Function of isletβcells in non-diabetic population with hyperinsulinemia

中华老年多器官疾病杂志 Pub Date : 2011-01-01 DOI:10.3724/sp.j.1264.2011.00002

T. Hui

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Abstract

Objective To analyze the function of islet(3 cells in population who had normal glucose tolerance(NGT) or impaired glucose regulation(IGR) with hyperinsulinemia(HINS).Methods A total of 634 adults diagnosed as NGT or IGR with HINS by 75g oral glucose tolerance test(OGTT) were included for the analysis of the islet(3 cells function.Results In HINS group,homeostasis model insulin resistance index(HOMA-IR),⊿I_(120)/⊿G_(120),the first and second phase insulin secretion index were significantly higher than those in non-HINS group of non-diabetic population(P0.05),but insulin sensitive index(ISI)-Stumvoll and HOMA beta cells function index/insulin resistance(HBCI/IR) were significantly lower(P0.05).There was no significant difference in⊿I_(120)/⊿G_(120)/IR between the two groups(P0.05).In IGR with HINS group,HBCI,HBCI/IR,and the first and second phase insulin secretion index were significantly lower than those in NGT with HINS group(P0.05).There was no significant difference in HOMA-IR and ISI-Stumvoll between the two groups(P0.05).Conclusions Although the absolute insulin secretion is increasing in the NGT or IGR population with HINS,the isletβcells function decreases gradually.NGT or IGR with HINS are the transition state in the progress of diabetes mellitus,and the early detection and interference are strongly recommended.

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非糖尿病高胰岛素血症人群胰岛β细胞的功能

目的分析糖耐量正常(NGT)或糖调节功能受损(IGR)伴高胰岛素血症(HINS)患者胰岛3细胞的功能。方法对634例经75g口服糖耐量试验(OGTT)诊断为NGT或IGR合并HINS的成人进行胰岛3细胞功能分析。结果HINS组非糖尿病人群体内稳态模型胰岛素抵抗指数(HOMA-IR)、⊿I_(120)/⊿G_(120)、第一、二期胰岛素分泌指数均显著高于非HINS组(P0.05)，而胰岛素敏感指数(ISI)-Stumvoll、HOMA β细胞功能指数/胰岛素抵抗指数(HBCI/IR)均显著低于非HINS组(P0.05)。两组患者的⊿i(120)/⊿G_(120)/IR比较，差异无统计学意义(P0.05)。IGR合并HINS组患者HBCI、HBCI/IR及一、二期胰岛素分泌指数均显著低于NGT合并HINS组(P0.05)。两组患者HOMA-IR、ISI-Stumvoll比较，差异无统计学意义(P0.05)。结论在HINS患者中，虽然NGT或IGR人群的绝对胰岛素分泌增加，但胰岛β细胞功能逐渐下降。NGT或IGR伴HINS是糖尿病发展的过渡状态，建议早期发现并干预。

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来源期刊

中华老年多器官疾病杂志

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3039

期刊介绍： Chinese Journal of Multiple Organ Diseases in the Elderly (monthly) is a medical academic journal under the supervision of PLA General Hospital, sponsored by PLA General Hospital Medical Innovation Research Department, National Clinical Medical Research Center for Geriatric Diseases (PLA General Hospital), and Department of Cardiovascular Medicine of the Sixth Medical Center of PLA General Hospital, and publicly issued at home and abroad. This journal was founded in June 2002 and is a Chinese Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), and is included in major domestic retrieval systems and well-known domestic and foreign retrieval systems such as the American Chemical Abstracts. As the only academic journal in China that reflects multi-organ diseases in the elderly, Chinese Journal of Multiple Organ Diseases in the Elderly mainly exchanges the diagnosis and treatment experience and lessons of cardiovascular diseases in the elderly, especially cardiovascular diseases in the elderly combined with other diseases, diseases of more than two organs in the elderly, and other multiple diseases in the elderly, explores their pathogenesis and effective diagnosis and treatment measures, and focuses on reporting the latest clinical, basic and preventive achievements and experiences in the research of the above diseases in my country with innovative significance; the main readers are medical, scientific research and teaching personnel engaged in geriatric cardiology and (or) geriatric medicine and related diseases. The main columns include expert comments, special forums, clinical research, basic research, clinical pharmacy, case reports, new technologies and methods, clinical pathology discussions, reviews, academic trends, expert popular science lectures, etc.