting insulin(FINS) were detected.Insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance(HOMA-IR).Western blot and RT-PCR were used to measure TIMP-1 and MMP-13 expressions in hepatic tissue.Histological observation and immunohistochemical staining ofα-smooth muscle actin(α-SMA) were also performed.Results Serum levels of ALT,AST,FPG,FINS and HOMA-IR were significantly higher in NASH group than in normal control group(P0.01).Compared with NASH group,serum levels of ALT,FPG, FINS and HOMA-IR decreased significantly(P0.01),and AST level also decreased,but with no significance(P0.05).Telmisartan improved significantly hepatic inflammation and fibrosis(P0.01),decreased HOMA-IR significantly(P0.01),reduced expresseions ofα-SMA and TIMP-1,and increased expressions of MMP-13 in hepatic tissue(P0.01).Conclusion Telmisartan can improve insulin resistance and prevent hepatic fibrosis in NASH rats.","PeriodicalId":10086,"journal":{"name":"Chinese Journal of Multiple Organ Diseases in the Elderly","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70071542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0