{"title":"Canine Blood Sugar and Lactic Acid Responses to Adrenergic Amines after Ganglion Block*","authors":"R.S. McCutcheon","doi":"10.1002/jps.3030491108","DOIUrl":"https://doi.org/10.1002/jps.3030491108","url":null,"abstract":"<div><p>Since preliminary studies indicated that a ganglionic block before infusions of some adrenergic amines resulted in an increased production of blood lactic acid and blood sugar, it was postulated that this might be due to an interruption of Cori's cycle. This experiment shows that there is a significant increase in lactic acid produced by two of the drugs after blocking and an indication that two others also have this effect. The results on blood sugar were not significant. Evidence is presented here that the conversion of lactic acid to glycogen in the liver is blocked or inhibited by use of the ganglion blocking agent, mecamylamine, accounting for an accumulation of blood lactic acid under the conditions of the experiment.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 714-716"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91727652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Note on the Hydrophile-Lipophile Balance of Tragacanth*","authors":"Wallace L. Guess","doi":"10.1002/jps.3030491115","DOIUrl":"10.1002/jps.3030491115","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 736"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74520360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal chemistry. 2nd ed. Edited by Alfred Burger. Interscience Publishers, Inc., 250 Fifth Ave., New York 1, N. Y., 1960. xiii + 1243 pp. 17.5 × 25 cm. Price $37.50","authors":"","doi":"10.1002/jps.3030491127","DOIUrl":"10.1002/jps.3030491127","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 740"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134826580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oxidation-reduction potentials of organic systems. By W. Mansfield Clark. The Williams & Wilkins Co., 428 East Preston St., Baltimore 2, Md., 1960. xi + 584 pp. 15 × 23 cm. Price $13.50","authors":"","doi":"10.1002/jps.3030491129","DOIUrl":"10.1002/jps.3030491129","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 740"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134881296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herbert Sheppard, Thomas F. Mowles, Albert J. Plummer
{"title":"Determination of Hydrochlorothiazide in Urine*","authors":"Herbert Sheppard, Thomas F. Mowles, Albert J. Plummer","doi":"10.1002/jps.3030491110","DOIUrl":"https://doi.org/10.1002/jps.3030491110","url":null,"abstract":"<div><p>Hydrochlorothiazide may be determined in urine by extracting with ethyl acetate and either reacting directly with chromotropic acid or hydrolyzing first with alkali followed by diazotization and condensation with N-(1-naphthyl)-ethylene diamine hydrochloride.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 722-723"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91727650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biochemistry of plants and animals. By M. Frank Mallette, Paul M. Althouse, and Carl O. Clagett. John Wiley & Sons, Inc., 440 Fourth Ave., New York 16, N. Y., 1960. xiii + 552 pp. 15 × 23 cm. Price $8.50","authors":"","doi":"10.1002/jps.3030491135","DOIUrl":"10.1002/jps.3030491135","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 740"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491135","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134801209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Précis de chimie biologique. Vol. 2. By J. E. Courtois and R. Perlè. Masson et Cie., 120, Boulevard Saint-Germain, Paris 6e, France, 1960. viii + 620 pp. 16 × 21 cm. Price 46 NF","authors":"","doi":"10.1002/jps.3030491132","DOIUrl":"10.1002/jps.3030491132","url":null,"abstract":"","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 740"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134807725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antimicrobial Activity, In Vitro, of Chlorhexidine*","authors":"C.A. Lawrence","doi":"10.1002/jps.3030491113","DOIUrl":"https://doi.org/10.1002/jps.3030491113","url":null,"abstract":"<div><p>Comparative <em>in vitro</em> tests indicate that chlorhexidine has greater antibacterial activity than benzalkonium chloride, a combination of <em>o</em>-phenyl- and <em>p</em>-<em>tert</em>-amyl-phenol, and an iodine-polyvinylpyrrolidone complex under the test conditions. Chlorhexidine in relatively high dilutions was effective against several cultures of Gram-negative bacteria in the phenol coefficient test. In moderate concentrations, it was active against staphylococci and anaerobes.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 731-734"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91727649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isotonic Solutions XI*","authors":"Edward P. Winters , William J. Husa","doi":"10.1002/jps.3030491107","DOIUrl":"10.1002/jps.3030491107","url":null,"abstract":"<div><p>The effects of various sympathomimetic amine salts and phenothiazine derivatives in preventing hemolysis of human erythrocytes were studied. In some instances rabbit erythrocytes were used. The results indicated that in solutions of increasing concentrations of sympathomimetic amine salts, hemolysis initially decreased, then abruptly increased, followed by a second greater decrease and increase. In the presence of 0.6 per cent sodium chloride there was no hemolysis until a certain concentration of sympathomimetic amine salt was reached, which closely coincided with the concentration of the same drug that resulted in the final increase in hemolysis when sodium chloride was not present. Freezing point depressions and pH values of the compounds employed in the hemolytic method were determined. The compounds were tested for reactions with human serum and oxyhemoglobin. The phenothiazine derivatives tested were found to be unsuited for investigation by the hemolytic method.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Pages 709-713"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85678205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Note on a Revised Sugar Coating Procedure for Tablets*","authors":"S.J. Tucker, A.B. Rednick","doi":"10.1002/jps.3030491117","DOIUrl":"https://doi.org/10.1002/jps.3030491117","url":null,"abstract":"<div><p>A method is presented which describes a revised sugar coating procedure. The procedure eliminates the rounding and smoothing operations usually employed in pan-coated tablets. The resulting coating is approximately one-half as thick as the standard method and coating time is greatly reduced.</p></div>","PeriodicalId":100839,"journal":{"name":"Journal of the American Pharmaceutical Association (Scientific ed.)","volume":"49 11","pages":"Page 738"},"PeriodicalIF":0.0,"publicationDate":"1960-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jps.3030491117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91727645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}