胃肠道肿瘤中RASAL1表达及ras活性的研究进展

中华老年多器官疾病杂志 Pub Date : 2011-01-01 DOI:10.3724/sp.j.1264.2011.00020

L. Chengyu, Xie Honghu

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引用次数: 0

摘要

大约20%的人类肿瘤与ras基因突变有关。Ras蛋白控制负责细胞增殖、分化、存活和凋亡的细胞信号通路。Ras蛋白属于小gtpase大家族，在响应各种细胞外刺激时被激活。RASAL1作为ras GTPase的激活蛋白，可以抑制ras的激活。ras和RASAL1活性的调控可能引导肿瘤靶向治疗的方向。检测ras和RASAL1活性可为胃肠道肿瘤的诊断和预后提供更多相关信息。本文就ras蛋白的结构、生化特性及其突变在肿瘤中的作用作一综述。我们进一步讨论了RASAL1对ras活性的抑制作用。最后，我们对ras和RASAL1与胃肠道肿瘤的相关性进行了评论。

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RASAL1 expression and ras activity with gastrointestinal tumors:a review

Approximately 20%of human tumors are associated with mutations of ras genes.Ras proteins control cellular signaling pathways responsible for cell proliferation,differentiation,survival and apoptosis.Ras proteins belong to the large family of small GTPases,which are activated in response to various extracellular stimuli.RASAL1,as a ras GTPase activating protein,inhibits ras activation. Regulation of ras and RASAL1 activities may lead the direction of target treatment of tumors.Detection of ras and RASAL1 activities can provide more relevant information about diagnosis and prognosis of gastrointestinal tumors.In this paper,we reviewed the structure,the biochemical properties of ras proteins,and the role of its mutations in tumors.We further discussed the inhibitive effects of RASAL1 on ras activities.Finally,we commented the correlation of ras and RASAL1 with gastrointestinal tumors.

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来源期刊

中华老年多器官疾病杂志

自引率

0.00%

发文量

3039

期刊介绍： Chinese Journal of Multiple Organ Diseases in the Elderly (monthly) is a medical academic journal under the supervision of PLA General Hospital, sponsored by PLA General Hospital Medical Innovation Research Department, National Clinical Medical Research Center for Geriatric Diseases (PLA General Hospital), and Department of Cardiovascular Medicine of the Sixth Medical Center of PLA General Hospital, and publicly issued at home and abroad. This journal was founded in June 2002 and is a Chinese Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), and is included in major domestic retrieval systems and well-known domestic and foreign retrieval systems such as the American Chemical Abstracts. As the only academic journal in China that reflects multi-organ diseases in the elderly, Chinese Journal of Multiple Organ Diseases in the Elderly mainly exchanges the diagnosis and treatment experience and lessons of cardiovascular diseases in the elderly, especially cardiovascular diseases in the elderly combined with other diseases, diseases of more than two organs in the elderly, and other multiple diseases in the elderly, explores their pathogenesis and effective diagnosis and treatment measures, and focuses on reporting the latest clinical, basic and preventive achievements and experiences in the research of the above diseases in my country with innovative significance; the main readers are medical, scientific research and teaching personnel engaged in geriatric cardiology and (or) geriatric medicine and related diseases. The main columns include expert comments, special forums, clinical research, basic research, clinical pharmacy, case reports, new technologies and methods, clinical pathology discussions, reviews, academic trends, expert popular science lectures, etc.